Cardinals vs Giants Prediction, Odds & Player Prop Bets Today – MLB, Sep 27

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San Francisco Giants' Wilmer Flores (41) throws to first against the Los Angeles Dodgers during a baseball game in San Francisco, Friday, Sept. 29, 2023. (AP Photo/Jed Jacobsohn)
(AP Photo/Jed Jacobsohn)
BetMGM Betting @BETMGM Sep 27, 2024, 11:00 AM
  • The Giants are -130 favorites vs the Cardinals
  • Cardinals vs Giants Over / Under today: 7.5 Runs
  • Cardinals / Giants TV Channel: BSMW | NSBA | MLBN

The St. Louis Cardinals (+115) visit Oracle Park to take on the San Francisco Giants (-135) on Friday, September 27, 2024. First pitch is scheduled for 10:15pm EDT in San Francisco, CA.

This season, the Cardinals are 81-78 against the spread (ATS), while the Giants are 80-79 ATS.

Cardinals vs Giants Starting Pitchers Today:

  • Cardinals starting pitcher: Miles Mikolas 9-11, 5.39 ERA
  • Giants starting pitcher: Landen Roupp 1-1, 2.72 ERA

Cardinals vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals+1.5 -210O 7.5 -120+115
Giants -1.5 +170U 7.5 +100-135

Cardinals vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Friday‘s MLB game with 53.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Cardinals vs Giants and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Cardinals players for Friday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Masyn Winn has hit the Home Runs Over in 6 of his last 36 games (+18.50 Units / 51% ROI)
  • Masyn Winn has hit the Singles Under in 17 of his last 23 games (+14.55 Units / 62% ROI)
  • Miles Mikolas has hit the Walks Allowed Under in 21 of his last 27 games (+12.40 Units / 27% ROI)
  • Alec Burleson has hit the Hits Under in 12 of his last 15 away games (+10.60 Units / 39% ROI)
  • Lars Nootbaar has hit the Total Bases Over in 12 of his last 14 away games (+9.90 Units / 47% ROI)

And here are some favorite MLB player prop bets for Giants players for Friday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Michael Conforto has hit the Home Runs Over in 4 of his last 7 games (+22.20 Units / 317% ROI)
  • Matt Chapman has hit the Singles Under in his last 11 games (+11.00 Units / 71% ROI)
  • LaMonte Wade Jr has hit the Hits Under in 25 of his last 47 games (+10.75 Units / 21% ROI)
  • Grant McCray has hit the Hits Runs and RBIs Under in 11 of his last 14 games (+8.40 Units / 46% ROI)
  • Mark Canha has hit the Runs Under in 10 of his last 11 games (+8.35 Units / 44% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 28 of their last 48 games (+8.05 Units / 15% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 20 of their last 34 games (+7.60 Units / 19% ROI)
  • The St. Louis Cardinals have hit the Team Total Under in 18 of their last 27 away games (+7.45 Units / 24% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 13 of their last 19 games (+6.95 Units / 30% ROI)
  • The St. Louis Cardinals have covered the Run Line in 23 of their last 38 games (+6.15 Units / 12% ROI)
  • The San Francisco Giants have hit the Team Total Under in 18 of their last 24 games at home (+11.35 Units / 40% ROI)
  • The San Francisco Giants have hit the Game Total Under in 19 of their last 30 games at home (+8.40 Units / 26% ROI)
  • The San Francisco Giants have hit the Moneyline in 7 of their last 9 games (+7.40 Units / 80% ROI)
  • The San Francisco Giants have covered the Run Line in 8 of their last 10 games (+6.50 Units / 49% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 12 games at home (+6.10 Units / 45% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 81-78 against the Run Line (-4.85 Units / -2.25% ROI).

  • 81-78 when betting on the Moneyline for -7.2 Units / -3.78% ROI
  • 72-80 when betting on the total runs Over for -16.5 Units / -9.49% ROI
  • 80-72 when betting on the total runs Under for +0.35 Units / 0.2% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 80-79 against the Run Line (-5.9 Units / -2.84% ROI).

