Athletics vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

Cleveland Guardians' Myles Straw attempts to run to first after grounding out to Los Angeles Angels starting pitcher Kenny Rosenberg who threw to first baseman Mike Moustakas during the first inning of a baseball game, Sunday, Sept. 10, 2023, in Anaheim, Calif.
(AP Photo/Ryan Sun)
  • The Guardians are -190 favorites vs the Athletics
  • Athletics vs Guardians Over / Under today: 7.5 Runs
  • Athletics / Guardians TV Channel: BSGL | NSCA | ESPN+

The Oakland Athletics (+155) visit Progressive Field to take on the Cleveland Guardians (-190) on Sunday, April 21, 2024. First pitch is scheduled for 1:40pm EDT in Cleveland, OH.

This season, the Athletics are 8-13 against the spread (ATS), while the Guardians are 14-7 ATS.

Athletics vs Guardians Starting Pitchers Today:

  • Athletics starting pitcher: Ross Stripling 0-4, 5.40 ERA
  • Guardians starting pitcher: Tanner Bibee 1-0, 4.91 ERA

Athletics vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Athletics+1.5 -135O 7.5 -110+155
Guardians -1.5 +110U 7.5 -110-190

Athletics vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Sunday‘s MLB game with 59.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Athletics players for Sunday‘s game, looking at profitable historical betting trends:

Best Athletics Player Prop Bets Today:

  • Lawrence Butler has hit the Hits Runs and RBIs Under in 13 of his last 17 away games (+9.70 Units / 50% ROI)
  • Lawrence Butler has hit the Total Bases Under in 13 of his last 17 away games (+8.85 Units / 48% ROI)
  • Lawrence Butler has hit the Hits Under in 13 of his last 17 away games (+8.75 Units / 47% ROI)
  • JP Sears has hit the Earned Runs Under in 12 of his last 15 away games (+8.65 Units / 44% ROI)
  • JJ Bleday has hit the Singles Over in 11 of his last 18 games (+8.20 Units / 46% ROI)

And here are some favorite MLB player prop bets for Guardians players for Sunday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Tanner Bibee has hit the Earned Runs Under in 19 of his last 26 games (+9.75 Units / 30% ROI)
  • Kole Calhoun has hit the Singles Under in 18 of his last 24 games (+8.75 Units / 21% ROI)
  • Will Brennan has hit the Singles Under in his last 6 games (+7.45 Units / 124% ROI)
  • Kole Calhoun has hit the Runs Under in 11 of his last 13 games at home (+6.95 Units / 26% ROI)
  • Andres Gimenez has hit the Singles Over in 10 of his last 13 games (+6.60 Units / 42% ROI)
  • The Oakland Athletics have hit the Team Total Under in 74 of their last 128 games (+12.88 Units / 9% ROI)
  • The Oakland Athletics have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 15 games (+11.14 Units / 60% ROI)
  • The Oakland Athletics have hit the Game Total Over in 48 of their last 84 games (+9.75 Units / 10% ROI)
  • The Oakland Athletics have covered the 1st Five Innings (F5) Run Line in 29 of their last 52 away games (+6.81 Units / 12% ROI)
  • The Oakland Athletics have hit the 1st Five Innings (F5) Moneyline in 6 of their last 14 away games (+5.70 Units / 40% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 49 of their last 75 games at home (+21.70 Units / 26% ROI)
  • The Cleveland Guardians have covered the Run Line in 64 of their last 120 games (+6.20 Units / 4% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 34 games (+4.72 Units / 12% ROI)
  • The Cleveland Guardians have hit the Moneyline in 35 of their last 62 games at home (+4.25 Units / 5% ROI)

Athletics Against the Spread (ATS) Record

Against the spread this season, the Athletics are 10-11 against the Run Line (-4.35 Units / -15.93% ROI).

  • 8-13 when betting on the Moneyline for -2.3 Units / -10.6% ROI
  • 11-10 when betting on the total runs Over for +0.1 Units / 0.44% ROI
  • 10-11 when betting on the total runs Under for -2.4 Units / -10.21% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 14-7 against the Run Line (+6.45 Units / 22.67% ROI).

