Cincinnati Reds vs St. Louis Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Jun 22

  • The Cincinnati Reds are -115 favorites vs the St. Louis Cardinals
  • Cincinnati Reds vs St. Louis Cardinals Over / Under today: 9.5 Runs
  • Cincinnati Reds / St. Louis Cardinals TV Channel: FDOH | FDMW

The Cincinnati Reds (-115) visit Busch Stadium to take on the St. Louis Cardinals (-105) on Sunday, June 22, 2025. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the Cincinnati Reds are 39-38 against the spread (ATS), while the St. Louis Cardinals are 43-34 ATS.

Cincinnati Reds vs St. Louis Cardinals Starting Pitchers Today:

  • Cincinnati Reds starting pitcher: , ERA
  • St. Louis Cardinals starting pitcher: , ERA

Cincinnati Reds vs. St. Louis Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Cincinnati Reds-1.5 +140O 9.5 -120-115
St. Louis Cardinals +1.5 -170U 9.5 +100-105

Cincinnati Reds vs St. Louis Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the will win Sunday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Cincinnati Reds players for Sunday‘s game, looking at profitable historical betting trends:

Best Cincinnati Reds Player Prop Bets Today:

  • Elly De La Cruz has hit the Home Runs Over in 6 of his last 9 away games (+31.80 Units / 353% ROI)
  • Elly De La Cruz has hit the Runs Over in 17 of his last 25 games (+11.00 Units / 42% ROI)
  • Santiago Espinal has hit the Hits Runs and RBIs Under in 13 of his last 15 games (+10.90 Units / 60% ROI)
  • TJ Friedl has hit the Total Bases Over in 17 of his last 25 games (+10.00 Units / 27% ROI)
  • Matt McLain has hit the Singles Over in 11 of his last 15 games (+9.95 Units / 66% ROI)

And here are some favorite MLB player prop bets for St. Louis Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best St. Louis Cardinals Player Prop Best Bets Today:

  • Willson Contreras has hit the RBIs Over in 14 of his last 20 games (+15.15 Units / 76% ROI)
  • Nolan Arenado has hit the Home Runs Over in 3 of his last 10 games (+12.80 Units / 128% ROI)
  • Masyn Winn has hit the Runs Over in 16 of his last 25 games at home (+11.00 Units / 43% ROI)
  • Masyn Winn has hit the Hits Runs and RBIs Over in 17 of his last 25 games at home (+8.15 Units / 27% ROI)
  • Brendan Donovan has hit the Total Bases Under in 15 of his last 20 games at home (+7.95 Units / 25% ROI)
  • The Cincinnati Reds have hit the Game Total Under in 32 of their last 54 games (+7.75 Units / 13% ROI)
  • The Cincinnati Reds have hit the 1st Five Innings (F5) Team Total Under in 15 of their last 24 away games (+6.20 Units / 23% ROI)
  • The Cincinnati Reds have hit the Moneyline in 9 of their last 14 games (+5.15 Units / 34% ROI)
  • The Cincinnati Reds have covered the 1st Five Innings (F5) Run Line in 37 of their last 67 games (+3.95 Units / 5% ROI)
  • The Cincinnati Reds have hit the Team Total Over in 6 of their last 8 games (+3.65 Units / 39% ROI)
  • The St. Louis Cardinals have covered the Run Line in 28 of their last 44 games (+13.80 Units / 25% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 33 of their last 54 games (+11.95 Units / 19% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 25 of their last 38 games at home (+11.82 Units / 27% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 18 of their last 28 games (+6.95 Units / 20% ROI)
  • The St. Louis Cardinals have hit the Game Total Over in 15 of their last 25 games at home (+6.25 Units / 23% ROI)

Cincinnati Reds Against the Spread (ATS) Record

Against the spread this season, the Cincinnati Reds are 41-35 against the Run Line (-1 Units / -0.95% ROI).

  • 39-38 when betting on the Moneyline for -1.85 Units / -2.01% ROI
  • 34-42 when betting on the total runs Over for -11.6 Units / -13.78% ROI
  • 42-34 when betting on the total runs Under for +4.7 Units / 5.52% ROI

St. Louis Cardinals Against the Spread (ATS) Record

Against the spread this season, the St. Louis Cardinals are 43-34 against the Run Line (+5 Units / 4.82% ROI).

  • 42-35 when betting on the Moneyline for +6.3 Units / 7.03% ROI
  • 41-32 when betting on the total runs Over for +5.8 Units / 6.86% ROI
  • 32-41 when betting on the total runs Under for -13.25 Units / -15.62% ROI

St. Louis Cardinals vs Cincinnati Reds Home Run Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +290 0.5 -375
Christian Encarnacion-Strand (CIN) 0.5 +375 0.5 -500
Nolan Arenado (STL) 0.5 +400 0.5 -550
Elly De La Cruz (CIN) 0.5 +400 0.5 -525
Masyn Winn (STL) 0.5 +400 0.5 -550

St. Louis Cardinals vs Cincinnati Reds Total Hits Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 -275 0.5 +200
Nolan Arenado (STL) 0.5 -250 0.5 +180
TJ Friedl (CIN) 0.5 -250 0.5 +190
Thomas Saggese (STL) 0.5 -250 0.5 +190
Spencer Steer (CIN) 0.5 -235 0.5 +180

St. Louis Cardinals vs Cincinnati Reds RBI Prop Bets Today

Over Under
Willson Contreras (STL) 0.5 +125 0.5 -160
Elly De La Cruz (CIN) 0.5 +135 0.5 -175
Christian Encarnacion-Strand (CIN) 0.5 +135 0.5 -175
Nolan Arenado (STL) 0.5 +145 0.5 -190
Spencer Steer (CIN) 0.5 +145 0.5 -190

St. Louis Cardinals vs Cincinnati Reds Strikeout Prop Bets Today

Over Under
Miles Mikolas (STL) 3.5 -115 3.5 -110
Andrew Abbott (CIN) 4.5 +115 4.5 -155

starting pitcher – away

St. Louis Cardinals Starting Pitcher Stats & Trends

starting pitcher – home

Cincinnati Reds Keys to the Game vs. the St. Louis Cardinals

keys to the game – away

St. Louis Cardinals Keys to the Game vs. the Cincinnati Reds

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.