The highest-scoring game in NCAA Tournament history was in 1990 when No. 11 seed Loyola Marymount blew out No. 3 seed Michigan, 149-115, in the second round.
The 264 combined points are easily the most in tournament history. Loyola Marymount has been part of the five highest-scoring games.
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Highest-Scoring Games in March Madness History
| Total Points | Year | Round | Teams |
| 264 | 1990 | Second round | Loyola Marymount over Michigan, 149-115 |
| 234 | 1988 | First round | Loyola Marymount over Wyoming, 119-115 |
| 232 | 1990 | Elite Eight | UNLV over Loyola Marymount, 131-101 |
| 221 | 1989 | First round | Arkansas over Loyola Marymount, 120-101 |
| 220 | 1988 | Second round | UNC over Loyola Marymount, 123-97 |
| 216 | 2005 | Second round | West Virginia over Wake Forest, 111-105 |
| 214 | 1994 | First round | Tulsa over UCLA, 112-102 |
| 207 | 1992 | Elite Eight | Duke over Kentucky, 104-103 |
| 207 | 2007 | First round | Tennessee over Long Beach State, 121-86 |
| 206 | 1987 | Second round | UNC over Michigan, 109-97 |
| 206 | 1988 | Sweet 16 | Oklahoma over Louisville, 108-98 |
| 206 | 2002 | Second round | UCLA over Cincinnati, 105-101 |
| 205 | 1989 | Second round | Oklahoma over Louisana Tech, 124-81 |
| 205 | 1994 | Second round | Missouri over Wisconsin, 109-96 |
| 204 | 1992 | Second round | Kentucky over Iowa State, 106-98 |
| 203 | 1990 | First round | Loyola Marymount over Iowa State, 111-98 |
| 202 | 2004 | First round | UAB over Washington, 102-100 |
| 200 | 1988 | First round | Iowa over Florida State, 102-98 |
| 200 | 2008 | First round | Western Kentucky over Drake, 101-99 |
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