Guardians vs Tigers Prediction, Odds & Player Prop Bets Today – MLB, May 22

(AP Photo/Jeff Chiu)
  • The Tigers are -140 favorites vs the Guardians
  • Guardians vs Tigers Over / Under today: 8 Runs
  • Guardians / Tigers TV Channel: GDTV | FDDT | MLBN

The Cleveland Guardians (+110) visit Comerica Park to take on the Detroit Tigers (-130) on Thursday, May 22, 2025. First pitch is scheduled for 6:40pm EDT in Detroit, MI.

This season, the Guardians are 26-22 against the spread (ATS), while the Tigers are 28-22 ATS.

Guardians vs Tigers Starting Pitchers Today:

  • Guardians starting pitcher: Tanner Bibee 3-4, 4.12 ERA
  • Tigers starting pitcher: Jack Flaherty 2-5, 4.44 ERA

Guardians vs. Tigers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians+1.5 -200O 8 -115+110
Tigers -1.5 +165U 8 -105-130

Guardians vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Tigers will win Thursday‘s MLB game with 54.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Thursday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Daniel Schneemann has hit the Home Runs Over in 2 of his last 8 away games (+7.40 Units / 93% ROI)
  • Tanner Bibee has hit the Strikeouts Under in 8 of his last 9 games (+7.05 Units / 58% ROI)
  • Tanner Bibee has hit the Earned Runs Under in 16 of his last 25 games (+6.15 Units / 19% ROI)
  • Daniel Schneemann has hit the Hits Over in his last 6 games (+6.00 Units / 60% ROI)
  • Tanner Bibee has hit the Hits Allowed Over in 13 of his last 20 games (+6.00 Units / 25% ROI)

And here are some favorite MLB player prop bets for Tigers players for Thursday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

  • Zach McKinstry has hit the Total Bases Over in 17 of his last 20 games at home (+12.75 Units / 41% ROI)
  • Riley Greene has hit the Home Runs Over in 3 of his last 8 games at home (+12.70 Units / 159% ROI)
  • Zach McKinstry has hit the Hits Runs and RBIs Over in 16 of his last 20 games at home (+12.40 Units / 50% ROI)
  • Zach McKinstry has hit the Hits Over in 17 of his last 20 games at home (+12.05 Units / 36% ROI)
  • Zach McKinstry has hit the Singles Over in 13 of his last 20 games at home (+7.50 Units / 36% ROI)
  • The Cleveland Guardians have hit the Moneyline in 23 of their last 39 games (+7.30 Units / 16% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 8 of their last 11 games (+5.80 Units / 47% ROI)
  • The Cleveland Guardians have hit the Team Total Over in 7 of their last 10 away games (+3.45 Units / 30% ROI)
  • The Cleveland Guardians have covered the Run Line in 8 of their last 14 away games (+1.55 Units / 8% ROI)
  • The Detroit Tigers have hit the Moneyline in 33 of their last 47 games (+16.90 Units / 25% ROI)
  • The Detroit Tigers have hit the Team Total Over in 34 of their last 50 games (+16.00 Units / 27% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 50 games (+14.38 Units / 25% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Moneyline in 29 of their last 49 games (+10.80 Units / 15% ROI)
  • The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 31 of their last 49 games (+9.55 Units / 16% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 24-24 against the Run Line (-4.1 Units / -6.05% ROI).

  • 26-22 when betting on the Moneyline for +4.15 Units / 7.48% ROI
  • 22-23 when betting on the total runs Over for -2.65 Units / -5.08% ROI
  • 23-22 when betting on the total runs Under for -1.1 Units / -2.06% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 28-22 against the Run Line (+3.4 Units / 5.25% ROI).

  • 33-17 when betting on the Moneyline for +13.9 Units / 19.48% ROI
  • 25-21 when betting on the total runs Over for +2.2 Units / 4.02% ROI
  • 21-25 when betting on the total runs Under for -6.45 Units / -11.61% ROI

Tigers vs Guardians Home Run Prop Bets Today

Over Under
Kerry Carpenter (DET) 0.5 +375 0.5 -525
Riley Greene (DET) 0.5 +525 0.5 -750
Jose Ramirez (CLE) 0.5 +550 0.5 -800
Kyle Manzardo (CLE) 0.5 +575 0.5 -900
Spencer Torkelson (DET) 0.5 +575 0.5 -800

Tigers vs Guardians Total Hits Prop Bets Today

Over Under
Gleyber Torres (DET) 0.5 -250 0.5 +185
Steven Kwan (CLE) 0.5 -235 0.5 +175
Kerry Carpenter (DET) 0.5 -225 0.5 +170
Riley Greene (DET) 0.5 -210 0.5 +155
Jose Ramirez (CLE) 0.5 -210 0.5 +155

