Cubs vs Reds Prediction, Odds & Player Prop Bets Today – MLB, May 25

Cincinnati Reds' Spencer Steer runs while flying out during the fourth inning of a baseball game against the Houston Astros, Friday, June 16, 2023, in Houston.
(AP Photo/Eric Christian Smith)
  • The Cubs are -125 favorites vs the Reds
  • Cubs vs Reds Over / Under today: 9 Runs
  • Cubs / Reds TV Channel: FDOH | MARQ | MLBN

The Chicago Cubs (-135) visit Great American Ball Park to take on the Cincinnati Reds (+115) on Sunday, May 25, 2025. First pitch is scheduled for 1:40pm EDT in Cincinnati, OH.

This season, the Cubs are 31-21 against the spread (ATS), while the Reds are 29-24 ATS.

Cubs vs Reds Starting Pitchers Today:

  • Cubs starting pitcher: Ben Brown 3-3, 5.48 ERA
  • Reds starting pitcher: Nick Lodolo 4-4, 3.24 ERA

Cubs vs. Reds Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cubs-1.5 +125O 9 -110-135
Reds +1.5 -150U 9 -110+115

Cubs vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Sunday‘s MLB game with 51.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cubs players for Sunday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Bets Today:

  • Pete Crow-Armstrong has hit the Runs Over in 15 of his last 25 away games (+12.00 Units / 47% ROI)
  • Kyle Tucker has hit the RBIs Over in 10 of his last 15 away games (+11.55 Units / 77% ROI)
  • Dansby Swanson has hit the Singles Over in 14 of his last 20 games (+10.95 Units / 54% ROI)
  • Kyle Tucker has hit the Home Runs Over in 4 of his last 10 away games (+10.80 Units / 108% ROI)
  • Dansby Swanson has hit the Hits Over in 16 of his last 20 games (+9.50 Units / 28% ROI)

And here are some favorite MLB player prop bets for Reds players for Sunday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

  • Will Benson has hit the Home Runs Over in 4 of his last 5 games at home (+15.70 Units / 314% ROI)
  • Matt McLain has hit the Runs Under in 19 of his last 25 games (+10.85 Units / 28% ROI)
  • Will Benson has hit the RBIs Over in his last 5 games at home (+10.10 Units / 202% ROI)
  • Spencer Steer has hit the Hits Over in his last 10 games (+10.00 Units / 52% ROI)
  • Nick Lodolo has hit the Earned Runs Over in 9 of his last 10 games at home (+8.65 Units / 72% ROI)
  • The Chicago Cubs have hit the Team Total Over in 31 of their last 47 games (+12.05 Units / 21% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 28 of their last 50 games (+11.95 Units / 17% ROI)
  • The Chicago Cubs have hit the Game Total Over in 29 of their last 47 games (+11.60 Units / 23% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 30 of their last 48 games (+9.05 Units / 16% ROI)
  • The Chicago Cubs have hit the Moneyline in 29 of their last 46 games (+8.20 Units / 12% ROI)
  • The Cincinnati Reds have hit the Game Total Under in 22 of their last 30 games (+13.00 Units / 39% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 19 games (+6.65 Units / 30% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 5 of their last 6 games at home (+5.00 Units / 60% ROI)
  • The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 5 of their last 6 games at home (+4.30 Units / 62% ROI)
  • The Cincinnati Reds have hit the Moneyline in 5 of their last 6 games at home (+3.95 Units / 50% ROI)

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 27-25 against the Run Line (+2.22 Units / 3.45% ROI).

  • 31-21 when betting on the Moneyline for +6.1 Units / 8.36% ROI
  • 31-18 when betting on the total runs Over for +11.55 Units / 20.42% ROI
  • 18-31 when betting on the total runs Under for -16.3 Units / -28.18% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 29-24 against the Run Line (-0.45 Units / -0.61% ROI).

  • 26-27 when betting on the Moneyline for -4.75 Units / -7.23% ROI
  • 20-32 when betting on the total runs Over for -14.7 Units / -25.45% ROI
  • 32-20 when betting on the total runs Under for +9.95 Units / 16.91% ROI

Reds vs Cubs Home Run Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +350 0.5 -450
Elly De La Cruz (CIN) 0.5 +360 0.5 -500
Kyle Tucker (CHC) 0.5 +375 0.5 -500
Will Benson (CIN) 0.5 +375 0.5 -500
Austin Hays (CIN) 0.5 +425 0.5 -550

Reds vs Cubs Total Hits Prop Bets Today

Over Under
Carson Kelly (CHC) 0.5 -250 0.5 +190
Dansby Swanson (CHC) 0.5 -225 0.5 +170
Jose Trevino (CIN) 0.5 -220 0.5 +160
Austin Hays (CIN) 0.5 -210 0.5 +160
Ian Happ (CHC) 0.5 -210 0.5 +160

Reds vs Cubs RBI Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +130 0.5 -165
Carson Kelly (CHC) 0.5 +135 0.5 -185
Austin Hays (CIN) 0.5 +140 0.5 -190
Elly De La Cruz (CIN) 0.5 +150 0.5 -200
Nico Hoerner (CHC) 0.5 +155 0.5 -210

Reds vs Cubs Strikeout Prop Bets Today

Over Under
Ben Brown (CHC) 5.5 -145 5.5 +110
Nick Lodolo (CIN) 4.5 -135 4.5 +105

Ben Brown has thrown his curveball 49% of the time (201/407) with runners in scoring position since last season — highest in MLB among starting pitchers with at least 84 total CB; League Avg: 16% — 100th Percentile.

