Diamondbacks vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, May 24

St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
  • The Diamondbacks are -105 favorites vs the Cardinals
  • Diamondbacks vs Cardinals Over / Under today: 8 Runs
  • Diamondbacks / Cardinals TV Channel: DBTV | FDMW

The Arizona Diamondbacks (-105) visit Busch Stadium to take on the St. Louis Cardinals (-115) on Saturday, May 24, 2025. First pitch is scheduled for 2:15pm EDT in St. Louis, MO, MO.

This season, the Diamondbacks are 26-25 against the spread (ATS), while the Cardinals are 31-20 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

  • Diamondbacks starting pitcher: Merrill Kelly 5-2, 3.28 ERA
  • Cardinals starting pitcher: Matthew Liberatore 3-3, 2.93 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks-1.5 +165O 8 -120-105
Cardinals +1.5 -200U 8 +100-115

Diamondbacks vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Saturday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Gabriel Moreno has hit the Home Runs Over in 3 of his last 10 games (+20.00 Units / 200% ROI)
  • Randal Grichuk has hit the Runs Under in 20 of his last 25 away games (+11.20 Units / 24% ROI)
  • Geraldo Perdomo has hit the Hits Over in 16 of his last 20 games (+10.40 Units / 34% ROI)
  • Geraldo Perdomo has hit the Total Bases Over in 16 of his last 20 games (+9.80 Units / 32% ROI)
  • Merrill Kelly has hit the Earned Runs Under in 11 of his last 15 games (+6.70 Units / 35% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Alec Burleson has hit the Home Runs Over in 4 of his last 10 games (+28.00 Units / 280% ROI)
  • Ivan Herrera has hit the Runs Over in 10 of his last 15 games (+10.15 Units / 67% ROI)
  • Victor Scott II has hit the Total Bases Over in his last 10 games at home (+10.00 Units / 74% ROI)
  • Victor Scott II has hit the Hits Over in his last 10 games at home (+10.00 Units / 74% ROI)
  • Ivan Herrera has hit the Hits Runs and RBIs Over in 12 of his last 15 games (+9.05 Units / 54% ROI)
  • The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 23 of their last 35 games (+11.10 Units / 27% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 21 of their last 35 games (+10.40 Units / 21% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 16 of their last 22 games (+9.45 Units / 40% ROI)
  • The Arizona Diamondbacks have hit the Team Total Under in 10 of their last 15 away games (+4.30 Units / 24% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 16 away games (+3.80 Units / 20% ROI)
  • The St. Louis Cardinals have covered the Run Line in 16 of their last 18 games (+15.20 Units / 60% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 19 of their last 28 games (+11.40 Units / 36% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 24 of their last 37 games (+9.10 Units / 20% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 16 of their last 25 games at home (+6.57 Units / 23% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 18 of their last 41 games (+6.35 Units / 14% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 23-28 against the Run Line (-9.81 Units / -14.79% ROI).

  • 26-25 when betting on the Moneyline for -4.1 Units / -6% ROI
  • 22-26 when betting on the total runs Over for -6.8 Units / -12.1% ROI
  • 26-22 when betting on the total runs Under for +1.6 Units / 2.86% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 31-20 against the Run Line (+6.4 Units / 8.76% ROI).

  • 28-23 when betting on the Moneyline for +5.75 Units / 10.11% ROI
  • 26-23 when betting on the total runs Over for +0.7 Units / 1.25% ROI
  • 23-26 when betting on the total runs Under for -5.8 Units / -10.31% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Over Under
Ketel Marte (ARI) 0.5 +425 0.5 -600
Eugenio Suarez (ARI) 0.5 +500 0.5 -700
Lars Nootbaar (STL) 0.5 +575 0.5 -900
Lourdes Gurriel Jr (ARI) 0.5 +600 0.5 -900
Tim Tawa (ARI) 0.5 +625 0.5 -1000

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Over Under
Brendan Donovan (STL) 0.5 -250 0.5 +190
Gabriel Moreno (ARI) 0.5 -250 0.5 +190
Lars Nootbaar (STL) 0.5 -225 0.5 +170
Eugenio Suarez (ARI) 0.5 -210 0.5 +160
Masyn Winn (STL) 0.5 -210 0.5 +160

Cardinals vs Diamondbacks RBI Prop Bets Today

Over Under
Lourdes Gurriel Jr (ARI) 0.5 +135 0.5 -185
Ketel Marte (ARI) 0.5 +155 0.5 -210
Eugenio Suarez (ARI) 0.5 +160 0.5 -210
Ivan Herrera (STL) 0.5 +160 0.5 -210
Alec Burleson (STL) 0.5 +185 0.5 -250

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Over Under
Matthew Liberatore (STL) 3.5 -150 3.5 +115
Merrill Kelly (ARI) 4.5 +120 4.5 -155

Merrill Kelly has allowed an OBP of just .178 (90 PA’s) when going through the lineup the second time in a game this season — best among among NL Starters; League Avg: .295 — 100th Percentile.

