Guardians vs Tigers Prediction, Odds & Player Prop Bets Today – MLB, May 23

(AP Photo/Carlos Osorio)
  • The Guardians are +100 favorites vs the Tigers
  • Guardians vs Tigers Over / Under today: 8.5 Runs
  • Guardians / Tigers TV Channel: GDTV | FDDT

The Cleveland Guardians (+100) visit Comerica Park to take on the Detroit Tigers (-120) on Friday, May 23, 2025. First pitch is scheduled for 7:10pm EDT in Detroit, MI, MI.

This season, the Guardians are 27-22 against the spread (ATS), while the Tigers are 28-23 ATS.

Guardians vs Tigers Starting Pitchers Today:

  • Guardians starting pitcher: Slade Cecconi 0-1, 5.41 ERA
  • Tigers starting pitcher: Jackson Jobe 4-0, 4.12 ERA

Guardians vs. Tigers Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Guardians-1.5 +165O 8.5 -105+100
Tigers +1.5 -200U 8.5 -115-120

Guardians vs Tigers Prediction for Today’s Game

Based on recent trends the model predicts the Tigers will win Friday‘s MLB game with 54.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Guardians players for Friday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Bets Today:

  • Daniel Schneemann has hit the Home Runs Over in 2 of his last 9 away games (+6.40 Units / 71% ROI)
  • Daniel Schneemann has hit the Hits Over in 6 of his last 7 games (+4.70 Units / 42% ROI)
  • Angel Martinez has hit the Runs Over in 5 of his last 9 away games (+4.40 Units / 49% ROI)
  • Daniel Schneemann has hit the Singles Over in 5 of his last 7 games (+4.35 Units / 62% ROI)
  • Lane Thomas has hit the Walks Under in his last 4 games (+4.00 Units / 47% ROI)

And here are some favorite MLB player prop bets for Tigers players for Friday‘s game, looking at profitable historical betting trends:

Best Tigers Player Prop Best Bets Today:

  • Zach McKinstry has hit the Hits Runs and RBIs Over in 16 of his last 20 games at home (+12.40 Units / 50% ROI)
  • Zach McKinstry has hit the Total Bases Over in 17 of his last 20 games at home (+12.40 Units / 39% ROI)
  • Riley Greene has hit the Home Runs Over in 3 of his last 9 games at home (+11.70 Units / 130% ROI)
  • Zach McKinstry has hit the Hits Over in 17 of his last 20 games at home (+11.65 Units / 34% ROI)
  • Zach McKinstry has hit the Singles Over in 13 of his last 20 games at home (+7.50 Units / 36% ROI)
  • The Cleveland Guardians have hit the Moneyline in 24 of their last 40 games (+8.40 Units / 18% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 9 of their last 12 games (+6.80 Units / 50% ROI)
  • The Cleveland Guardians have hit the Team Total Over in 8 of their last 11 away games (+4.45 Units / 35% ROI)
  • The Cleveland Guardians have covered the Run Line in 9 of their last 15 away games (+2.55 Units / 12% ROI)
  • The Detroit Tigers have hit the Moneyline in 33 of their last 48 games (+15.60 Units / 22% ROI)
  • The Detroit Tigers have hit the Team Total Over in 34 of their last 51 games (+14.55 Units / 24% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Team Total Over in 32 of their last 51 games (+12.88 Units / 22% ROI)
  • The Detroit Tigers have hit the 1st Five Innings (F5) Moneyline in 29 of their last 50 games (+9.50 Units / 13% ROI)
  • The Detroit Tigers have covered the 1st Five Innings (F5) Run Line in 31 of their last 50 games (+8.55 Units / 14% ROI)

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 25-24 against the Run Line (-3.1 Units / -4.44% ROI).

  • 27-22 when betting on the Moneyline for +5.25 Units / 9.3% ROI
  • 22-24 when betting on the total runs Over for -3.75 Units / -7.04% ROI
  • 24-22 when betting on the total runs Under for -0.1 Units / -0.18% ROI

Tigers Against the Spread (ATS) Record

Against the spread this season, the Tigers are 28-23 against the Run Line (+2.4 Units / 3.65% ROI).

  • 33-18 when betting on the Moneyline for +12.6 Units / 17.34% ROI
  • 25-22 when betting on the total runs Over for +1.1 Units / 1.97% ROI
  • 22-25 when betting on the total runs Under for -5.45 Units / -9.62% ROI

Tigers vs Guardians Home Run Prop Bets Today

Over Under
Kerry Carpenter (DET) 0.5 +375 0.5 -500
Riley Greene (DET) 0.5 +425 0.5 -600
Jose Ramirez (CLE) 0.5 +475 0.5 -650
Kyle Manzardo (CLE) 0.5 +500 0.5 -700
Spencer Torkelson (DET) 0.5 +500 0.5 -700

