Diamondbacks vs Dodgers Prediction, Odds & Player Prop Bets Today – MLB, May 21

Los Angeles Dodgers' Max Muncy celebrates his solo home run off Tampa Bay Rays pitcher Tyler Glasnow during the second inning of a baseball game Saturday, May 27, 2023, in St. Petersburg, Fla.
(AP Photo/Chris O'Meara)
  • The Dodgers are -130 favorites vs the Diamondbacks
  • Diamondbacks vs Dodgers Over / Under today: 9 Runs
  • Diamondbacks / Dodgers TV Channel: DBTV | SNLA

The Arizona Diamondbacks (+120) visit Dodger Stadium to take on the Los Angeles Dodgers (-145) on Wednesday, May 21, 2025. First pitch is scheduled for 10:10pm EDT in Los Angeles, CA, CA.

This season, the Diamondbacks are 26-23 against the spread (ATS), while the Dodgers are 23-25 ATS.

Diamondbacks vs Dodgers Starting Pitchers Today:

  • Diamondbacks starting pitcher: Corbin Burnes 3-1, 2.58 ERA
  • Dodgers starting pitcher: Dustin May 1-4, 4.44 ERA

Diamondbacks vs. Dodgers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks+1.5 -165O 9 -105+120
Dodgers -1.5 +140U 9 -115-145

Diamondbacks vs Dodgers Prediction for Today’s Game

Based on recent trends the model predicts the Dodgers will win Wednesday‘s MLB game with 55.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Wednesday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Gabriel Moreno has hit the Home Runs Over in 3 of his last 9 games (+21.00 Units / 233% ROI)
  • Geraldo Perdomo has hit the Total Bases Over in 17 of his last 20 games (+13.40 Units / 45% ROI)
  • Geraldo Perdomo has hit the Hits Over in 17 of his last 20 games (+13.30 Units / 42% ROI)
  • Pavin Smith has hit the Runs Over in 14 of his last 25 away games (+8.65 Units / 34% ROI)
  • Corbin Burnes has hit the Walks Allowed Under in 11 of his last 15 away games (+8.50 Units / 48% ROI)

And here are some favorite MLB player prop bets for Dodgers players for Wednesday‘s game, looking at profitable historical betting trends:

Best Dodgers Player Prop Best Bets Today:

  • Andy Pages has hit the Home Runs Over in 4 of his last 9 games at home (+17.40 Units / 193% ROI)
  • Mookie Betts has hit the RBIs Over in 12 of his last 20 games (+11.75 Units / 59% ROI)
  • Shohei Ohtani has hit the Total Bases Over in 16 of his last 20 games (+11.45 Units / 46% ROI)
  • Shohei Ohtani has hit the Runs Over in 19 of his last 25 games at home (+9.65 Units / 22% ROI)
  • Michael Conforto has hit the Hits Under in 16 of his last 25 games (+9.30 Units / 37% ROI)
  • The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 21 of their last 33 games (+9.05 Units / 23% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 19 of their last 33 games (+8.40 Units / 18% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 14 of their last 20 games (+7.45 Units / 34% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 28 of their last 49 games (+4.35 Units / 8% ROI)
  • The Arizona Diamondbacks have hit the Moneyline in 10 of their last 17 away games (+4.05 Units / 21% ROI)
  • The Los Angeles Dodgers have hit the Game Total Over in 11 of their last 13 games at home (+8.80 Units / 61% ROI)
  • The Los Angeles Dodgers have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 17 games at home (+3.55 Units / 17% ROI)
  • The Los Angeles Dodgers have hit the Team Total Over in 10 of their last 16 games at home (+3.40 Units / 19% ROI)
  • The Los Angeles Dodgers have hit the Moneyline in 18 of their last 26 games at home (+0.45 Units / 1% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 23-26 against the Run Line (-7.21 Units / -11.32% ROI).

  • 26-23 when betting on the Moneyline for -1.95 Units / -2.95% ROI
  • 22-24 when betting on the total runs Over for -4.65 Units / -8.6% ROI
  • 24-22 when betting on the total runs Under for -0.4 Units / -0.74% ROI

Dodgers Against the Spread (ATS) Record

Against the spread this season, the Dodgers are 23-25 against the Run Line (-3.5 Units / -5.88% ROI).

  • 30-19 when betting on the Moneyline for -3.25 Units / -3.38% ROI
  • 28-21 when betting on the total runs Over for +5.45 Units / 10.09% ROI
  • 21-28 when betting on the total runs Under for -9.15 Units / -17.01% ROI

Dodgers vs Diamondbacks Home Run Prop Bets Today

Over Under
Shohei Ohtani (LAD) 0.5 +220 0.5 -275
Corbin Carroll (ARI) 0.5 +340 0.5 -450
Eugenio Suarez (ARI) 0.5 +375 0.5 -525
Ketel Marte (ARI) 0.5 +375 0.5 -500
Andy Pages (LAD) 0.5 +475 0.5 -700

Dodgers vs Diamondbacks Total Hits Prop Bets Today

Over Under
Shohei Ohtani (LAD) 0.5 -275 0.5 +195
Corbin Carroll (ARI) 0.5 -250 0.5 +180
Lourdes Gurriel Jr (ARI) 0.5 -250 0.5 +185
Freddie Freeman (LAD) 0.5 -250 0.5 +185
Josh Naylor (ARI) 0.5 -235 0.5 +175

