Astros vs Cubs Prediction, Odds & Player Prop Bets Today – MLB, Apr 25

Chicago Cubs' Nico Hoerner watches his RBI sacrifice fly during the fifth inning of a baseball game against the Colorado Rockies Saturday, Sept. 23, 2023, in Chicago. Chicago won 6-3. (AP Photo/Paul Beaty)
(AP Photo/Paul Beaty)
  • The Astros are -130 favorites vs the Cubs
  • Astros vs Cubs Over / Under today: 8 Runs
  • Astros / Cubs TV Channel: MARQ | SCHN

The Houston Astros (-125) visit Wrigley Field to take on the Chicago Cubs (+105) on Thursday, April 25, 2024. First pitch is scheduled for 2:20pm EDT in Chicago, IL.

This season, the Astros are 7-18 against the spread (ATS), while the Cubs are 17-7 ATS.

Astros vs Cubs Starting Pitchers Today:

  • Astros starting pitcher: Justin Verlander 1-0, 3.00 ERA
  • Cubs starting pitcher: Javier Assad 2-0, 2.11 ERA

Astros vs. Cubs Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Astros-1.5 +140O 7.5 -110-125
Cubs +1.5 -165U 7.5 -110+105

Astros vs Cubs Prediction for Today’s Game

Based on recent trends the model predicts the Astros will win Thursday‘s MLB game with 53.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Astros players for Thursday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Bets Today:

  • Michael Brantley has hit the Home Runs Over in 2 of his last 8 away games (+7.00 Units / 88% ROI)
  • Michael Brantley has hit the Runs Under in 8 of his last 9 games (+5.65 Units / 30% ROI)
  • Michael Brantley has hit the Hits Under in 8 of his last 14 games (+5.45 Units / 29% ROI)
  • Michael Brantley has hit the Hits Runs and RBIs Under in 9 of his last 12 games (+5.20 Units / 35% ROI)
  • Michael Brantley has hit the Singles Under in 6 of his last 7 away games (+5.10 Units / 67% ROI)

And here are some favorite MLB player prop bets for Cubs players for Thursday‘s game, looking at profitable historical betting trends:

Best Cubs Player Prop Best Bets Today:

  • No trends found
  • The Houston Astros have hit the Moneyline in 36 of their last 48 away games (+20.35 Units / 31% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Over in 40 of their last 60 away games (+16.18 Units / 22% ROI)
  • The Houston Astros have covered the Run Line in 40 of their last 62 away games (+15.50 Units / 18% ROI)
  • The Houston Astros have hit the Game Total Over in 37 of their last 61 games (+15.00 Units / 22% ROI)
  • The Houston Astros have hit the Team Total Over in 34 of their last 51 away games (+13.80 Units / 23% ROI)
  • The Chicago Cubs have hit the 1st Five Innings (F5) Team Total Over in 38 of their last 66 games (+9.21 Units / 12% ROI)
  • The Chicago Cubs have hit the Game Total Under in 21 of their last 32 games (+8.75 Units / 25% ROI)
  • The Chicago Cubs have hit the Moneyline in 23 of their last 34 games at home (+7.75 Units / 15% ROI)
  • The Chicago Cubs have covered the Run Line in 36 of their last 68 games at home (+7.75 Units / 10% ROI)
  • The Chicago Cubs have hit the Team Total Over in 35 of their last 61 games at home (+6.79 Units / 10% ROI)

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 8-17 against the Run Line (+0 Units / 0% ROI).

  • 7-18 when betting on the Moneyline for +0 Units / 0% ROI
  • 8-15 when betting on the total runs Over for +0 Units / 0% ROI
  • 15-8 when betting on the total runs Under for +0 Units / 0% ROI

Cubs Against the Spread (ATS) Record

Against the spread this season, the Cubs are 17-7 against the Run Line (+0 Units / 0% ROI).

  • 15-9 when betting on the Moneyline for +0 Units / 0% ROI
  • 11-13 when betting on the total runs Over for +0 Units / 0% ROI
  • 13-11 when betting on the total runs Under for +0 Units / 0% ROI

Cubs vs Astros Home Run Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +350 0.5 -450
Christopher Morel (CHC) 0.5 +475 0.5 -650
Kyle Tucker (HOU) 0.5 +650 0.5 -1100
Matt Mervis (CHC) 0.5 +650 0.5 -1000
Michael Busch (CHC) 0.5 +650 0.5 -1100

Cubs vs Astros Total Hits Prop Bets Today

Over Under
Nico Hoerner (CHC) 0.5 -250 0.5 +180
Yordan Alvarez (HOU) 0.5 -250 0.5 +180
Kyle Tucker (HOU) 0.5 -225 0.5 +170
Yainer Diaz (HOU) 0.5 -225 0.5 +165
Jeremy Pena (HOU) 0.5 -210 0.5 +155

Cubs vs Astros RBI Prop Bets Today

Over Under
Yordan Alvarez (HOU) 0.5 +150 0.5 -200
Yainer Diaz (HOU) 0.5 +165 0.5 -225
Kyle Tucker (HOU) 0.5 +170 0.5 -225
Alex Bregman (HOU) 0.5 +170 0.5 -225
Christopher Morel (CHC) 0.5 +180 0.5 -250

Cubs vs Astros Strikeout Prop Bets Today

Over Under

Opponents are hitting just .227 (15-for-66) against Justin Verlander on the first pitch of at-bats since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .350 — 100th Percentile.

Justin Verlander has allowed an OPS of just .542 (495 PA’s) when going through the lineup the second time in a game since the 2022 season — 2nd best in MLB among starting pitchers with at least 138 total IP; League Avg: .712 — 98th Percentile.

