Giants vs Pirates Prediction, Odds & Player Prop Bets Today – MLB, May 21

Pittsburgh Pirates' Jack Suwinski follows through on a single during the fourth inning of a baseball game against the Miami Marlins, Saturday, June 24, 2023, in Miami.
(AP Photo/Lynne Sladky)
  • The Giants are -135 favorites vs the Pirates
  • Giants vs Pirates Over / Under today: 7.5 Runs
  • Giants / Pirates TV Channel: SNPT | NSBA

The San Francisco Giants (-135) visit PNC Park to take on the Pittsburgh Pirates (+115) on Tuesday, May 21, 2024. First pitch is scheduled for 6:40pm EDT in Pittsburgh, PA.

This season, the Giants are 23-25 against the spread (ATS), while the Pirates are 26-22 ATS.

Giants vs Pirates Starting Pitchers Today:

  • Giants starting pitcher: Logan Webb 4-4, 3.04 ERA
  • Pirates starting pitcher: Martin Perez 1-3, 4.90 ERA

Giants vs. Pirates Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Giants-1.5 +120O 8.5 +100-135
Pirates +1.5 -145U 8.5 -120+115

Giants vs Pirates Prediction for Today’s Game

Based on recent trends the model predicts the Giants will win Tuesday‘s MLB game with 56.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Giants players for Tuesday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Bets Today:

  • Thairo Estrada has hit the Home Runs Over in 4 of his last 19 games (+20.00 Units / 105% ROI)
  • Matt Chapman has hit the Total Bases Under in 28 of his last 40 games (+12.45 Units / 22% ROI)
  • Matt Chapman has hit the RBIs Under in 22 of his last 27 games (+12.10 Units / 23% ROI)
  • Mike Yastrzemski has hit the Singles Over in 14 of his last 26 games (+10.80 Units / 42% ROI)
  • Wilmer Flores has hit the Hits Under in 11 of his last 19 games (+9.65 Units / 47% ROI)

And here are some favorite MLB player prop bets for Pirates players for Tuesday‘s game, looking at profitable historical betting trends:

Best Pirates Player Prop Best Bets Today:

  • Oneil Cruz has hit the Home Runs Over in 4 of his last 8 games at home (+15.30 Units / 191% ROI)
  • Jared Triolo has hit the Runs Under in 20 of his last 23 games (+13.55 Units / 27% ROI)
  • Rowdy Tellez has hit the Hits Runs and RBIs Under in 18 of his last 24 games (+10.55 Units / 32% ROI)
  • Oneil Cruz has hit the Total Bases Over in 11 of his last 12 games at home (+10.20 Units / 62% ROI)
  • Bryan Reynolds has hit the RBIs Under in his last 9 games at home (+9.00 Units / 40% ROI)
  • The San Francisco Giants have hit the Team Total Under in 26 of their last 41 games (+9.25 Units / 19% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 16 games (+8.10 Units / 43% ROI)
  • The San Francisco Giants have hit the 1st Five Innings (F5) Moneyline in 7 of their last 8 games (+6.95 Units / 65% ROI)
  • The San Francisco Giants have covered the 1st Five Innings (F5) Run Line in 7 of their last 8 games (+6.20 Units / 64% ROI)
  • The San Francisco Giants have hit the Game Total Over in 14 of their last 23 away games (+5.40 Units / 22% ROI)
  • The Pittsburgh Pirates have hit the Team Total Under in 27 of their last 37 games (+16.40 Units / 39% ROI)
  • The Pittsburgh Pirates have hit the 1st Five Innings (F5) Team Total Under in 23 of their last 37 games (+9.35 Units / 22% ROI)
  • The Pittsburgh Pirates have hit the Game Total Under in 21 of their last 37 games (+6.90 Units / 17% ROI)
  • The Pittsburgh Pirates have covered the Run Line in 8 of their last 9 games (+6.85 Units / 48% ROI)
  • The Pittsburgh Pirates have covered the 1st Five Innings (F5) Run Line in 4 of their last 5 games (+3.10 Units / 50% ROI)

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 23-25 against the Run Line (-3.05 Units / -4.98% ROI).

