Diamondbacks vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, May 25

St. Louis Cardinals' Jordan Walker warms up before a baseball game against the Milwaukee Brewers Thursday, Sept. 28, 2023, in Milwaukee. (AP Photo/Aaron Gash)
(AP Photo/Aaron Gash)
  • The Diamondbacks are +105 favorites vs the Cardinals
  • Diamondbacks vs Cardinals Over / Under today: 7.5 Runs
  • Diamondbacks / Cardinals TV Channel: DBTV | FDMW

The Arizona Diamondbacks (+105) visit Busch Stadium to take on the St. Louis Cardinals (-125) on Sunday, May 25, 2025. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the Diamondbacks are 26-26 against the spread (ATS), while the Cardinals are 32-20 ATS.

Diamondbacks vs Cardinals Starting Pitchers Today:

  • Diamondbacks starting pitcher: Brandon Pfaadt 7-3, 3.86 ERA
  • Cardinals starting pitcher: Sonny Gray 5-1, 4.05 ERA

Diamondbacks vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks+1.5 -225O 7.5 -120+105
Cardinals -1.5 +170U 7.5 +100-125

Diamondbacks vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Sunday‘s MLB game with 53.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Gabriel Moreno has hit the Home Runs Over in 2 of his last 4 games (+15.00 Units / 375% ROI)
  • Geraldo Perdomo has hit the Hits Over in 19 of his last 25 games (+11.65 Units / 30% ROI)
  • Geraldo Perdomo has hit the Total Bases Over in 19 of his last 25 games (+11.10 Units / 30% ROI)
  • Pavin Smith has hit the Walks Under in 9 of his last 10 games (+7.90 Units / 51% ROI)
  • Ketel Marte has hit the Runs Over in 8 of his last 9 games (+7.00 Units / 64% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Sunday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Alec Burleson has hit the Home Runs Over in 3 of his last 10 games (+17.50 Units / 175% ROI)
  • Ivan Herrera has hit the Runs Over in 10 of his last 15 games (+10.05 Units / 67% ROI)
  • Ivan Herrera has hit the Hits Runs and RBIs Over in 12 of his last 15 games (+9.05 Units / 54% ROI)
  • Lars Nootbaar has hit the Total Bases Over in 17 of his last 25 games at home (+8.20 Units / 23% ROI)
  • Victor Scott II has hit the Hits Over in 9 of his last 10 games at home (+7.55 Units / 55% ROI)
  • The Arizona Diamondbacks have covered the 1st Five Innings (F5) Run Line in 24 of their last 36 games (+12.10 Units / 28% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 21 of their last 36 games (+10.40 Units / 21% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 16 of their last 23 games (+8.35 Units / 33% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 17 away games (+4.85 Units / 24% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 29 of their last 52 games (+3.35 Units / 5% ROI)
  • The St. Louis Cardinals have covered the Run Line in 17 of their last 19 games (+16.20 Units / 61% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 20 of their last 29 games (+12.40 Units / 38% ROI)
  • The St. Louis Cardinals have covered the 1st Five Innings (F5) Run Line in 24 of their last 38 games (+8.10 Units / 18% ROI)
  • The St. Louis Cardinals have hit the Team Total Over in 17 of their last 26 games at home (+7.57 Units / 26% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Moneyline in 18 of their last 42 games (+6.35 Units / 13% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 23-29 against the Run Line (-10.81 Units / -16.06% ROI).

  • 26-26 when betting on the Moneyline for -5.1 Units / -7.36% ROI
  • 23-26 when betting on the total runs Over for -5.8 Units / -10.12% ROI
  • 26-23 when betting on the total runs Under for +0.5 Units / 0.88% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 32-20 against the Run Line (+7.4 Units / 9.92% ROI).

  • 29-23 when betting on the Moneyline for +6.75 Units / 11.62% ROI
  • 27-23 when betting on the total runs Over for +1.7 Units / 2.98% ROI
  • 23-27 when betting on the total runs Under for -6.9 Units / -12.03% ROI

Cardinals vs Diamondbacks Home Run Prop Bets Today

Over Under
Eugenio Suarez (ARI) 0.5 +400 0.5 -550
Corbin Carroll (ARI) 0.5 +550 0.5 -800
Ketel Marte (ARI) 0.5 +625 0.5 -1000
Lars Nootbaar (STL) 0.5 +675 0.5 -1100
Lourdes Gurriel Jr (ARI) 0.5 +700 0.5 -1100

Cardinals vs Diamondbacks Total Hits Prop Bets Today

Over Under
Masyn Winn (STL) 0.5 -250 0.5 +180
Lars Nootbaar (STL) 0.5 -235 0.5 +180
Alec Burleson (STL) 0.5 -225 0.5 +170
Ivan Herrera (STL) 0.5 -225 0.5 +170
Lourdes Gurriel Jr (ARI) 0.5 -225 0.5 +170

Cardinals vs Diamondbacks RBI Prop Bets Today

Over Under
Ivan Herrera (STL) 0.5 +150 0.5 -200
Eugenio Suarez (ARI) 0.5 +165 0.5 -220
Lourdes Gurriel Jr (ARI) 0.5 +175 0.5 -235
Corbin Carroll (ARI) 0.5 +180 0.5 -235
Nolan Arenado (STL) 0.5 +185 0.5 -250

Cardinals vs Diamondbacks Strikeout Prop Bets Today

Over Under
Sonny Gray (STL) 5.5 -130 5.5 +100
Brandon Pfaadt (ARI) 4.5 +120 4.5 -155

Opponents have a Hard-Hit Rate of 67% (18/27) against Brandon Pfaadt in late innings since last season — highest in MLB among starting pitchers with at least 84 total IP; League Avg: 39% — first Percentile.

