Diamondbacks vs Giants Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

San Francisco Giants' Thairo Estrada rounds first after hitting a solo home run against the Los Angeles Dodgers during the sixth inning of a baseball game in Los Angeles, Friday, Sept. 22, 2023. (AP Photo/Alex Gallardo)
(AP Photo/Alex Gallardo)
  • The Diamondbacks are -105 favorites vs the Giants
  • Diamondbacks vs Giants Over / Under today: 7.5 Runs
  • Diamondbacks / Giants TV Channel: NSBA | DBTV

The Arizona Diamondbacks (-105) visit Oracle Park to take on the San Francisco Giants (-115) on Sunday, April 21, 2024. First pitch is scheduled for 4:05pm EDT in San Francisco, CA.

This season, the Diamondbacks are 10-12 against the spread (ATS), while the Giants are 9-13 ATS.

Diamondbacks vs Giants Starting Pitchers Today:

  • Diamondbacks starting pitcher: Merrill Kelly 2-0, 2.19 ERA
  • Giants starting pitcher: Jordan Hicks 2-0, 1.54 ERA

Diamondbacks vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Diamondbacks-1.5 +165O 7.5 -105-105
Giants +1.5 -200U 7.5 -115-115

Diamondbacks vs Giants Prediction for Today’s Game

Based on recent trends the model predicts the Diamondbacks will win Sunday‘s MLB game with 51.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Sunday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Merrill Kelly has hit the Earned Runs Under in 23 of his last 33 games (+10.65 Units / 24% ROI)
  • Buddy Kennedy has hit the Hits Under in his last 7 games (+9.30 Units / 94% ROI)
  • Merrill Kelly has hit the Strikeouts Over in 21 of his last 34 games (+8.45 Units / 22% ROI)
  • Evan Longoria has hit the Singles Over in 9 of his last 15 away games (+7.95 Units / 53% ROI)
  • Buddy Kennedy has hit the Total Bases Under in his last 7 games (+7.80 Units / 70% ROI)

And here are some favorite MLB player prop bets for Giants players for Sunday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Logan Webb has hit the Pitching Outs Over in 25 of his last 34 games (+16.25 Units / 37% ROI)
  • Blake Snell has hit the Earned Runs Under in 21 of his last 29 games (+12.35 Units / 33% ROI)
  • Matt Chapman has hit the Total Bases Under in 18 of his last 25 games at home (+10.60 Units / 31% ROI)
  • Matt Chapman has hit the Hits Runs and RBIs Under in 17 of his last 24 games at home (+7.45 Units / 24% ROI)
  • Austin Slater has hit the Total Bases Under in 15 of his last 22 games (+7.15 Units / 22% ROI)
  • The Arizona Diamondbacks have hit the Game Total Under in 56 of their last 99 games (+14.00 Units / 13% ROI)
  • The Arizona Diamondbacks have hit the Moneyline in 37 of their last 63 games (+11.20 Units / 15% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Team Total Under in 54 of their last 93 games (+10.82 Units / 10% ROI)
  • The Arizona Diamondbacks have hit the Team Total Over in 42 of their last 70 away games (+10.10 Units / 12% ROI)
  • The Arizona Diamondbacks have hit the 1st Five Innings (F5) Moneyline in 29 of their last 61 games (+9.29 Units / 13% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Under in 73 of their last 115 games (+27.02 Units / 20% ROI)
  • The San Francisco Giants have hit the Team Total Under in 55 of their last 85 games (+22.17 Units / 22% ROI)
  • The San Francisco Giants have hit the Game Total Under in 54 of their last 85 games (+21.55 Units / 23% ROI)
  • The San Francisco Giants have hit the Moneyline in 28 of their last 47 games at home (+5.40 Units / 8% ROI)
  • The San Francisco Giants have covered the Run Line in 36 of their last 73 games at home (+1.15 Units / 1% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 11-11 against the Run Line (-0.55 Units / -2.03% ROI).