Ben Brown has thrown his curveball 48% of the time (107/223) with runners in scoring position this season — highest in MLB among starting pitchers with at least 20 total CB; League Avg: 16% — 100th Percentile.

Ben Brown has thrown his curveball 37% of the time (623/1,664) since last season — 3rd highest in MLB among starting pitchers with at least 84 total CB; League Avg: 15% — 98th Percentile.

Ben Brown has thrown his curveball 41% of the time (180/437) against right-handed batters this season — 2nd highest in MLB among starting pitchers with at least 20 total CB; League Avg: 13% — 98th Percentile.

Reds Starting Pitcher Stats & Trends

Opponents are hitting .500 (12-for-24) against Nick Lodolo on low fastballs this season — highest among qualified SPs in MLB; League Avg: .259 — first Percentile.

Nick Lodolo has allowed a slugging percentage of just .259 (21 Total Bases / 81 ABs) when going through the lineup the second time in a game this season — tied for 4th best among qualified SPs in MLB; League Avg: .374 — 96th Percentile.

Opponents are hitting .324 (134-for-413) against Nick Lodolo at home since the 2023 season — highest in MLB among starting pitchers with at least 149 total IP; League Avg: .242 — 0 Percentile.

Opponents have a line drive rate of just 15% (25/161) against Nick Lodolo when going through the lineup the third time in a game since the 2023 season — 2nd lowest in MLB among starting pitchers with at least 149 total IP; League Avg: 24% — 98th Percentile.

Cubs Keys to the Game vs. the Reds

The Cubs are 15-5 (.750) after a loss this season — best in MLB; League Avg: .492.

The Cubs are 16-11 (.593) on the road this season — tied for 2nd best in MLB; League Avg: .436.

The Cubs are 43-12 (.782) when they’ve scored in the first inning since last season — best in MLB; League Avg: .635.

The Cubs are 2-17 (.105) when trailing entering the 9th inning this season — 5th best in MLB; League Avg: .041.

Reds Keys to the Game vs. the Cubs

The Reds were just 5-16 (.238) when tied entering the 8th inning in the 2024 season — lowest in MLB; League Avg: .500.

The Reds are just 14-29 (.326) when tied entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .500.

The Reds were just 4-63 (.060) when trailing entering the 8th inning in the 2024 season — 4th lowest in MLB; League Avg: .100.

The Reds are just 6-82 (.068) when trailing entering the 7th inning since last season — 2nd lowest in MLB; League Avg: .140.

The Cubs are batting .426 on the first pitch of at-bats this season — best in MLB; League Avg: .341.

Cubs hitters have an OPS of .836 (1,088 PA’s) on the road this season — best in MLB; League Avg: .698.

Cubs hitters are slugging .488 against LHP this season — 2nd best in MLB; League Avg: .376.

Cubs hitters have struck out in just 18% of it’s PA’s against LHP this season — 2nd best in MLB; League Avg: 23%.

Reds hitters slugged just .151 on pitches out of the zone in the 2024 season — lowest in MLB; League Avg: .204.

The Reds are batting just .126 on pitches out of the zone since the 2023 season — lowest in MLB; League Avg: .150.

Reds hitters are slugging just .154 on pitches out of the zone since last season — lowest in MLB; League Avg: .203.

The Reds are batting just .214 against LHP this season — 5th lowest in MLB; League Avg: .238.

Batters facing the Cubs pitchers have struck out in the zone 46% of the time this season — 3rd lowest in MLB; League Avg: 50%. this season — 3rd lowest in MLB; League Avg: 50%.

Cubs pitchers had an ERA of 3.08 (733.0 IP) at home in the 2024 season — 2nd best in MLB; League Avg: 3.98.

Cubs pitchers have walked 9% of batters when facing the leadoff batter in the inning since last season — 2nd highest in MLB; League Avg: 8%.

Opponents have a miss rate of just 24% against Cubs pitchers since last season — tied for 4th lowest in MLB; League Avg: 25%.

Opponents have a groundball rate of just 39% against Reds pitchers since the 2023 season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 39% against Reds pitchers since last season — lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in 2023 — 2nd lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in the 2024 season — lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.