Giants vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, May 5

Chicago Cubs' Ian Happ watches his grand slam off Pittsburgh Pirates starting pitcher Mitch Keller during the fifth inning of a baseball game Wednesday, Sept. 20, 2023, in Chicago. (AP Photo/Charles Rex Arbogast)
(AP Photo/Charles Rex Arbogast)
  • The Cubs are -150 favorites vs the Giants
  • Giants vs Cubs Over / Under today: 7.5 Runs
  • Giants / Cubs TV Channel: MARQ | NSBA

The San Francisco Giants (+135) visit Wrigley Field to take on the Chicago Cubs (-160) on Monday, May 5, 2025. First pitch is scheduled for 7:40pm EDT in Chicago, IL.

This season, the Giants are 22-13 against the spread (ATS), while the Cubs are 19-16 ATS.

Giants vs Cubs Starting Pitchers Today:

  • Giants starting pitcher: Landen Roupp 2-2, 5.16 ERA
  • Cubs starting pitcher: Matthew Boyd 2-2, 2.68 ERA

Giants vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Giants+1.5 -170O 7.5 -118+135
Cubs -1.5 +140U 7.5 -102-160

Giants vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Monday‘s MLB game with 55.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Giants vs Cubs and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

  • Heliot Ramos has hit the Runs Over in 11 of his last 15 away games (+11.10 Units / 73% ROI)
  • Heliot Ramos has hit the Home Runs Over in 2 of his last 4 games (+10.10 Units / 253% ROI)
  • Jung Hoo Lee has hit the Hits Over in 13 of his last 15 away games (+10.00 Units / 31% ROI)
  • Matt Chapman has hit the Total Bases Under in 15 of his last 20 away games (+9.15 Units / 33% ROI)
  • Matt Chapman has hit the RBIs Under in 19 of his last 25 games (+9.10 Units / 20% ROI)

And here are some favorite MLB player prop bets for Cubs players for Monday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • Pete Crow-Armstrong has hit the Runs Over in 15 of his last 25 games (+14.35 Units / 57% ROI)
  • Pete Crow-Armstrong has hit the Home Runs Over in 2 of his last 5 games at home (+12.50 Units / 250% ROI)
  • Ian Happ has hit the Hits Over in 19 of his last 25 games (+9.95 Units / 23% ROI)
  • Kyle Tucker has hit the RBIs Over in 9 of his last 15 games (+9.30 Units / 62% ROI)
  • Ian Happ has hit the Singles Over in 16 of his last 25 games (+9.25 Units / 36% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 17 games (+6.55 Units / 31% ROI)
  • The San Francisco Giants have hit the Team Total Over in 11 of their last 16 away games (+6.00 Units / 34% ROI)
  • The San Francisco Giants have hit the Moneyline in 21 of their last 33 games (+5.60 Units / 12% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 11 of their last 17 away games (+3.90 Units / 19% ROI)
  • The San Francisco Giants have hit the Game Total Over in 5 of their last 15 away games (+2.70 Units / 16% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 25 of their last 31 games (+18.65 Units / 51% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 23 of their last 33 games (+17.25 Units / 40% ROI)
  • The Chicago Cubs have hit the Team Total Over in 20 of their last 30 games (+8.60 Units / 25% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 29 games (+7.75 Units / 23% ROI)
  • The Chicago Cubs have hit the Moneyline in 19 of their last 29 games (+7.75 Units / 21% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 17-18 against the Run Line (+0.15 Units / 0.33% ROI).

  • 22-13 when betting on the Moneyline for +5.55 Units / 10.96% ROI
  • 20-14 when betting on the total runs Over for +4.65 Units / 8.12% ROI
  • 14-20 when betting on the total runs Under for -8.25 Units / -14.08% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 19-16 against the Run Line (+4.4 Units / 10.07% ROI).

  • 21-14 when betting on the Moneyline for +5.65 Units / 13.09% ROI
  • 20-13 when betting on the total runs Over for +6 Units / 11.5% ROI
  • 13-20 when betting on the total runs Under for -9.35 Units / -16.94% ROI

Cubs vs Giants Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +425 0.5 -600
Willy Adames (SF) 0.5 +525 0.5 -750
Heliot Ramos (SF) 0.5 +575 0.5 -900
Seiya Suzuki (CHC) 0.5 +675 0.5 -1100
Kyle Tucker (CHC) 0.5 +675 0.5 -1100

Cubs vs Giants Total Hits Prop Bets Today

Over Under
Nico Hoerner (CHC) 0.5 -235 0.5 +180
Jung-hoo Lee (SF) 0.5 -210 0.5 +160
Heliot Ramos (SF) 0.5 -200 0.5 +155
Kyle Tucker (CHC) 0.5 -185 0.5 +140
Ian Happ (CHC) 0.5 -185 0.5 +140