  • 79-80 when betting on the Moneyline for -9.3 Units / -4.6% ROI
  • 81-71 when betting on the total runs Over for +3.25 Units / 1.86% ROI
  • 71-81 when betting on the total runs Under for -18.1 Units / -10.33% ROI

Giants vs Cardinals Home Run Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +320 0.5 -400
Mike Yastrzemski (SF) 0.5 +450 0.5 -650
Paul Goldschmidt (STL) 0.5 +600 0.5 -900
Heliot Ramos (SF) 0.5 +600 0.5 -900
LaMonte Wade Jr (SF) 0.5 +650 0.5 -1000

Giants vs Cardinals Total Hits Prop Bets Today

Over Under
Brendan Donovan (STL) 0.5 -275 0.5 +195
Mike Yastrzemski (SF) 0.5 -250 0.5 +185
LaMonte Wade Jr (SF) 0.5 -250 0.5 +175
Paul Goldschmidt (STL) 0.5 -250 0.5 +180
Nolan Arenado (STL) 0.5 -225 0.5 +170

Giants vs Cardinals RBI Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +120 0.5 -155
Heliot Ramos (SF) 0.5 +165 0.5 -225
Paul Goldschmidt (STL) 0.5 +170 0.5 -225
Nolan Arenado (STL) 0.5 +180 0.5 -250
Mike Yastrzemski (SF) 0.5 +180 0.5 -250

Giants vs Cardinals Strikeout Prop Bets Today

Over Under
Miles Mikolas (STL) 3.5 -175 3.5 +130
Landen Roupp (SF) 4.5 +125 4.5 -165

Miles Mikolas has allowed a slugging percentage of .543 (178 Total Bases / 328 ABs) on non-fastballs this season — highest among qualified SPs in MLB; League Avg: .354 — first Percentile.

Opponents have a two strike miss rate of just 14% (71/505) against Miles Mikolas this season — lowest among qualified SPs in MLB; League Avg: 25% — first Percentile.

Opponents are hitting .299 (98-for-328) against Miles Mikolas’ non-fastballs this season — highest among qualified SPs in MLB; League Avg: .216 — first Percentile.

Right-handed hitters have a miss rate of just 15% (106/695) against Miles Mikolas this season — lowest among qualified SPs in MLB; League Avg: 26% — first Percentile.

Giants Starting Pitcher Stats & Trends

Landen Roupp has thrown his curveball 36% of the time (72/197) when he’s behind in the count this season — 2nd highest among qualified RPs in MLB*; League Avg: 10% — 98th Percentile.

Left-handed hitters have a swing rate of just 37% (153/415) against Landen Roupp this season — lowest among NL Relievers; League Avg: 48% — first Percentile.

Landen Roupp has walked 17 of 91 left-handed batters (19%) this season — 4th highest among NL Relievers; League Avg: 9% — fourth Percentile.

Landen Roupp has a strike rate of just 58% (239/415) vs left-handed batters this season — 2nd lowest among NL Relievers; League Avg: 64% — second Percentile.

Cardinals Keys to the Game vs. the Giants

The Cardinals are just 24-38 (.387) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .574.

The Cardinals are 40-20 (.667) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are 21-13 (.618) after a loss as underdogs this season — best in MLB; League Avg: .434.

The Cardinals are 24-16 (.600) when tied entering the 8th inning since the 2023 season — 3rd best in MLB; League Avg: .500.

Giants Keys to the Game vs. the Cardinals

The Giants are just 51-77 (.398) after a road loss since the 2022 season — 5th lowest in MLB; League Avg: .464.

The Giants are 30-201 (.130) when trailing entering the 8th inning since the 2022 season — tied for 4th best in MLB; League Avg: .095.

The Giants are just 35-49 (.417) after a road loss since the 2023 season — 5th lowest in MLB; League Avg: .474.

The Giants are 131-4 (.970) when leading entering the 9th inning since the 2023 season — 4th best in MLB; League Avg: .949.

Cardinals hitters have an OPS of just .694 (3,302 PA’s) against LHP since last season — 4th lowest in MLB; League Avg: .727.

The Cardinals are batting just .239 against LHP since last season — tied for 5th lowest in MLB; League Avg: .250.

The Cardinals are just 44-70 (.364) against the run line (-29.8% ROI) after a road win since the 2022 season — lowest in MLB; League Avg: .484.

The Cardinals are batting .249 with two outs since the 2022 season — tied for 3rd best in MLB; League Avg: .236.

The Giants are batting just .216 with two outs this season — 3rd lowest in MLB; League Avg: .235.

Giants hitters are slugging just .249 with two-strikes since last season — tied for 3rd lowest in MLB; League Avg: .269.

The Giants are batting just .220 with two outs since last season — 2nd lowest in MLB; League Avg: .236.

Giants hitters have 866 strikeouts in 3,451 PA’s (25%) against LHP since last season — 4th highest in MLB; League Avg: 23%.

Opponents have a groundball rate of 46% against Cardinals pitchers since last season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 46% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2022 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers this season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 50% against Giants pitchers this month (22 games) — highest in MLB; League Avg: 43%.

Giants vs. Cardinals Injuries Tonight That May Affect Prop Bets 

  • San Francisco Giants – No Injuries Reported
  • St. Louis Cardinals – No Injuries Reported

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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.