White Sox vs Twins Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

Minnesota Twins' Christian Vazquez (8) bunts allowing Manuel Margot to score against the Miami Marlins during the seventh inning of a baseball game, Wednesday, Sept. 25, 2024, in Minneapolis. The Twins won 8-3.
(AP Photo/Craig Lassig)
  • The Twins are -250 favorites vs the White Sox
  • White Sox vs Twins Over / Under today: 8.5 Runs
  • White Sox / Twins TV Channel: TWTV | CHSN | KMSP

The Chicago White Sox (+200) visit Target Field to take on the Minnesota Twins (-250) on Tuesday, April 22, 2025. First pitch is scheduled for 7:40pm EDT in Minneapolis, MN, MN.

This season, the White Sox are 5-17 against the spread (ATS), while the Twins are 9-13 ATS.

White Sox vs Twins Starting Pitchers Today:

  • White Sox starting pitcher: Davis Martin 1-2, 4.84 ERA
  • Twins starting pitcher: Bailey Ober 1-1, 6.16 ERA

White Sox vs. Twins Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 +100O 8.5 -102+200
Twins -1.5 -120U 8.5 -118-250

White Sox vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Tuesday‘s MLB game with 66.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Andrew Benintendi has hit the Home Runs Over in 3 of his last 10 games (+13.10 Units / 131% ROI)
  • Jacob Amaya has hit the Hits Under in 18 of his last 25 games (+9.95 Units / 34% ROI)
  • Jacob Amaya has hit the Total Bases Under in 18 of his last 25 games (+9.90 Units / 34% ROI)
  • Jacob Amaya has hit the Singles Under in 13 of his last 15 games (+9.35 Units / 33% ROI)
  • Jacob Amaya has hit the Hits Runs and RBIs Under in 16 of his last 25 games (+9.05 Units / 35% ROI)

And here are some favorite MLB player prop bets for Twins players for Tuesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

  • Edouard Julien has hit the Runs Under in 9 of his last 10 games (+7.55 Units / 39% ROI)
  • Ty France has hit the Hits Under in 6 of his last 8 games (+7.10 Units / 89% ROI)
  • Carlos Correa has hit the Singles Under in 13 of his last 20 games (+6.05 Units / 28% ROI)
  • Ty France has hit the RBIs Over in 4 of his last 6 games at home (+5.85 Units / 98% ROI)
  • Edouard Julien has hit the Hits Runs and RBIs Over in 10 of his last 15 games (+5.60 Units / 29% ROI)
  • The Chicago White Sox have hit the Team Total Under in 12 of their last 15 games (+8.55 Units / 46% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 13 games (+7.15 Units / 47% ROI)
  • The Chicago White Sox have hit the Game Total Under in 9 of their last 14 games (+4.55 Units / 29% ROI)
  • The Chicago White Sox have covered the Run Line in 5 of their last 8 away games (+2.45 Units / 26% ROI)
  • The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 11 of their last 15 games (+7.30 Units / 41% ROI)
  • The Minnesota Twins have hit the Game Total Under in 9 of their last 13 games (+5.85 Units / 41% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 13 games (+5.10 Units / 34% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 6 of their last 8 games at home (+4.65 Units / 47% ROI)
  • The Minnesota Twins have hit the Team Total Over in 6 of their last 8 games at home (+3.80 Units / 37% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 11-11 against the Run Line (-1.2 Units / -4.52% ROI).

  • 5-17 when betting on the Moneyline for -8.95 Units / -40.68% ROI
  • 9-11 when betting on the total runs Over for -3.05 Units / -12.68% ROI
  • 11-9 when betting on the total runs Under for +1 Units / 4.11% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 9-13 against the Run Line (-4.2 Units / -15.3% ROI).

  • 7-15 when betting on the Moneyline for -10.9 Units / -40.15% ROI
  • 8-11 when betting on the total runs Over for -4.1 Units / -16.87% ROI
  • 11-8 when betting on the total runs Under for +2.2 Units / 9.13% ROI

Twins vs White Sox Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +260 0.5 -325
Luis Robert (CWS) 0.5 +425 0.5 -600
Andrew Vaughn (CWS) 0.5 +500 0.5 -700
Ryan Jeffers (MIN) 0.5 +500 0.5 -700
Carlos Correa (MIN) 0.5 +525 0.5 -750

Twins vs White Sox Total Hits Prop Bets Today

Over Under
Ty France (MIN) 0.5 -250 0.5 +190
Byron Buxton (MIN) 0.5 -250 0.5 +185
Carlos Correa (MIN) 0.5 -250 0.5 +190
Trevor Larnach (MIN) 0.5 -220 0.5 +165
Edouard Julien (MIN) 0.5 -210 0.5 +155