  • 10-12 when betting on the Moneyline for -4.7 Units / -15.67% ROI
  • 11-11 when betting on the total runs Over for -1.35 Units / -5.49% ROI
  • 11-11 when betting on the total runs Under for -0.9 Units / -3.77% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 9-13 against the Run Line (-5.2 Units / -18.87% ROI).

  • 10-12 when betting on the Moneyline for -5 Units / -17.83% ROI
  • 13-9 when betting on the total runs Over for +3.3 Units / 13.84% ROI
  • 9-13 when betting on the total runs Under for -5.55 Units / -22.56% ROI

Giants vs Diamondbacks Home Run Prop Bets Today

Over Under
Jorge Soler (SF) 0.5 +400 0.5 -550
Matt Chapman (SF) 0.5 +475 0.5 -700
Joc Pederson (ARI) 0.5 +650 0.5 -1000
Ketel Marte (ARI) 0.5 +775 0.5 -1400
Eugenio Suarez (ARI) 0.5 +800 0.5 -1400

Giants vs Diamondbacks Total Hits Prop Bets Today

Over Under
Lourdes Gurriel Jr. (ARI) 0.5 -275 0.5 +195
Christian Walker (ARI) 0.5 -210 0.5 +160
Gabriel Moreno (ARI) 0.5 -210 0.5 +160
Jake McCarthy (ARI) 0.5 -210 0.5 +155
Joc Pederson (ARI) 0.5 -200 0.5 +150

Giants vs Diamondbacks RBI Prop Bets Today

Over Under
Lourdes Gurriel Jr. (ARI) 0.5 +135 0.5 -185
Christian Walker (ARI) 0.5 +155 0.5 -210
Jorge Soler (SF) 0.5 +155 0.5 -210
Joc Pederson (ARI) 0.5 +170 0.5 -225
Matt Chapman (SF) 0.5 +170 0.5 -225

Giants vs Diamondbacks Strikeout Prop Bets Today

Over Under

Opponents are hitting just .191 (52-for-272) against Merrill Kelly when going through the lineup the first time in a game since last season — 2nd best among qualified SPs in MLB; League Avg: .232 — 97th Percentile.

Merrill Kelly has a strikeout rate of 36% (13 SO in 36 PAs) when going through the lineup the first time in a game this season — tied for 9th best among qualified SPs in MLB; League Avg: 26% — 91st Percentile.

Merrill Kelly has located his sliders away 92% of the time (56/61) this season — highest among in NL; League Avg: 53% — 100th Percentile.

Merrill Kelly has located his pitches away 63% of the time (51/81) when behind in the count this season — 2nd highest among in NL; League Avg: 44% — 97th Percentile.

Giants Starting Pitcher Stats & Trends

Jordan Hicks has allowed an OBP of just .116 (43 PA’s) against right-handed batters this season — best among qualified SPs in MLB; League Avg: .292 — 100th Percentile.

Jordan Hicks has thrown 424 fastballs at 100+ MPH since last season — most among in NL — 100th Percentile.

Right-handed batters are hitting just .095 (4-for-42) against Jordan Hicks this season — best among qualified SPs in MLB; League Avg: .233 — 100th Percentile.

Opponents have a miss rate of just 15% (15/99) against Jordan Hicks on the first pitch of at-bats since last season — 3rd lowest among qualified RPs in MLB*; League Avg: 29% — third Percentile.

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are just 126-23 (.846) when leading entering the 8th inning since the 2022 season — lowest in MLB; League Avg: .906.

The Diamondbacks are just 142-15 (.904) when leading entering the 9th inning since the 2022 season — lowest in MLB; League Avg: .951.

The Diamondbacks are just 79-9 (.898) when leading entering the 9th inning since the 2023 season — 3rd lowest in MLB; League Avg: .948.

The Diamondbacks are just 36-16 (.692) when they’ve had 5 or more XBH since the 2022 season — 3rd lowest in MLB; League Avg: .796.

Giants Keys to the Game vs. the Diamondbacks

The Giants are 45-7 (.865) when they’ve had 5 or more XBH since the 2022 season — tied for 4th best in MLB; League Avg: .796.

