Astros vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Apr 24

Chicago Cubs' Ian Happ watches his grand slam off Pittsburgh Pirates starting pitcher Mitch Keller during the fifth inning of a baseball game Wednesday, Sept. 20, 2023, in Chicago. (AP Photo/Charles Rex Arbogast)
(AP Photo/Charles Rex Arbogast)
  • The Astros are -110 favorites vs the Cubs
  • Astros vs Cubs Over / Under today: 8 Runs
  • Astros / Cubs TV Channel: MARQ | SCHN

The Houston Astros (-105) visit Wrigley Field to take on the Chicago Cubs (-115) on Wednesday, April 24, 2024. First pitch is scheduled for 7:40pm EDT in Chicago, IL.

This season, the Astros are 7-17 against the spread (ATS), while the Cubs are 16-6 ATS.

Astros vs Cubs Starting Pitchers Today:

  • Astros starting pitcher: Spencer Arrighetti 0-2, 11.58 ERA
  • Cubs starting pitcher: Jameson Taillon 1-0, 1.80 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros-1.5 +155O 8 -110-105
Cubs +1.5 -190U 8 -110-115

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Wednesday‘s MLB game with 51.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Astros vs Cubs and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Astros players for Wednesday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • player high – away 

And here are some favorite MLB player prop bets for Cubs players for Wednesday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • player  high – home
  • The Houston Astros have hit the Moneyline in 36 of their last 48 away games (+20.35 Units / 31% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 40 of their last 60 away games (+16.18 Units / 22% ROI)
  • The Houston Astros have covered the Run Line in 40 of their last 62 away games (+15.50 Units / 18% ROI)
  • The Houston Astros have hit the Game Total Over in 37 of their last 61 games (+15.00 Units / 22% ROI)
  • The Houston Astros have hit the Team Total Over in 34 of their last 51 away games (+13.80 Units / 23% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 38 of their last 66 games (+9.21 Units / 12% ROI)
  • The Chicago Cubs have hit the Game Total Under in 21 of their last 32 games (+8.75 Units / 25% ROI)
  • The Chicago Cubs have hit the Moneyline in 23 of their last 34 games at home (+7.75 Units / 15% ROI)
  • The Chicago Cubs have covered the Run Line in 36 of their last 68 games at home (+7.75 Units / 10% ROI)
  • The Chicago Cubs have hit the Team Total Over in 35 of their last 61 games at home (+6.79 Units / 10% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-16 against the Run Line (+0 Units / 0% ROI).

  • 7-17 when betting on the Moneyline for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Over for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Under for +0 Units / 0% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 16-6 against the Run Line (+0 Units / 0% ROI).

  • 14-8 when betting on the Moneyline for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Over for +0 Units / 0% ROI
  • 0-0 when betting on the total runs Under for +0 Units / 0% ROI

Cubs vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +400 0.5 -550
Christopher Morel (CHC) 0.5 +625 0.5 -1000
Kyle Tucker (HOU) 0.5 +650 0.5 -1000
Yainer Diaz (HOU) 0.5 +725 0.5 -1200
Matt Mervis (CHC) 0.5 +775 0.5 -1400

Cubs vs Astros Total Hits Prop Bets Today

Over Under
Nico Hoerner (CHC) 0.5 -250 0.5 +195
Jeremy Pena (HOU) 0.5 -225 0.5 +165
Yainer Diaz (HOU) 0.5 -210 0.5 +160
Jose Altuve (HOU) 0.5 -200 0.5 +150
Kyle Tucker (HOU) 0.5 -200 0.5 +150

Cubs vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +175 0.5 -250
Kyle Tucker (HOU) 0.5 +180 0.5 -250
Yainer Diaz (HOU) 0.5 +180 0.5 -250
Alex Bregman (HOU) 0.5 +185 0.5 -250
Christopher Morel (CHC) 0.5 +185 0.5 -250

Cubs vs Astros Strikeout Prop Bets Today

Over Under

Spencer Arrighetti has limited playing time.

Cubs Starting Pitcher Stats & Trends

Jameson Taillon has walked 19 of 745 right-handed batters (3%) since the 2022 season — 2nd best in MLB among starting pitchers with at least 138 total IP; League Avg: 7% — 99th Percentile.

Jameson Taillon has allowed an average Exit Velocity of just 86.5 MPH on the first pitch of at-bats since the 2022 season (148 balls in play) — 3rd best in MLB among starting pitchers with at least 138 total IP; League Avg: 89.9

Jameson Taillon has a first-pitch strike rate of 70% (474/673) since last season — highest in MLB among starting pitchers with at least 73 total IP; League Avg: 62% — 100th Percentile.

