Houston Astros vs Los Angeles Angels Prediction, Odds & Player Prop Bets Today – MLB, Jun 21

  • The Houston Astros are -105 favorites vs the Los Angeles Angels
  • Houston Astros vs Los Angeles Angels Over / Under today: 8.5 Runs
  • Houston Astros / Los Angeles Angels TV Channel: FDW | SCHN

The Houston Astros (-105) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (-115) on Saturday, June 21, 2025. First pitch is scheduled for 9:38pm EDT in Anaheim, CA.

This season, the Houston Astros are 44-32 against the spread (ATS), while the Los Angeles Angels are 38-37 ATS.

Houston Astros vs Los Angeles Angels Starting Pitchers Today:

  • Houston Astros starting pitcher: , ERA
  • Los Angeles Angels starting pitcher: , ERA

Houston Astros vs. Los Angeles Angels Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Houston Astros-1.5 +155O 8.5 -120-105
Los Angeles Angels +1.5 -190U 8.5 +100-115

Houston Astros vs Los Angeles Angels Prediction for Today’s Game

Based on recent trends the model predicts the will win Saturday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Houston Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Houston Astros Player Prop Bets Today:

  • Mauricio Dubon has hit the Home Runs Over in 3 of his last 10 away games (+25.00 Units / 250% ROI)
  • Jeremy Pena has hit the Hits Over in 17 of his last 25 games (+16.35 Units / 51% ROI)
  • Jake Meyers has hit the Singles Over in 19 of his last 25 away games (+12.40 Units / 43% ROI)
  • Christian Walker has hit the Total Bases Under in 15 of his last 20 games (+9.65 Units / 34% ROI)
  • Jeremy Pena has hit the Runs Over in 14 of his last 20 games (+8.15 Units / 37% ROI)

And here are some favorite MLB player prop bets for Los Angeles Angels players for Saturday‘s game, looking at profitable historical betting trends:

Best Los Angeles Angels Player Prop Best Bets Today:

  • Nolan Schanuel has hit the Home Runs Over in 2 of his last 6 games (+16.00 Units / 267% ROI)
  • Taylor Ward has hit the Singles Under in 20 of his last 25 games at home (+12.25 Units / 33% ROI)
  • Taylor Ward has hit the Hits Under in 14 of his last 25 games at home (+10.15 Units / 41% ROI)
  • Jo Adell has hit the Runs Over in 12 of his last 20 games (+9.10 Units / 46% ROI)
  • Jose Soriano has hit the Walks Allowed Over in 11 of his last 15 games (+7.55 Units / 36% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 24 of their last 33 away games (+15.35 Units / 40% ROI)
  • The Houston Astros have hit the Team Total Under in 46 of their last 76 games (+12.90 Units / 14% ROI)
  • The Houston Astros have hit the Moneyline in 27 of their last 41 games (+11.30 Units / 21% ROI)
  • The Houston Astros have covered the Run Line in 38 of their last 68 games (+10.87 Units / 13% ROI)
  • The Houston Astros have hit the Game Total Under in 27 of their last 43 games (+10.85 Units / 23% ROI)
  • The Los Angeles Angels have hit the Moneyline in 24 of their last 44 games (+13.05 Units / 28% ROI)
  • The Los Angeles Angels have covered the Run Line in 22 of their last 33 games (+10.00 Units / 24% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 17 games (+7.15 Units / 35% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 21 of their last 46 games (+6.30 Units / 13% ROI)
  • The Los Angeles Angels have hit the Game Total Under in 15 of their last 25 games (+6.15 Units / 22% ROI)

Houston Astros Against the Spread (ATS) Record

Against the spread this season, the Houston Astros are 40-36 against the Run Line (+6.22 Units / 6.57% ROI).

  • 44-32 when betting on the Moneyline for +5.3 Units / 5.28% ROI
  • 30-43 when betting on the total runs Over for -16.95 Units / -20.36% ROI
  • 43-30 when betting on the total runs Under for +10.1 Units / 12.02% ROI

Los Angeles Angels Against the Spread (ATS) Record

Against the spread this season, the Los Angeles Angels are 38-37 against the Run Line (-8.45 Units / -8.41% ROI).

  • 36-39 when betting on the Moneyline for +5.9 Units / 7.16% ROI
  • 37-35 when betting on the total runs Over for -1.58 Units / -1.91% ROI
  • 35-37 when betting on the total runs Under for -5.52 Units / -6.71% ROI

Los Angeles Angels vs Houston Astros Home Run Prop Bets Today

Over Under
Jo Adell (LAA) 0.5 +340 0.5 -450
Mike Trout (LAA) 0.5 +350 0.5 -450
Zach Neto (LAA) 0.5 +375 0.5 -500
Taylor Ward (LAA) 0.5 +400 0.5 -550
Logan O'Hoppe (LAA) 0.5 +425 0.5 -625

Los Angeles Angels vs Houston Astros Total Hits Prop Bets Today

Over Under
Jose Altuve (HOU) 0.5 -275 0.5 +200
Mike Trout (LAA) 0.5 -235 0.5 +180
Cam Smith (HOU) 0.5 -235 0.5 +180
Mauricio Dubon (HOU) 0.5 -220 0.5 +160
Taylor Ward (LAA) 0.5 -220 0.5 +165

Los Angeles Angels vs Houston Astros RBI Prop Bets Today

Over Under
Mike Trout (LAA) 0.5 +150 0.5 -200
Taylor Ward (LAA) 0.5 +150 0.5 -200
Yainer Diaz (HOU) 0.5 +155 0.5 -210
Zach Neto (LAA) 0.5 +165 0.5 -220
Jo Adell (LAA) 0.5 +170 0.5 -220

Los Angeles Angels vs Houston Astros Strikeout Prop Bets Today

Over Under
Josรฉ Soriano (LAA) 4.5 -118 4.5 -110

starting pitcher – away

Los Angeles Angels Starting Pitcher Stats & Trends

starting pitcher – home

Houston Astros Keys to the Game vs. the Los Angeles Angels

keys to the game – away

Los Angeles Angels Keys to the Game vs. the Houston Astros

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.