Twins vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Mar 27

St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
  • The Twins are -110 favorites vs the Cardinals
  • Twins vs Cardinals Over / Under today: 7.5 Runs
  • Twins / Cardinals TV Channel: TWTV | FDMW

The Minnesota Twins (-115) visit Busch Stadium to take on the St. Louis Cardinals (-105) on Thursday, March 27, 2025. First pitch is scheduled for 4:15pm EDT in St. Louis, MO, USA.

This preseason, the Twins are 10-10 against the spread (ATS), while the Cardinals are 9-10 ATS.

Twins vs Cardinals Starting Pitchers Today:

  • Twins starting pitcher: Pablo Lopez 0-0, 0.00 ERA
  • Cardinals starting pitcher: Sonny Gray 0-0, 0.00 ERA

Twins vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Twins-1.5 +154O 7.5 -115-115
Cardinals +1.5 -190U 7.5 -105-105

Twins vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Thursday‘s MLB game with 52.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Twins players for Thursday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

  • Pablo Lopez has hit the Walks Allowed Under in 19 of his last 25 games (+10.55 Units / 27% ROI)
  • Matt Wallner has hit the Runs Under in his last 8 away games (+8.00 Units / 70% ROI)
  • Ryan Jeffers has hit the Hits Under in 5 of his last 6 away games (+6.30 Units / 105% ROI)
  • Ryan Jeffers has hit the RBIs Under in his last 6 away games (+6.00 Units / 39% ROI)
  • Pablo Lopez has hit the Hits Allowed Over in 16 of his last 25 games (+5.95 Units / 20% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Thursday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Sonny Gray has hit the Strikeouts Over in 8 of his last 10 games (+5.00 Units / 38% ROI)
  • Sonny Gray has hit the Pitching Outs Over in 4 of his last 5 games (+3.00 Units / 38% ROI)
  • Sonny Gray has hit the Walks Allowed Under in 7 of his last 10 games at home (+2.55 Units / 17% ROI)
  • Sonny Gray has hit the Earned Runs Under in 3 of his last 4 games (+2.15 Units / 42% ROI)
  • Sonny Gray has hit the Hits Allowed Under in 3 of his last 4 games (+2.00 Units / 48% ROI)
  • The Minnesota Twins have hit the Game Total Over in 55 of their last 96 games (+16.90 Units / 16% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in their last 4 games (+4.20 Units / 79% ROI)
  • The Minnesota Twins have covered the Run Line in 3 of their last 6 away games (+0.35 Units / 5% ROI)
  • The St. Louis Cardinals have covered the Run Line in 26 of their last 41 games (+9.15 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 18 of their last 27 games at home (+9.10 Units / 31% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 22 of their last 37 games (+8.90 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 14 of their last 21 games at home (+7.35 Units / 30% ROI)

Twins Against the Spread (ATS) Record

Against the spread this preseason, the Twins were 10-12 against the Run Line (-2.85 Units / -10.59% ROI).

  • 10-10 when betting on the Moneyline for -2.35 Units / -7.76% ROI
  • 10-12 when betting on the total runs Over for -3.1 Units / -12.92% ROI
  • 12-10 when betting on the total runs Under for +0.9 Units / 3.69% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this preseason, the Cardinals were 9-10 against the Run Line (+0.2 Units / 0.93% ROI).

  • 7-12 when betting on the Moneyline for -6.9 Units / -27.88% ROI
  • 9-8 when betting on the total runs Over for +0.2 Units / 0.92% ROI
  • 8-9 when betting on the total runs Under for -2.15 Units / -9.64% ROI

Cardinals vs Twins Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +425 0.5 -600
Trevor Larnach (MIN) 0.5 +700 0.5 -1200
Lars Nootbaar (STL) 0.5 +775 0.5 -1400
Ryan Jeffers (MIN) 0.5 +875 0.5 -1600
Willi Castro (MIN) 0.5 +900 0.5 -1600

Cardinals vs Twins Total Hits Prop Bets Today

Over Under
Brendan Donovan (STL) 0.5 -250 0.5 +185
Carlos Correa (MIN) 0.5 -225 0.5 +170
Lars Nootbaar (STL) 0.5 -220 0.5 +160
Nolan Arenado (STL) 0.5 -190 0.5 +145
Ty France (MIN) 0.5 -190 0.5 +145

Cardinals vs Twins RBI Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +170 0.5 -225
Nolan Arenado (STL) 0.5 +185 0.5 -250
Brendan Donovan (STL) 0.5 +200 0.5 -275
Trevor Larnach (MIN) 0.5 +210 0.5 -275
Ryan Jeffers (MIN) 0.5 +220 0.5 -295

Cardinals vs Twins Strikeout Prop Bets Today

Over Under
Sonny Gray (STL) 5.5 -140 5.5 +105

Twins Keys to the Game vs. the Cardinals

The Twins are 140-2 (.986) when leading entering the 9th inning since the 2023 season — best in MLB; League Avg: .949.

The Twins were just 32-46 (.410) vs the top 10 runs allowed teams in 2024 They play the Marlins (29th best runs allowed) today.

The Twins are 27-110 (.197) when trailing entering the 7th inning since the 2023 season — tied for 3rd best in MLB; League Avg: .142.

The Twins are 62-26 (.705) when they’ve scored in the first inning since the 2023 season — 4th best in MLB; League Avg: .626.

Cardinals Keys to the Game vs. the Twins

The Cardinals were 18-9 (.667) when tied entering the 7th inning in 2024 — tied for 3rd best in MLB; League Avg: .500.

The Cardinals are just 10-141 (.066) when trailing entering the 8th inning since the 2023 season — 4th lowest in MLB; League Avg: .100.

The Cardinals are 24-17 (.585) when tied entering the 8th inning since the 2023 season — 5th best in MLB; League Avg: .500.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in 2024 — tied for 2nd best in MLB; League Avg: .950.

Twins hitters struck out 1,274 times in 4,710 PA’s (27%) against RHP in 2023 — highest in MLB; League Avg: 23%.

The Twins were just 14-29 (.326) against the run line (-32.5% ROI) vs top 10 scoring offenses in 2024 They play the Marlins (27th best runs scored) today.

The Twins have scored 1.75 runs per game (568/324) in late innings since the 2023 season — tied for best in MLB; League Avg: 1.45.

The Twins batted just .150 with two-strikes in 2023 — lowest in MLB; League Avg: .172.

The Cardinals are batting .249 with two outs since the 2022 season — 3rd best in MLB; League Avg: .236.

The Cardinals won only 43% of their home games in the 2023 season — 5th lowest in MLB; League Avg: 52%.

Cardinals hitters put 39% of their swings in play on the first pitch of at-bats in 2023 — 2nd highest in MLB; League Avg: 35%.

The Cardinals are batting .165 on pitches out of the zone since the 2022 season — tied for 3rd best in MLB; League Avg: .153.

Twins pitchers walked 433 of 6,078 batters (7%) in the 2024 season — 3rd best in MLB; League Avg: 8%.

Twins pitchers walked 443 of 6,028 batters (7%) in 2023 — tied for 3rd best in MLB; League Avg: 9%.

Twins pitchers had a strikeout rate of 47% with two-strikes in 2023 — best in MLB; League Avg: 43%.

Twins pitchers have a strikeout rate of 26% when facing the leadoff batter in the inning since the 2023 season — best in MLB; League Avg: 22%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers walked 95 of 1,431 batters (7%) when facing the leadoff batter in the inning in 2023 — 2nd best in MLB; League Avg: 8%.

Cardinals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.