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The Sweet 16 for the 2025 NCAA Tournament will be played at four locations:
- Prudential Center in Newark, NJ
- Chase Center in San Francisco
- State Farm Arena in Atlanta
- Lucas Oil Stadium in Indianapolis
2025 Sweet 16 Schedule
| Date | Matchup | Location |
|---|---|---|
| Thursday, March 27 | East Region TBD | Prudential Center |
| Thursday, March 27 | East Region TBD | Prudential Center |
| Thursday, March 27 | West Region TBD | Chase Center |
| Thursday, March 27 | West Region TBD | Chase Center |
| Friday, March 28 | South Region TBD | State Farm Arena |
| Friday, March 28 | South Region TBD | State Farm Arena |
| Friday, March 28 | Midwest Region TBD | Lucas Oil Stadium |
| Friday, March 28 | Midwest Region TBD | Lucas Oil Stadium |
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