- The Cubs are -275 favorites vs the White Sox
- White Sox vs Cubs Over / Under today: 10 Runs
- White Sox / Cubs TV Channel: MARQ | CHSN
The Chicago White Sox (+220) visit Wrigley Field to take on the Chicago Cubs (-275) on Saturday, May 17, 2025. First pitch is scheduled for 2:20pm EDT in Chicago, IL.
This season, the White Sox are 14-31 against the spread (ATS), while the Cubs are 23-22 ATS.
White Sox vs Cubs Starting Pitchers Today:
- White Sox starting pitcher: Sean Burke 2-4, 4.19 ERA
- Cubs starting pitcher: Matthew Boyd 3-2, 2.76 ERA
White Sox vs. Cubs Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| White Sox | +2.5 -135 | O 10 -115 | +220 |
| Cubs | -2.5 +110 | U 10 -105 | -275 |
White Sox vs Cubs Prediction for Today’s Game
Based on recent trends the model predicts the Cubs will win Saturday‘s MLB game with 68.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:
Best White Sox Player Prop Bets Today:
- Lenyn Sosa has hit the Home Runs Over in 2 of his last 10 away games (+9.00 Units / 90% ROI)
- Lenyn Sosa has hit the Total Bases Over in 8 of his last 10 away games (+6.40 Units / 43% ROI)
- Michael A. Taylor has hit the Hits Runs and RBIs Under in 15 of his last 25 games (+5.75 Units / 22% ROI)
- Lenyn Sosa has hit the Hits Over in 18 of his last 25 games (+5.70 Units / 12% ROI)
- Michael A. Taylor has hit the Singles Under in 12 of his last 15 games (+5.60 Units / 16% ROI)
And here are some favorite MLB player prop bets for Cubs players for Saturday‘s game, looking at profitable historical betting trends:
Best Cubs Player Prop Best Bets Today:
- Matthew Boyd has hit the Strikeouts Over in 12 of his last 15 games (+9.25 Units / 51% ROI)
- Matthew Boyd has hit the Hits Allowed Over in his last 5 games (+5.20 Units / 87% ROI)
- Matthew Boyd has hit the Pitching Outs Over in 5 of his last 7 games (+2.60 Units / 32% ROI)
- Matthew Boyd has hit the Walks Allowed Under in 3 of his last 4 games (+2.45 Units / 51% ROI)
- Matthew Boyd has hit the Earned Runs Over in 4 of his last 6 games (+2.20 Units / 32% ROI)
White Sox Best Bets Today:
Cubs Best Bets Today:
White Sox Against the Spread (ATS) Record
Against the spread this season, the White Sox are 24-21 against the Run Line (+0.8 Units / 1.52% ROI).
- 14-31 when betting on the Moneyline for -8.86 Units / -19.65% ROI
- 20-23 when betting on the total runs Over for -5.45 Units / -10.97% ROI
- 23-20 when betting on the total runs Under for +1.05 Units / 2.13% ROI
Cubs Against the Spread (ATS) Record
Against the spread this season, the Cubs are 23-22 against the Run Line (+0.67 Units / 1.18% ROI).
- 26-19 when betting on the Moneyline for +3.85 Units / 6.36% ROI
- 26-17 when betting on the total runs Over for +7.65 Units / 15.76% ROI
- 17-26 when betting on the total runs Under for -12.1 Units / -23.98% ROI
Cubs vs White Sox Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Kyle Tucker (CHC) | 0.5 +240 | 0.5 -300 |
| Pete Crow-Armstrong (CHC) | 0.5 +250 | 0.5 -300 |
| Michael Busch (CHC) | 0.5 +300 | 0.5 -400 |
| Seiya Suzuki (CHC) | 0.5 +310 | 0.5 -400 |
| Andrew Vaughn (CWS) | 0.5 +333 | 0.5 -450 |
Cubs vs White Sox Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Pete Crow-Armstrong (CHC) | 0.5 -275 | 0.5 +195 |
| Lenyn Sosa (CWS) | 0.5 -235 | 0.5 +175 |
| Kyle Tucker (CHC) | 0.5 -235 | 0.5 +175 |
| Andrew Vaughn (CWS) | 0.5 -225 | 0.5 +170 |
| Seiya Suzuki (CHC) | 0.5 -210 | 0.5 +160 |
Cubs vs White Sox RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Pete Crow-Armstrong (CHC) | 0.5 +110 | 0.5 -145 |
| Kyle Tucker (CHC) | 0.5 +115 | 0.5 -150 |
| Seiya Suzuki (CHC) | 0.5 +125 | 0.5 -165 |
| Michael Busch (CHC) | 0.5 +130 | 0.5 -165 |
| Carson Kelly (CHC) | 0.5 +150 | 0.5 -200 |
Cubs vs White Sox Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Sean Burke (CWS) | 3.5 -155 | 3.5 +115 |
| Matthew Boyd (CHC) | 6.5 +120 | 6.5 -155 |
White Sox Starting Pitcher Stats & Trends
Sean Burke has walked 19% of left-handed batters this season — highest among qualified SPs in MLB; League Avg: 8% — first Percentile.