Twins vs White Sox RBI Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +115 0.5 -150
Carlos Correa (MIN) 0.5 +150 0.5 -200
Ty France (MIN) 0.5 +155 0.5 -200
Trevor Larnach (MIN) 0.5 +165 0.5 -220
Ryan Jeffers (MIN) 0.5 +165 0.5 -220

Twins vs White Sox Strikeout Prop Bets Today

Over Under
Bailey Ober (MIN) 6.5 +105 6.5 -140
Davis Martin (CWS) 4.5 +125 4.5 -160

Davis Martin has allowed a slugging percentage of .643 (18 Total Bases / 28 ABs) on low non-fastballs this season — highest among qualified SPs in MLB; League Avg: .289 — first Percentile.

Davis Martin has a strikeout rate of just 8% (3 SO in 36 PAs) when going through the lineup the first time in a game this season — lowest among among AL Starters; League Avg: 23% — second Percentile.

Davis Martin has allowed a slugging percentage of .609 (28 Total Bases / 46 ABs) on non-fastballs this season — 3rd highest among qualified SPs in MLB; League Avg: .338 — third Percentile.

Davis Martin has allowed an OPS of .904 (99 PA’s) this season — 2nd highest among qualified SPs in MLB; League Avg: .671 — second Percentile.

Twins Starting Pitcher Stats & Trends

Opponents had a groundball rate of just 34% (161/469) against Bailey Ober in the 2024 season — 3rd lowest among qualified SPs in MLB; League Avg: 43% — fifth Percentile.

Opponents have a groundball rate of just 33% (61/185) against Bailey Ober in two-strike counts since last season — lowest among qualified SPs in MLB; League Avg: 45% — second Percentile.

Opponents batted just .187 (26-for-139) against Bailey Ober when going through the lineup the third time in a game in the 2024 season — 2nd best among qualified SPs in MLB; League Avg: .258 — 98th Percentile.

Opponents have a groundball rate of just 34% (179/530) against Bailey Ober since last season — tied for lowest among qualified SPs in MLB; League Avg: 43% — third Percentile.

White Sox Keys to the Game vs. the Twins

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

The White Sox are just 27-66 (.290) at home since last season — lowest in MLB; League Avg: .532.

The White Sox are just 19-72 (.209) on the road since last season — lowest in MLB; League Avg: .467.

The White Sox are just 105-199 (.345) when allowing 5 or more extra base hits since the 2023 season — lowest in MLB; League Avg: .538.

Twins Keys to the Game vs. the White Sox

The Twins are just 1-82 (.012) when trailing entering the 9th inning since last season — 2nd lowest in MLB; League Avg: .048.

The Twins are just 5-9 (.357) after a loss this season — 3rd lowest in MLB; League Avg: .523.

The Twins are just 7-3 (.700) when leading entering the 7th inning this season — 3rd lowest in MLB; League Avg: .884.

The Twins are just 0-14 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .033.

White Sox hitters have an OBP of just .282 (9,523 PA’s) against RHP since the 2023 season — lowest in MLB; League Avg: .315.

White Sox hitters had an OBP of just .278 (5,869 PA’s) in the 2024 season — lowest in MLB; League Avg: .312.

White Sox hitters have an OBP of just .277 (6,662 PA’s) since last season — lowest in MLB; League Avg: .312.

White Sox hitters have an OBP of just .212 (6,731 PA’s) with two-strikes since the 2023 season — lowest in MLB; League Avg: .247.

Twins hitters have an OBP of just .205 (161 PA’s) against LHP this season — lowest in MLB; League Avg: .308.

The Twins are batting just .141 against LHP this season — lowest in MLB; League Avg: .232.

Twins hitters slugged .716 on the first pitch of at-bats in the 2023 season — 2nd best in MLB; League Avg: .596.

Twins hitters have an OPS of just .460 (161 PA’s) against LHP this season — lowest in MLB; League Avg: .678.

The White Sox won just 11% of games in which their opponents scored first last season — lowest in MLB; League Avg: 31%.

White Sox pitchers have walked 10% of batters since last season — highest in MLB; League Avg: 8%.

White Sox pitchers have won only 12% of games in which they have allowed their opponent to score in three different innings since the 2023 season — lowest in MLB; League Avg: 27%.

White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.

Twins pitchers have walked 7% of batters this season — 2nd best in MLB; League Avg: 9%.

Twins pitchers had a strikeout rate of 26% in 2023 — best in MLB; League Avg: 23%.

Twins pitchers have walked 7% of batters since last season — tied for 2nd best in MLB; League Avg: 8%.

Opponents have a groundball rate of just 39% against Twins pitchers this season — 4th lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.