Giants vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, May 6

Chicago Cubs' Nico Hoerner watches his RBI sacrifice fly during the fifth inning of a baseball game against the Colorado Rockies Saturday, Sept. 23, 2023, in Chicago. Chicago won 6-3. (AP Photo/Paul Beaty)
(AP Photo/Paul Beaty)
  • The Cubs are -155 favorites vs the Giants
  • Giants vs Cubs Over / Under today: 8 Runs
  • Giants / Cubs TV Channel: MARQ | NSBA

The San Francisco Giants (+125) visit Wrigley Field to take on the Chicago Cubs (-155) on Tuesday, May 6, 2025. First pitch is scheduled for 7:40pm EDT in Chicago, IL, IL.

This season, the Giants are 22-14 against the spread (ATS), while the Cubs are 20-16 ATS.

Giants vs Cubs Starting Pitchers Today:

  • Giants starting pitcher: Justin Verlander 0-2, 4.34 ERA
  • Cubs starting pitcher: Colin Rea 2-0, 1.46 ERA

Giants vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Giants+1.5 -175O 8 -102+125
Cubs -1.5 +145U 8 -118-155

Giants vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Cubs will win Tuesday‘s MLB game with 57.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

  • Luis Matos has hit the Home Runs Over in 2 of his last 4 games (+17.50 Units / 438% ROI)
  • Matt Chapman has hit the RBIs Under in 19 of his last 25 games (+9.10 Units / 20% ROI)
  • Heliot Ramos has hit the Runs Over in 10 of his last 15 away games (+8.75 Units / 58% ROI)
  • Matt Chapman has hit the Total Bases Under in 14 of his last 20 away games (+7.15 Units / 26% ROI)
  • Matt Chapman has hit the Singles Under in 12 of his last 15 games (+6.95 Units / 28% ROI)

And here are some favorite MLB player prop bets for Cubs players for Tuesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • Pete Crow-Armstrong has hit the Home Runs Over in 3 of his last 7 games (+17.90 Units / 256% ROI)
  • Pete Crow-Armstrong has hit the Runs Over in 15 of his last 25 games (+13.85 Units / 55% ROI)
  • Nico Hoerner has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+10.80 Units / 38% ROI)
  • Ian Happ has hit the Hits Over in 16 of his last 20 games (+10.55 Units / 30% ROI)
  • Michael Busch has hit the Singles Under in 20 of his last 25 games at home (+10.35 Units / 22% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 18 games (+5.25 Units / 23% ROI)
  • The San Francisco Giants have hit the Team Total Over in 11 of their last 17 away games (+5.00 Units / 27% ROI)
  • The San Francisco Giants have hit the Moneyline in 21 of their last 34 games (+4.60 Units / 9% ROI)
  • The San Francisco Giants have hit the Game Total Over in their last 5 away games (+3.00 Units / 58% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 11 of their last 18 away games (+2.75 Units / 12% ROI)
  • The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 26 of their last 32 games (+19.65 Units / 52% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 24 of their last 34 games (+18.25 Units / 41% ROI)
  • The Chicago Cubs have hit the Team Total Over in 21 of their last 31 games (+9.60 Units / 26% ROI)
  • The Chicago Cubs have covered the Run Line in 18 of their last 30 games (+9.00 Units / 25% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 30 games (+8.75 Units / 25% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 17-19 against the Run Line (-1.35 Units / -2.91% ROI).

  • 22-14 when betting on the Moneyline for +4.55 Units / 8.81% ROI
  • 21-14 when betting on the total runs Over for +5.65 Units / 9.69% ROI
  • 14-21 when betting on the total runs Under for -9.45 Units / -15.8% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 20-16 against the Run Line (+5.7 Units / 12.75% ROI).

  • 22-14 when betting on the Moneyline for +6.65 Units / 14.81% ROI
  • 21-13 when betting on the total runs Over for +7 Units / 13.16% ROI
  • 13-21 when betting on the total runs Under for -10.55 Units / -18.7% ROI

Cubs vs Giants Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +340 0.5 -450
Seiya Suzuki (CHC) 0.5 +350 0.5 -450
Willy Adames (SF) 0.5 +360 0.5 -500
Kyle Tucker (CHC) 0.5 +400 0.5 -525
Carson Kelly (CHC) 0.5 +425 0.5 -625

Cubs vs Giants Total Hits Prop Bets Today

Over Under
Jung-hoo Lee (SF) 0.5 -275 0.5 +195
Nico Hoerner (CHC) 0.5 -225 0.5 +170
Seiya Suzuki (CHC) 0.5 -210 0.5 +160
Kyle Tucker (CHC) 0.5 -210 0.5 +160
Willy Adames (SF) 0.5 -200 0.5 +155