  • 23-25 when betting on the Moneyline for -6.65 Units / -10.94% ROI
  • 23-23 when betting on the total runs Over for -2 Units / -3.82% ROI
  • 23-23 when betting on the total runs Under for -2.55 Units / -4.78% ROI

Pirates Against the Spread (ATS) Record

Against the spread this season, the Pirates are 26-22 against the Run Line (+1.76 Units / 2.7% ROI).

  • 22-26 when betting on the Moneyline for -6 Units / -10.62% ROI
  • 21-24 when betting on the total runs Over for -5.1 Units / -9.64% ROI
  • 24-21 when betting on the total runs Under for +1.23 Units / 2.33% ROI

Pirates vs Giants Home Run Prop Bets Today

Over Under
Jorge Soler (SF) 0.5 +260 0.5 -350
Matt Chapman (SF) 0.5 +400 0.5 -550
Heliot Ramos (SF) 0.5 +525 0.5 -750
Wilmer Flores (SF) 0.5 +550 0.5 -800
Marco Luciano (SF) 0.5 +575 0.5 -900

Pirates vs Giants Total Hits Prop Bets Today

Over Under
Oneil Cruz (PIT) 0.5 -250 0.5 +175
Andrew McCutchen (PIT) 0.5 -250 0.5 +180
Bryan Reynolds (PIT) 0.5 -250 0.5 +180
Wilmer Flores (SF) 0.5 -250 0.5 +175
Nick Gonzales (PIT) 0.5 -225 0.5 +165

Pirates vs Giants RBI Prop Bets Today

Over Under
Matt Chapman (SF) 0.5 +120 0.5 -155
Jorge Soler (SF) 0.5 +130 0.5 -175
Connor Joe (PIT) 0.5 +165 0.5 -225
Luis Matos (SF) 0.5 +165 0.5 -225
Heliot Ramos (SF) 0.5 +165 0.5 -225

Pirates vs Giants Strikeout Prop Bets Today

Over Under
Martin Perez (PIT) 3.5 -160 3.5 +125
Logan Webb (SF) 4.5 -155 4.5 +120

Logan Webb has thrown his changeup 45% of the time (566/1,248) with two-strikes since last season — highest among qualified SPs in MLB; League Avg: 13% — 100th Percentile.

Logan Webb has thrown his changeup 38% of the time (1,110/2,908) in non-two strike counts since last season — highest among qualified SPs in MLB; League Avg: 14% — 100th Percentile.

Logan Webb has thrown his changeup 40% of the time (1,676/4,156) since last season — highest among qualified SPs in MLB; League Avg: 14% — 100th Percentile.

Logan Webb has thrown his changeup 42% of the time (79/189) when he’s behind in the count this season — highest among in MLB; League Avg: 15% — 100th Percentile.

Pirates Starting Pitcher Stats & Trends

Martin Perez has located his fastball inside 56% of the time (173/311) this season — 2nd highest among qualified SPs in MLB; League Avg: 33% — 98th Percentile.

Opponents have a miss rate of just 13% (8/60) against Martin Perez on the first pitch of at-bats this season — 2nd lowest among in MLB; League Avg: 25% — fourth Percentile.

Martin Perez has allowed a slugging percentage of .765 (39 Total Bases / 51 ABs) when going through the lineup the third time in a game this season — 2nd highest among qualified SPs in MLB; League Avg: .401 — second Percentile.

Opponents are hitting .311 (23-for-74) against Martin Perez’s non-fastballs this season — 6th highest among qualified SPs in MLB; League Avg: .215 — seventh Percentile.

Giants Keys to the Game vs. the Pirates

The Giants are just 26-28 (.481) after a win as favorites since the 2023 season — 5th lowest in MLB; League Avg: .576.

The Giants are just 42-62 (.404) on the road since the 2023 season — 5th lowest in MLB; League Avg: .480.

The Giants are 31-16 (.660) after a home loss since the 2023 season — 3rd best in MLB; League Avg: .512.

The Giants are just 38-66 (.365) after a road loss since the 2022 season — 4th lowest in MLB; League Avg: .461.

Pirates Keys to the Game vs. the Giants

The Pirates are just 14-22 (.389) when tied entering the 8th inning since the 2022 season — 3rd lowest in MLB; League Avg: .500.

The Pirates are just 43-76 (.361) after a win as underdogs since the 2022 season — 5th lowest in MLB; League Avg: .414.

The Pirates are 47-8 (.855) when they’ve had 10 or more hits since the 2023 season — tied for 2nd best in MLB; League Avg: .737.

