Duke vs. Houston Prediction, Odds: March Madness

The 2025 Final Four from the Alamodome begins with Houston taking on title favorites Duke. 

The Cougars cruised into the national semifinals with an easy win over Tennessee in the Elite 8. In the round prior, a last-second winner provided a 62-60 win over Purdue. 

Duke used a 20-point win over Alabama in the regional final to reach this round after a seven-point win over Arizona. Through four rounds, no team has held Duke under 85 points. 

Bet on Duke vs. Houston and other March Madness matchups with up-to-date college basketball odds. 

Duke vs. Houston Odds, March Madness

• Duke Moneyline: -210
• Houston Moneyline: +170
• Game Spread: Duke -4.5 (-110), Houston +4.5 (-110)
• Game Over/Under: 136.5 Points (-110/-110)

Duke vs. Houston Prediction

Based on one historically profitable NCAAB betting system, the Duke vs. Houston prediction for Saturday’s game is the Duke Spread (-4.5, -110).

Essentially, this system recommends betting on strong free-throw shooting teams against teams with a strong record defending the arc. 

Since the 2006 NCAA Tournament, teams priced between -20 and +2 are 53-15-1 ATS, assuming two factors:

• The team’s free throw percentage falls between 77.2% and 82.2%
• The opponent’s defensive three-point percentage falls between 28.5% and 35.7%

Those teams have excelled both at short spreads and in later rounds. 

When you consider only teams that fall between -6 and +2, they improve to 45-10 against the spread, including 25-4 over the previous 29 qualifying games. 

Irrespective of the team’s spread, these teams excel late in the tournament. 

This system has registered five times in either the Final Four or National Championship with those teams finishing 5-0 ATS. 

When this system registers in the Elite Eight or later, these teams improve to 11-1 ATS over the same timeframe. 

As a result, bettors should consider laying the points with Duke in the Final Four on Saturday. 

Duke vs. Houston: NCAAB Public Betting