Brewers vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

MLB betting odds, predictions and betting odds for today's games
(AP Photo)
  • The Cardinals are -165 favorites vs the Brewers
  • Brewers vs Cardinals Over / Under today: 7.5 Runs
  • Brewers / Cardinals TV Channel: BSMW | BSWI

The Milwaukee Brewers (+140) visit Busch Stadium to take on the St. Louis Cardinals (-165) on Sunday, April 21, 2024. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the Brewers are 13-6 against the spread (ATS), while the Cardinals are 12-9 ATS.

Brewers vs Cardinals Starting Pitchers Today:

  • Brewers starting pitcher: Colin Rea 2-0, 2.70 ERA
  • Cardinals starting pitcher: Sonny Gray 2-0, 0.00 ERA

Brewers vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Brewers+1.5 -150O 7.5 -115+140
Cardinals -1.5 +125U 7.5 -105-165

Brewers vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 54.7% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Brewers players for Sunday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

  • Owen Miller has hit the Hits Under in 6 of his last 7 away games (+8.10 Units / 78% ROI)
  • Wade Miley has hit the Strikeouts Under in 16 of his last 22 games (+7.00 Units / 21% ROI)
  • Freddy Peralta has hit the Pitching Outs Over in 12 of his last 16 games (+6.85 Units / 33% ROI)
  • Freddy Peralta has hit the Strikeouts Over in 15 of his last 24 games (+6.50 Units / 24% ROI)
  • Andruw Monasterio has hit the Singles Under in 16 of his last 25 away games (+5.00 Units / 15% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Victor Scott II has hit the Singles Under in 15 of his last 17 games (+11.70 Units / 43% ROI)
  • Victor Scott II has hit the Hits Under in 13 of his last 17 games (+11.25 Units / 64% ROI)
  • Victor Scott II has hit the Total Bases Under in 13 of his last 17 games (+11.20 Units / 64% ROI)
  • Sonny Gray has hit the Earned Runs Under in 12 of his last 15 games (+9.00 Units / 48% ROI)
  • Nolan Gorman has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+7.70 Units / 38% ROI)
  • The Milwaukee Brewers have covered the Run Line in 27 of their last 43 games (+12.00 Units / 21% ROI)
  • The Milwaukee Brewers have hit the Moneyline in 58 of their last 96 games (+11.05 Units / 9% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 27 of their last 42 games (+10.58 Units / 20% ROI)
  • The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 29 of their last 46 games (+10.08 Units / 18% ROI)
  • The Milwaukee Brewers have hit the Game Total Under in 33 of their last 61 away games (+6.55 Units / 10% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 32 of their last 58 games (+5.80 Units / 9% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 13 of their last 26 games (+5.50 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 11 games (+4.82 Units / 37% ROI)
  • The St. Louis Cardinals have covered the Run Line in 49 of their last 92 games (+1.55 Units / 1% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 11-8 against the Run Line (+2.45 Units / 8.97% ROI).

  • 13-6 when betting on the Moneyline for +7.45 Units / 35.22% ROI
  • 13-6 when betting on the total runs Over for +6.55 Units / 31.19% ROI
  • 6-13 when betting on the total runs Under for -8.15 Units / -38.9% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 12-9 against the Run Line (+3.3 Units / 12.5% ROI).

  • 9-12 when betting on the Moneyline for -2.5 Units / -10.37% ROI
  • 7-12 when betting on the total runs Over for -6.05 Units / -26.25% ROI
  • 12-7 when betting on the total runs Under for +4.5 Units / 19.44% ROI

Cardinals vs Brewers Home Run Prop Bets Today

Over Under
Rhys Hoskins (MIL) 0.5 +475 0.5 -700
Nolan Gorman (STL) 0.5 +500 0.5 -750
William Contreras (MIL) 0.5 +575 0.5 -900
Nolan Arenado (STL) 0.5 +600 0.5 -900
Willy Adames (MIL) 0.5 +625 0.5 -1000

Cardinals vs Brewers Total Hits Prop Bets Today

Over Under
Brendan Donovan (STL) 0.5 -275 0.5 +200
William Contreras (MIL) 0.5 -250 0.5 +185
Nolan Arenado (STL) 0.5 -225 0.5 +175
Lars Nootbaar (STL) 0.5 -225 0.5 +165
Willson Contreras (STL) 0.5 -210 0.5 +155

Cardinals vs Brewers RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +135 0.5 -175
Rhys Hoskins (MIL) 0.5 +170 0.5 -225
Willson Contreras (STL) 0.5 +175 0.5 -225
Nolan Gorman (STL) 0.5 +185 0.5 -250
Lars Nootbaar (STL) 0.5 +190 0.5 -250

Cardinals vs Brewers Strikeout Prop Bets Today

Over Under

Opponents have a Hard-Hit Rate of 52% (90/172) against Colin Rea when going through the lineup the second time in a game since last season — 2nd highest in MLB among starting pitchers with at least 72 total IP; League Avg: 40% — first Percentile.

Colin Rea has walked 1 of 49 batters (2%) — 5th best in MLB over the last two weeks; League Avg: 8% — 95th Percentile.

Colin Rea has allowed a slugging percentage of just .217 (20 Total Bases / 92 ABs) when going through the lineup the third time in a game since last season — best in MLB among starting pitchers with at least 72 total IP; League Avg: .443 — 100th Percentile.

