Diamondbacks vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
  • The Diamondbacks are -110 favorites vs the Cardinals
  • Diamondbacks vs Cardinals Over / Under today: 8.5 Runs
  • Diamondbacks / Cardinals TV Channel: BSMW | DBTV

The Arizona Diamondbacks (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on Monday, April 22, 2024. First pitch is scheduled for 7:45pm EDT in St. Louis, MO.

This season, the Diamondbacks are 11-12 against the spread (ATS), while the Cardinals are 12-10 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

  • Diamondbacks starting pitcher: Brandon Pfaadt 1-1, 5.33 ERA
  • Cardinals starting pitcher: Lance Lynn 1-0, 2.18 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks-1.5 +155O 8.5 -110-105
Cardinals +1.5 -190U 8.5 -110-115

Diamondbacks vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Monday‘s MLB game with 51.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Monday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Merrill Kelly has hit the Earned Runs Under in 23 of his last 33 games (+10.65 Units / 24% ROI)
  • Merrill Kelly has hit the Strikeouts Over in 21 of his last 34 games (+8.45 Units / 22% ROI)
  • Evan Longoria has hit the Singles Over in 9 of his last 15 away games (+7.95 Units / 53% ROI)
  • Zac Gallen has hit the Pitching Outs Over in 20 of his last 31 games (+7.60 Units / 18% ROI)
  • Christian Walker has hit the Hits Under in 7 of his last 10 games (+7.25 Units / 57% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Monday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Kyle Gibson has hit the Earned Runs Over in 10 of his last 13 games at home (+7.40 Units / 52% ROI)
  • Jordan Walker has hit the Singles Under in his last 7 games at home (+7.00 Units / 74% ROI)
  • Lance Lynn has hit the Strikeouts Under in 10 of his last 13 games (+6.50 Units / 37% ROI)
  • Jordan Walker has hit the Hits Runs and RBIs Under in his last 5 games at home (+5.45 Units / 86% ROI)
  • Ivan Herrera has hit the Hits Runs and RBIs Over in 8 of his last 12 games (+4.95 Units / 36% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 56 of their last 99 games (+14.00 Units / 13% ROI)
  • The Arizona Diamondbacks have hit the Moneyline in 37 of their last 63 games (+11.20 Units / 15% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 54 of their last 93 games (+10.82 Units / 10% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 42 of their last 70 away games (+10.10 Units / 12% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 29 of their last 61 games (+9.29 Units / 13% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 32 of their last 58 games (+5.80 Units / 9% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 13 of their last 26 games (+5.50 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 11 games (+4.82 Units / 37% ROI)
  • The St. Louis Cardinals have covered the Run Line in 49 of their last 92 games (+1.55 Units / 1% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 12-11 against the Run Line (+0.45 Units / 1.56% ROI).

  • 11-12 when betting on the Moneyline for -3.55 Units / -11.45% ROI
  • 11-11 when betting on the total runs Over for -1.35 Units / -5.24% ROI
  • 11-11 when betting on the total runs Under for -0.9 Units / -3.61% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 12-10 against the Run Line (+2.3 Units / 8.39% ROI).

  • 9-13 when betting on the Moneyline for -4.1 Units / -15.95% ROI
  • 7-13 when betting on the total runs Over for -7.1 Units / -29.46% ROI
  • 13-7 when betting on the total runs Under for +5.5 Units / 22.63% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Over Under
Joc Pederson (ARI) 0.5 +300 0.5 -375
Nolan Gorman (STL) 0.5 +350 0.5 -450
Ketel Marte (ARI) 0.5 +350 0.5 -450
Willson Contreras (STL) 0.5 +375 0.5 -550
Nolan Arenado (STL) 0.5 +400 0.5 -550

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Over Under
Brendan Donovan (STL) 0.5 -275 0.5 +200
Lourdes Gurriel Jr. (ARI) 0.5 -250 0.5 +185
Nolan Arenado (STL) 0.5 -225 0.5 +165
Willson Contreras (STL) 0.5 -225 0.5 +175
Lars Nootbaar (STL) 0.5 -225 0.5 +170

Cardinals vs Diamondbacks RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +130 0.5 -165
Lourdes Gurriel Jr. (ARI) 0.5 +130 0.5 -175
Joc Pederson (ARI) 0.5 +135 0.5 -185
Christian Walker (ARI) 0.5 +145 0.5 -190
Ketel Marte (ARI) 0.5 +145 0.5 -190

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Over Under

Brandon Pfaadt has a first-pitch strike rate of 78% (79/101) this season — 2nd highest among qualified SPs in MLB; League Avg: 63% — 98th Percentile.