Sean Burke has a strike rate of just 56% (201/360) vs left-handed batters this season — lowest among qualified SPs in MLB; League Avg: 63% — first Percentile.
Sean Burke has walked 22% of batters when going through the lineup the first time in a game this month (3 games) — highest among among AL Starters; League Avg: 6% — first Percentile.
Sean Burke has thrown his fastball for a strike just 56% (198/354) of the time this season — lowest among qualified SPs in MLB; League Avg: 67% — first Percentile.
Cubs Starting Pitcher Stats & Trends
Matthew Boyd has a in-zone of just 35% (81/232) in two strike counts this season — tied for 3rd lowest among qualified SPs in MLB; League Avg: 43% — fourth Percentile.
Matthew Boyd has walked 3% of batters when going through the lineup the second time in a game this season — 5th best among qualified SPs in MLB; League Avg: 7% — 95th Percentile.
Matthew Boyd has a in-zone of just 35% (81/232) in two strike counts this season — 2nd lowest among among NL Starters; League Avg: 43% — fourth Percentile.
Matthew Boyd has walked 3% of batters when going through the lineup the second time in a game this season — best among among NL Starters; League Avg: 7% — 100th Percentile.
White Sox Keys to the Game vs. the Cubs
The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.
The White Sox were just 41-121 (.253) in the 2024 season — lowest in MLB; League Avg: .500.
The White Sox were just 26-95 (.215) after a loss in the 2024 season — lowest in MLB; League Avg: .504.
The White Sox are just 45-26 (.634) when leading entering the 7th inning since last season — lowest in MLB; League Avg: .861.
Cubs Keys to the Game vs. the White Sox
The Cubs are 14-5 (.737) after a loss this season — 2nd best in MLB; League Avg: .500.
The Cubs are just 0-13 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .121.
The Cubs are 2-16 (.111) when trailing entering the 9th inning this season — 4th best in MLB; League Avg: .045.
The Cubs are 8-2 (.800) when they’ve scored in the first inning this season — 4th best in MLB; League Avg: .612.
White Sox Hitting Stats & Trends
White Sox hitters have an OBP of just .284 (10,150 PA’s) against RHP since the 2023 season — lowest in MLB; League Avg: .316.
White Sox hitters are slugging just .327 against RHP this season — lowest in MLB; League Avg: .401.
White Sox hitters had an OBP of just .276 (4,359 PA’s) against RHP in the 2024 season — lowest in MLB; League Avg: .311.
White Sox hitters are slugging just .359 against RHP since the 2023 season — lowest in MLB; League Avg: .406.
Cubs Hitting Stats & Trends
Cubs hitters have struck out in just 18% of it’s PA’s against LHP this season — 2nd best in MLB; League Avg: 23%.
Cubs hitters have an OPS of .831 (415 PA’s) against LHP this season — 3rd best in MLB; League Avg: .686.
Cubs hitters are slugging .478 on the road this season — best in MLB; League Avg: .385.
Cubs hitters are slugging .485 against LHP this season — 3rd best in MLB; League Avg: .375.
White Sox Pitching Stats & Trends
White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.
White Sox pitchers have walked 10% of batters since last season — highest in MLB; League Avg: 8%.
The White Sox have won just 12% of games in which their opponents scored first since last season — lowest in MLB; League Avg: 32%.
The White Sox have won just 17% of games in which their opponents scored first since the 2023 season — lowest in MLB; League Avg: 33%.
Cubs Pitching Stats & Trends
The Cubs allowed 3.41 runs per game (276/81) at home in the 2024 season — 2nd best in MLB; League Avg: 4.41.
Cubs pitchers had an ERA of 3.08 (733.0 IP) at home in the 2024 season — 2nd best in MLB; League Avg: 3.98.
Cubs pitchers have walked 9% of batters when facing the leadoff batter in the inning since last season — 2nd highest in MLB; League Avg: 8%.
Cubs pitchers have walked 6% of batters this month (14 games) — 2nd best in MLB; League Avg: 8%.
More MLB Reading:
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