Dodgers vs Diamondbacks RBI Prop Bets Today

Over Under
Shohei Ohtani (LAD) 0.5 +130 0.5 -165
Teoscar Hernandez (LAD) 0.5 +135 0.5 -185
Corbin Carroll (ARI) 0.5 +140 0.5 -185
Ketel Marte (ARI) 0.5 +150 0.5 -200
Eugenio Suarez (ARI) 0.5 +155 0.5 -210

Dodgers vs Diamondbacks Strikeout Prop Bets Today

Over Under
Corbin Burnes (ARI) 5.5 +145 5.5 -190

Corbin Burnes has located his fastball inside 70% of the time (378/543) since the 2023 season — highest among qualified SPs in MLB; League Avg: 34% — 100th Percentile.

34% of Corbin Burnes’ strikeouts are in the zone since last season — lowest among qualified SPs in MLB; League Avg: 49% — second Percentile.

Corbin Burnes threw fastballs down 63% of the time (164/262) in 2023 — highest among qualified SPs in MLB; League Avg: 27% — 100th Percentile.

Corbin Burnes had second base stolen on him 39 times in the 2024 season — most in MLB — 100th Percentile.

Dodgers Starting Pitcher Stats & Trends

Dustin May has not walked any of the 18 batters that they have faced when going through the lineup the second time in a game over the last 14 days — tied for best among NL Starters over the last two weeks; League Avg: 7% — 100th Percentile.

Left-handed hitters have a groundball rate of 57% (42/74) against Dustin May this season — 6th highest in MLB among starting pitchers with at least 18 total IP; League Avg: 42% — 95th Percentile.

Dustin May has a strikeout rate of 53% (9 SO in 17 PAs) with runners in scoring position this month (3 games) — best among qualified SPs in MLB; League Avg: 22% — 100th Percentile.

Dustin May has allowed an OPS of .991 (27 PA’s) when going through the lineup the first time in a game this month (3 games) — 8th highest among qualified SPs in MLB; League Avg: .635 — eighth Percentile.

Diamondbacks Keys to the Game vs. the Dodgers

The Diamondbacks are 154-37 (.802) when allowing 4 or fewer runs since the 2023 season — 2nd best in MLB; League Avg: .725.

The Diamondbacks are just 24-2 (.923) when leading entering the 9th inning this season — tied for 5th lowest in MLB; League Avg: .956.

The Diamondbacks were 67-15 (.807) when they allowed 4 or fewer runs in the 2024 season — 3rd best in MLB; League Avg: .723.

The Diamondbacks are 56-39 (.589) after a loss since last season — 5th best in MLB; League Avg: .501.

Dodgers Keys to the Game vs. the Diamondbacks

The Dodgers are 192-35 (.846) when allowing 4 or fewer runs since the 2023 season — best in MLB; League Avg: .725.

The Dodgers are 17-4 (.810) when tied entering the 7th inning since last season — best in MLB; League Avg: .499.

The Dodgers were 15-3 (.833) when tied entering the 8th inning in the 2024 season — best in MLB; League Avg: .500.

The Dodgers are 27-14 (.659) when tied entering the 7th inning since the 2023 season — best in MLB; League Avg: .499.

Diamondbacks hitters have struck out in just 17% of it’s PA’s against LHP this season — best in MLB; League Avg: 23%.

The Diamondbacks are batting .277 against LHP since last season — best in MLB; League Avg: .244.

The Diamondbacks batted .284 against LHP in the 2024 season — best in MLB; League Avg: .245.

Diamondbacks hitters have an OBP of .347 (4,069 PA’s) at home since last season — best in MLB; League Avg: .317.

Dodgers hitters are slugging .461 against LHP since the 2023 season — 2nd best in MLB; League Avg: .404.

Dodgers hitters have an OBP of .340 (10,431 PA’s) against RHP since the 2023 season — best in MLB; League Avg: .316.

Dodgers hitters are slugging .453 since last season — best in MLB; League Avg: .398.

Dodgers hitters are slugging .496 against LHP this season — 2nd best in MLB; League Avg: .375.

The Diamondbacks pitchers have allowed their opponents to score first in just 40% of their games since last season — lowest in MLB; League Avg: 50%.

Opponents had a miss rate of just 24% against Diamondbacks pitchers in the 2024 season — tied for 4th lowest in MLB; League Avg: 25%.

Diamondbacks pitchers had an ERA of 4.68 (739.0 IP) at home in the 2024 season — 3rd highest in MLB; League Avg: 3.98.

Diamondbacks pitchers have a in-zone of just 48% this season — 2nd lowest in MLB; League Avg: 51%.

The Dodgers have won 42% of games in which their opponents scored first since the 2023 season — highest in MLB; League Avg: 33%.

Dodgers pitchers walked 454 of 6,018 batters (7%) in 2023 — 5th best in MLB; League Avg: 9%.

The Dodgers have won 48% of home games in which their opponents scored first since the 2023 season — 2nd highest in MLB; League Avg: 37%.

Dodgers pitchers have a strikeout rate of 24% this season — tied for 5th best in MLB; League Avg: 22%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.