Cardinals vs Reds Prediction, Odds & Player Prop Bets Today – MLB, Apr 28

Cincinnati Reds' Blake Dunn rounds the bases to score on a base hit by Matt McLain during the third inning of a spring training baseball game against the Los Angeles Angels, Tuesday, March 18, 2025, in Goodyear, Ariz. (AP Photo/Matt York)
  • The Cardinals are +100 favorites vs the Reds
  • Cardinals vs Reds Over / Under today: 9 Runs
  • Cardinals / Reds TV Channel: FDOH | FDMW | MLBN

The St. Louis Cardinals (+100) visit Great American Ball Park to take on the Cincinnati Reds (-120) on Monday, April 28, 2025. First pitch is scheduled for 6:40pm EDT in Cincinnati, OH, OH.

This season, the Cardinals are 12-16 against the spread (ATS), while the Reds are 16-12 ATS.

Cardinals vs Reds Starting Pitchers Today:

  • Cardinals starting pitcher: Andre Pallante 2-1, 4.11 ERA
  • Reds starting pitcher: Nick Martinez 0-3, 5.47 ERA

Cardinals vs. Reds Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cardinals-1.5 +155O 9.5 -110+100
Reds +1.5 -190U 9.5 -110-120

Cardinals vs Reds Prediction for Today’s Game

Based on recent trends the model predicts the Reds will win Monday‘s MLB game with 51.5% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Bets Today:

  • Masyn Winn has hit the Hits Over in 12 of his last 15 away games (+10.75 Units / 51% ROI)
  • Masyn Winn has hit the Hits Runs and RBIs Over in 12 of his last 15 away games (+9.25 Units / 53% ROI)
  • Masyn Winn has hit the Total Bases Over in 12 of his last 15 away games (+9.00 Units / 43% ROI)
  • Brendan Donovan has hit the Singles Over in 18 of his last 25 away games (+8.45 Units / 26% ROI)
  • Victor Scott II has hit the Runs Over in 10 of his last 20 away games (+6.10 Units / 31% ROI)

And here are some favorite MLB player prop bets for Reds players for Monday‘s game, looking at profitable historical betting trends:

Best Reds Player Prop Best Bets Today:

  • Jose Trevino has hit the Hits Under in 19 of his last 25 games at home (+16.80 Units / 66% ROI)
  • Jose Trevino has hit the Total Bases Under in 19 of his last 25 games at home (+16.35 Units / 62% ROI)
  • Jose Trevino has hit the Hits Runs and RBIs Under in 20 of his last 25 games at home (+15.30 Units / 45% ROI)
  • Jose Trevino has hit the Singles Under in 21 of his last 25 games at home (+15.05 Units / 42% ROI)
  • Matt McLain has hit the Home Runs Over in 3 of his last 7 games at home (+10.60 Units / 151% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 10 of their last 17 games (+3.50 Units / 19% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 9 of their last 14 games (+3.25 Units / 20% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 12 away games (+3.05 Units / 20% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 8 of their last 18 games (+2.90 Units / 14% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 16 of their last 28 games (+2.70 Units / 8% ROI)
  • The Cincinnati Reds have hit the Moneyline in 12 of their last 18 games (+6.95 Units / 31% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Moneyline in 11 of their last 17 games (+6.65 Units / 29% ROI)
  • The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 12 of their last 18 games (+5.70 Units / 27% ROI)
  • The Cincinnati Reds have covered the Run Line in 16 of their last 25 games (+5.55 Units / 16% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 11 of their last 16 games (+5.40 Units / 27% ROI)

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 13-15 against the Run Line (-7.15 Units / -17.35% ROI).

  • 12-16 when betting on the Moneyline for -4.55 Units / -14.54% ROI
  • 15-11 when betting on the total runs Over for +2.75 Units / 8.89% ROI
  • 11-15 when betting on the total runs Under for -5.55 Units / -18.11% ROI

Reds Against the Spread (ATS) Record

Against the spread this season, the Reds are 16-12 against the Run Line (+1.2 Units / 3.02% ROI).

