Guardians vs Nationals Prediction, Odds & Player Prop Bets Today – MLB, May 6

(AP Photo/Terrance Williams)
  • The Guardians are -120 favorites vs the Nationals
  • Guardians vs Nationals Over / Under today: 9 Runs
  • Guardians / Nationals TV Channel: GDTV | MAS2

The Cleveland Guardians (-118) visit Nationals Park to take on the Washington Nationals (-102) on Tuesday, May 6, 2025. First pitch is scheduled for 6:55pm EDT in Washington, DC.

This season, the Guardians are 20-14 against the spread (ATS), while the Nationals are 18-17 ATS.

Guardians vs Nationals Starting Pitchers Today:

  • Guardians starting pitcher: Luis Ortiz 2-3, 4.79 ERA
  • Nationals starting pitcher: Jake Irvin 2-1, 4.08 ERA

Guardians vs. Nationals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +140O 9.5 -120-118
Nationals +1.5 -170U 9.5 +100-102

Guardians vs Nationals Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 53.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Daniel Schneemann has hit the Home Runs Over in 3 of his last 9 away games (+23.00 Units / 256% ROI)
  • Steven Kwan has hit the Total Bases Over in 18 of his last 25 away games (+14.95 Units / 49% ROI)
  • Steven Kwan has hit the Singles Over in 21 of his last 25 away games (+14.55 Units / 38% ROI)
  • Steven Kwan has hit the Hits Runs and RBIs Over in 20 of his last 25 away games (+14.30 Units / 46% ROI)
  • Steven Kwan has hit the Hits Over in 18 of his last 25 away games (+11.45 Units / 25% ROI)

And here are some favorite MLB player prop bets for Nationals players for Tuesday‘s game, looking at profitable historical betting trends:

Best Nationals Player Prop Best Bets Today:

  • James Wood has hit the Home Runs Over in 4 of his last 10 games at home (+16.90 Units / 169% ROI)
  • CJ Abrams has hit the Hits Over in his last 10 games (+10.00 Units / 51% ROI)
  • James Wood has hit the Total Bases Over in 18 of his last 25 games at home (+9.15 Units / 24% ROI)
  • Nate Lowe has hit the Walks Under in 12 of his last 15 games at home (+8.50 Units / 38% ROI)
  • Dylan Crews has hit the Hits Runs and RBIs Under in his last 7 games (+7.00 Units / 73% ROI)
  • The Cleveland Guardians have hit the Moneyline in 17 of their last 25 games (+10.15 Units / 34% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 18 away games (+5.55 Units / 25% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 19 of their last 31 games (+5.40 Units / 14% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 4 of their last 6 away games (+2.85 Units / 44% ROI)
  • The Cleveland Guardians have hit the Game Total Over in 5 of their last 16 away games (+2.70 Units / 16% ROI)
  • The Washington Nationals have hit the Team Total Over in 13 of their last 16 games at home (+10.10 Units / 52% ROI)
  • The Washington Nationals have hit the Moneyline in 9 of their last 14 games at home (+7.00 Units / 49% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 15 games at home (+6.65 Units / 36% ROI)
  • The Washington Nationals have covered the Run Line in 17 of their last 28 games (+6.50 Units / 19% ROI)
  • The Washington Nationals have hit the 1st Five Innings (F5) Moneyline in 10 of their last 16 games at home (+6.10 Units / 36% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 17-17 against the Run Line (-3.75 Units / -7.68% ROI).

  • 20-14 when betting on the Moneyline for +7 Units / 17.52% ROI
  • 17-15 when betting on the total runs Over for +0.85 Units / 1.56% ROI
  • 15-17 when betting on the total runs Under for -3.5 Units / -6.37% ROI

Nationals Against the Spread (ATS) Record

Against the spread this season, the Nationals are 18-17 against the Run Line (-0.35 Units / -0.81% ROI).

  • 16-19 when betting on the Moneyline for +0.35 Units / 0.96% ROI
  • 17-17 when betting on the total runs Over for -1.4 Units / -2.53% ROI
  • 17-17 when betting on the total runs Under for -1.7 Units / -3.02% ROI

Nationals vs Guardians Home Run Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +320 0.5 -400
Kyle Manzardo (CLE) 0.5 +333 0.5 -450
Carlos Santana (CLE) 0.5 +400 0.5 -550
CJ Abrams (WAS) 0.5 +400 0.5 -525
Bo Naylor (CLE) 0.5 +425 0.5 -600

