Guardians vs Angels Prediction, Odds & Player Prop Bets Today – MLB, Apr 6

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  • The Guardians are -110 favorites vs the Angels
  • Guardians vs Angels Over / Under today: 9 Runs
  • Guardians / Angels TV Channel: FDW | GDTV | MLBN

The Cleveland Guardians (-115) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (-105) on Sunday, April 6, 2025. First pitch is scheduled for 4:07pm EDT in Anaheim, CA.

This season, the Guardians are 3-5 against the spread (ATS), while the Angels are 3-5 ATS.

Guardians vs Angels Starting Pitchers Today:

  • Guardians starting pitcher: Luis Ortiz 0-1, 14.55 ERA
  • Angels starting pitcher: Tyler Anderson 0-0, 5.79 ERA

Guardians vs. Angels Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +145O 9 -105-115
Angels +1.5 -175U 9 -115-105

Guardians vs Angels Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 52.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Jose Ramirez has hit the Home Runs Over in 4 of his last 10 away games (+13.40 Units / 134% ROI)
  • Lane Thomas has hit the Hits Over in 17 of his last 20 away games (+11.80 Units / 30% ROI)
  • Steven Kwan has hit the Hits Runs and RBIs Over in 13 of his last 15 away games (+11.15 Units / 61% ROI)
  • Lane Thomas has hit the Runs Under in his last 10 away games (+10.00 Units / 54% ROI)
  • Steven Kwan has hit the Singles Over in 13 of his last 15 away games (+9.70 Units / 41% ROI)

And here are some favorite MLB player prop bets for Angels players for Sunday‘s game, looking at profitable historical betting trends:

Best Angels Player Prop Best Bets Today:

  • Logan O’Hoppe has hit the Home Runs Over in 4 of his last 6 games (+19.70 Units / 328% ROI)
  • Mike Trout has hit the RBIs Over in his last 5 games (+8.20 Units / 164% ROI)
  • Nolan Schanuel has hit the Runs Over in 5 of his last 6 games (+7.10 Units / 118% ROI)
  • Nolan Schanuel has hit the Hits Runs and RBIs Over in his last 6 games (+6.95 Units / 109% ROI)
  • Nolan Schanuel has hit the Total Bases Over in his last 6 games (+6.90 Units / 81% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 47 of their last 79 games (+17.00 Units / 19% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games (+5.60 Units / 69% ROI)
  • The Cleveland Guardians have hit the Moneyline in 87 of their last 157 games (+5.20 Units / 3% ROI)
  • The Cleveland Guardians have covered the Run Line in 23 of their last 43 games (+3.45 Units / 6% ROI)
  • The Los Angeles Angels have hit the Team Total Under in 21 of their last 32 games at home (+8.15 Units / 21% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Over in 19 of their last 29 games (+8.05 Units / 23% ROI)
  • The Los Angeles Angels have hit the Game Total Under in 30 of their last 56 games at home (+7.35 Units / 12% ROI)
  • The Los Angeles Angels have covered the Run Line in 34 of their last 61 games at home (+6.05 Units / 8% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 4-4 against the Run Line (-1.2 Units / -9.76% ROI).

  • 3-5 when betting on the Moneyline for -2.05 Units / -23.3% ROI
  • 5-3 when betting on the total runs Over for +1.85 Units / 21.14% ROI
  • 3-5 when betting on the total runs Under for -2.4 Units / -27.12% ROI

Angels Against the Spread (ATS) Record

Against the spread this season, the Angels are 3-5 against the Run Line (-3.35 Units / -30.59% ROI).

  • 5-3 when betting on the Moneyline for +2.15 Units / 22.63% ROI
  • 6-2 when betting on the total runs Over for +3.8 Units / 42.46% ROI
  • 2-6 when betting on the total runs Under for -4.45 Units / -51.45% ROI

Angels vs Guardians Home Run Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +320 0.5 -400
Jhonkensy Noel (CLE) 0.5 +360 0.5 -500
Mike Trout (LAA) 0.5 +400 0.5 -525
Carlos Santana (CLE) 0.5 +425 0.5 -625
Lane Thomas (CLE) 0.5 +475 0.5 -700

Angels vs Guardians Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -275 0.5 +200
Luis Rengifo (LAA) 0.5 -235 0.5 +180
Taylor Ward (LAA) 0.5 -220 0.5 +165
Steven Kwan (CLE) 0.5 -210 0.5 +160
Nolan Schanuel (LAA) 0.5 -190 0.5 +140

Angels vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +150 0.5 -200
Mike Trout (LAA) 0.5 +155 0.5 -200
Carlos Santana (CLE) 0.5 +155 0.5 -210
Jorge Soler (LAA) 0.5 +155 0.5 -210
Lane Thomas (CLE) 0.5 +170 0.5 -225

Luis Ortiz had a strike rate of just 61% (238/391) when he’s behind in the count in 2023 — 3rd lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 69% — second Percentile.

