- The Cubs are -225 favorites vs the White Sox
- White Sox vs Cubs Over / Under today: 11.5 Runs
- White Sox / Cubs TV Channel: MARQ | CHSN | MLBN
The Chicago White Sox (+185) visit Wrigley Field to take on the Chicago Cubs (-225) on Friday, May 16, 2025. First pitch is scheduled for 2:20pm EDT in Chicago, IL, IL.
This season, the White Sox are 14-30 against the spread (ATS), while the Cubs are 22-22 ATS.
White Sox vs Cubs Starting Pitchers Today:
- White Sox starting pitcher: Shane Smith 1-2, 2.08 ERA
- Cubs starting pitcher: Cade Horton 1-0, 6.76 ERA
White Sox vs. Cubs Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| White Sox | +1.5 -105 | O 11.5 -105 | +185 |
| Cubs | -1.5 -115 | U 11.5 -115 | -225 |
White Sox vs Cubs Prediction for Today’s Game
Based on recent trends the model predicts the Cubs will win Friday‘s MLB game with 64.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for White Sox players for Friday‘s game, looking at profitable historical betting trends:
Best White Sox Player Prop Bets Today:
- Lenyn Sosa has hit the Home Runs Over in 2 of his last 10 away games (+9.00 Units / 90% ROI)
- Andrew Vaughn has hit the Runs Under in 13 of his last 15 away games (+8.95 Units / 30% ROI)
- Shane Smith has hit the Earned Runs Under in his last 7 games (+7.65 Units / 81% ROI)
- Andrew Vaughn has hit the Singles Under in 14 of his last 20 away games (+7.25 Units / 31% ROI)
- Andrew Vaughn has hit the Hits Over in 12 of his last 15 games (+6.80 Units / 22% ROI)
And here are some favorite MLB player prop bets for Cubs players for Friday‘s game, looking at profitable historical betting trends:
Best Cubs Player Prop Best Bets Today:
- Seiya Suzuki has hit the Walks Under in 22 of his last 25 games (+15.40 Units / 34% ROI)
- Dansby Swanson has hit the Runs Over in 12 of his last 20 games (+9.50 Units / 47% ROI)
- Pete Crow-Armstrong has hit the Hits Over in 19 of his last 25 games (+9.35 Units / 21% ROI)
- Dansby Swanson has hit the Home Runs Over in 2 of his last 5 games (+9.20 Units / 184% ROI)
- Nico Hoerner has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+8.30 Units / 29% ROI)
White Sox Best Bets Today:
- The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 16 of their last 21 games (+11.80 Units / 51% ROI)
- The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 10 of their last 20 games (+9.90 Units / 49% ROI)
- The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 20 away games (+9.60 Units / 40% ROI)
- The Chicago White Sox have hit the Game Total Under in 15 of their last 21 away games (+8.50 Units / 37% ROI)
- The Chicago White Sox have hit the Team Total Under in 15 of their last 22 away games (+7.65 Units / 29% ROI)
Cubs Best Bets Today:
- The Chicago Cubs have covered the 1st Five Innings (F5) Run Line in 28 of their last 40 games (+14.20 Units / 30% ROI)
- The Chicago Cubs have hit the 1st Five Innings (F5) Moneyline in 26 of their last 42 games (+13.70 Units / 24% ROI)
- The Chicago Cubs have hit the Team Total Over in 25 of their last 39 games (+8.55 Units / 18% ROI)
- The Chicago Cubs have hit the Game Total Over in 23 of their last 39 games (+6.70 Units / 16% ROI)
- The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 23 of their last 38 games (+5.31 Units / 12% ROI)
White Sox Against the Spread (ATS) Record
Against the spread this season, the White Sox are 24-20 against the Run Line (+1.8 Units / 3.48% ROI).
- 14-30 when betting on the Moneyline for -7.86 Units / -17.82% ROI
- 19-23 when betting on the total runs Over for -6.45 Units / -13.27% ROI
- 23-19 when betting on the total runs Under for +2.15 Units / 4.46% ROI
Cubs Against the Spread (ATS) Record
Against the spread this season, the Cubs are 22-22 against the Run Line (-0.33 Units / -0.59% ROI).
- 25-19 when betting on the Moneyline for +2.85 Units / 4.89% ROI
- 25-17 when betting on the total runs Over for +6.65 Units / 14.01% ROI
- 17-25 when betting on the total runs Under for -11 Units / -22.29% ROI
Cubs vs White Sox Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Seiya Suzuki (CHC) | 0.5 +240 | 0.5 -300 |
| Kyle Tucker (CHC) | 0.5 +240 | 0.5 -300 |
| Michael Busch (CHC) | 0.5 +280 | 0.5 -350 |
| Luis Robert (CWS) | 0.5 +280 | 0.5 -350 |
| Dansby Swanson (CHC) | 0.5 +290 | 0.5 -375 |
Cubs vs White Sox Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Dansby Swanson (CHC) | 0.5 -250 | 0.5 +185 |
| Luis Robert (CWS) | 0.5 -235 | 0.5 +175 |
| Carson Kelly (CHC) | 0.5 -225 | 0.5 +170 |
| Michael Busch (CHC) | 0.5 -225 | 0.5 +170 |
| Nico Hoerner (CHC) | 0.5 -225 | 0.5 +175 |
Cubs vs White Sox RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Kyle Tucker (CHC) | 0.5 -105 | 0.5 -125 |
| Seiya Suzuki (CHC) | 0.5 +100 | 0.5 -135 |
| Pete Crow-Armstrong (CHC) | 0.5 +110 | 0.5 -145 |
| Michael Busch (CHC) | 0.5 +120 | 0.5 -155 |
| Carson Kelly (CHC) | 0.5 +125 | 0.5 -165 |
Cubs vs White Sox Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Cade Horton (CHC) | 4.5 -125 | 4.5 -105 |
| Shane Smith (CWS) | 4.5 +125 | 4.5 -160 |
White Sox Starting Pitcher Stats & Trends
Opponents are hitting just .093 (7-for-75) against Shane Smith with two-strikes this season — best among among AL Starters; League Avg: .165 — 100th Percentile.
