Clemson vs Pitt Prediction, Odds & Best Prop Bets โ€“ NCAAF, Week 12

Pittsburgh wide receiver Daejon Reynolds (3) tries to make a catch during the first half of an NCAA college football game against Notre Dame Saturday, Oct. 28, 2023, in South Bend, Ind. (AP Photo/Michael Caterina)
(AP Photo/Michael Caterina)
  • Clemson is a -10 point favorite vs. Pitt
  • Clemson vs. Pittsburgh Total (Over/Under): 53.5 points
  • TV Channel: ESPN

The Clemson Tigers (7-2) visit Acrisure Stadium to take on the Pittsburgh Panthers (7-2) on Nov. 16 in Pittsburgh, PA. Kickoff is scheduled for 12:00pm EST.

Clemson is a betting favorite in Week 12, with the spread sitting at -10 (-110).

The Clemson vs. Pittsburgh Over/Under is 53.5 total points.

Bet now on Pitt vs Clemson & all NCAAF games with BetMGM

Clemson vs. Pittsburgh Odds, Spread, Over/Under:

SpreadTotal (O/U)Moneyline
Clemson-10 -11053.5 -110-375
Pittsburgh +10 -11053.5 -110+300

Clemson vs Pittsburgh Prediction:

The winning team model predicts Clemson will win this game with 76.3% confidence, based on game simulations, offensive & defensive matchups and recent game results.

This winning team prediction factors in up-to-date player injuries for both Clemson and Pitt, key player performances this season and recent team trends.

Clemson vs Pittsburgh Spread Prediction:

Based on recent against-the-spread trends, the model predicts Pittsburgh will cover the spread with 86.8% confidence.

This prediction against the spread factors in ATS performances for both teams, opening and current betting lines plus public and sharp money already wagered on this matchup.


Bet now on Pitt vs Clemson and all games with BetMGM


  • Clemson has hit the Moneyline in 10 of their last 12 games (+5.10 Units / 6% ROI)
  • Clemson has hit the Game Total Under in 4 of their last 6 away games (+2.90 Units / 44% ROI)
  • Clemson have covered the 1H Spread in 4 of their last 6 away games (+1.80 Units / 28% ROI)
  • Clemson has hit the 1Q Game Total Under in 7 of their last 11 games (+1.80 Units / 14% ROI)
  • Clemson has hit the 1H Game Total Under in 7 of their last 12 games (+1.55 Units / 12% ROI)
  • Pittsburgh have covered the 1H Spread in 6 of their last 7 games at home (+6.00 Units / 76% ROI)
  • Pittsburgh has hit the 1H Moneyline in 6 of their last 7 games at home (+6.00 Units / 11% ROI)
  • Pittsburgh has hit the 1Q Moneyline in 4 of their last 5 games at home (+4.00 Units / 37% ROI)
  • Pittsburgh has hit the Moneyline in 8 of their last 11 games (+3.25 Units / 4% ROI)
  • Pittsburgh have covered the Spread in 5 of their last 7 games at home (+2.75 Units / 35% ROI)

We’ve highlighted some favorite college football player prop bets for Clemson players, looking at profitable historical betting trends:

Best Clemson Player Prop Bets Today

  • Jake Briningstool has hit the Receiving Yards Over in his last 2 away games (+2.00 Units / 83% ROI)
  • Antonio Williams has hit the Receiving Yards Over in his last 2 away games (+2.00 Units / 83% ROI)
  • Phil Mafah has hit the Rushing Yards Over in his last 2 games (+2.00 Units / 83% ROI)
  • Cade Klubnik has hit the Rushing Yards Under in his last game (+1.00 Units / 83% ROI)
  • Tyler Brown has hit the Receiving Yards Under in his last game (+1.00 Units / 80% ROI)

Top NCAAF player prop bets for Pittsburgh players, looking at profitable historical betting trends:

Best Pittsburgh Player Prop Best Bets Today

  • Konata Mumpfield has hit the Receiving Yards Under in his last 3 games at home (+3.00 Units / 83% ROI)
  • Desmond Reid has hit the Receiving Yards Over in his last 2 games (+2.00 Units / 83% ROI)
  • Kenny Johnson has hit the Receiving Yards Under in his last 2 games at home (+2.00 Units / 83% ROI)
  • Eli Holstein has hit the Passing Yards Under in his last game (+1.00 Units / 83% ROI)
  • Gavin Bartholomew has hit the Receiving Yards Under in his last game (+1.00 Units / 83% ROI)

Clemson Against the Spread (ATS) Record

Clemson is 5-4 against the spread this college football season (+0.6 Units / 6.09% ROI).

