Guardians vs Padres Prediction, Odds & Player Prop Bets Today – MLB, Mar 31

(AP Photo/Derrick Tuskan)
  • The Padres are -135 favorites vs the Guardians
  • Guardians vs Padres Over / Under today: 8 Runs
  • Guardians / Padres TV Channel: GDTV | PDTV

The Cleveland Guardians (+115) visit Petco Park to take on the San Diego Padres (-135) on Monday, March 31, 2025. First pitch is scheduled for 9:40pm EDT in San Diego, CA.

This season, the Guardians are 2-1 against the spread (ATS), while the Padres are 3-1 ATS.

Guardians vs Padres Starting Pitchers Today:

  • Guardians starting pitcher: Luis Ortiz 0-0, 0.00 ERA
  • Padres starting pitcher: Kyle Hart 0-0, 0.00 ERA

Guardians vs. Padres Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians+1.5 -190O 8 -105+115
Padres -1.5 +155U 8 -115-135

Guardians vs Padres Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Monday‘s MLB game with 54.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Guardians vs Padres and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Guardians players for Monday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Jose Ramirez has hit the Home Runs Over in 4 of his last 9 away games (+13.50 Units / 150% ROI)
  • Lane Thomas has hit the Hits Over in 14 of his last 15 away games (+12.30 Units / 41% ROI)
  • Steven Kwan has hit the Hits Runs and RBIs Over in his last 10 away games (+10.30 Units / 82% ROI)
  • Steven Kwan has hit the Total Bases Over in his last 8 away games (+9.85 Units / 97% ROI)
  • Jose Ramirez has hit the Singles Under in his last 8 away games (+8.00 Units / 80% ROI)

And here are some favorite MLB player prop bets for Padres players for Monday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Best Bets Today:

  • Luis Arraez has hit the Hits Under in 17 of his last 20 games (+14.60 Units / 39% ROI)
  • Fernando Tatis Jr. has hit the Total Bases Over in 18 of his last 25 games (+13.65 Units / 51% ROI)
  • Jason Heyward has hit the Home Runs Over in 3 of his last 9 games at home (+13.20 Units / 147% ROI)
  • Jake Cronenworth has hit the Singles Under in 17 of his last 20 games (+12.05 Units / 38% ROI)
  • Jake Cronenworth has hit the Hits Runs and RBIs Under in 19 of his last 25 games (+11.50 Units / 33% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 47 of their last 79 games (+17.00 Units / 19% ROI)
  • The Cleveland Guardians have hit the Moneyline in 93 of their last 166 games (+7.95 Units / 4% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games (+5.60 Units / 69% ROI)
  • The Cleveland Guardians have covered the Run Line in 23 of their last 43 games (+3.45 Units / 6% ROI)
  • The San Diego Padres have hit the Moneyline in 60 of their last 92 games (+22.10 Units / 17% ROI)
  • The San Diego Padres have hit the Game Total Over in 30 of their last 52 games at home (+7.80 Units / 14% ROI)
  • The San Diego Padres have covered the Run Line in 71 of their last 137 games (+5.90 Units / 3% ROI)
  • The San Diego Padres have hit the Team Total Under in 13 of their last 21 games at home (+3.45 Units / 13% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Team Total Under in 22 of their last 38 games at home (+3.40 Units / 7% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 3-0 against the Run Line (+3 Units / 53.57% ROI).

  • 2-1 when betting on the Moneyline for +1.45 Units / 46.03% ROI
  • 2-1 when betting on the total runs Over for +1 Units / 31.25% ROI
  • 1-2 when betting on the total runs Under for -1.2 Units / -35.29% ROI

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 3-1 against the Run Line (+2.6 Units / 51.49% ROI).

  • 4-0 when betting on the Moneyline for +4.3 Units / 92.47% ROI
  • 1-2 when betting on the total runs Over for -1.15 Units / -26.14% ROI
  • 2-1 when betting on the total runs Under for +0.75 Units / 16.85% ROI

Padres vs Guardians Home Run Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +375 0.5 -525
Jose Ramirez (CLE) 0.5 +425 0.5 -600
Jackson Merrill (SD) 0.5 +450 0.5 -650
Jhonkensy Noel (CLE) 0.5 +475 0.5 -700
Manny Machado (SD) 0.5 +500 0.5 -700