Justin Verlander has allowed an OBP of just .249 (494 PA’s) when going through the lineup the second time in a game since the 2022 season — 3rd best in MLB among starting pitchers with at least 138 total IP; League Avg: .307 — 97th Percentile.

Justin Verlander has allowed a slugging percentage of just .268 (162 Total Bases / 605 ABs) vs left-handed batters since the 2022 season — best in MLB among starting pitchers with at least 138 total IP; League Avg: .401 — 100th Percentile.

Cubs Starting Pitcher Stats & Trends

Opponents are hitting just .129 (15-for-116) against Javier Assad with runners in scoring position since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .255 — 100th Percentile.

Javier Assad has allowed an OPS of just .408 (134 PA’s) with runners in scoring position since last season — best in MLB among starting pitchers with at least 74 total IP; League Avg: .740 — 100th Percentile.

Javier Assad has a strike rate of just 61% (635/1,047) against right-handed batters since last season — 4th lowest in MLB among starting pitchers with at least 74 total IP; League Avg: 65% — second Percentile.

Opponents have a Hard-Hit Rate of just 19% (5/26) against Javier Assad on fastballs this season — best in MLB among starting pitchers with at least 9 total IP; League Avg: 46% — 100th Percentile.

Astros Keys to the Game vs. the Cubs

The Astros are 16-15 (.516) after a loss as underdogs since the 2022 season — 4th best in MLB; League Avg: .410.

The Astros are 96-25 (.793) when they’ve hit 2 or more home runs since the 2022 season — 3rd best in MLB; League Avg: .697.

The Astros are 42-26 (.618) after a road loss since the 2022 season — 2nd best in MLB; League Avg: .461.

The Astros are 13-11 (.542) after a loss as underdogs since the 2023 season — 5th best in MLB; League Avg: .424.

Cubs Keys to the Game vs. the Astros

The Cubs are just 35-38 (.479) after a loss as favorites since the 2022 season — 3rd lowest in MLB; League Avg: .589.

The Cubs are 22-18 (.550) after a loss as underdogs since the 2023 season — 4th best in MLB; League Avg: .424.

The Cubs are just 21-27 (.438) when tied entering the 7th inning since the 2022 season — 5th lowest in MLB; League Avg: .500.

Astros hitters have just 699 strikeouts in 3,955 PA’s (18%) against LHP since the 2022 season — best in MLB; League Avg: 22%.

Astros hitters are slugging .547 in lefty-lefty matchups since last season — best in MLB; League Avg: .374.

14% of Astros’ hitters plate appearances have lasted only one pitch (1,786/13,273 PA’s) since the 2022 season — highest in MLB; League Avg: 11%.

The Astros have won 90% of road games in which they have scored three or more runs in an inning since the 2022 season — highest in MLB; League Avg: 74%.

The Cubs are batting just .186 with two outs this season — 2nd lowest in MLB; League Avg: .230.

The Cubs have a winning percentage of 75% at home this season — tied for best in MLB; League Avg: 49%.

Cubs hitters are slugging .461 against LHP since last season — 3rd best in MLB; League Avg: .414.

Cubs hitters have an OPS of .867 (184 PA’s) against LHP this season — best in MLB; League Avg: .699.

Opponents have a groundball batting average of .333 against Astros pitchers with runners on base this season — 2nd highest in MLB; League Avg: .260.

Astros pitchers have allowed opponents to score in three different innings in 38% of their games since the 2022 season — lowest in MLB; League Avg: 46%.

Astros pitchers have an ERA of 5.91 (105.0 IP) over the last 14 days — 2nd highest in MLB; League Avg: 3.82.

Astros pitchers have a strikeout rate of 45% with two-strikes since the 2022 season — tied for 2nd best in MLB; League Avg: 42%.

The Cubs pitchers allowed an average Exit Velocity of just 88.3 MPH in the 2023 season (4,045 balls in play) — 2nd best in MLB; League Avg: 89.0

Cubs pitchers allowed an average Exit Velocity of 88.3 MPH (4,045 batted balls) in the 2023 season — 2nd best in MLB; League Avg: 89.0.

The Cubs pitchers have allowed their opponents to score first in just 29% of their games this season — 3rd lowest in MLB; League Avg: 50%.

Opponents have a groundball batting average of just .230 against Cubs pitchers with runners on base since last season — 2nd best in MLB; League Avg: .259.

Cubs vs. Astros Injuries Tonight That May Affect Prop Bets 

  • Patrick Wisdom (Chicago Cubs): Back, 10-Day IL
  • Justin Steele (Chicago Cubs): Hamstring, 15-Day IL
  • Brennen Davis (Chicago Cubs): Undisclosed, Out
  • Tyler Duffey (Chicago Cubs): Back, Day-To-Day
  • Jameson Taillon (Chicago Cubs): Back, 15-Day IL
  • Caleb Kilian (Chicago Cubs): Shoulder, 60-Day IL
  • Grae Kessinger (Houston Astros): Hamstring, Day-To-Day
  • Justin Verlander (Houston Astros): Shoulder, 15-Day IL
  • Penn Murfee (Houston Astros): Elbow, 15-Day IL
  • Kendall Graveman (Houston Astros): Shoulder, 60-Day IL
  • Jose Abreu (Houston Astros): Hand, Day-To-Day
  • Jose Urquidy (Houston Astros): Forearm, 15-Day IL
  • Oliver Ortega (Houston Astros): Elbow, 15-Day IL
  • Lance McCullers (Houston Astros): Forearm, 60-Day IL
  • Bennett Sousa (Houston Astros): Shoulder, 15-Day IL
  • Forrest Whitley (Houston Astros): Finger, 7-Day IL
  • Shawn Dubin (Houston Astros): Forearm, 15-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.