  • Clemson is 7-2 when betting on the Moneyline for +2.1 Units / 2.56% ROI
  • Clemson is 3-5 when betting the Over for -2.5 Units / -25.25% ROI
  • Clemson is 5-3 when betting the Under for +1.7 Units / 17.17% ROI

Pittsburgh Against the Spread (ATS) Record

Pitt is 6-3 against the spread this college football season (+2.65 Units / 26.63% ROI).

  • Pittsburgh is 7-2 when betting on the Moneyline for +3.25 Units / 4.34% ROI
  • Pittsburgh is 4-5 when betting the Over for -1.5 Units / -15.15% ROI
  • Pittsburgh is 5-4 when betting the Under for +0.6 Units / 6.06% ROI

Clemson: Keys to the Game vs. Pittsburgh

Clemson is 9-2 (.818) when the opposing team rushes more than 30 times since the 2023 season– 3rd-best among Power Conference Teams; Average: .490

Clemson is 9-2 (.818) when the opposing team rushes more than 30 times since the 2023 season– 4th-best in FBS; Average: .446

Clemson is 16-3 (.842) when rushing at least 4 yards in a play 10 or more times since the 2023 season– 12th-best in FBS; Average: .582

Clemson is 13-3 (.812) when allowing less than 5 explosive passes since the 2023 season– 14th-best among Power Conference Teams; Average: .683

Pittsburgh: Keys to the Game vs. Clemson

Pittsburgh is 2-7 (.222) when allowing an average of more than 5 yards on first down plays since the 2023 season– T-5th-worst among Power Conference Teams; Average: .491

Pittsburgh is 6-5 (.545) when rushing more than 30 times since the 2023 season– T-15th-worst among Power Conference Teams; Average: .671

Pittsburgh is 4-9 (.308) when allowing 100 or more rushing yards since the 2023 season– T-11th-worst among Power Conference Teams; Average: .470

Pittsburgh is 1-6 (.143) when losing at least one fumble since the 2023 season– T-12th-worst in FBS; Average: .440

Matchup Notes for Clemson vs. Pittsburgh

Pittsburgh has 15 receiving touchdowns in the Red Zone this season — T-5th-most among FBS skill players. Clemson’s defense has allowed 10 receiving touchdowns in the Red Zone this season — T-4th-most among ACC defenses.

Pittsburgh’s RBs has 4 receiving touchdowns in the Red Zone this season — T-most among FBS RBs. Clemson’s defense has allowed 10 receiving touchdowns in the Red Zone this season — T-4th-most among ACC defenses.

Pittsburgh’s RBs has rushed for 924 yards on 165 carries (5.6 YPC) this season — T-29th-best among FBS RBs. Clemson’s defense have allowed 4.4 YPC this season — T-3rd-worst among ACC defenses.

Clemson’s QBs has thrown for 2,411 passing yards in 9 games (267.9 YPG) this season — 31st-best among FBS teams. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 4th-worst among ACC defenses.

Clemson’s QBs has thrown for 2,411 passing yards in 9 games (267.9 YPG) this season — 31st-best among FBS teams. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 21st-worst among FBS defenses.

Clemson’s offense has thrown for 2,473 passing yards in 9 games (274.8 YPG) this season — 24th-best among FBS offenses. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 4th-worst among ACC defenses.

Clemson Offensive Stats & Trends

Clemson’s QBs has thrown for 2,411 passing yards in 9 games (267.9 YPG) this season — 31st-best among FBS teams. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 4th-worst among ACC defenses.

