- The Cardinals are -135 favorites vs the Royals
- Royals vs Cardinals Over / Under today: 8.5 Runs
- Royals / Cardinals TV Channel: FDMW | FDKC
The Kansas City Royals (+105) visit Busch Stadium to take on the St. Louis Cardinals (-125) on Wednesday, June 4, 2025. First pitch is scheduled for 7:45pm EDT in St. Louis, MO, MO.
This season, the Royals are 32-29 against the spread (ATS), while the Cardinals are 35-25 ATS.
Royals vs Cardinals Starting Pitchers Today:
- Royals starting pitcher: Noah Cameron 2-1, 1.05 ERA
- Cardinals starting pitcher: Miles Mikolas 4-2, 3.88 ERA
Royals vs. Cardinals Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Royals | +1.5 -220 | O 8 +100 | +105 |
| Cardinals | -1.5 +165 | U 8 -120 | -125 |
Royals vs Cardinals Prediction for Today’s Game
Based on recent trends the model predicts the Cardinals will win Wednesday‘s MLB game with 54.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
Bet now on Royals vs Cardinals and all games with BetMGM
We’ve highlighted some favorite MLB player prop bets for Royals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Royals Player Prop Bets Today:
- Salvador Perez has hit the Runs Under in 22 of his last 25 games (+15.95 Units / 37% ROI)
- Vinnie Pasquantino has hit the Singles Over in 20 of his last 25 games (+15.20 Units / 56% ROI)
- Vinnie Pasquantino has hit the Hits Over in 20 of his last 25 games (+10.95 Units / 22% ROI)
- Maikel Garcia has hit the Hits Runs and RBIs Over in 12 of his last 15 games (+8.50 Units / 45% ROI)
- Nick Loftin has hit the Home Runs Over in 1 of his last 4 games (+8.00 Units / 200% ROI)
And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today:
- Alec Burleson has hit the Home Runs Over in 3 of his last 10 games at home (+15.40 Units / 154% ROI)
- Alec Burleson has hit the Total Bases Over in 17 of his last 25 games (+11.05 Units / 33% ROI)
- Nolan Arenado has hit the Hits Under in 12 of his last 20 games (+10.35 Units / 52% ROI)
- Ivan Herrera has hit the Runs Under in his last 8 games (+8.00 Units / 59% ROI)
- Victor Scott II has hit the Singles Over in 10 of his last 15 games at home (+7.95 Units / 53% ROI)
Royals Best Bets Today:
- The Kansas City Royals have hit the Team Total Under in 44 of their last 61 games (+26.80 Units / 38% ROI)
- The Kansas City Royals have hit the Game Total Under in 35 of their last 53 games (+16.20 Units / 28% ROI)
- The Kansas City Royals have covered the Run Line in 15 of their last 17 away games (+12.10 Units / 44% ROI)
- The Kansas City Royals have hit the Moneyline in 24 of their last 39 games (+11.20 Units / 22% ROI)
- The Kansas City Royals have covered the 1st Five Innings (F5) Run Line in 14 of their last 17 away games (+10.25 Units / 48% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have covered the Run Line in 20 of their last 27 games (+14.20 Units / 40% ROI)
- The St. Louis Cardinals have hit the Moneyline in 24 of their last 37 games (+11.45 Units / 27% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 19 of their last 28 games at home (+9.57 Units / 30% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 20 games at home (+4.98 Units / 21% ROI)
- The St. Louis Cardinals have hit the Game Total Over in 9 of their last 15 games at home (+4.60 Units / 28% ROI)
Royals Against the Spread (ATS) Record
Against the spread this season, the Royals are 32-29 against the Run Line (-6.1 Units / -6.87% ROI).
- 32-29 when betting on the Moneyline for +3.7 Units / 4.9% ROI
- 22-38 when betting on the total runs Over for -19.22 Units / -28.94% ROI
- 38-22 when betting on the total runs Under for +13.7 Units / 20.21% ROI
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 35-25 against the Run Line (+5.4 Units / 6.46% ROI).