Padres vs Guardians Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -275 0.5 +200
Fernando Tatis Jr. (SD) 0.5 -250 0.5 +190
Steven Kwan (CLE) 0.5 -225 0.5 +170
Manny Machado (SD) 0.5 -220 0.5 +165
Lane Thomas (CLE) 0.5 -210 0.5 +160

Padres vs Guardians RBI Prop Bets Today

Over Under
Jackson Merrill (SD) 0.5 +125 0.5 -165
Manny Machado (SD) 0.5 +130 0.5 -175
Carlos Santana (CLE) 0.5 +160 0.5 -210
Lane Thomas (CLE) 0.5 +170 0.5 -225
Jose Ramirez (CLE) 0.5 +170 0.5 -225

Padres vs Guardians Strikeout Prop Bets Today

Over Under
Kyle Hart (SD) 3.5 -118 3.5 -110

Luis Ortiz had a strike rate of just 61% (238/391) when he’s behind in the count in 2023 — 3rd lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 69% — second Percentile.

Luis Ortiz walked 12 of 80 batters (15%) when going through the lineup the third time in a game in 2023 — 3rd highest in MLB among starting pitchers with at least 64 total IP; League Avg: 8% — second Percentile.

Luis Ortiz allowed an OBP of .428 (152 PA’s) versus the top of the order in 2023 — 2nd highest in MLB among starting pitchers with at least 64 total IP; League Avg: .328 — first Percentile.

Opponents had a Hard-Hit Rate of 58% (130/224) against Luis Ortiz on pitches in the strike zone in the 2023 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 46% — 0 Percentile.

Padres Starting Pitcher Stats & Trends

Kyle Hart has limited playing time.

Guardians Keys to the Game vs. the Padres

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians were just 3-61 (.047) when trailing entering the 8th inning in the 2024 season — 2nd lowest in MLB; League Avg: .100.

The Guardians were 33-12 (.733) when they scored in the first inning in the 2024 season — 4th best in MLB; League Avg: .641.

The Guardians were 66-9 (.880) when they scored 5 or more runs in the 2024 season — tied for 3rd best in MLB; League Avg: .804.

Padres Keys to the Game vs. the Guardians

The Padres were 19-47 (.288) when they allowed 5 or more runs in the 2024 season — best in MLB; League Avg: .196.

The Padres were 55-38 (.591) after a win in the 2024 season — best in MLB; League Avg: .497.

The Padres were 48-33 (.593) on the road in the 2024 season — 2nd best in MLB; League Avg: .478.

The Padres are 129-21 (.860) when scoring 5 or more runs since last season — 3rd best in MLB; League Avg: .792.

Guardians hitters struck out just 791 times in 4,186 PA’s (19%) against RHP in 2023 — best in MLB; League Avg: 23%.

Guardians hitters had a Hard-Hit Rate of just 34% against RHP in the 2023 season — lowest in MLB; League Avg: 40%.

Guardians hitters have a swing rate of 64% with two-strikes since the 2023 season — highest in MLB; League Avg: 60%.

The Guardians have an average Exit Velocity of 87.6 MPH since the 2023 season — lowest in MLB; League Avg: 88.9.

Padres hitters have just 291 strikeouts in 1,666 PA’s (17%) against LHP since last season — best in MLB; League Avg: 23%.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

The Padres batted .275 on the road in the 2024 season — best in MLB; League Avg: .242.

Padres hitters have just 814 strikeouts in 4,575 PA’s (18%) against RHP since last season — best in MLB; League Avg: 23%.

Opponents have a groundball rate of just 32% against Guardians pitchers this season — 2nd lowest in MLB; League Avg: 45%.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a groundball batting average of just .209 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Opponents had a groundball rate of just 32% against Guardians pitchers over the last 14 days of the regular season (3 games) — 2nd lowest in MLB; League Avg: 45%.

The Padres pitchers allowed an average Exit Velocity of just 87.9 MPH in the 2023 season (3,922 balls in play) — best in MLB; League Avg: 89.0

Opponents had a groundball rate of 45% against Padres pitchers in 2023 — 3rd highest in MLB; League Avg: 43%.

Padres pitchers allowed an average Exit Velocity of 87.9 MPH (3,922 batted balls) in the 2023 season — best in MLB; League Avg: 89.0.

Padres pitchers had an ERA of 3.73 (1441.0 IP) in 2023 — tied for best in MLB; League Avg: 4.33.

More MLB Reading:


Bet now on Guardians vs Padres and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

Split First Bet Offer FBO March Matchups 1080x610
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.