Clemson’s QBs has thrown for 2,411 passing yards in 9 games (267.9 YPG) this season — 31st-best among FBS teams. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 21st-worst among FBS defenses.

Clemson’s offense has thrown for 2,473 passing yards in 9 games (274.8 YPG) this season — 24th-best among FBS offenses. Pittsburgh’s defense has allowed 251.7 passing yards per game this season — 4th-worst among ACC defenses.

Clemson RBs have averaged 8.4 yards from scrimmage per touch (185 yards / 22 touches) on 3rd and short this season– 4th-best among FBS Teams; Average: 4.5

Clemson Skill Players have averaged just 9.2 yards per reception (808 yards/88 catches) in the 4th quarter since the 2023 season– 2nd-worst among Power Conference Teams; Average: 12.3

Pittsburgh Offensive Stats & Trends

Pittsburgh RBs have averaged 9.2 yards from scrimmage per touch (619 yards / 67 touches) on 2nd down this season– best among FBS Teams; Average: 5.5

Pittsburgh RBs have averaged 11.5 yards from scrimmage per touch (138 yards / 12 touches) in close and late situations this season– 2nd-best among FBS Teams; Average: 5.4

Pittsburgh Skill Players have caught 9 touchdown passes in the 4th quarter this season– T-most among FBS Teams

Pittsburgh Skill Players have caught 9 touchdown passes in the 4th quarter this season– T-most among Power Conference Teams

Pittsburgh RBs have picked up first downs on 5 receptions in the Red Zone this season– most among FBS Teams

Clemson Tigers Defensive Stats & Trends

Clemson has allowed a Completion Pct of just 12% (1 completions/8 attempts) on 3rd and short this season– best among Power Conference Teams; Average: 60%

Clemson has allowed a Completion Pct of just 53% (377 completions/706 attempts) since the 2023 season– 2nd-best in FBS; Average: 61%

Clemson has allowed a Completion Pct of just 53% (182 completions/344 attempts) in the 1st half since the 2023 season– 2nd-best in FBS; Average: 62%

Clemson has allowed first downs on 38% of rush attempts in close and late situations this season– worst among Power Conference Teams; Average: 21%

Clemson has allowed a Completion Pct of just 40% (10 completions/25 attempts) on 3rd and short since the 2023 season– T-2nd-best in FBS; Average: 62%

Pittsburgh Panthers Defensive Stats & Trends

Pittsburgh has allowed passes of 20+ yards on 24 of 109 attempts (22%) on 3rd and long since the 2023 season– worst among Power Conference Teams; Average: 9%

Pittsburgh has allowed passes of 20+ yards on 24 of 109 attempts (22%) on 3rd and long since the 2023 season– worst in FBS; Average: 9%

Pittsburgh has allowed passes of 20+ yards on 14 of 62 attempts (23%) on 3rd and long this season– worst among Power Conference Teams; Average: 9%

Pittsburgh has allowed passes of 20+ yards on 14 of 62 attempts (23%) on 3rd and long this season– 2nd-worst in FBS; Average: 10%

Pittsburgh allowed passes of 20+ yards on 10 of 47 attempts (21%) on 3rd and long in the 2023 season– T-best in FBS; Average: 9%


Bet now on Pitt vs Clemson and all games with BetMGM


More College Football Betting at BetMGM

BetMGM is the best online sportsbook for college football betting.

Whether youโ€™re a first-time bettor checking out the best sportsbook promos, a casual fan betting on Georgia football national championship odds, Michigan football odds, or Ohio State playoff odds, or a longtime diehard breaking down trends for live sports betting, there are entertainment options for everyone.

Visit the sportsbook today to place a college football bet online!

BetMGM First Bet Offer
About the Author

Shane Jackson

Read More @Sjacksonmgm

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.

Shane Jackson is a Web Content Writer for BetMGM, covering MLB and NBA. After graduating from the University of Kansas, his previous stops include MLB.com, Lawrence Journal-World, Manhattan Mercury, Bet Chicago Sports, WynnBET, and Sportsbook Review.