Brandon Pfaadt has allowed a slugging percentage of .667 (28 Total Bases / 42 ABs) on non-fastballs this season — 2nd highest among qualified SPs in MLB; League Avg: .335 — second Percentile.

Opponents have a first pitch chase rate of 38% (14/37) against Brandon Pfaadt this season — highest among qualified SPs in MLB; League Avg: 15% — 100th Percentile.

Brandon Pfaadt has not walked any of the 36 batters that he has faced when going through the lineup the second time in a game this season — tied for best among qualified SPs in MLB; League Avg: 7% — 100th Percentile.

Cardinals Starting Pitcher Stats & Trends

Lance Lynn has located his fastball away 60% of the time (121/200) this season — highest among in NL; League Avg: 41% — 100th Percentile.

Lance Lynn has allowed 48 home runs since last season — most among pitchers in MLB — 100th Percentile.

Lance Lynn has allowed a slugging percentage of .481 (139 Total Bases / 289 ABs) when going through the lineup the first time in a game since last season — 2nd highest among qualified SPs in MLB; League Avg: .389 — fifth Percentile.

Lance Lynn has located his pitches away 64% of the time (54/84) when behind in the count this season — 2nd highest among qualified SPs in MLB; League Avg: 45% — 98th Percentile.

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are just 80-9 (.899) when leading entering the 9th inning since the 2023 season — 3rd lowest in MLB; League Avg: .948.

The Diamondbacks are just 59-39 (.602) when they’ve hit 2 or more home runs since the 2022 season — 3rd lowest in MLB; League Avg: .697.

The Diamondbacks are just 127-23 (.847) when leading entering the 8th inning since the 2022 season — lowest in MLB; League Avg: .906.

The Diamondbacks are just 143-15 (.905) when leading entering the 9th inning since the 2022 season — lowest in MLB; League Avg: .951.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are 27-10 (.730) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 6-81 (.069) when trailing entering the 7th inning since the 2023 season — 2nd lowest in MLB; League Avg: .144.

The Cardinals are just 38-52 (.422) at home since the 2023 season — tied for 3rd lowest in MLB; League Avg: .515.

The Cardinals are 11-6 (.647) when tied entering the 8th inning since the 2023 season — 4th best in MLB; League Avg: .500.

team hitters – away

team hitters – home

Diamondbacks pitchers have a strikeout rate of just 20% in close and late situations since the 2022 season — lowest in MLB; League Avg: 25%.

Opponents have a groundball rate of just 41% against Diamondbacks pitchers since the 2022 season — 5th lowest in MLB; League Avg: 43%.

Diamondbacks pitchers have walked 62 of 875 batters (7%) this season — 4th best in MLB; League Avg: 9%.

Diamondbacks pitchers have a strikeout rate of just 15% in close and late situations this season — lowest in MLB; League Avg: 25%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — tied for 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 47% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Cardinals pitchers have walked 10 of 194 batters (5%) when facing the leadoff batter in the inning this season — 5th best in MLB; League Avg: 9%.

Cardinals vs. Diamondbacks Injuries Tonight That May Affect Prop Bets 

  • Dylan Carlson (St. Louis Cardinals): Shoulder, 10-Day IL
  • Keynan Middleton (St. Louis Cardinals): Forearm, 15-Day IL
  • Lars Nootbaar (St. Louis Cardinals): Ribs, 10-Day IL
  • Drew Rom (St. Louis Cardinals): Biceps, 15-Day IL
  • Sonny Gray (St. Louis Cardinals): Hamstring, 15-Day IL
  • Riley O’Brien (St. Louis Cardinals): Forearm, 15-Day IL
  • Tommy Edman (St. Louis Cardinals): Wrist, 10-Day IL
  • Packy Naughton (St. Louis Cardinals): Elbow, Out
  • Jordan Lawlar (Arizona Diamondbacks): Thumb, 60-Day IL
  • Alek Thomas (Arizona Diamondbacks): Hamstring, Day-To-Day
  • Eduardo Rodriguez (Arizona Diamondbacks): Shoulder, 15-Day IL
  • Paul Sewald (Arizona Diamondbacks): Oblique, 15-Day IL
  • Jose Castillo (Arizona Diamondbacks): Hand, 7-Day IL
  • Drey Jameson (Arizona Diamondbacks): Elbow, 60-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.