The Giants are 20-3 (.870) when they’ve had 5 or more XBH since the 2023 season — 5th best in MLB; League Avg: .791.

The Giants are 26-14 (.650) after a home loss since the 2023 season — 5th best in MLB; League Avg: .509.

The Giants are 75-1 (.987) when leading entering the 9th inning since the 2023 season — tied for best in MLB; League Avg: .948.

Diamondbacks hitters have put 41% of their swings in play against LHP since last season — highest in MLB; League Avg: 37%.

The Diamondbacks are batting .309 against LHP this season — best in MLB; League Avg: .248.

Diamondbacks hitters have put 40% of their swings in play against LHP since the 2022 season — highest in MLB; League Avg: 37%.

Diamondbacks hitters have an OBP of .362 (344 PA’s) against LHP this season — 3rd best in MLB; League Avg: .323.

Giants hitters are slugging just .400 when facing the starting pitcher for the 3rd time in a game since the 2022 season — lowest in MLB; League Avg: .448.

The Giants are batting just .241 when facing the starting pitcher for the 3rd time in a game since the 2022 season — lowest in MLB; League Avg: .266.

Giants hitters have an OPS of just .686 (2,039 PA’s) against LHP since last season — 4th lowest in MLB; League Avg: .738.

Giants hitters have an OBP of just .308 (2,039 PA’s) against LHP since last season — 5th lowest in MLB; League Avg: .323.

Diamondbacks pitchers have a strikeout rate of just 20% in close and late situations since the 2022 season — lowest in MLB; League Avg: 25%.

Diamondbacks pitchers have walked 59 of 840 batters (7%) this season — 5th best in MLB; League Avg: 9%.

Opponents have a groundball rate of just 41% against Diamondbacks pitchers since the 2022 season — 5th lowest in MLB; League Avg: 43%.

Diamondbacks pitchers have a strikeout rate of just 21% in late innings since the 2022 season — 2nd lowest in MLB; League Avg: 24%.

Opponents have a groundball rate of 49% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 49% against Giants pitchers since the 2022 season — highest in MLB; League Avg: 43%.

Opponents have a miss rate of just 22% against Giants pitchers this season — tied for lowest in MLB; League Avg: 25%.

Giants pitchers have walked 901 of 12,912 batters (7%) since the 2022 season — tied for best in MLB; League Avg: 8%.

Giants vs. Diamondbacks Injuries Tonight That May Affect Prop Bets 

  • Alex Cobb (San Francisco Giants): Hip, 15-Day IL
  • Cole Waites (San Francisco Giants): Elbow, 60-Day IL
  • Mike Yastrzemski (San Francisco Giants): Personal, Paternity
  • Tristan Beck (San Francisco Giants): Arm, 60-Day IL
  • Wade Meckler (San Francisco Giants): Undisclosed, 7-Day IL
  • Robbie Ray (San Francisco Giants): Elbow, 60-Day IL
  • Sean Hjelle (San Francisco Giants): Elbow, 15-Day IL
  • Luke Jackson (San Francisco Giants): Back, 15-Day IL
  • Wilmer Flores (San Francisco Giants): Shoulder, Day-To-Day
  • Thomas Szapucki (San Francisco Giants): Pectoral, 60-Day IL
  • Scott Alexander (San Francisco Giants): Ribs, 15-Day IL
  • Ethan Small (San Francisco Giants): Oblique, 60-Day IL
  • Jordan Lawlar (Arizona Diamondbacks): Thumb, 60-Day IL
  • Alek Thomas (Arizona Diamondbacks): Hamstring, Day-To-Day
  • Eduardo Rodriguez (Arizona Diamondbacks): Shoulder, 15-Day IL
  • Paul Sewald (Arizona Diamondbacks): Oblique, 15-Day IL
  • Jose Castillo (Arizona Diamondbacks): Hand, 7-Day IL
  • Drey Jameson (Arizona Diamondbacks): Elbow, 60-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.