Royals vs Giants Prediction, Odds & Player Prop Bets Today – MLB, May 21

San Francisco Giants' Wilmer Flores (41) throws to first against the Los Angeles Dodgers during a baseball game in San Francisco, Friday, Sept. 29, 2023. (AP Photo/Jed Jacobsohn)
(AP Photo/Jed Jacobsohn)
  • The Giants are -210 favorites vs the Royals
  • Royals vs Giants Over / Under today: 7.5 Runs
  • Royals / Giants TV Channel: NSBA | FDKC

The Kansas City Royals (+180) visit Oracle Park to take on the San Francisco Giants (-220) on Wednesday, May 21, 2025. First pitch is scheduled for 3:45pm EDT in San Francisco, CA, CA.

This season, the Royals are 27-23 against the spread (ATS), while the Giants are 24-25 ATS.

Royals vs Giants Starting Pitchers Today:

  • Royals starting pitcher: Daniel Lynch 3-0, 1.29 ERA
  • Giants starting pitcher: Logan Webb 5-3, 2.44 ERA

Royals vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Royals+1.5 -125O 7.5 -125+180
Giants -1.5 +105U 7.5 +105-220

Royals vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Wednesday‘s MLB game with 63.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Royals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Bets Today:

  • Salvador Perez has hit the Runs Under in 22 of his last 25 games (+17.65 Units / 43% ROI)
  • Vinnie Pasquantino has hit the Home Runs Over in 4 of his last 10 away games (+15.20 Units / 152% ROI)
  • Salvador Perez has hit the Hits Under in 8 of his last 9 games (+9.65 Units / 71% ROI)
  • Salvador Perez has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+9.65 Units / 60% ROI)
  • Salvador Perez has hit the Singles Under in 12 of his last 15 away games (+8.15 Units / 41% ROI)

And here are some favorite MLB player prop bets for Giants players for Wednesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Jung Hoo Lee has hit the Home Runs Over in 2 of his last 7 games (+16.00 Units / 229% ROI)
  • Mike Yastrzemski has hit the Singles Over in 14 of his last 20 games (+11.20 Units / 55% ROI)
  • Heliot Ramos has hit the Runs Over in 12 of his last 20 games (+8.45 Units / 42% ROI)
  • Mike Yastrzemski has hit the Hits Over in 16 of his last 20 games at home (+8.30 Units / 23% ROI)
  • Heliot Ramos has hit the RBIs Under in 16 of his last 20 games at home (+6.45 Units / 14% ROI)
  • The Kansas City Royals have hit the Team Total Under in 38 of their last 50 games (+25.75 Units / 44% ROI)
  • The Kansas City Royals have hit the Game Total Under in 30 of their last 42 games (+17.95 Units / 39% ROI)
  • The Kansas City Royals have hit the 1st Five Innings (F5) Team Total Under in 31 of their last 49 games (+12.10 Units / 21% ROI)
  • The Kansas City Royals have hit the Moneyline in 19 of their last 28 games (+11.50 Units / 30% ROI)
  • The Kansas City Royals have covered the Run Line in 11 of their last 12 away games (+9.50 Units / 48% ROI)
  • The San Francisco Giants have hit the Team Total Under in 19 of their last 30 games (+7.70 Units / 23% ROI)
  • The San Francisco Giants have hit the Moneyline in 28 of their last 47 games (+5.45 Units / 8% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 22 games at home (+5.15 Units / 20% ROI)
  • The San Francisco Giants have hit the Game Total Under in 14 of their last 22 games at home (+5.10 Units / 21% ROI)
  • The San Francisco Giants have covered the Run Line in 7 of their last 11 games at home (+3.15 Units / 22% ROI)

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 26-24 against the Run Line (-5.1 Units / -7.03% ROI).

  • 27-23 when betting on the Moneyline for +4 Units / 6.31% ROI
  • 16-33 when betting on the total runs Over for -19.77 Units / -36.26% ROI
  • 33-16 when betting on the total runs Under for +15.45 Units / 27.85% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 24-25 against the Run Line (-0.2 Units / -0.32% ROI).

  • 29-20 when betting on the Moneyline for +5.4 Units / 7.95% ROI
  • 26-22 when betting on the total runs Over for +2.15 Units / 4.05% ROI
  • 22-26 when betting on the total runs Under for -7.05 Units / -12.88% ROI

Giants vs Royals Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +400 0.5 -550
Willy Adames (SF) 0.5 +500 0.5 -750
Heliot Ramos (SF) 0.5 +525 0.5 -750
Wilmer Flores (SF) 0.5 +725 0.5 -1200
Bobby Witt Jr. (KC) 0.5 +750 0.5 -1200

Giants vs Royals Total Hits Prop Bets Today

Over Under
Maikel Garcia (KC) 0.5 -275 0.5 +195
Jung-hoo Lee (SF) 0.5 -275 0.5 +200
Vinnie Pasquantino (KC) 0.5 -275 0.5 +195
Jonathan India (KC) 0.5 -235 0.5 +175
Salvador Perez (KC) 0.5 -235 0.5 +180

Giants vs Royals RBI Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +135 0.5 -175
Vinnie Pasquantino (KC) 0.5 +160 0.5 -210
Heliot Ramos (SF) 0.5 +165 0.5 -220
Willy Adames (SF) 0.5 +170 0.5 -225
Salvador Perez (KC) 0.5 +170 0.5 -220

Giants vs Royals Strikeout Prop Bets Today

Over Under
Logan Webb (SF) 5.5 +120 5.5 -155

Daniel Lynch has struck out just 6% (2/36) of left-handed batters he faced this season — lowest among qualified RPs in MLB; League Avg: 23% — 0 Percentile.