  • 15-6 when betting on the Moneyline for +8.65 Units / 30.19% ROI
  • 13-7 when betting on the total runs Over for +5.3 Units / 22.89% ROI
  • 7-13 when betting on the total runs Under for -7.4 Units / -32.03% ROI

Guardians vs Athletics Home Run Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 +550 0.5 -800
Seth Brown (ะžะะš) 0.5 +575 0.5 -900
Bo Naylor (CLE) 0.5 +600 0.5 -900
JJ Bleday (OAK) 0.5 +625 0.5 -1000
Jose Ramirez (CLE) 0.5 +650 0.5 -1000

Guardians vs Athletics Total Hits Prop Bets Today

Over Under
Andres Gimenez (CLE) 0.5 -250 0.5 +185
Abraham Toro (OAK) 0.5 -210 0.5 +160
Tyler Freeman (CLE) 0.5 -200 0.5 +155
Brayan Rocchio (CLE) 0.5 -200 0.5 +150
Seth Brown (ะžะะš) 0.5 -190 0.5 +145

Guardians vs Athletics RBI Prop Bets Today

Over Under
Josh Naylor (CLE) 0.5 +120 0.5 -160
Jose Ramirez (CLE) 0.5 +125 0.5 -165
Will Brennan (CLE) 0.5 +180 0.5 -250
Seth Brown (ะžะะš) 0.5 +185 0.5 -250
Bo Naylor (CLE) 0.5 +185 0.5 -250

Guardians vs Athletics Strikeout Prop Bets Today

Over Under

Opponents have a groundball rate of just 26% (6/23) against Ross Stripling in two-strike counts this season — 4th lowest among qualified SPs in MLB; League Avg: 46% — fourth Percentile.

Opponents have a miss rate of just 18% (33/181) against Ross Stripling this season — 2nd lowest among in AL; League Avg: 26% — fourth Percentile.

Opponents are hitting .364 (12-for-33) against Ross Stripling when going through the lineup the first time in a game this season — highest among in AL; League Avg: .219 — second Percentile.

Opponents are hitting .262 (60-for-229) against Ross Stripling with two-strikes since last season — 2nd highest in MLB among starting pitchers with at least 72 total IP; League Avg: .173 — first Percentile.

Guardians Starting Pitcher Stats & Trends

Opponents are hitting .412 (7-for-17) against Tanner Bibee’s elevated fastball this season — 2nd highest in MLB among starting pitchers with at least 7 total IP; League Avg: .223 — third Percentile.

Tanner Bibee has allowed a slugging percentage of .765 (13 Total Bases / 17 ABs) on elevated fastballs this season — 2nd highest in MLB among starting pitchers with at least 7 total IP; League Avg: .366 — third Percentile.

Tanner Bibee has allowed a .625 SLG vs left-handed batters this season — fifth worst among starting pitchers with at least 7 total IP– sixth Percentile. He allowed a SLG of just .270 vs left-handed batters last season — second best among starting pitchers with at least 64 total IP– 99th Percentile.

Tanner Bibee has allowed a slugging percentage of .537 (22 Total Bases / 41 ABs) when ahead in the count this season — 3rd highest in MLB among starting pitchers with at least 7 total IP; League Avg: .287 — second Percentile.

Athletics Keys to the Game vs. the Guardians

The Athletics are just 5-8 (.385) after a win as favorites since the 2022 season — lowest in MLB; League Avg: .590.

The Athletics are just 94-65 (.591) when allowing 4 or fewer runs since the 2022 season — lowest in MLB; League Avg: .720.

The Athletics are just 35-75 (.318) after a home loss since the 2022 season — lowest in MLB; League Avg: .516.

The Athletics are just 15-55 (.214) vs the top 10 runs allowed teams since the 2023 season — lowest in MLB; League Avg: .453.

Guardians Keys to the Game vs. the Athletics

The Guardians are 35-119 (.227) when trailing entering the 7th inning since the 2022 season — best in MLB; League Avg: .132.