  • 15-13 when betting on the Moneyline for +2.55 Units / 7.69% ROI
  • 13-14 when betting on the total runs Over for -2.4 Units / -7.78% ROI
  • 14-13 when betting on the total runs Under for -0.25 Units / -0.81% ROI

Reds vs Cardinals Home Run Prop Bets Today

Over Under
Nolan Gorman (STL) 0.5 +333 0.5 -450
Willson Contreras (STL) 0.5 +375 0.5 -525
Austin Hays (CIN) 0.5 +425 0.5 -600
Jordan Walker (STL) 0.5 +450 0.5 -625
Lars Nootbaar (STL) 0.5 +500 0.5 -700

Reds vs Cardinals Total Hits Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 -275 0.5 +195
Austin Hays (CIN) 0.5 -250 0.5 +190
Brendan Donovan (STL) 0.5 -250 0.5 +195
Lars Nootbaar (STL) 0.5 -235 0.5 +175
Nolan Arenado (STL) 0.5 -225 0.5 +170

Reds vs Cardinals RBI Prop Bets Today

Over Under
Austin Hays (CIN) 0.5 +110 0.5 -150
Nolan Arenado (STL) 0.5 +155 0.5 -210
Elly De La Cruz (CIN) 0.5 +155 0.5 -210
Willson Contreras (STL) 0.5 +160 0.5 -210
Nolan Gorman (STL) 0.5 +170 0.5 -225

Reds vs Cardinals Strikeout Prop Bets Today

Over Under
Andre Pallante (STL) 3.5 -145 3.5 +110
Nick Martinez (CIN) 4.5 -110 4.5 -118

Opponents had a groundball rate of 77% (173/226) against Andre Pallante in 2023 — highest among NL Relievers; League Avg: 45% — 100th Percentile.

Opponents had a groundball rate of 73% (55/75) against Andre Pallante in two-strike counts in 2023 — highest among qualified RPs in MLB; League Avg: 45% — 100th Percentile.

Opponents had a groundball rate of 77% (173/226) against Andre Pallante in 2023 — highest among qualified RPs in MLB; League Avg: 45% — 100th Percentile.

Left-handed hitters had a groundball rate of 77% (102/132) against Andre Pallante in 2023 — highest among NL Relievers; League Avg: 45% — 100th Percentile.

Reds Starting Pitcher Stats & Trends

Opponents have a Hard-Hit Rate of just 33% (66/202) against Nick Martinez on fastballs since last season — 2nd best in MLB among starting pitchers with at least 75 total IP; League Avg: 45% — 99th Percentile.

Opponents had a groundball rate of 74% (32/43) against Nick Martinez’s curve and slider in 2023 — highest among qualified RPs in MLB*; League Avg: 42% — 100th Percentile.

Nick Martinez has walked 3% of left-handed batters since last season — best in MLB among starting pitchers with at least 75 total IP; League Avg: 8% — 100th Percentile.

Nick Martinez walked 3% of batters in the 2024 season — 3rd best in MLB among starting pitchers with at least 64 total IP; League Avg: 7% — 98th Percentile.

Cardinals Keys to the Game vs. the Reds

The Cardinals are just 0-10 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .115.

The Cardinals are just 0-10 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .084.

The Cardinals are just 2-11 (.154) on the road this season — 2nd lowest in MLB; League Avg: .393.

The Cardinals are just 11-3 (.786) when leading entering the 7th inning this season — 5th lowest in MLB; League Avg: .885.

Reds Keys to the Game vs. the Cardinals

The Reds are just 14-27 (.341) when tied entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .500.

The Reds were just 5-16 (.238) when tied entering the 8th inning in the 2024 season — lowest in MLB; League Avg: .500.

The Reds were just 4-63 (.060) when trailing entering the 8th inning in the 2024 season — 4th lowest in MLB; League Avg: .100.

The Reds are just 6-16 (.273) when tied entering the 8th inning since last season — 2nd lowest in MLB; League Avg: .500.

The Cardinals are batting .221 on pitches out of the zone this season — best in MLB; League Avg: .148.

Cardinals hitters are slugging .278 on pitches out of the zone this season — best in MLB; League Avg: .199.

The Cardinals have a winning percentage of just 15% on the road since the 2023 season — 2nd lowest in MLB; League Avg: 39%.

Cardinals hitters have an OBP of .353 (294 PA’s) against LHP this season — 5th best in MLB; League Avg: .311.

The Reds are batting just .118 on pitches out of the zone since last season — lowest in MLB; League Avg: .150.

Reds hitters have chased 24% of pitches out of the zone against LHP this season — tied for lowest in MLB; League Avg: 29%.

The Reds are batting just .127 on pitches out of the zone since the 2023 season — 2nd lowest in MLB; League Avg: .150.

Reds hitters have an OPS of just .590 (277 PA’s) at home this month (8 games) — 2nd lowest in MLB; League Avg: .728.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 26%.

Cardinals pitchers had a strikeout rate of just 38% with two-strikes in 2023 — tied for 2nd lowest in MLB; League Avg: 43%.

Batters facing the Cardinals pitchers have struck out in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.

Opponents have a groundball rate of just 36% against Reds pitchers this season — lowest in MLB; League Avg: 43%.

Opponents have a groundball rate of just 39% against Reds pitchers since the 2023 season — lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in the 2024 season — lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 39% against Reds pitchers in 2023 — 2nd lowest in MLB; League Avg: 43%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.