- The Astros are -118 favorites vs the Cardinals
- Astros vs Cardinals Over / Under today: 8.5 Runs
- Astros / Cardinals TV Channel: FDMW | SCHN
The Houston Astros (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on Wednesday, April 16, 2025. First pitch is scheduled for 1:15pm EDT in St. Louis, MO.
This season, the Astros are 8-9 against the spread (ATS), while the Cardinals are 9-8 ATS.
Astros vs Cardinals Starting Pitchers Today:
- Astros starting pitcher: Ronel Blanco 1-1, 7.15 ERA
- Cardinals starting pitcher: Steven Matz 0-0, 2.32 ERA
Astros vs. Cardinals Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| Astros | -1.5 +165 | O 8.5 -118 | -105 |
| Cardinals | +1.5 -200 | U 8.5 -102 | -115 |
Astros vs Cardinals Prediction for Today’s Game
Based on recent trends the model predicts the Astros will win Wednesday‘s MLB game with 52.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
Bet now on Astros vs Cardinals and all games with BetMGM
We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:
Best Astros Player Prop Bets Today:
- Isaac Paredes has hit the Home Runs Over in 3 of his last 5 games (+14.40 Units / 288% ROI)
- Christian Walker has hit the RBIs Under in 18 of his last 20 games (+13.20 Units / 31% ROI)
- Yainer Diaz has hit the Hits Runs and RBIs Under in 16 of his last 20 away games (+12.60 Units / 54% ROI)
- Isaac Paredes has hit the Singles Over in 17 of his last 25 away games (+12.10 Units / 47% ROI)
- Yainer Diaz has hit the Total Bases Under in 19 of his last 25 away games (+11.90 Units / 34% ROI)
And here are some favorite MLB player prop bets for Cardinals players for Wednesday‘s game, looking at profitable historical betting trends:
Best Cardinals Player Prop Best Bets Today:
- Brendan Donovan has hit the Hits Over in his last 10 games (+10.95 Units / 54% ROI)
- Jordan Walker has hit the Home Runs Over in 2 of his last 7 games at home (+9.50 Units / 136% ROI)
- Nolan Arenado has hit the RBIs Over in 6 of his last 10 games at home (+7.20 Units / 72% ROI)
- Brendan Donovan has hit the Total Bases Over in 8 of his last 10 games (+6.95 Units / 52% ROI)
- Michael Siani has hit the Hits Runs and RBIs Under in 13 of his last 20 games (+6.95 Units / 28% ROI)
Astros Best Bets Today:
- The Houston Astros have hit the Game Total Under in 92 of their last 162 games (+21.20 Units / 12% ROI)
- The Houston Astros have covered the Run Line in 83 of their last 162 games (+4.85 Units / 2% ROI)
- The Houston Astros have hit the 1st Five Innings (F5) Moneyline in 37 of their last 81 away games (+2.55 Units / 2% ROI)
- The Houston Astros have covered the 1st Five Innings (F5) Run Line in 44 of their last 81 away games (+0.90 Units / 1% ROI)
- The Houston Astros have hit the Moneyline in 44 of their last 81 away games (+0.90 Units / 1% ROI)
Cardinals Best Bets Today:
- The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 8 of their last 11 games at home (+4.85 Units / 35% ROI)
- The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 6 of their last 11 games at home (+3.95 Units / 30% ROI)
- The St. Louis Cardinals have covered the Run Line in 44 of their last 86 games at home (+3.90 Units / 4% ROI)
- The St. Louis Cardinals have hit the Team Total Over in 7 of their last 11 games at home (+3.05 Units / 26% ROI)
Astros Against the Spread (ATS) Record
Against the spread this season, the Astros are 8-9 against the Run Line (-0.55 Units / -2.48% ROI).
- 8-9 when betting on the Moneyline for -2.95 Units / -13.98% ROI
- 7-8 when betting on the total runs Over for -1.95 Units / -10.29% ROI
- 8-7 when betting on the total runs Under for +0.35 Units / 1.9% ROI
Cardinals Against the Spread (ATS) Record
Against the spread this season, the Cardinals are 9-8 against the Run Line (-0.9 Units / -3.57% ROI).