The Guardians are just 8-16 (.333) when tied entering the 7th inning since the 2023 season — lowest in MLB; League Avg: .500.

The Guardians are just 7-16 (.304) when tied entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .500.

The Guardians are 97-24 (.802) when they’ve had 10 or more hits since the 2022 season — 5th best in MLB; League Avg: .730.

Athletics hitters have an OBP of just .289 (12,588 PA’s) since the 2022 season — lowest in MLB; League Avg: .316.

The Athletics are batting just .226 against LHP since the 2022 season — lowest in MLB; League Avg: .249.

Athletics hitters have an OBP of just .285 (6,277 PA’s) at home since the 2022 season — lowest in MLB; League Avg: .320.

Athletics hitters have an OPS of just .642 (9,211 PA’s) against RHP since the 2022 season — lowest in MLB; League Avg: .717.

Guardians hitters have just 2,425 strikeouts in 13,078 PA’s (18%) since the 2022 season — best in MLB; League Avg: 23%.

Guardians hitters have missed on just 22% of swings since the 2022 season — best in MLB; League Avg: 26%.

Guardians hitters have put just 34% of balls in play to the left side of the field since last season — lowest in MLB; League Avg: 39%.

Guardians hitters have put 46% of balls in play to the right side of the field this season — highest in MLB; League Avg: 37%.

Opponents have a groundball rate of just 39% against Athletics pitchers since last season — lowest in MLB; League Avg: 43%.

The Athletics have won just 18% of games in which their opponents scored first since the 2022 season — lowest in MLB; League Avg: 32%.

Athletics pitchers have an ERA of 5.31 (1607.1 IP) since last season — 2nd highest in MLB; League Avg: 4.30.

Athletics pitchers have an ERA of 5.89 (744.2 IP) on the road since last season — highest in MLB; League Avg: 4.40.

Opponents have a miss rate of 30% against Guardians pitchers this season — best in MLB; League Avg: 25%.

Guardians pitchers have a strikeout rate of 29% with runners in scoring position this season — best in MLB; League Avg: 21%.

The Guardians have allowed 0.43 runs per game (9/21) in late innings this season — best in MLB; League Avg: 1.34.

Opponents have a groundball rate of just 41% against Guardians pitchers since last season — 5th lowest in MLB; League Avg: 43%.

Guardians vs. Athletics Injuries Tonight That May Affect Prop Bets 

  • Daniel Espino (Cleveland Guardians): Shoulder, Out
  • Gavin Williams (Cleveland Guardians): Elbow, 15-Day IL
  • Ben Lively (Cleveland Guardians): Illness, 15-Day IL
  • Luis Ortiz (Cleveland Guardians): Ankle, 15-Day IL
  • Xzavion Curry (Cleveland Guardians): Illness, 15-Day IL
  • Joey Cantillo (Cleveland Guardians): Hamstring, Out
  • Angel Martinez (Cleveland Guardians): Foot, 10-Day IL
  • Sam Hentges (Cleveland Guardians): Finger, 15-Day IL
  • Trevor Stephan (Cleveland Guardians): Elbow, 60-Day IL
  • George Valera (Cleveland Guardians): Hamstring, Out
  • James Karinchak (Cleveland Guardians): Shoulder, 60-Day IL
  • Ken Waldichuk (Oakland Athletics): Elbow, 60-Day IL
  • Aledmys Diaz (Oakland Athletics): Calf, 60-Day IL
  • Freddy Tarnok (Oakland Athletics): Hip, 15-Day IL
  • James Kaprielian (Oakland Athletics): Shoulder, Out
  • Trevor Gott (Oakland Athletics): Elbow, 60-Day IL
  • Drew Rucinski (Oakland Athletics): Back, Out
  • Sean Newcomb (Oakland Athletics): Knee, 60-Day IL
  • Luis Medina (Oakland Athletics): Knee, 15-Day IL
  • Angel Felipe (Oakland Athletics): Elbow, 60-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.