Guardians vs Reds Prediction, Odds & Player Prop Bets Today – MLB, May 17

Cincinnati Reds' Spencer Steer runs while flying out during the fourth inning of a baseball game against the Houston Astros, Friday, June 16, 2023, in Houston.
(AP Photo/Eric Christian Smith)
  • The Guardians are -130 favorites vs the Reds
  • Guardians vs Reds Over / Under today: 9.5 Runs
  • Guardians / Reds TV Channel: FDOH | GDTV

The Cleveland Guardians (-130) visit Great American Ball Park to take on the Cincinnati Reds (+105) on Saturday, May 17, 2025. First pitch is scheduled for 6:40pm EDT in Cincinnati, OH.

This season, the Guardians are 25-19 against the spread (ATS), while the Reds are 25-21 ATS.

Guardians vs Reds Starting Pitchers Today:

  • Guardians starting pitcher: Slade Cecconi 0-0, 0.00 ERA
  • Reds starting pitcher: Brent Suter 1-0, 2.05 ERA

Guardians vs. Reds Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +125O 10 -118-130
Reds +1.5 -155U 10 -102+105

Guardians vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Saturday‘s MLB game with 54.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Saturday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Luis Ortiz has hit the Walks Allowed Over in 5 of his last 6 games (+5.25 Units / 74% ROI)
  • Luis Ortiz has hit the Hits Allowed Under in 4 of his last 6 games (+2.60 Units / 39% ROI)
  • Luis Ortiz has hit the Strikeouts Over in 4 of his last 6 games (+2.25 Units / 32% ROI)
  • Luis Ortiz has hit the Earned Runs Over in 3 of his last 4 away games (+2.05 Units / 49% ROI)
  • Luis Ortiz has hit the Pitching Outs Under in 3 of his last 4 away games (+1.45 Units / 26% ROI)

And here are some favorite MLB player prop bets for Reds players for Saturday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

  • No trends found

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 22-22 against the Run Line (-3.35 Units / -5.51% ROI).

  • 25-19 when betting on the Moneyline for +6.3 Units / 12.28% ROI
  • 21-20 when betting on the total runs Over for -0.5 Units / -1.04% ROI
  • 20-21 when betting on the total runs Under for -2.95 Units / -6.05% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 25-21 against the Run Line (-1.65 Units / -2.55% ROI).

  • 22-24 when betting on the Moneyline for -4.95 Units / -8.65% ROI
  • 18-27 when betting on the total runs Over for -11.45 Units / -22.81% ROI
  • 27-18 when betting on the total runs Under for +7.05 Units / 13.82% ROI

Reds vs Guardians Home Run Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +310 0.5 -400
Austin Hays (CIN) 0.5 +320 0.5 -400
Jhonkensy Noel (CLE) 0.5 +340 0.5 -450
Carlos Santana (CLE) 0.5 +350 0.5 -450
Elly De La Cruz (CIN) 0.5 +360 0.5 -500

Reds vs Guardians Total Hits Prop Bets Today

Over Under
Gabriel Arias (CLE) 0.5 -250 0.5 +195
Elly De La Cruz (CIN) 0.5 -235 0.5 +175
Austin Hays (CIN) 0.5 -225 0.5 +170
Angel Martรญnez (CLE) 0.5 -220 0.5 +165
Gavin Lux (CIN) 0.5 -200 0.5 +150

Reds vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +110 0.5 -140
Austin Hays (CIN) 0.5 +120 0.5 -160
Carlos Santana (CLE) 0.5 +120 0.5 -155
Elly De La Cruz (CIN) 0.5 +145 0.5 -190
Kyle Manzardo (CLE) 0.5 +150 0.5 -200

Reds vs Guardians Strikeout Prop Bets Today

Over Under
Brent Suter (CIN) 1.5 +185 1.5 -250

Slade Cecconi had an ERA of 6.66 (77.0 IP)in the 2024 season — 3rd highest in MLB among starting pitchers with at least 64 total IP; League Avg: 3.97 — first Percentile.

Opponents had a groundball batting average of .345 (29 GB hits out of 84 GBs) against Slade Cecconi in the 2024 season — 3rd highest in MLB among starting pitchers with at least 64 total IP; League Avg: .245 — first Percentile.

Slade Cecconi allowed a slugging percentage of .527 (165 Total Bases / 313 ABs) in the 2024 season — 6th highest in MLB among starting pitchers with at least 64 total IP; League Avg: .404 — third Percentile.

Slade Cecconi struck out just 16% (26/164) of left-handed batters he faced in the 2024 season — 10th lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 22% — seventh Percentile.

Reds Starting Pitcher Stats & Trends

Brent Suter has an average fastball velocity of just 86.8 MPH since the 2023 season — 3rd lowest among qualified RPs in MLB; League Avg: 94.6 — first Percentile.

Brent Suter had an average fastball velocity of just 86.4 MPH in the 2024 season — 3rd lowest among qualified RPs in MLB; League Avg: 94.7 — first Percentile.

Brent Suter has an average fastball velocity of just 86.5 MPH since last season — 2nd lowest among NL Relievers; League Avg: 94.8 — second Percentile.

Brent Suter has picked-off 5 runners while trailing since the 2023 season — most among qualified RPs in MLB — 100th Percentile.

Guardians Keys to the Game vs. the Reds

The Guardians are 92-3 (.968) when leading entering the 7th inning since last season — best in MLB; League Avg: .861.

The Guardians are 98-2 (.980) when leading entering the 8th inning since last season — best in MLB; League Avg: .902.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians are 13-2 (.867) vs bottom 10 scoring offenses this season They play the Reds (16th best runs scored) today.

Reds Keys to the Game vs. the Guardians

The Reds are just 14-29 (.326) when tied entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .500.

The Reds are just 10-20 (.333) when tied entering the 7th inning since last season — tied for 2nd lowest in MLB; League Avg: .499.

The Reds are just 6-80 (.070) when trailing entering the 7th inning since last season — 3rd lowest in MLB; League Avg: .139.

The Reds are just 0-19 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .045.

The Guardians are batting just .293 in hitter’s counts since last season — lowest in MLB; League Avg: .335.

Guardians hitters struck out just 791 times in 4,186 PA’s (19%) against RHP in 2023 — best in MLB; League Avg: 23%.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

Guardians hitters struck out just 1,142 times in 6,096 PA’s (19%) in the 2023 season — best in MLB; League Avg: 23%.

The Reds are batting just .117 on pitches out of the zone since last season — lowest in MLB; League Avg: .150.

The Reds are batting just .126 on pitches out of the zone since the 2023 season — lowest in MLB; League Avg: .150.

The Reds are batting just .224 against LHP since last season — 3rd lowest in MLB; League Avg: .244.

Reds hitters are slugging just .154 on pitches out of the zone since last season — lowest in MLB; League Avg: .203.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a groundball batting average of just .223 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .263.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents have a groundball rate of just 39% against Reds pitchers since the 2023 season — lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in 2023 — 2nd lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in the 2024 season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 38% against Reds pitchers this season — 2nd lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.