Shane Smith has allowed a slugging percentage of just .203 (13 Total Bases / 64 ABs) when going through the lineup the second time in a game this season — best among qualified SPs in MLB; League Avg: .381 — 100th Percentile.
Shane Smith has allowed a slugging percentage of just .269 (42 Total Bases / 156 ABs) this season — 4th best among among AL Starters; League Avg: .381 — 93rd Percentile.
Shane Smith has allowed a slugging percentage of just .120 (9 Total Bases / 75 ABs) with two-strikes this season — 2nd best among among AL Starters; League Avg: .256 — 97th Percentile.
Cubs Starting Pitcher Stats & Trends
Hitters have swung at 71% of Cade Horton’s pitches (15/21) with two-strikes over the last 14 days — 8th highest in NL over the last two weeks; League Avg: 60% — 91st Percentile.
Hitters have swung at 71% of Cade Horton’s pitches (15/21) with two-strikes this month (1 game) — 10th highest among NL Relievers; League Avg: 60% — 89th Percentile.
Cade Horton has thrown at least two strikes in his first three pitches to 43% (6/14) of opposing batters this month (1 game) — tied for 14th lowest among among 222 qualified RPs in MLB; League Avg: 64% — seventh Percentile.
White Sox Keys to the Game vs. the Cubs
The White Sox are just 91-40 (.695) when leading entering the 7th inning since the 2023 season — lowest in MLB; League Avg: .860.
The White Sox are just 35-115 (.233) after a loss since last season — lowest in MLB; League Avg: .502.
The White Sox are just 39-218 (.152) when scoring 4 or fewer runs since the 2023 season — lowest in MLB; League Avg: .274.
The White Sox are just 45-26 (.634) when leading entering the 7th inning since last season — lowest in MLB; League Avg: .861.
Cubs Keys to the Game vs. the White Sox
The Cubs are 14-1 (.933) when they’ve had 10 or more hits this season — best in MLB; League Avg: .741.
The Cubs are just 0-13 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .119.
The Cubs are 13-5 (.722) after a loss this season — 2nd best in MLB; League Avg: .502.
The Cubs are 40-12 (.769) when they’ve scored in the first inning since last season — 2nd best in MLB; League Avg: .634.
White Sox Hitting Stats & Trends
White Sox hitters have an OBP of just .213 (7,167 PA’s) with two-strikes since the 2023 season — lowest in MLB; League Avg: .247.
White Sox hitters are slugging just .321 against RHP this season — lowest in MLB; League Avg: .401.
The White Sox have a winning percentage of just 22% on the road since last season — lowest in MLB; League Avg: 47%.
The White Sox are batting just .292 on the first pitch of at-bats since last season — lowest in MLB; League Avg: .335.
Cubs Hitting Stats & Trends
Cubs hitters are slugging .482 against LHP this season — 3rd best in MLB; League Avg: .375.
Cubs hitters have struck out in just 18% of it’s PA’s against LHP this season — 2nd best in MLB; League Avg: 23%.
Cubs hitters have an OPS of .807 (879 PA’s) on the road this season — 2nd best in MLB; League Avg: .694.
Cubs hitters have an OPS of .824 (409 PA’s) against LHP this season — 3rd best in MLB; League Avg: .686.
White Sox Pitching Stats & Trends
The White Sox have won just 17% of games in which their opponents scored first since the 2023 season — lowest in MLB; League Avg: 33%.
White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.
White Sox pitchers have won only 12% of games in which they have allowed their opponent to score in three different innings since the 2023 season — lowest in MLB; League Avg: 27%.
The White Sox have won just 12% of games in which their opponents scored first since last season — lowest in MLB; League Avg: 32%.
Cubs Pitching Stats & Trends
Cubs pitchers have walked 9% of batters when facing the leadoff batter in the inning since last season — 2nd highest in MLB; League Avg: 8%.
The Cubs allowed 3.41 runs per game (276/81) at home in the 2024 season — 2nd best in MLB; League Avg: 4.41.
Cubs pitchers had an ERA of 3.08 (733.0 IP) at home in the 2024 season — 2nd best in MLB; League Avg: 3.98.
Cubs pitchers walked 127 of 1,437 batters (9%) when facing the leadoff batter in the inning in the 2024 season — 3rd highest in MLB; League Avg: 7%.
More MLB Reading:
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