Jameson Taillon has walked 9 of 337 right-handed batters (3%) since last season — 4th best in MLB among starting pitchers with at least 73 total IP; League Avg: 7% — 97th Percentile.

Astros Keys to the Game vs. the Cubs

The Astros are 41-34 (.547) vs top 10 scoring offenses since the 2022 season — 2nd best in MLB; League Avg: .420.

The Astros are 62-43 (.590) after a road win since the 2022 season — 2nd best in MLB; League Avg: .492.

The Astros are 42-25 (.627) after a road loss since the 2022 season — 2nd best in MLB; League Avg: .461.

The Astros are 105-68 (.607) on the road since the 2022 season — 3rd best in MLB; League Avg: .476.

Cubs Keys to the Game vs. the Astros

The Cubs are 22-18 (.550) after a loss as underdogs since the 2023 season — 4th best in MLB; League Avg: .425.

The Cubs are 53-31 (.631) after a win as favorites since the 2022 season — tied for 5th best in MLB; League Avg: .589.

The Cubs are just 13-26 (.333) after a win as underdogs since the 2023 season — 4th lowest in MLB; League Avg: .423.

The Cubs are just 21-27 (.438) when tied entering the 7th inning since the 2022 season — 5th lowest in MLB; League Avg: .500.

Astros hitters have just 698 strikeouts in 3,953 PA’s (18%) against LHP since the 2022 season — best in MLB; League Avg: 22%.

Astros hitters have just 377 strikeouts in 2,103 PA’s (18%) against LHP since last season — best in MLB; League Avg: 22%.

Astros hitters have put 43% of their swings in play on pitches 95 mph or greater this season — highest in MLB; League Avg: 34%.

The Astros have a winning percentage of 63% on the road since the 2022 season — best in MLB; League Avg: 48%.

Cubs hitters have an OPS of .867 (184 PA’s) against LHP this season — 2nd best in MLB; League Avg: .698.

The Cubs are batting .270 against LHP since last season — 4th best in MLB; League Avg: .253.

The Cubs are batting just .181 with two outs this season — 2nd lowest in MLB; League Avg: .230.

Cubs hitters are slugging .506 against LHP this season — best in MLB; League Avg: .381.

Astros pitchers have an ERA of 6.51 (105.0 IP) over the last 14 days — highest in MLB; League Avg: 3.82.

Opponents have a miss rate of 28% against Astros pitchers since the 2022 season — 2nd best in MLB; League Avg: 26%.

Astros pitchers have a strikeout rate of 25% since the 2022 season — 2nd best in MLB; League Avg: 23%.

Astros pitchers have a strikeout rate of 45% with two-strikes since the 2022 season — tied for 2nd best in MLB; League Avg: 42%.

The longest HR allowed by the Cubs pitchers this season traveled 460.0 feet — — 2nd longest in MLB; League Avg: 441.8

Opponents have a groundball batting average of just .230 against Cubs pitchers with runners on base since last season — 2nd best in MLB; League Avg: .259.

Opponents have a groundball batting average of just .206 against Cubs pitchers with the shift since the 2022 season — 3rd best in MLB; League Avg: .231.

Cubs pitchers have an ERA of 3.18 (99.0 IP) at home this season — 5th best in MLB; League Avg: 3.93.

Cubs vs. Astros Injuries Tonight That May Affect Prop Bets 

  • Patrick Wisdom (Chicago Cubs): Back, 10-Day IL
  • Justin Steele (Chicago Cubs): Hamstring, 15-Day IL
  • Brennen Davis (Chicago Cubs): Undisclosed, Out
  • Tyler Duffey (Chicago Cubs): Back, Day-To-Day
  • Jameson Taillon (Chicago Cubs): Back, 15-Day IL
  • Caleb Kilian (Chicago Cubs): Shoulder, 60-Day IL
  • Grae Kessinger (Houston Astros): Hamstring, Day-To-Day
  • Justin Verlander (Houston Astros): Shoulder, 15-Day IL
  • Penn Murfee (Houston Astros): Elbow, 15-Day IL
  • Kendall Graveman (Houston Astros): Shoulder, 60-Day IL
  • Jose Abreu (Houston Astros): Hand, Day-To-Day
  • Jose Urquidy (Houston Astros): Forearm, 15-Day IL
  • Oliver Ortega (Houston Astros): Elbow, 15-Day IL
  • Lance McCullers (Houston Astros): Forearm, 60-Day IL
  • Bennett Sousa (Houston Astros): Shoulder, 15-Day IL
  • Forrest Whitley (Houston Astros): Finger, 7-Day IL
  • Shawn Dubin (Houston Astros): Forearm, 15-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.