Cubs vs Giants RBI Prop Bets Today

Over Under
Seiya Suzuki (CHC) 0.5 +135 0.5 -175
Matt Chapman (SF) 0.5 +150 0.5 -200
Carson Kelly (CHC) 0.5 +165 0.5 -220
Kyle Tucker (CHC) 0.5 +170 0.5 -225
Ian Happ (CHC) 0.5 +170 0.5 -225

Cubs vs Giants Strikeout Prop Bets Today

Over Under
Justin Verlander (SF) 4.5 -120 4.5 -105
Colin Rea (CHC) 4.5 -120 4.5 -110

Opponents had a groundball batting average of .398 (33 GB hits out of 83 GBs) against Justin Verlander in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: .245 — 0 Percentile.

Opponents had a line drive rate of 35% (47/135) versus Justin Verlander on non-fastballs in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 23% — 0 Percentile.

Opponents are hitting .393 (11-for-28) against Justin Verlander with runners in scoring position this season — highest among qualified SPs in MLB; League Avg: .242 — first Percentile.

Justin Verlander has walked 14% of left-handed batters this season — tied for 4th highest among qualified SPs in MLB; League Avg: 8% — seventh Percentile.

Cubs Starting Pitcher Stats & Trends

Opponents had a miss rate of just 19% (240/1,241) against Colin Rea in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 26% — third Percentile.

Colin Rea had a strikeout rate of just 17% (50/285) when going through the lineup the first time in a game in the 2024 season — 2nd lowest among qualified SPs in MLB; League Avg: 25% — third Percentile.

Opponents batted .278 (72-for-259) against Colin Rea when going through the lineup the first time in a game in the 2024 season — 5th highest among qualified SPs in MLB; League Avg: .231 — eighth Percentile.

Colin Rea allowed a slugging percentage of .447 (293 Total Bases / 656 ABs) in the 2024 season — 5th highest among qualified SPs in MLB; League Avg: .390 — eighth Percentile.

Giants Keys to the Game vs. the Cubs

The Giants are 3-10 (.231) when trailing entering the 8th inning this season — best in MLB; League Avg: .082.

The Giants are 7-1 (.875) when they’ve had 10 or more hits this season — 5th best in MLB; League Avg: .741.

The Giants were just 20-24 (.455) vs bottom 10 scoring offenses in the 2024 season They play the Reds (16th best runs scored) today.

The Giants are 5-3 (.625) vs top 10 scoring offenses this season They play the Cubs (12th best runs scored) today.

Cubs Keys to the Game vs. the Giants

The Cubs are 10-3 (.769) after a loss this season — best in MLB; League Avg: .501.

The Cubs are 12-7 (.632) on the road this season — 2nd best in MLB; League Avg: .418.

The Cubs are just 0-8 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .123.

The Cubs are 80-49 (.620) vs bottom 10 scoring offenses since the 2023 season They play the Giants (17th best runs scored) today.

The Giants batted just .151 with two-strikes in the 2023 season — 2nd lowest in MLB; League Avg: .172.

Giants hitters had an OBP of just .307 (1,790 PA’s) against LHP in the 2023 season — 5th lowest in MLB; League Avg: .323.

Giants hitters had an OBP of just .232 (3,303 PA’s) with two-strikes in 2023 — 2nd lowest in MLB; League Avg: .249.

The Giants are batting just .129 on pitches out of the zone since last season — 2nd lowest in MLB; League Avg: .150.

Cubs hitters are slugging .513 against LHP this season — best in MLB; League Avg: .372.

Cubs hitters have struck out in just 17% of it’s PA’s against LHP this season — 2nd best in MLB; League Avg: 23%.

Cubs hitters have an OPS of .879 (341 PA’s) against LHP this season — best in MLB; League Avg: .681.

Cubs hitters are slugging .497 on the road this season — best in MLB; League Avg: .378.

Opponents had a groundball rate of 50% against Giants pitchers in 2023 — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2023 season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB; League Avg: 43%.

Batters facing the Cubs pitchers have struck out in the zone 45% of the time this season — 2nd lowest in MLB; League Avg: 51%. this season — 2nd lowest in MLB; League Avg: 51%.

Batters facing the Cubs pitchers have struck out in the zone 48% of the time since the 2023 season — tied for 2nd lowest in MLB; League Avg: 49%. since the 2023 season — tied for 2nd lowest in MLB; League Avg: 49%.

Cubs pitchers induced opposing hitters to ground into just 80 double plays in 1,126 opportunities (7%) in the 2024 season — 2nd lowest in MLB; League Avg: 10%.

Opponents have a groundball rate of just 39% against Cubs pitchers this season — 4th lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.