Division opponents batted .302 against Brandon Pfaadt (60-for-199) in the 2024 season — 2nd highest among qualified SPs in MLB; League Avg: .234 — third Percentile.

Brandon Pfaadt has a strikeout rate of just 27% (15 SO in 55 PAs) with two-strikes this month (4 games) — lowest among among NL Starters; League Avg: 44% — second Percentile.

Opponents batted .383 (41-for-107) against Brandon Pfaadt on the first pitch of at-bats in the 2024 season — tied for 9th highest among qualified SPs in MLB; League Avg: .330 — 19th Percentile.

Cardinals Starting Pitcher Stats & Trends

Sonny Gray has a strikeout rate of 47% (17 SO in 36 PAs) when going through the lineup the second time in a game this month (4 games) — best among among NL Starters; League Avg: 23% — 100th Percentile.

Sonny Gray had a strikeout rate of 58% (203/350) with two-strikes in the 2024 season — best among qualified SPs in MLB; League Avg: 43% — 100th Percentile.

Sonny Gray allowed an OBP of just .160 (350 PA’s) with two-strikes in the 2024 season — 2nd best among qualified SPs in MLB; League Avg: .232 — 98th Percentile.

Sonny Gray allowed an OPS of just .321 (350 PA’s) with two-strikes in the 2024 season — 2nd best among qualified SPs in MLB; League Avg: .486 — 98th Percentile.

Diamondbacks Keys to the Game vs. the Cardinals

The Diamondbacks are just 24-2 (.923) when leading entering the 9th inning this season — 5th lowest in MLB; League Avg: .957.

The Diamondbacks are 17-70 (.193) when trailing entering the 7th inning since last season — tied for 4th best in MLB; League Avg: .140.

The Diamondbacks are just 171-14 (.924) when leading entering the 9th inning since the 2023 season — 4th lowest in MLB; League Avg: .950.

The Diamondbacks are 58-49 (.542) on the road since last season — 4th best in MLB; League Avg: .468.

Cardinals Keys to the Game vs. the Diamondbacks

The Cardinals are just 0-15 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .128.

The Cardinals are just 0-18 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .041.

The Cardinals are just 10-157 (.060) when trailing entering the 8th inning since the 2023 season — 3rd lowest in MLB; League Avg: .098.

The Cardinals are just 58-60 (.492) vs bottom 10 scoring offenses since the 2023 season They play the Diamondbacks (first best runs scored) today.

Diamondbacks hitters have an OBP of .347 (4,069 PA’s) at home since last season — best in MLB; League Avg: .317.

Diamondbacks hitters are slugging .423 with two-strikes over the last 14 days — best in MLB; League Avg: .266.

Diamondbacks hitters have struck out in just 16% of it’s PA’s against LHP this season — best in MLB; League Avg: 23%.

The Diamondbacks have scored 1.87 runs per game (401/214) in late innings since last season — best in MLB; League Avg: 1.44.

The Cardinals are batting .185 on pitches out of the zone this season — best in MLB; League Avg: .148.

The Cardinals have scored first in 77% of their road games this season — highest in MLB; League Avg: 55%.

Cardinals hitters have an OBP of .269 (995 PA’s) with two-strikes this season — 5th best in MLB; League Avg: .249.

The Cardinals are batting .187 with two-strikes this season — tied for 4th best in MLB; League Avg: .171.

Diamondbacks pitchers had a strikeout rate of just 21% in the 2024 season — 5th lowest in MLB; League Avg: 23%.

Diamondbacks pitchers have a in-zone of just 48% this season — 2nd lowest in MLB; League Avg: 51%.

Batters facing the Diamondbacks pitchers have struck out in the zone 48% of the time since the 2023 season — 3rd lowest in MLB; League Avg: 49%. since the 2023 season — 3rd lowest in MLB; League Avg: 49%.

The Diamondbacks pitchers have allowed their opponents to score first in just 35% of their games on the road since last season — lowest in MLB; League Avg: 44%.

Opponents have a miss rate of just 22% against Cardinals pitchers this season — lowest in MLB; League Avg: 25%.

The Cardinals pitchers have allowed their opponents to score first in just 23% of their games on the road this season — lowest in MLB; League Avg: 45%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2023 season — 2nd lowest in MLB; League Avg: 25%.

Opponents had a miss rate of just 23% against Cardinals pitchers in 2023 — 2nd lowest in MLB; League Avg: 26%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.