Nationals vs Guardians Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -250 0.5 +185
CJ Abrams (WAS) 0.5 -225 0.5 +175
Luis Garcia (WAS) 0.5 -220 0.5 +165
Keibert Ruiz (WAS) 0.5 -210 0.5 +155
Alex Call (WAS) 0.5 -200 0.5 +150

Nationals vs Guardians RBI Prop Bets Today

Over Under
Kyle Manzardo (CLE) 0.5 +135 0.5 -175
Jose Ramirez (CLE) 0.5 +135 0.5 -175
Nathaniel Lowe (WAS) 0.5 +150 0.5 -200
Keibert Ruiz (WAS) 0.5 +155 0.5 -210
Carlos Santana (CLE) 0.5 +160 0.5 -210

Nationals vs Guardians Strikeout Prop Bets Today

Over Under
Jake Irvin (WAS) 4.5 +100 4.5 -130

Opponents have a miss rate of just 7% (4/62) against Ben Lively with runners in scoring position this season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.

Opponents have a groundball rate of just 31% (35/112) against Ben Lively this season — 5th lowest among qualified SPs in MLB; League Avg: 43% — fifth Percentile.

Luis Ortiz has walked 12% of batters when going through the lineup the first time in a game since the 2023 season — 3rd highest in MLB among starting pitchers with at least 142 total IP; League Avg: 8% — second Percentile.

Opponents have a miss rate of just 7% (4/62) against Ben Lively with runners in scoring position this season — lowest among among AL Starters; League Avg: 25% — second Percentile.

Nationals Starting Pitcher Stats & Trends

Jake Irvin has thrown his curveball 34% of the time (37/110) when he’s behind in the count this season — 2nd highest among among NL Starters; League Avg: 10% — 96th Percentile.

Jake Irvin has thrown his curveball 39% of the time (244/631) this season — 2nd highest among qualified SPs in MLB; League Avg: 16% — 98th Percentile.

Right-handed hitters had a chase rate of just 20% (102/502) against Jake Irvin in 2023 — lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 30% — 0 Percentile.

Jake Irvin has thrown his curveball 37% of the time (64/173) on the first pitch of at-bats this season — highest among among NL Starters; League Avg: 16% — 100th Percentile.

Guardians Keys to the Game vs. the Nationals

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians are 87-3 (.967) when leading entering the 7th inning since last season — best in MLB; League Avg: .860.

The Guardians were just 3-61 (.047) when trailing entering the 8th inning in the 2024 season — 2nd lowest in MLB; League Avg: .100.

The Guardians are just 4-74 (.051) when trailing entering the 8th inning since last season — 3rd lowest in MLB; League Avg: .097.

Nationals Keys to the Game vs. the Guardians

The Nationals are 2-18 (.100) when trailing entering the 9th inning this season — 3rd best in MLB; League Avg: .039.

The Nationals are just 52-86 (.377) vs top 10 scoring offenses since the 2023 season They play the Guardians (14th best runs scored) today.

The Nationals were just 20-43 (.317) vs top 10 scoring offenses in the 2024 season They play the Dodgers (second best runs scored) today.

The Nationals are just 48-160 (.231) when scoring 4 or fewer runs since the 2023 season — tied for 5th lowest in MLB; League Avg: .273.

The Guardians batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

Guardians hitters have put just 34% of balls in play to the left side of the field since the 2023 season — lowest in MLB; League Avg: 38%.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

The Guardians have barrels in 4% of PA’s since the 2023 season (479/13,268) — lowest in MLB; League Avg: 5%.

The Nationals batted just .226 when facing the starting pitcher for the 3rd time in a game in the 2024 season — 2nd lowest in MLB; League Avg: .263.

Nationals hitters struck out just 340 times in 1,868 PA’s (18%) against LHP in 2023 — tied for best in MLB; League Avg: 23%.

Nationals hitters put 39% of their swings in play on pitches 95 mph or greater in 2023 — highest in MLB; League Avg: 34%.

Nationals hitters averaged just 3.76 pitches per plate appearance in 2023 — lowest in MLB; League Avg: 3.90.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

Opponents have a groundball batting average of just .220 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Opponents had a miss rate of just 23% against Nationals pitchers in 2023 — 3rd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 24% against Nationals pitchers since the 2023 season — 3rd lowest in MLB; League Avg: 26%.

Nationals pitchers have a strikeout rate of just 41% with two-strikes since last season — 5th lowest in MLB; League Avg: 42%.

Nationals pitchers allowed an OBP of .372 (1,428 PA’s) when facing the leadoff batter in the inning in 2023 — 2nd highest in MLB; League Avg: .316.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.