NFL Betting: Teams With Best Odds to Start 4-0

• The Broncos and Chargers have the leading NFL odds to start the season 4-0.
• Twelve teams have odds of starting 4-0 at +500 or better.

Winning in the NFL is hard enough, but stringing together four consecutive wins is even more difficult.

The Broncos and Chargers have leading NFL betting odds to begin the 2022 season 4-0 at +275. Here’s a full look at other teams who could go undefeated in their first four outings.

Teams With Best Odds to Start 4-0

Predicting Teams Most Likely to Start 4-0

Los Angeles Chargers

The Chargers don’t have an easy beginning to their season, but they have the talent to start strong.

They open the year by taking on the much-improved Las Vegas Raiders at home. Then they face another AFC West foe in the Chiefs on the road. Either of those games are easily losable.

However, the Chargers’ pass rush should win out against the Raiders and cause fits for Derek Carr. And in the second game, Justin Herbert and other Chargers skill players like Keenan Allen and Austin Ekeler should take advantage of Kansas City’s vulnerable defense.

The Chargers’ next two games are against the Jaguars and Texans. Both should be winnable.

Predicting #NFL records: @chargers
14-3
W vs LV
W @ KC
W vs JAX
W @ HOU
W @ CLV
W vs DEN
W vs SEA
W @ ATL
L @ SF
L vs KC
W @ ARZ
W @ LV
W vs MIA
W vs TEN
W @ IND
L vs Rams
W @ DEN

— Colton Pool (@CPoolReporter) August 14, 2022

Buffalo Bills

The Bills are another Super Bowl odds favorite, so logically they should be favored in quite a few games. They’re tied for the eight-best odds to start 4-0 at +400, though, because of a tough beginning of the season.

Starting the year on the road across the country against the defending Super Bowl champion Rams won’t be easy. But the Bills are a complete team, featuring one of the best secondaries in the league, so they should be ready.

The Bills then play the Titans, Dolphins and Ravens. None of those games will be easy, but if the Bills do beat the Rams to start, then they’ve proven they’re an elite team that should be capable of winning in those contests as well.

Predicting #NFL records: @BuffaloBills
14-3
W @ Rams
W vs. TEN
W @ MIA
W @ BAL
W vs. PIT
L @ KC
W vs. GB
W @ Jets
W vs. MIN
L vs. CLV
W @ DET
L @ NE
W vs. Jets
W vs. MIA
W @ CHI
W @ CIN
W vs. NE

— Colton Pool (@CPoolReporter) August 6, 2022

San Francisco 49ers

The 49ers’ future greatly depends on the performance of second-year quarterback Trey Lance, who now appears to be the starter after being drafted third overall in 2021. The team has the same odds to start 4-0 as the Bills at +400.

But Lance is talented enough to propel the rest of this roster, loaded with talent on both sides of the ball, to success. That includes early on in the season.

The 49ers begin the year at Chicago and then against the Seahawks. However, they then face the Broncos on the road and Rams at home back-to-back.

The 49ers will have an advantage up front against both of those teams, however.