Merrill Kelly has allowed an OBP of just .178 (90 PA’s) when going through the lineup the second time in a game this season — 2nd best among qualified SPs in MLB; League Avg: .289 — 98th Percentile.

Merrill Kelly has allowed an OPS of just .387 (90 PA’s) when going through the lineup the second time in a game this season — best among qualified SPs in MLB; League Avg: .666 — 100th Percentile.

Opponents are hitting just .140 (12-for-86) against Merrill Kelly when going through the lineup the second time in a game this season — 2nd best among qualified SPs in MLB; League Avg: .230 — 98th Percentile.

Cardinals Starting Pitcher Stats & Trends

Matthew Liberatore’s K:BB ratio is 11.3 (34/3) against right-handed batters this season — 2nd best among qualified SPs in MLB; League Avg: 3.2 — 98th Percentile.

Matthew Liberatore has walked 2% of right-handed batters this season — best among qualified SPs in MLB; League Avg: 7% — 100th Percentile.

Matthew Liberatore has a first-pitch strike rate of 80% (71/89) this month (4 games) — highest among qualified SPs in MLB; League Avg: 63% — 100th Percentile.

Matthew Liberatore walked 4 of 138 left-handed batters (3%) in the 2024 season — 4th best among qualified RPs in MLB; League Avg: 9% — 96th Percentile.

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are 6-81 (.068) when trailing entering the 9th inning since last season — tied for 5th best in MLB; League Avg: .048.

The Diamondbacks are just 24-2 (.923) when leading entering the 9th inning this season — tied for 5th lowest in MLB; League Avg: .958.

The Diamondbacks are just 19-6 (.760) when leading entering the 7th inning this season — 3rd lowest in MLB; League Avg: .872.

The Diamondbacks are just 171-14 (.924) when leading entering the 9th inning since the 2023 season — 4th lowest in MLB; League Avg: .950.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are just 0-15 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .127.

The Cardinals are just 0-16 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .089.

The Cardinals are 17-8 (.680) at home this season — tied for 5th best in MLB; League Avg: .560.

The Cardinals are just 0-18 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .041.

Diamondbacks hitters have struck out in just 17% of it’s PA’s against LHP this season — best in MLB; League Avg: 23%.

Diamondbacks hitters had an OBP of .337 (6,284 PA’s) in the 2024 season — best in MLB; League Avg: .312.

Diamondbacks hitters have an OBP of .334 (5,723 PA’s) against RHP since last season — 2nd best in MLB; League Avg: .313.

Diamondbacks hitters are slugging .473 against RHP this season — best in MLB; League Avg: .402.

The Cardinals have scored first in 77% of their road games this season — highest in MLB; League Avg: 55%.

The Cardinals are batting .188 on pitches out of the zone this season — best in MLB; League Avg: .148.

Cardinals hitters have an OBP of .354 (935 PA’s) at home this season — 2nd best in MLB; League Avg: .323.

Cardinals hitters have struck out in just 18% of it’s PA’s against RHP this season — 2nd best in MLB; League Avg: 22%.

The Diamondbacks pitchers have allowed their opponents to score first in just 40% of their games since last season — tied for lowest in MLB; League Avg: 50%.

Opponents had a miss rate of just 24% against Diamondbacks pitchers in the 2024 season — tied for 4th lowest in MLB; League Avg: 25%.

Batters facing the Diamondbacks pitchers have struck out in the zone 48% of the time since the 2023 season — 3rd lowest in MLB; League Avg: 49%. since the 2023 season — 3rd lowest in MLB; League Avg: 49%.

Diamondbacks pitchers had an ERA of 4.68 (739.0 IP) at home in the 2024 season — 3rd highest in MLB; League Avg: 3.98.

Batters facing the Cardinals pitchers have struck out in the zone 46% of the time since last season — 2nd lowest in MLB; League Avg: 50%. since last season — 2nd lowest in MLB; League Avg: 50%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 25%.

The Cardinals pitchers have allowed their opponents to score first in just 23% of their games on the road this season — lowest in MLB; League Avg: 45%.

Cardinals pitchers have a strikeout rate of just 20% since the 2023 season — 2nd lowest in MLB; League Avg: 23%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.