Luis Ortiz has allowed an OBP of .500 (26 PA’s) this season — tied for 4th highest in MLB among starting pitchers with at least 2 total IP; League Avg: .307 — third Percentile.

Opponents batted just .263 (62-for-236) against Luis Ortiz in non-two strike counts in the 2024 season — tied for best in MLB among starting pitchers with at least 64 total IP; League Avg: .330 — 100th Percentile.

Luis Ortiz has allowed an OPS of 1.261 (15 PA’s) vs left-handed batters this season — 3rd highest in MLB among starting pitchers with at least 2 total IP; League Avg: .737 — third Percentile.

Angels Starting Pitcher Stats & Trends

Tyler Anderson has thrown his changeup 33% of the time (263/787) on the first pitch of at-bats since last season — highest among qualified SPs in MLB; League Avg: 12% — 100th Percentile.

Tyler Anderson threw his changeup 32% of the time (199/629) on the first pitch of at-bats in 2023 — highest in MLB among starting pitchers with at least 64 total CH; League Avg: 10% — 100th Percentile.

Tyler Anderson threw his changeup 34% of the time (257/765) on the first pitch of at-bats in the 2024 season — highest among qualified SPs in MLB; League Avg: 12% — 100th Percentile.

Tyler Anderson has thrown his changeup 35% of the time (768/2,174) in non-two strike counts since last season — highest among qualified SPs in MLB; League Avg: 17% — 100th Percentile.

Guardians Keys to the Game vs. the Angels

The Guardians were 54-38 (.587) after a win in the 2024 season — 3rd best in MLB; League Avg: .496.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

The Guardians were 25-2 (.926) when they had 5 or more XBH in the 2024 season — 4th best in MLB; League Avg: .809.

Angels Keys to the Game vs. the Guardians

The Angels are just 119-13 (.902) when leading entering the 9th inning since last season — 3rd lowest in MLB; League Avg: .950.

The Angels were just 32-49 (.395) at home in the 2024 season — 3rd lowest in MLB; League Avg: .521.

The Angels were just 11-37 (.229) when their opponents score in the first inning in the 2024 season — 2nd lowest in MLB; League Avg: .359.

The Angels were just 39-59 (.398) after a loss in the 2024 season — 2nd lowest in MLB; League Avg: .504.

Guardians hitters have put just 34% of balls in play to the left side of the field since the 2023 season — lowest in MLB; League Avg: 38%.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

Guardians hitters have put 41% of balls in play to the right side of the field since the 2023 season — highest in MLB; League Avg: 37%.

The Guardians have an average Exit Velocity of 87.6 MPH since the 2023 season — lowest in MLB; League Avg: 88.9.

Angels hitters have an OPS of 2.505 (11 PA’s) against pitchers who have thrown at least 80 pitches in a game this season — best in MLB; League Avg: .731.

The Angels have scored first in just 30% of their home games since the 2023 season — lowest in MLB; League Avg: 44%.

The Angels had a winning percentage of just 40% at home last season — 3rd lowest in MLB; League Avg: 52%.

The Angels scored first in just 25% of their home games last season — lowest in MLB; League Avg: 44%.

Opponents have a groundball batting average of just .211 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

Opponents have a groundball batting average of just .229 against Guardians pitchers with runners on base since the 2023 season — best in MLB; League Avg: .261.

Angels pitchers walked 135 of 1,436 batters (9%) when facing the leadoff batter in the inning in the 2024 season — highest in MLB; League Avg: 7%.

Angels pitchers have walked 139 of 1,509 batters (9%) when facing the leadoff batter in the inning since last season — highest in MLB; League Avg: 8%.

Angels pitchers walked 150 of 1,434 batters (10%) when facing the leadoff batter in the inning in 2023 — highest in MLB; League Avg: 8%.

Angels pitchers have walked 289 of 2,943 batters (10%) when facing the leadoff batter in the inning since the 2023 season — highest in MLB; League Avg: 8%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.