- 33-27 when betting on the Moneyline for +5.8 Units / 8.5% ROI
- 32-25 when betting on the total runs Over for +4.5 Units / 6.83% ROI
- 25-32 when betting on the total runs Under for -10.4 Units / -15.72% ROI
Cardinals vs Royals Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Bobby Witt Jr. (KC) | 0.5 +375 | 0.5 -500 |
| Willson Contreras (STL) | 0.5 +400 | 0.5 -550 |
| Nolan Arenado (STL) | 0.5 +450 | 0.5 -625 |
| Salvador Perez (KC) | 0.5 +475 | 0.5 -700 |
| Vinnie Pasquantino (KC) | 0.5 +475 | 0.5 -650 |
Cardinals vs Royals Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Salvador Perez (KC) | 0.5 -275 | 0.5 +200 |
| Vinnie Pasquantino (KC) | 0.5 -275 | 0.5 +195 |
| Willson Contreras (STL) | 0.5 -250 | 0.5 +185 |
| Jonathan India (KC) | 0.5 -250 | 0.5 +190 |
| Ivan Herrera (STL) | 0.5 -250 | 0.5 +190 |
Cardinals vs Royals RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Vinnie Pasquantino (KC) | 0.5 +125 | 0.5 -160 |
| Willson Contreras (STL) | 0.5 +135 | 0.5 -185 |
| Nolan Arenado (STL) | 0.5 +145 | 0.5 -190 |
| Bobby Witt Jr. (KC) | 0.5 +145 | 0.5 -190 |
| Ivan Herrera (STL) | 0.5 +145 | 0.5 -190 |
Cardinals vs Royals Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Miles Mikolas (STL) | 2.5 -160 | 2.5 +125 |
| Noah Cameron (KC) | 3.5 -118 | 3.5 -110 |
Royals Starting Pitcher Stats & Trends
Noah Cameron has induced opposing hitters to ground into 3 double plays in 10 opportunities (30%) this season — 2nd best in MLB among starting pitchers with at least 23 total IP; League Avg: 10% — 99th Percentile.
Noah Cameron has allowed an OPS of just .437 (98 PA’s) this season — best in MLB among starting pitchers with at least 23 total IP; League Avg: .706 — 100th Percentile.
Noah Cameron has thrown inside pitches 44% of the time (148/334) this season — 2nd highest in MLB among starting pitchers with at least 23 total IP; League Avg: 30% — 99th Percentile.
Noah Cameron has allowed a slugging percentage of just .222 (20 Total Bases / 90 ABs) this season — best in MLB among starting pitchers with at least 23 total IP; League Avg: .397 — 100th Percentile.
Cardinals Starting Pitcher Stats & Trends
Opponents had a two strike miss rate of just 14% (74/529) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.
Right-handed hitters have a miss rate of just 15% (134/896) against Miles Mikolas since last season — lowest among qualified SPs in MLB; League Avg: 27% — second Percentile.
Opponents batted .307 (104-for-339) against Miles Mikolas’ non-fastballs in the 2024 season — highest among qualified SPs in MLB; League Avg: .217 — first Percentile.
Opponents had a miss rate of just 16% (221/1,347) against Miles Mikolas in the 2024 season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.
Royals Keys to the Game vs. the Cardinals
The Royals were just 4-50 (.074) when they allowed 5 or more runs in the 2024 season — 2nd lowest in MLB; League Avg: .196.
The Royals are just 7-65 (.097) when allowing 5 or more runs since last season — 2nd lowest in MLB; League Avg: .192.
The Royals are just 27-142 (.160) when allowing 5 or more runs since the 2023 season — 5th lowest in MLB; League Avg: .204.
The Royals are 21-1 (.955) when leading entering the 7th inning this season — 2nd best in MLB; League Avg: .865.
Cardinals Keys to the Game vs. the Royals
The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.
The Cardinals are just 6-83 (.067) when trailing entering the 8th inning since last season — 5th lowest in MLB; League Avg: .098.
The Cardinals are just 10-160 (.059) when trailing entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .099.
The Cardinals are just 0-19 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .095.
Royals Hitting Stats & Trends
Royals hitters had an OBP of just .280 (2,958 PA’s) on the road in 2023 — lowest in MLB; League Avg: .316.
Royals hitters struck out just 298 times in 1,502 PA’s (20%) against LHP in the 2024 season — tied for 3rd best in MLB; League Avg: 23%.
Royals hitters have struck out in just 19% of it’s PA’s since last season — 2nd best in MLB; League Avg: 22%.
Royals hitters have struck out in just 18% of it’s PA’s against RHP this season — best in MLB; League Avg: 21%.
Cardinals Hitting Stats & Trends
Cardinals hitters have an OBP of .324 (10,627 PA’s) against RHP since the 2023 season — tied for 5th best in MLB; League Avg: .316.
Cardinals hitters have an OPS of .740 (1,624 PA’s) against RHP this season — 5th best in MLB; League Avg: .719.
The Cardinals are batting .178 on pitches out of the zone this season — best in MLB; League Avg: .148.
The Cardinals have scored first in 72% of their road games this season — highest in MLB; League Avg: 55%.
Royals Pitching Stats & Trends
Royals pitchers picked-off 19 runners from first base in 2023 — best in MLB.
The longest HR allowed by the Royals pitchers in the 2024 season traveled 519.4 feet — — longest in MLB; League Avg: 470.4
Royals pitchers had an ERA of 5.39 (674.0 IP) on the road in 2023 — 2nd highest in MLB; League Avg: 4.44.
Royals pitchers had a strikeout rate of just 21% in 2023 — 5th lowest in MLB; League Avg: 23%.
Cardinals Pitching Stats & Trends
Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.
Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 25%.
Cardinals pitchers had a strikeout rate of just 19% in 2023 — 2nd lowest in MLB; League Avg: 23%.
Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.
More MLB Reading:
Bet now on Royals vs Cardinals and all games with BetMGM
Bet on MLB Odds at BetMGM
Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.
