Brewers vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Apr 25

(AP Photo/Jeff Roberson)
  • The Cardinals are -125 favorites vs the Brewers
  • Brewers vs Cardinals Over / Under today: 8 Runs
  • Brewers / Cardinals TV Channel: FDMW | FDWI

The Milwaukee Brewers (+105) visit Busch Stadium to take on the St. Louis Cardinals (-125) on Friday, April 25, 2025. First pitch is scheduled for 8:15pm EDT in St. Louis, MO, MO.

This season, the Brewers are 13-13 against the spread (ATS), while the Cardinals are 13-12 ATS.

Brewers vs Cardinals Starting Pitchers Today:

  • Brewers starting pitcher: Chad Patrick 1-1, 2.18 ERA
  • Cardinals starting pitcher: Matthew Liberatore 1-2, 3.60 ERA

Brewers vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Brewers+1.5 -220O 8 -105+105
Cardinals -1.5 +165U 8 -115-125

Brewers vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Friday‘s MLB game with 54.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Brewers players for Friday‘s game, looking at profitable historical betting trends:

Best Brewers Player Prop Bets Today:

  • Brice Turang has hit the Hits Over in 19 of his last 25 games (+14.15 Units / 31% ROI)
  • Rhys Hoskins has hit the Singles Over in 8 of his last 10 games (+11.60 Units / 116% ROI)
  • Christian Yelich has hit the Home Runs Over in 3 of his last 10 away games (+11.30 Units / 113% ROI)
  • Brice Turang has hit the Total Bases Over in 16 of his last 25 games (+9.85 Units / 32% ROI)
  • Brice Turang has hit the Hits Runs and RBIs Over in 17 of his last 25 games (+7.75 Units / 24% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Jordan Walker has hit the Home Runs Over in 2 of his last 8 games at home (+8.50 Units / 106% ROI)
  • Alec Burleson has hit the Runs Under in 9 of his last 10 games (+7.15 Units / 32% ROI)
  • Lars Nootbaar has hit the Total Bases Over in 8 of his last 9 games at home (+6.90 Units / 49% ROI)
  • Nolan Arenado has hit the Singles Under in 11 of his last 15 games (+6.60 Units / 37% ROI)
  • Lars Nootbaar has hit the Hits Over in 8 of his last 9 games at home (+6.15 Units / 37% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Moneyline in 15 of their last 22 games (+14.00 Units / 52% ROI)
  • The Milwaukee Brewers have covered the 1st Five Innings (F5) Run Line in 17 of their last 22 games (+12.40 Units / 50% ROI)
  • The Milwaukee Brewers have hit the 1st Five Innings (F5) Team Total Over in 15 of their last 19 games (+11.50 Units / 51% ROI)
  • The Milwaukee Brewers have hit the Game Total Under in 13 of their last 22 games (+5.40 Units / 22% ROI)
  • The Milwaukee Brewers have hit the Team Total Over in 12 of their last 18 games (+4.65 Units / 22% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 12 games at home (+6.00 Units / 41% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 7 of their last 12 games at home (+4.95 Units / 34% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 15 of their last 25 games (+4.50 Units / 16% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 5 of their last 6 games at home (+4.00 Units / 61% ROI)
  • The St. Louis Cardinals have covered the Run Line in 8 of their last 12 games at home (+3.85 Units / 22% ROI)

Brewers Against the Spread (ATS) Record

Against the spread this season, the Brewers are 12-14 against the Run Line (-4.45 Units / -13.17% ROI).

  • 13-13 when betting on the Moneyline for -0.55 Units / -1.75% ROI
  • 10-14 when betting on the total runs Over for -5.4 Units / -18.85% ROI
  • 14-10 when betting on the total runs Under for +3.05 Units / 10.68% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 13-12 against the Run Line (-3.35 Units / -8.96% ROI).

  • 10-15 when betting on the Moneyline for -5.45 Units / -19.96% ROI
  • 14-10 when betting on the total runs Over for +2.85 Units / 10.33% ROI
  • 10-14 when betting on the total runs Under for -5.45 Units / -19.89% ROI

Cardinals vs Brewers Home Run Prop Bets Today

Over Under
Rhys Hoskins (MIL) 0.5 +375 0.5 -500
Nolan Gorman (STL) 0.5 +425 0.5 -600
Willson Contreras (STL) 0.5 +475 0.5 -650
William Contreras (MIL) 0.5 +475 0.5 -700
Lars Nootbaar (STL) 0.5 +550 0.5 -800

Cardinals vs Brewers Total Hits Prop Bets Today

Over Under
William Contreras (MIL) 0.5 -250 0.5 +190
Brice Turang (MIL) 0.5 -250 0.5 +185
Brendan Donovan (STL) 0.5 -235 0.5 +175
Christian Yelich (MIL) 0.5 -210 0.5 +155
Alec Burleson (STL) 0.5 -210 0.5 +155