Opponents have a two strike miss rate of just 15% (7/48) against Daniel Lynch this season — 3rd lowest among AL Relievers; League Avg: 27% — third Percentile.

Daniel Lynch has allowed a slugging percentage of just .135 (10 Total Bases / 74 ABs) vs left-handed batters since last season — best among AL Relievers; League Avg: .361 — 100th Percentile.

Left-handed batters are hitting just .135 (10-for-74) against Daniel Lynch since last season — 4th best among AL Relievers; League Avg: .225 — 96th Percentile.

Giants Starting Pitcher Stats & Trends

Logan Webb has a strikeout rate of 30% vs right-handed batters this season — ninth highest among qualified SPs– 90th Percentile. He had a strikeout rate of just 18% vs right-handed batters last season — eighth lowest among qualified SPs– 13th Percentile.

Logan Webb has a strikeout rate of 57% (27 SO in 47 PAs) in PAs ending on elevated fastballs this season — best among qualified SPs in MLB; League Avg: 24% — 100th Percentile.

Opponents had a groundball rate of 57% (351/617) against Logan Webb in the 2024 season — 4th highest among qualified SPs in MLB; League Avg: 43% — 94th Percentile.

Opponents have a groundball rate of 57% (450/784) against Logan Webb since last season — 3rd highest among qualified SPs in MLB; League Avg: 43% — 96th Percentile.

Royals Keys to the Game vs. the Giants

The Royals were just 4-50 (.074) when they allowed 5 or more runs in the 2024 season — 2nd lowest in MLB; League Avg: .196.

The Royals are just 17-86 (.165) when allowing 2 or more home runs since the 2023 season — lowest in MLB; League Avg: .299.

The Royals are just 6-61 (.090) when allowing 5 or more runs since last season — 2nd lowest in MLB; League Avg: .191.

The Royals are 8-0 (1.000) when scoring 5 or more runs this season — best in MLB; League Avg: .823.

Giants Keys to the Game vs. the Royals

The Giants are 4-16 (.200) when trailing entering the 8th inning this season — best in MLB; League Avg: .089.

The Giants are 8-6 (.571) vs top 10 scoring offenses this season They play the Royals (12th best runs scored) today.

The Giants were just 20-24 (.455) vs bottom 10 scoring offenses in the 2024 season They play the Reds (16th best runs scored) today.

The Giants are 155-5 (.969) when leading entering the 9th inning since the 2023 season — 4th best in MLB; League Avg: .950.

Royals hitters have an OBP of just .287 (6,902 PA’s) on the road since the 2023 season — 3rd lowest in MLB; League Avg: .312.

Royals hitters had an OBP of just .280 (2,958 PA’s) on the road in 2023 — lowest in MLB; League Avg: .316.

Royals hitters have drawn walks in 7% of its PA’s against LHP since the 2023 season — tied for lowest in MLB; League Avg: 8%.

Royals hitters have struck out in just 19% of it’s PA’s against RHP since last season — 2nd best in MLB; League Avg: 22%.

Giants hitters had an OBP of just .299 (4,384 PA’s) against RHP in the 2024 season — tied for 3rd lowest in MLB; League Avg: .311.

Giants hitters had an OPS of just .683 (1,790 PA’s) against LHP in the 2023 season — 3rd lowest in MLB; League Avg: .742.

Giants hitters had an OBP of just .232 (3,303 PA’s) with two-strikes in 2023 — 2nd lowest in MLB; League Avg: .249.

Giants hitters have an OPS of just .696 (9,989 PA’s) against RHP since the 2023 season — 5th lowest in MLB; League Avg: .721.

Royals pitchers have walked 4% of batters this month (19 games) — best in MLB; League Avg: 8%.

The longest HR allowed by the Royals pitchers in the 2024 season traveled 519.4 feet — — longest in MLB; League Avg: 470.4

Royals pitchers have walked 7% of batters when facing the leadoff batter in the inning this season — 3rd best in MLB; League Avg: 8%.

Royals pitchers have walked 7% of batters this season — 2nd best in MLB; League Avg: 9%.

Opponents had a groundball rate of 50% against Giants pitchers in 2023 — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2023 season — highest in MLB; League Avg: 43%.

Opponents had a groundball rate of 49% against Giants pitchers in the 2024 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.