Tigers vs Guardians RBI Prop Bets Today

Over Under
Riley Greene (DET) 0.5 +165 0.5 -220
Jose Ramirez (CLE) 0.5 +190 0.5 -250
Spencer Torkelson (DET) 0.5 +195 0.5 -275
Kyle Manzardo (CLE) 0.5 +200 0.5 -275
Kerry Carpenter (DET) 0.5 +210 0.5 -295

Tigers vs Guardians Strikeout Prop Bets Today

Over Under
Tanner Bibee (CLE) 5.5 +120 5.5 -155
Jack Flaherty (DET) 5.5 +120 5.5 -155

Opponents are hitting just .087 (2-for-23) against Tanner Bibee on low fastballs this season — 3rd best among qualified SPs in MLB; League Avg: .264 — 97th Percentile.

Tanner Bibee has a strikeout rate of just 30% (35 SO in 117 PAs) with two-strikes this season — tied for 3rd lowest among qualified SPs in MLB; League Avg: 42% — fourth Percentile.

Tanner Bibee has allowed an OPS of 1.130 (77 PA’s) versus the 2-3-4 hitters this season — 2nd highest among qualified SPs in MLB; League Avg: .722 — second Percentile.

Tanner Bibee has picked-off 5 runners since last season — most among among AL Starters — 100th Percentile.

Tigers Starting Pitcher Stats & Trends

Jack Flaherty allowed an OBP of .453 (236 PA’s) versus the 2-3-4 hitters in 2023 — highest in MLB among starting pitchers with at least 64 total IP; League Avg: .325 — first Percentile.

Opponents had a miss rate of 32% (393/1,223) against Jack Flaherty in the 2024 season — 2nd best among qualified SPs in MLB; League Avg: 26% — 98th Percentile.

Jack Flaherty walked 9 of 252 batters (4%) when going through the lineup the first time in a game in the 2024 season — tied for 3rd best among qualified SPs in MLB; League Avg: 7% — 96th Percentile.

Jack Flaherty had a strikeout rate of 31% (78/252) when going through the lineup the first time in a game in the 2024 season — tied for 6th best among qualified SPs in MLB; League Avg: 25% — 91st Percentile.

Guardians Keys to the Game vs. the Tigers

The Guardians are 93-3 (.969) when leading entering the 7th inning since last season — best in MLB; League Avg: .860.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians are 22-0 (1.000) when leading entering the 8th inning this season — tied for best in MLB; League Avg: .906.

The Guardians are 13-2 (.867) vs bottom 10 scoring offenses this season They play the Tigers (19th best runs scored) today.

Tigers Keys to the Game vs. the Guardians

The Tigers were 18-54 (.250) when trailing entering the 7th inning in the 2024 season — best in MLB; League Avg: .143.

The Tigers were 13-55 (.191) when trailing entering the 8th inning in the 2024 season — best in MLB; League Avg: .100.

The Tigers are 28-5 (.848) when allowing 4 or fewer runs this season — best in MLB; League Avg: .708.

The Tigers are 26-2 (.929) when scoring 5 or more runs this season — 4th best in MLB; League Avg: .821.

Guardians hitters have put 41% of balls in play to the right side of the field since the 2023 season — highest in MLB; League Avg: 37%.

Guardians hitters have put just 34% of balls in play to the left side of the field since the 2023 season — lowest in MLB; League Avg: 38%.

Guardians hitters have a swing rate of 63% with two-strikes since last season — 2nd highest in MLB; League Avg: 60%.

Guardians hitters struck out just 1,142 times in 6,096 PA’s (19%) in the 2023 season — best in MLB; League Avg: 23%.

Tigers hitters had an OPS of just .659 (1,395 PA’s) against LHP in the 2024 season — 5th lowest in MLB; League Avg: .711.

Tigers hitters had an OBP of just .263 (1,445 PA’s) when leading off an inning in the 2024 season — lowest in MLB; League Avg: .305.

Tigers hitters had an OPS of just .679 (4,707 PA’s) against RHP in the 2023 season — 3rd lowest in MLB; League Avg: .732.

Tigers hitters have an OBP of just .286 (3,335 PA’s) when leading off an inning since the 2023 season — tied for lowest in MLB; League Avg: .311.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a groundball rate of just 39% against Guardians pitchers this season — 3rd lowest in MLB; League Avg: 43%.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

Opponents have a groundball batting average of just .222 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Tigers pitchers have walked 7% of batters since last season — 3rd best in MLB; League Avg: 8%.

Opponents have a groundball rate of 46% against Tigers pitchers this season — 5th highest in MLB; League Avg: 43%.

The Tigers have won 40% of road games in which their opponents scored first since last season — highest in MLB; League Avg: 26%.

Tigers pitchers walked 416 of 5,969 batters (7%) in the 2024 season — 2nd best in MLB; League Avg: 8%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.