Cincinnati Reds vs St. Louis Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Jun 21

  • The St. Louis Cardinals are -200 favorites vs the Cincinnati Reds
  • Cincinnati Reds vs St. Louis Cardinals Over / Under today: 9 Runs
  • Cincinnati Reds / St. Louis Cardinals TV Channel: FDOH | FDMW

The Cincinnati Reds (+165) visit Busch Stadium to take on the St. Louis Cardinals (-200) on Saturday, June 21, 2025. First pitch is scheduled for 2:15pm EDT in St. Louis, MO, MO.

This season, the Cincinnati Reds are 39-37 against the spread (ATS), while the St. Louis Cardinals are 43-33 ATS.

Cincinnati Reds vs St. Louis Cardinals Starting Pitchers Today:

  • Cincinnati Reds starting pitcher: , ERA
  • St. Louis Cardinals starting pitcher: , ERA

Cincinnati Reds vs. St. Louis Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cincinnati Reds+1.5 -125O 9 -110+165
St. Louis Cardinals -1.5 +105U 9 -110-200

Cincinnati Reds vs St. Louis Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the will win Saturday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Cincinnati Reds vs St. Louis Cardinals and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Cincinnati Reds players for Saturday‘s game, looking at profitable historical betting trends:

Best Cincinnati Reds Player Prop Bets Today:

  • TJ Friedl has hit the Home Runs Over in 4 of his last 10 away games (+28.10 Units / 281% ROI)
  • Gavin Lux has hit the Hits Over in 19 of his last 25 away games (+10.50 Units / 24% ROI)
  • TJ Friedl has hit the Total Bases Over in 17 of his last 25 games (+10.00 Units / 28% ROI)
  • Matt McLain has hit the Runs Under in 16 of his last 20 away games (+9.55 Units / 25% ROI)
  • Matt McLain has hit the Hits Runs and RBIs Under in 15 of his last 20 away games (+9.50 Units / 35% ROI)

And here are some favorite MLB player prop bets for St. Louis Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best St. Louis Cardinals Player Prop Best Bets Today:

  • Alec Burleson has hit the Total Bases Over in 21 of his last 25 games (+19.20 Units / 57% ROI)
  • Willson Contreras has hit the RBIs Over in 14 of his last 20 games (+15.15 Units / 76% ROI)
  • Nolan Arenado has hit the Home Runs Over in 2 of his last 6 games at home (+12.00 Units / 200% ROI)
  • Masyn Winn has hit the Runs Over in 16 of his last 25 games at home (+11.70 Units / 46% ROI)
  • Sonny Gray has hit the Walks Allowed Under in 12 of his last 15 games (+10.10 Units / 60% ROI)
  • The Cincinnati Reds have hit the Game Total Under in 32 of their last 53 games (+8.85 Units / 15% ROI)
  • The Cincinnati Reds have hit the Moneyline in 9 of their last 13 games (+6.15 Units / 43% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games (+5.20 Units / 66% ROI)
  • The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 37 of their last 66 games (+4.95 Units / 6% ROI)
  • The Cincinnati Reds have hit the Team Total Under in 12 of their last 20 games (+3.05 Units / 13% ROI)
  • The St. Louis Cardinals have covered the Run Line in 28 of their last 43 games (+14.80 Units / 27% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 32 of their last 53 games (+10.95 Units / 18% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 24 of their last 37 games at home (+10.67 Units / 25% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 17 of their last 27 games (+5.95 Units / 18% ROI)
  • The St. Louis Cardinals have hit the Game Total Over in 14 of their last 24 games at home (+5.25 Units / 20% ROI)

Cincinnati Reds Against the Spread (ATS) Record

Against the spread this season, the Cincinnati Reds are 40-35 against the Run Line (-2 Units / -1.91% ROI).

  • 39-37 when betting on the Moneyline for -0.85 Units / -0.93% ROI
  • 33-42 when betting on the total runs Over for -12.6 Units / -15.16% ROI
  • 42-33 when betting on the total runs Under for +5.8 Units / 6.9% ROI

St. Louis Cardinals Against the Spread (ATS) Record

Against the spread this season, the St. Louis Cardinals are 43-33 against the Run Line (+6 Units / 5.84% ROI).

  • 41-35 when betting on the Moneyline for +5.3 Units / 6.04% ROI
  • 40-32 when betting on the total runs Over for +4.8 Units / 5.75% ROI
  • 32-40 when betting on the total runs Under for -12.15 Units / -14.51% ROI

St. Louis Cardinals vs Cincinnati Reds Home Run Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +360 0.5 -500
Nolan Gorman (STL) 0.5 +425 0.5 -625
Lars Nootbaar (STL) 0.5 +475 0.5 -650
Elly De La Cruz (CIN) 0.5 +500 0.5 -700
Alec Burleson (STL) 0.5 +525 0.5 -750

St. Louis Cardinals vs Cincinnati Reds Total Hits Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 -250 0.5 +190
Elly De La Cruz (CIN) 0.5 -235 0.5 +175
Tyler Stephenson (CIN) 0.5 -210 0.5 +160
Santiago Espinal (CIN) 0.5 -210 0.5 +160
TJ Friedl (CIN) 0.5 -200 0.5 +150

St. Louis Cardinals vs Cincinnati Reds RBI Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +120 0.5 -160
Alec Burleson (STL) 0.5 +140 0.5 -185
Nolan Arenado (STL) 0.5 +145 0.5 -190
Masyn Winn (STL) 0.5 +150 0.5 -200
Tyler Stephenson (CIN) 0.5 +170 0.5 -220

St. Louis Cardinals vs Cincinnati Reds Strikeout Prop Bets Today

Over Under
Sonny Gray (STL) 5.5 -145 5.5 +110
Brent Suter (CIN) 1.5 -125 1.5 -105

starting pitcher – away

St. Louis Cardinals Starting Pitcher Stats & Trends

starting pitcher – home

Cincinnati Reds Keys to the Game vs. the St. Louis Cardinals

keys to the game – away

St. Louis Cardinals Keys to the Game vs. the Cincinnati Reds

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


Bet now on Cincinnati Reds vs St. Louis Cardinals and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

Split First Bet Offer FBO March Matchups 1080x610
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.