Cardinals vs Brewers RBI Prop Bets Today

Over Under
William Contreras (MIL) 0.5 +145 0.5 -190
Rhys Hoskins (MIL) 0.5 +150 0.5 -200
Jackson Chourio (MIL) 0.5 +175 0.5 -235
Brendan Donovan (STL) 0.5 +175 0.5 -235
Nolan Arenado (STL) 0.5 +180 0.5 -235

Cardinals vs Brewers Strikeout Prop Bets Today

Over Under
Matthew Liberatore (STL) 4.5 -105 4.5 -125
Chad Patrick (MIL) 4.5 +125 4.5 -165

Opponents have a groundball rate of just 18% (4/22) against Chad Patrick in two-strike counts this season — lowest in MLB among starting pitchers with at least 9 total IP; League Avg: 44% — 0 Percentile.

Chad Patrick has thrown elevated pitches 59% of the time (74/126) with two-strikes this season — highest in MLB among starting pitchers with at least 9 total IP; League Avg: 31% — 100th Percentile.

Chad Patrick has located his pitches away 64% of the time (81/126) with two-strikes this season — 2nd highest in MLB among starting pitchers with at least 9 total IP; League Avg: 49% — 99th Percentile.

Opponents have a groundball rate of just 30% (16/54) against Chad Patrick this month (4 games) — 2nd lowest among among NL Starters; League Avg: 44% — third Percentile.

Cardinals Starting Pitcher Stats & Trends

Matthew Liberatore has walked 2% of batters this season — 2nd best among qualified SPs in MLB; League Avg: 8% — 98th Percentile.

Matthew Liberatore walked 4 of 138 left-handed batters (3%) in the 2024 season — 4th best among qualified RPs in MLB; League Avg: 9% — 96th Percentile.

Matthew Liberatore has not walked any of the 36 batters that they have faced when going through the lineup the second time in a game this month (4 games) — tied for best among qualified SPs in MLB; League Avg: 7% — 100th Percentile.

Matthew Liberatore has allowed 5 home runs on the first pitch of at-bats since last season — most among NL Relievers — 100th Percentile.

Brewers Keys to the Game vs. the Cardinals

The Brewers are 27-16 (.628) when tied entering the 8th inning since the 2023 season — 2nd best in MLB; League Avg: .500.

The Brewers were 46-35 (.568) on the road in the 2024 season — tied for 4th best in MLB; League Avg: .478.

The Brewers were 40-28 (.588) after a loss in the 2024 season — tied for 4th best in MLB; League Avg: .504.

The Brewers are 67-31 (.684) when they’ve scored in the first inning since the 2023 season — 4th best in MLB; League Avg: .624.

Cardinals Keys to the Game vs. the Brewers

The Cardinals are just 16-139 (.103) when trailing entering the 7th inning since the 2023 season — 5th lowest in MLB; League Avg: .140.

The Cardinals are just 0-11 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .038.

The Cardinals are just 2-11 (.154) on the road this season — tied for 2nd lowest in MLB; League Avg: .387.

The Cardinals were 69-1 (.986) when leading entering the 9th inning in the 2024 season — tied for 2nd best in MLB; League Avg: .949.

Brewers hitters had 129 extra-base hits out of 494 total hits (just 26%) with two-strikes in 2023 — lowest in MLB; League Avg: 33%.

Brewers hitters have a swing rate of just 45% against RHP since last season — lowest in MLB; League Avg: 48%.

Brewers hitters came to the plate with runners in scoring position in 1,726 of their 6,170 plate appearances (28%) in the 2024 season — highest in MLB; League Avg: 25%.

Brewers hitters averaged 4.03 pitches per plate appearance against RHP in the 2024 season — highest in MLB; League Avg: 3.89.

The Cardinals are batting .222 on pitches out of the zone this season — best in MLB; League Avg: .147.

Cardinals hitters are slugging .280 on pitches out of the zone this season — best in MLB; League Avg: .198.

The Cardinals have won just 44% of games in which they have scored in at least three different innings this season — 2nd lowest in MLB; League Avg: 72%.

The Cardinals are batting .376 on changeups this season — best in MLB; League Avg: .235.

Batters facing the Brewers pitchers have struck out in the zone 55% of the time since last season — highest in MLB; League Avg: 50%. since last season — highest in MLB; League Avg: 50%.

Batters facing the Brewers pitchers have struck out in the zone 57% of the time this season — 2nd highest in MLB; League Avg: 51%. this season — 2nd highest in MLB; League Avg: 51%.

The Brewers pitchers have allowed their opponents to score first in just 27% of their games since last season — lowest in MLB; League Avg: 50%.

Opponents have a groundball rate of just 38% against Brewers pitchers this season — 2nd lowest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.

Batters facing the Cardinals pitchers have struck out in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.

Cardinals pitchers walked 95 of 1,431 batters (7%) when facing the leadoff batter in the inning in 2023 — 2nd best in MLB; League Avg: 8%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.