- 8-9 when betting on the Moneyline for -1.65 Units / -8.59% ROI
- 10-6 when betting on the total runs Over for +3.4 Units / 18.23% ROI
- 6-10 when betting on the total runs Under for -5.05 Units / -26.93% ROI
Cardinals vs Astros Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Christian Walker (HOU) | 0.5 +475 | 0.5 -700 |
| Willson Contreras (STL) | 0.5 +500 | 0.5 -700 |
| Lars Nootbaar (STL) | 0.5 +575 | 0.5 -900 |
| Jordan Walker (STL) | 0.5 +625 | 0.5 -1000 |
| Jose Altuve (HOU) | 0.5 +675 | 0.5 -1100 |
Cardinals vs Astros Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Yainer Diaz (HOU) | 0.5 -275 | 0.5 +200 |
| Brendan Donovan (STL) | 0.5 -250 | 0.5 +185 |
| Alec Burleson (STL) | 0.5 -210 | 0.5 +160 |
| Lars Nootbaar (STL) | 0.5 -200 | 0.5 +150 |
| Christian Walker (HOU) | 0.5 -200 | 0.5 +150 |
Cardinals vs Astros RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Isaac Paredes (HOU) | 0.5 +155 | 0.5 -210 |
| Christian Walker (HOU) | 0.5 +160 | 0.5 -220 |
| Yainer Diaz (HOU) | 0.5 +175 | 0.5 -235 |
| Nolan Arenado (STL) | 0.5 +185 | 0.5 -250 |
| Jose Altuve (HOU) | 0.5 +185 | 0.5 -250 |
Cardinals vs Astros Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Steven Matz (STL) | 2.5 -165 | 2.5 +130 |
| Ronel Blanco (HOU) | 4.5 -155 | 4.5 +120 |
Astros Starting Pitcher Stats & Trends
Opponents batted just .147 (33-for-225) against Ronel Blanco when going through the lineup the second time in a game in the 2024 season — best among qualified SPs in MLB; League Avg: .232 — 100th Percentile.
Ronel Blanco walked 33 of 270 batters (12%) when going through the lineup the first time in a game in the 2024 season — highest among qualified SPs in MLB; League Avg: 7% — first Percentile.
Opponents are hitting just .162 (49-for-303) against Ronel Blanco when going through the lineup the second time in a game since the 2023 season — best in MLB among starting pitchers with at least 135 total IP; League Avg: .247 — 100th Percentile.
Ronel Blanco has walked 37 of 297 batters (12%) when going through the lineup the first time in a game since last season — highest among qualified SPs in MLB; League Avg: 7% — first Percentile.
Cardinals Starting Pitcher Stats & Trends
Steven Matz has a strikeout rate of just 23% (6 SO in 26 PAs) with two-strikes this season — 8th lowest among qualified RPs in MLB; League Avg: 44% — sixth Percentile.
Steven Matz has a strikeout rate of just 12% (6 SO in 49 PAs) this season — tied for 10th lowest among NL Relievers; League Avg: 23% — 10th Percentile.
Steven Matz has a strike rate of 70% (49/70) vs left-handed batters this season — 10th highest among qualified RPs in MLB; League Avg: 63% — 90th Percentile.
Opponents have a two strike miss rate of just 13% (5/38) against Steven Matz this season — 13th lowest among NL Relievers; League Avg: 25% — 12th Percentile.
Astros Keys to the Game vs. the Cardinals
The Astros were just 5-13 (.278) when tied entering the 8th inning in the 2024 season — 3rd lowest in MLB; League Avg: .500.
The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.
The Astros are just 0-7 (.000) after a win this season — tied for lowest in MLB; League Avg: .467.
The Astros are just 13-23 (.361) when tied entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .500.
Cardinals Keys to the Game vs. the Astros
The Cardinals are just 117-23 (.836) when leading entering the 7th inning since the 2023 season — 5th lowest in MLB; League Avg: .859.
The Cardinals are just 0-6 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .117.
The Cardinals are 77-2 (.975) when leading entering the 9th inning since last season — 5th best in MLB; League Avg: .951.
The Cardinals are just 31-71 (.304) when their opponents score in the first inning since the 2023 season — 5th lowest in MLB; League Avg: .374.
Astros Hitting Stats & Trends
Astros hitters averaged just 3.65 pitches per plate appearance against RHP in the 2024 season — lowest in MLB; League Avg: 3.89.
Astros hitters have an OBP of .483 (58 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .325.
The Astros are batting .388 when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .251.
Astros hitters are averaging just 3.74 pitches per plate appearance since the 2023 season — lowest in MLB; League Avg: 3.89.
Cardinals Hitting Stats & Trends
The Cardinals are batting .220 on pitches out of the zone this season — best in MLB; League Avg: .145.
The Cardinals are batting .282 this season — best in MLB; League Avg: .235.
The Cardinals are batting .283 against LHP this season — 3rd best in MLB; League Avg: .228.
Cardinals hitters have an OBP of .369 (208 PA’s) against LHP this season — 2nd best in MLB; League Avg: .306.
Astros Pitching Stats & Trends
Astros pitchers have a strikeout rate of 28% this season — best in MLB; League Avg: 23%.
Opponents have a miss rate of 28% against Astros pitchers since last season — 2nd best in MLB; League Avg: 25%.
Opponents have a miss rate of 28% against Astros pitchers since the 2023 season — 2nd best in MLB; League Avg: 26%.
Opponents had a miss rate of 27% against Astros pitchers in the 2024 season — 2nd best in MLB; League Avg: 25%.
Cardinals Pitching Stats & Trends
The Cardinals have allowed 8.17 runs per game (49/6) on the road this season — highest in MLB; League Avg: 4.67.
Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.
Cardinals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.
Cardinals pitchers have an ERA of 7.08 (54.2 IP) on the road this season — highest in MLB; League Avg: 4.46.
More MLB Reading:
Bet now on Astros vs Cardinals and all games with BetMGM
Bet on MLB Odds at BetMGM
Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.