Cubs vs Giants RBI Prop Bets Today

Over Under
Nico Hoerner (CHC) 0.5 +160 0.5 -210
Michael Busch (CHC) 0.5 +165 0.5 -220
Carson Kelly (CHC) 0.5 +175 0.5 -235
Matt Chapman (SF) 0.5 +175 0.5 -225
Seiya Suzuki (CHC) 0.5 +180 0.5 -235

Cubs vs Giants Strikeout Prop Bets Today

Over Under
Landen Roupp (SF) 4.5 -135 4.5 +105
Matthew Boyd (CHC) 5.5 -120 5.5 -105

Landen Roupp threw his curveball 37% of the time (80/214) when behind in the count in the 2024 season — 2nd highest among qualified RPs in MLB*; League Avg: 11% — 98th Percentile.

Left-handed hitters had a swing rate of just 37% (175/470) against Landen Roupp in the 2024 season — lowest among qualified RPs in MLB*; League Avg: 48% — first Percentile.

Landen Roupp has thrown his curveball 41% of the time (220/531) this season — highest in MLB among starting pitchers with at least 13 total CB; League Avg: 15% — 100th Percentile.

Left-handed hitters had a swing rate of just 37% (175/470) against Landen Roupp in the 2024 season — lowest among NL Relievers; League Avg: 48% — first Percentile.

Cubs Starting Pitcher Stats & Trends

Matthew Boyd has thrown his changeup 33% of the time (38/114) when he’s behind in the count this season — highest among among NL Starters; League Avg: 15% — 100th Percentile.

Matthew Boyd has allowed an OBP of .338 (74 PA’s) with two-strikes this season — 3rd highest among qualified SPs in MLB; League Avg: .238 — third Percentile.

Opponents are hitting .246 (16-for-65) against Matthew Boyd with two-strikes this season — 4th highest among qualified SPs in MLB; League Avg: .165 — fourth Percentile.

Opponents are hitting .294 (15-for-51) against Matthew Boyd when going through the lineup the second time in a game this season — 10th highest among qualified SPs in MLB; League Avg: .231 — 12th Percentile.

Giants Keys to the Game vs. the Cubs

The Giants are 3-10 (.231) when trailing entering the 8th inning this season — best in MLB; League Avg: .082.

The Giants are 149-5 (.968) when leading entering the 9th inning since the 2023 season — 5th best in MLB; League Avg: .950.

The Giants are 1-12 (.077) when trailing entering the 9th inning this season — tied for 5th best in MLB; League Avg: .039.

The Giants are 7-1 (.875) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .741.

Cubs Keys to the Game vs. the Giants

The Cubs are 10-3 (.769) after a loss this season — best in MLB; League Avg: .501.

The Cubs are 12-7 (.632) on the road this season — 2nd best in MLB; League Avg: .418.

The Cubs are 1-11 (.083) when trailing entering the 9th inning this season — 4th best in MLB; League Avg: .039.

The Cubs are just 0-8 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .123.

Giants hitters had an OBP of just .299 (4,384 PA’s) against RHP in the 2024 season — tied for 3rd lowest in MLB; League Avg: .311.

Giants hitters slugged just .376 against LHP in the 2023 season — 3rd lowest in MLB; League Avg: .419.

Giants hitters have an OPS of just .695 (9,615 PA’s) against RHP since the 2023 season — 5th lowest in MLB; League Avg: .721.

The Giants are batting just .130 on pitches out of the zone since last season — 2nd lowest in MLB; League Avg: .150.

Cubs hitters have struck out in just 17% of it’s PA’s against LHP this season — 2nd best in MLB; League Avg: 23%.

Cubs hitters are slugging .513 against LHP this season — best in MLB; League Avg: .373.

Cubs hitters have an OPS of .879 (341 PA’s) against LHP this season — best in MLB; League Avg: .683.

Cubs hitters have an OPS of .836 (773 PA’s) on the road this season — best in MLB; League Avg: .686.

Opponents had a groundball rate of 50% against Giants pitchers in 2023 — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2023 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 39% against Cubs pitchers this season — 4th lowest in MLB; League Avg: 43%.

Opponents have a miss rate of just 24% against Cubs pitchers this season — tied for 5th lowest in MLB; League Avg: 25%.

Cubs pitchers induced opposing hitters to ground into just 80 double plays in 1,126 opportunities (7%) in the 2024 season — 2nd lowest in MLB; League Avg: 10%.

Opponents had a groundball batting average of just .220 against Cubs pitchers in 2023 — 2nd best in MLB; League Avg: .248.

More MLB Reading:


Bet now on Giants vs Cubs and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

Split First Bet Offer FBO March Matchups 1080x610
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.