Opponents are hitting .412 (7-for-17) against Colin Rea when going through the lineup the first time in a game — 3rd highest in MLB over the last two weeks; League Avg: .228 — third Percentile.

Cardinals Starting Pitcher Stats & Trends

Sonny Gray has allowed a slugging percentage of just .119 (25 Total Bases / 210 ABs) on sliders since last season — best in MLB among starting pitchers with at least 72 total IP; League Avg: .400 — 100th Percentile.

Sonny Gray has not walked any of the 39 batters that he has faced this season — best in MLB among starting pitchers with at least 7 total IP; League Avg: 8% — 100th Percentile.

Sonny Gray has allowed a slugging percentage of just .286 (82 Total Bases / 287 ABs) when going through the lineup the first time in a game since last season — best among qualified SPs in MLB; League Avg: .389 — 100th Percentile.

Sonny Gray has allowed a slugging percentage of just .175 (49 Total Bases / 280 ABs) on sliders since the 2022 season — best in MLB among starting pitchers with at least 137 total IP; League Avg: .382 — 100th Percentile.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 29-0 (1.000) when they’ve had 5 or more XBH since the 2023 season — best in MLB; League Avg: .791.

The Brewers are 72-12 (.857) when scoring 5 or more runs since the 2023 season — 2nd best in MLB; League Avg: .785.

The Brewers are 24-45 (.348) when allowing 5 or more runs since the 2023 season — 2nd best in MLB; League Avg: .215.

The Brewers are 18-12 (.600) when tied entering the 7th inning since the 2023 season — 4th best in MLB; League Avg: .500.

Cardinals Keys to the Game vs. the Brewers

The Cardinals are just 6-81 (.069) when trailing entering the 7th inning since the 2023 season — 2nd lowest in MLB; League Avg: .145.

The Cardinals are 27-10 (.730) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 4-88 (.043) when trailing entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .102.

The Cardinals are 12-9 (.571) when tied entering the 7th inning since the 2023 season — tied for 5th best in MLB; League Avg: .500.

Brewers hitters have an OPS of .850 (466 PA’s) on the road this season — best in MLB; League Avg: .695.

Brewers hitters have 150 extra-base hits out of 564 total hits (just 27%) with two-strikes since last season — lowest in MLB; League Avg: 33%.

Brewers hitters have 3 extra-base hits out of 16 total hits (just 19%) against LHP this season — lowest in MLB; League Avg: 31%.

Brewers hitters are slugging .485 on the road this season — 2nd best in MLB; League Avg: .380.

The Cardinals are batting just .190 against LHP this season — 2nd lowest in MLB; League Avg: .248.

Cardinals hitters have drawn 24 walks in 171 PA’s (14%) against LHP this season — 2nd best in MLB; League Avg: 9%.

Cardinals hitters are slugging just .362 on the first pitch of at-bats this season — 2nd lowest in MLB; League Avg: .559.

Cardinals hitters are slugging just .292 against LHP this season — 3rd lowest in MLB; League Avg: .387.

Opponents have a miss rate of just 23% against Brewers pitchers this season — 3rd lowest in MLB; League Avg: 25%.

Brewers pitchers have a strikeout rate of 45% with two-strikes since the 2022 season — tied for 4th best in MLB; League Avg: 42%.

Brewers pitchers have an ERA of 3.78 (801.0 IP) on the road since last season — best in MLB; League Avg: 4.40.

Brewers pitchers have allowed opponents to score in three different innings in 38% of their games since last season — lowest in MLB; League Avg: 49%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 47% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — tied for 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers have a strikeout rate of just 38% with two-strikes since last season — tied for 2nd lowest in MLB; League Avg: 42%.

Cardinals vs. Brewers Injuries Tonight That May Affect Prop Bets 

  • Dylan Carlson (St. Louis Cardinals): Shoulder, 10-Day IL
  • Keynan Middleton (St. Louis Cardinals): Forearm, 15-Day IL
  • Lars Nootbaar (St. Louis Cardinals): Ribs, 10-Day IL
  • Drew Rom (St. Louis Cardinals): Biceps, 15-Day IL
  • Sonny Gray (St. Louis Cardinals): Hamstring, 15-Day IL
  • Riley O’Brien (St. Louis Cardinals): Forearm, 15-Day IL
  • Tommy Edman (St. Louis Cardinals): Wrist, 10-Day IL
  • Packy Naughton (St. Louis Cardinals): Elbow, Out
  • J.C. Mejia (Milwaukee Brewers): Suspension, Suspension
  • Garrett Mitchell (Milwaukee Brewers): Finger, 10-Day IL
  • Christian Arroyo (Milwaukee Brewers): Wrist, 7-Day IL
  • Jeferson Quero (Milwaukee Brewers): Shoulder, Day-To-Day
  • Easton McGee (Milwaukee Brewers): Elbow, 60-Day IL
  • Wade Miley (Milwaukee Brewers): Shoulder, 15-Day IL
  • Devin Williams (Milwaukee Brewers): Back, 15-Day IL
  • Brandon Woodruff (Milwaukee Brewers): Shoulder, 60-Day IL
  • Taylor Clarke (Milwaukee Brewers): Knee, 15-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.