Mariners vs White Sox Prediction, Odds & Player Prop Bets Today – MLB, May 21

Chicago White Sox's watches the flight of the ball during a baseball game against the Los Angeles Angels Wednesday, May 31, 2023, in Chicago.
(AP Photo/Charles Rex Arbogast)
  • The Mariners are -150 favorites vs the White Sox
  • Mariners vs White Sox Over / Under today: 8 Runs
  • Mariners / White Sox TV Channel: RTNW | CHSN

The Seattle Mariners (-150) visit Rate Field to take on the Chicago White Sox (+125) on Wednesday, May 21, 2025. First pitch is scheduled for 2:10pm EDT in Chicago, IL, IL.

This season, the Mariners are 27-20 against the spread (ATS), while the White Sox are 25-24 ATS.

Mariners vs White Sox Starting Pitchers Today:

  • Mariners starting pitcher: Logan Evans 2-1, 2.53 ERA
  • White Sox starting pitcher: Shane Smith 1-3, 2.02 ERA

Mariners vs. White Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Mariners-1.5 +110O 8.5 -115-150
White Sox +1.5 -130U 8.5 -105+125

Mariners vs White Sox Prediction for Today’s Game

Based on recent trends the model predicts the Mariners will win Wednesday‘s MLB game with 56.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Mariners players for Wednesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

  • Rowdy Tellez has hit the Home Runs Over in 3 of his last 6 away games (+17.60 Units / 293% ROI)
  • J.P. Crawford has hit the Singles Over in 20 of his last 25 games (+17.35 Units / 63% ROI)
  • J.P. Crawford has hit the Hits Over in 22 of his last 25 games (+16.65 Units / 38% ROI)
  • J.P. Crawford has hit the Total Bases Over in 18 of his last 25 games (+11.60 Units / 35% ROI)
  • Dylan Moore has hit the Runs Over in 13 of his last 20 away games (+10.90 Units / 52% ROI)

And here are some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Best Bets Today:

  • Josh Rojas has hit the Runs Under in 14 of his last 15 games (+11.85 Units / 35% ROI)
  • Miguel Vargas has hit the Home Runs Over in 3 of his last 8 games (+10.15 Units / 127% ROI)
  • Andrew Vaughn has hit the Hits Over in 13 of his last 15 games at home (+9.45 Units / 33% ROI)
  • Shane Smith has hit the Earned Runs Under in his last 8 games (+8.65 Units / 77% ROI)
  • Josh Rojas has hit the Total Bases Under in 7 of his last 8 games (+7.40 Units / 91% ROI)
  • The Seattle Mariners have hit the Moneyline in 14 of their last 19 away games (+10.40 Units / 47% ROI)
  • The Seattle Mariners have hit the Team Total Over in 26 of their last 41 games (+9.35 Units / 20% ROI)
  • The Seattle Mariners have covered the Run Line in 21 of their last 35 games (+7.90 Units / 18% ROI)
  • The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Over in 25 of their last 41 games (+7.70 Units / 16% ROI)
  • The Seattle Mariners have hit the Game Total Over in 22 of their last 35 games (+7.60 Units / 20% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 18 of their last 26 games (+10.60 Units / 37% ROI)
  • The Chicago White Sox have hit the Team Total Under in 27 of their last 42 games (+10.00 Units / 20% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games (+8.20 Units / 17% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 11 of their last 23 games at home (+8.05 Units / 34% ROI)
  • The Chicago White Sox have hit the Game Total Under in 10 of their last 15 games (+5.65 Units / 34% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 25-22 against the Run Line (+3.2 Units / 5.41% ROI).

  • 27-20 when betting on the Moneyline for +2.85 Units / 4.55% ROI
  • 25-20 when betting on the total runs Over for +2.9 Units / 5.64% ROI
  • 20-25 when betting on the total runs Under for -7.82 Units / -15.03% ROI

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 25-24 against the Run Line (-1.25 Units / -2.2% ROI).

  • 15-34 when betting on the Moneyline for -10.36 Units / -21.1% ROI
  • 21-25 when betting on the total runs Over for -6.65 Units / -12.29% ROI
  • 25-21 when betting on the total runs Under for +1.95 Units / 3.63% ROI

White Sox vs Mariners Home Run Prop Bets Today

Over Under
Cal Raleigh (SEA) 0.5 +220 0.5 -275
Jorge Polanco (SEA) 0.5 +350 0.5 -450
Rowdy Tellez (SEA) 0.5 +375 0.5 -525
Julio Rodriguez (SEA) 0.5 +375 0.5 -500
Randy Arozarena (SEA) 0.5 +425 0.5 -600

White Sox vs Mariners Total Hits Prop Bets Today

Over Under
Julio Rodriguez (SEA) 0.5 -275 0.5 +195
Jorge Polanco (SEA) 0.5 -235 0.5 +175
Cal Raleigh (SEA) 0.5 -225 0.5 +175
J.P. Crawford (SEA) 0.5 -220 0.5 +165
Leody Taveras (SEA) 0.5 -210 0.5 +155