The Pirates are just 28-43 (.394) after a road win since the 2022 season — 4th lowest in MLB; League Avg: .488.

Giants hitters are slugging just .404 when facing the starting pitcher for the 3rd time in a game since the 2022 season — lowest in MLB; League Avg: .447.

The Giants are batting just .244 when facing the starting pitcher for the 3rd time in a game since the 2022 season — lowest in MLB; League Avg: .266.

The Giants are batting just .158 with two-strikes since the 2022 season — 4th lowest in MLB; League Avg: .170.

Games involving the Giants went UNDER in 66% of their games (27.1% ROI) after a home loss since the 2023 season — highest in MLB; League Avg: 49%.

Pirates hitters have an OPS of just .628 (1,282 PA’s) against RHP this season — 2nd lowest in MLB; League Avg: .699.

Pirates hitters have 164 strikeouts in 476 PA’s (34%) in lefty-lefty matchups since last season — highest in MLB; League Avg: 24%.

The Pirates are batting just .153 with two-strikes since the 2022 season — 2nd lowest in MLB; League Avg: .170.

Pirates hitters are slugging just .496 on the first pitch of at-bats since the 2022 season — lowest in MLB; League Avg: .574.

Opponents have a groundball rate of 49% against Giants pitchers since the 2022 season — highest in MLB; League Avg: 43%.

Opponents have a groundball rate of 50% against Giants pitchers since last season — highest in MLB; League Avg: 43%.

Giants pitchers have walked 23 of 420 batters (6%) when facing the leadoff batter in the inning this season — 2nd best in MLB; League Avg: 8%.

Giants pitchers have walked 110 of 1,859 batters (6%) when facing the leadoff batter in the inning since last season — best in MLB; League Avg: 8%.

Pirates pitchers are throwing just 3.75 pitches per plate appearance this season — lowest in MLB; League Avg: 3.89.

Pirates pitchers have walked 1,333 of 14,308 batters (9%) since the 2022 season — 5th highest in MLB; League Avg: 8%.

Pirates pitchers have a strikeout rate of 44% with two-strikes this season — 5th best in MLB; League Avg: 42%.

Pirates pitchers have won 38% of games in which they have allowed their opponent to score in three different innings this season — 4th highest in MLB; League Avg: 26%.

Pirates vs. Giants Injuries Tonight That May Affect Prop Bets 

  • Miguel Andujar (Pittsburgh Pirates): Knee, 10-Day IL
  • Colin Holderman (Pittsburgh Pirates): Illness, 15-Day IL
  • Johan Oviedo (Pittsburgh Pirates): Elbow, 60-Day IL
  • Dauri Moreta (Pittsburgh Pirates): Elbow, 60-Day IL
  • Carmen Mlodzinski (Pittsburgh Pirates): Elbow, 15-Day IL
  • Vince Velasquez (Pittsburgh Pirates): Elbow, Out
  • Mike Burrows (Pittsburgh Pirates): Elbow, Out
  • JT Brubaker (Pittsburgh Pirates): Elbow, 60-Day IL
  • Max Kranick (Pittsburgh Pirates): Hamstring, 15-Day IL
  • Endy Rodriguez (Pittsburgh Pirates): Elbow, 60-Day IL
  • Ji Hwan Bae (Pittsburgh Pirates): Hip, 10-Day IL
  • Alex Cobb (San Francisco Giants): Hip, 15-Day IL
  • Cole Waites (San Francisco Giants): Elbow, 60-Day IL
  • Mike Yastrzemski (San Francisco Giants): Personal, Paternity
  • Tristan Beck (San Francisco Giants): Arm, 60-Day IL
  • Wade Meckler (San Francisco Giants): Undisclosed, 7-Day IL
  • Robbie Ray (San Francisco Giants): Elbow, 60-Day IL
  • Sean Hjelle (San Francisco Giants): Elbow, 15-Day IL
  • Luke Jackson (San Francisco Giants): Back, 15-Day IL
  • Wilmer Flores (San Francisco Giants): Shoulder, Day-To-Day
  • Thomas Szapucki (San Francisco Giants): Pectoral, 60-Day IL
  • Scott Alexander (San Francisco Giants): Ribs, 15-Day IL
  • Ethan Small (San Francisco Giants): Oblique, 60-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.