Tigers vs Guardians Total Hits Prop Bets Today

Over Under
Steven Kwan (CLE) 0.5 -250 0.5 +185
Kerry Carpenter (DET) 0.5 -235 0.5 +180
Riley Greene (DET) 0.5 -225 0.5 +170
Lane Thomas (CLE) 0.5 -210 0.5 +160
Jose Ramirez (CLE) 0.5 -210 0.5 +155

Tigers vs Guardians RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +145 0.5 -190
Riley Greene (DET) 0.5 +155 0.5 -210
Kyle Manzardo (CLE) 0.5 +165 0.5 -220
Kerry Carpenter (DET) 0.5 +175 0.5 -235
Lane Thomas (CLE) 0.5 +195 0.5 -250

Tigers vs Guardians Strikeout Prop Bets Today

Over Under
Slade Cecconi (ARI) 4.5 -120 4.5 -110
Jackson Jobe (DET) 4.5 +120 4.5 -155

Slade Cecconi has not allowed a hit in the first inning in any of his last six games dating back to June 18th, 2024 — Andrew Abbott has the longest active streak at 9.

Slade Cecconi had an ERA of 6.66 (77.0 IP)in the 2024 season — 3rd highest in MLB among starting pitchers with at least 64 total IP; League Avg: 3.97 — first Percentile.

Slade Cecconi induced opposing hitters to ground into just 1 double play in 51 opportunities (2%) in the 2024 season — lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 10% — 0 Percentile.

Opponents had a groundball batting average of .345 (29 GB hits out of 84 GBs) against Slade Cecconi in the 2024 season — 3rd highest in MLB among starting pitchers with at least 64 total IP; League Avg: .245 — first Percentile.

Tigers Starting Pitcher Stats & Trends

Jackson Jobe has a strike rate of just 54% (128/236) in two strike counts this season — lowest in MLB among starting pitchers with at least 19 total IP; League Avg: 64% — 0 Percentile.

Jackson Jobe has walked 17% of batters when going through the lineup the second time in a game this season — highest in MLB among starting pitchers with at least 19 total IP; League Avg: 7% — 0 Percentile.

Jackson Jobe has walked 19% of right-handed batters in his last two starts — highest in MLB over the last two weeks; League Avg: 6% — first Percentile.

Jackson Jobe has a in-zone of just 29% (80/272) when ahead in the count this season — 2nd lowest in MLB among starting pitchers with at least 19 total IP; League Avg: 42% — first Percentile.

Guardians Keys to the Game vs. the Tigers

The Guardians are 94-3 (.969) when leading entering the 7th inning since last season — best in MLB; League Avg: .860.

The Guardians are 18-8 (.692) when tied entering the 7th inning since last season — 3rd best in MLB; League Avg: .499.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

The Guardians are 105-0 (1.000) when leading entering the 9th inning since last season — best in MLB; League Avg: .951.

Tigers Keys to the Game vs. the Guardians

The Tigers were 13-55 (.191) when trailing entering the 8th inning in the 2024 season — best in MLB; League Avg: .100.

The Tigers are 59-6 (.908) when they’ve had 10 or more hits since last season — best in MLB; League Avg: .748.

The Tigers were 36-5 (.878) when they hit 2 or more home runs in the 2024 season — best in MLB; League Avg: .711.

The Tigers are 17-6 (.739) at home this season — 2nd best in MLB; League Avg: .561.

The Guardians are batting just .293 in hitter’s counts since last season — lowest in MLB; League Avg: .335.

Guardians hitters had an OPS of just .662 (1,910 PA’s) against LHP in the 2023 season — lowest in MLB; League Avg: .742.

Guardians hitters slugged just .367 against LHP in the 2023 season — lowest in MLB; League Avg: .419.

Guardians hitters struck out just 351 times in 1,910 PA’s (18%) against LHP in 2023 — 3rd best in MLB; League Avg: 23%.

Tigers hitters slugged just .362 against LHP in the 2024 season — 5th lowest in MLB; League Avg: .397.

Tigers hitters had an OBP of just .300 (741 PA’s) when facing the starting pitcher for the 3rd time in a game in 2023 — lowest in MLB; League Avg: .330.

Tigers hitters slugged just .171 on pitches out of the zone in 2023 — 3rd lowest in MLB; League Avg: .211.

The Tigers are batting just .148 with two-strikes this season — tied for 3rd lowest in MLB; League Avg: .170.

Opponents have a groundball batting average of just .223 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Tigers pitchers walked 416 of 5,969 batters (7%) in the 2024 season — 2nd best in MLB; League Avg: 8%.

Opponents have a miss rate of 27% against Tigers pitchers since last season — tied for 5th best in MLB; League Avg: 25%.

Tigers pitchers had an ERA of 2.93 (464.0 IP) against division opponents in 2023 — best in MLB; League Avg: 4.32.

The Tigers have won 40% of road games in which their opponents scored first since last season — highest in MLB; League Avg: 26%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.