White Sox vs Mariners RBI Prop Bets Today

Over Under
Cal Raleigh (SEA) 0.5 +100 0.5 -130
Julio Rodriguez (SEA) 0.5 +155 0.5 -210
Jorge Polanco (SEA) 0.5 +155 0.5 -210
Randy Arozarena (SEA) 0.5 +180 0.5 -235
Rowdy Tellez (SEA) 0.5 +180 0.5 -235

White Sox vs Mariners Strikeout Prop Bets Today

Over Under
Logan Evans (SEA) 3.5 -110 3.5 -120
Shane Smith (CWS) 5.5 +145 5.5 -190

Logan Evans has a first-pitch strike rate of just 45% (21/47) in his last two starts — 2nd lowest in MLB over the last two weeks; League Avg: 63% — second Percentile.

Logan Evans has a first-pitch strike rate of just 45% (21/47) over the last 14 days — lowest among AL Starters over the last two weeks; League Avg: 64% — second Percentile.

Opponents have a swing rate of just 13% (6/47) against Logan Evans on the first pitch of at-bats in his last two starts — lowest in MLB over the last two weeks; League Avg: 32% — first Percentile.

Opponents have a swing rate of just 13% (6/47) against Logan Evans on the first pitch of at-bats over the last 14 days — lowest among AL Starters over the last two weeks; League Avg: 33% — second Percentile.

White Sox Starting Pitcher Stats & Trends

Opponents are hitting just .101 (9-for-89) against Shane Smith with two-strikes this season — 2nd best among among AL Starters; League Avg: .165 — 97th Percentile.

Shane Smith has allowed a slugging percentage of just .169 (15 Total Bases / 89 ABs) with two-strikes this season — 3rd best among among AL Starters; League Avg: .256 — 95th Percentile.

Shane Smith has a in-zone of 56% (416/737) this season — 4th best among qualified SPs in MLB; League Avg: 51% — 96th Percentile.

Right-handed hitters have a miss rate of 32% (56/176) against Shane Smith this season — 9th best among qualified SPs in MLB; League Avg: 25% — 89th Percentile.

Mariners Keys to the Game vs. the White Sox

The Mariners are 3-17 (.150) when trailing entering the 9th inning this season — best in MLB; League Avg: .043.

The Mariners are 20-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .909.

The Mariners are 171-3 (.983) when leading entering the 9th inning since the 2023 season — best in MLB; League Avg: .950.

The Mariners are 90-16 (.849) when they’ve had 10 or more hits since the 2023 season — best in MLB; League Avg: .739.

White Sox Keys to the Game vs. the Mariners

The White Sox were just 26-95 (.215) after a loss in the 2024 season — lowest in MLB; League Avg: .504.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox were just 23-58 (.284) at home in the 2024 season — lowest in MLB; League Avg: .521.

The White Sox are just 46-26 (.639) when leading entering the 7th inning since last season — lowest in MLB; League Avg: .860.

The Mariners are batting just .226 when facing the starting pitcher for the 3rd time in a game since the 2023 season — lowest in MLB; League Avg: .264.

The Mariners batted just .207 when facing the starting pitcher for the 3rd time in a game in the 2024 season — lowest in MLB; League Avg: .263.

The Mariners are batting just .209 when facing the starting pitcher for the 3rd time in a game since last season — lowest in MLB; League Avg: .262.

The Mariners are batting just .214 at home since last season — lowest in MLB; League Avg: .246.

White Sox hitters have an OBP of just .284 (10,256 PA’s) against RHP since the 2023 season — lowest in MLB; League Avg: .316.

White Sox hitters had an OBP of just .278 (5,869 PA’s) in the 2024 season — lowest in MLB; League Avg: .312.

White Sox hitters have an OBP of just .285 (13,613 PA’s) since the 2023 season — lowest in MLB; League Avg: .316.

The White Sox have a winning percentage of just 35% at home since the 2023 season — lowest in MLB; League Avg: 53%.

Mariners pitchers walked 76 of 1,441 batters (5%) when facing the leadoff batter in the inning in the 2024 season — best in MLB; League Avg: 7%.

Mariners pitchers allowed an OBP of just .251 (1,441 PA’s) when facing the leadoff batter in the inning in the 2024 season — best in MLB; League Avg: .305.

Mariners pitchers have allowed an OBP of just .262 (1,868 PA’s) when facing the leadoff batter in the inning since last season — best in MLB; League Avg: .307.

Mariners pitchers allowed an OBP of just .276 (5,788 PA’s) in the 2024 season — best in MLB; League Avg: .312.

White Sox pitchers have won only 7% of games in which they have allowed their opponent to score in three different innings since last season — lowest in MLB; League Avg: 26%.

In games when their opponents have scored three or more runs in an inning, the White Sox have won just just 4% of the time since last season — lowest in MLB; League Avg: 24%.

White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.

White Sox pitchers have won only 12% of games in which they have allowed their opponent to score in three different innings since the 2023 season — lowest in MLB; League Avg: 27%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.