Houston Astros vs Los Angeles Angels Prediction, Odds & Player Prop Bets Today – MLB, Jun 22

  • The Houston Astros are -120 favorites vs the Los Angeles Angels
  • Houston Astros vs Los Angeles Angels Over / Under today: 9 Runs
  • Houston Astros / Los Angeles Angels TV Channel: FDW | SCHN | KCOP

The Houston Astros (-120) visit Angel Stadium of Anaheim to take on the Los Angeles Angels (+100) on Sunday, June 22, 2025. First pitch is scheduled for 4:07pm EDT in Anaheim, CA.

This season, the Houston Astros are 44-33 against the spread (ATS), while the Los Angeles Angels are 39-37 ATS.

Houston Astros vs Los Angeles Angels Starting Pitchers Today:

  • Houston Astros starting pitcher: , ERA
  • Los Angeles Angels starting pitcher: , ERA

Houston Astros vs. Los Angeles Angels Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Houston Astros-1.5 +135O 9 -105-120
Los Angeles Angels +1.5 -165U 9 -115+100

Houston Astros vs Los Angeles Angels Prediction for Today’s Game

Based on recent trends the model predicts the will win Sunday‘s MLB game with confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Houston Astros players for Sunday‘s game, looking at profitable historical betting trends:

Best Houston Astros Player Prop Bets Today:

  • Mauricio Dubon has hit the Home Runs Over in 3 of his last 10 away games (+25.00 Units / 250% ROI)
  • Jake Meyers has hit the Hits Over in 23 of his last 25 away games (+19.25 Units / 39% ROI)
  • Jake Meyers has hit the Singles Over in 20 of his last 25 away games (+14.75 Units / 51% ROI)
  • Jose Altuve has hit the Total Bases Under in 15 of his last 20 away games (+8.85 Units / 28% ROI)
  • Jeremy Pena has hit the Runs Over in 14 of his last 20 games (+8.15 Units / 37% ROI)

And here are some favorite MLB player prop bets for Los Angeles Angels players for Sunday‘s game, looking at profitable historical betting trends:

Best Los Angeles Angels Player Prop Best Bets Today:

  • Luis Rengifo has hit the Home Runs Over in 2 of his last 7 games (+16.50 Units / 236% ROI)
  • Mike Trout has hit the Singles Over in 17 of his last 25 games (+12.70 Units / 50% ROI)
  • Jo Adell has hit the Runs Over in 13 of his last 20 games (+11.35 Units / 57% ROI)
  • Mike Trout has hit the RBIs Under in 13 of his last 15 games at home (+9.15 Units / 33% ROI)
  • Taylor Ward has hit the Hits Under in 13 of his last 25 games at home (+7.50 Units / 30% ROI)
  • The Houston Astros have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 34 away games (+16.40 Units / 41% ROI)
  • The Houston Astros have hit the Team Total Under in 47 of their last 77 games (+14.00 Units / 15% ROI)
  • The Houston Astros have hit the Moneyline in 27 of their last 42 games (+10.30 Units / 18% ROI)
  • The Houston Astros have hit the Game Total Under in 27 of their last 44 games (+9.75 Units / 20% ROI)
  • The Houston Astros have covered the Run Line in 38 of their last 69 games (+8.87 Units / 10% ROI)
  • The Los Angeles Angels have hit the Moneyline in 25 of their last 45 games (+14.05 Units / 29% ROI)
  • The Los Angeles Angels have covered the Run Line in 23 of their last 34 games (+11.70 Units / 27% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Team Total Over in 13 of their last 18 games (+8.15 Units / 37% ROI)
  • The Los Angeles Angels have hit the 1st Five Innings (F5) Moneyline in 22 of their last 47 games (+7.30 Units / 14% ROI)
  • The Los Angeles Angels have hit the Game Total Under in 15 of their last 26 games (+5.05 Units / 18% ROI)

Houston Astros Against the Spread (ATS) Record

Against the spread this season, the Houston Astros are 40-37 against the Run Line (+4.22 Units / 4.37% ROI).

  • 44-33 when betting on the Moneyline for +4.3 Units / 4.24% ROI
  • 31-43 when betting on the total runs Over for -15.95 Units / -18.91% ROI
  • 43-31 when betting on the total runs Under for +9 Units / 10.57% ROI

Los Angeles Angels Against the Spread (ATS) Record

Against the spread this season, the Los Angeles Angels are 39-37 against the Run Line (-6.75 Units / -6.65% ROI).

  • 37-39 when betting on the Moneyline for +6.9 Units / 8.24% ROI
  • 38-35 when betting on the total runs Over for -0.58 Units / -0.69% ROI
  • 35-38 when betting on the total runs Under for -6.62 Units / -7.94% ROI

Los Angeles Angels vs Houston Astros Home Run Prop Bets Today

Over Under
Mike Trout (LAA) 0.5 +230 0.5 -295
Christian Walker (HOU) 0.5 +280 0.5 -350
Zach Neto (LAA) 0.5 +320 0.5 -400
Logan O'Hoppe (LAA) 0.5 +325 0.5 -450
Jo Adell (LAA) 0.5 +340 0.5 -450

Los Angeles Angels vs Houston Astros Total Hits Prop Bets Today

Over Under
Zach Neto (LAA) 0.5 -250 0.5 +190
Isaac Paredes (HOU) 0.5 -250 0.5 +190
Christian Walker (HOU) 0.5 -250 0.5 +185
Mike Trout (LAA) 0.5 -235 0.5 +175
Jake Meyers (HOU) 0.5 -225 0.5 +170

Los Angeles Angels vs Houston Astros RBI Prop Bets Today

Over Under
Mike Trout (LAA) 0.5 +115 0.5 -150
Yainer Diaz (HOU) 0.5 +130 0.5 -165
Isaac Paredes (HOU) 0.5 +135 0.5 -185
Christian Walker (HOU) 0.5 +140 0.5 -185
Logan O'Hoppe (LAA) 0.5 +155 0.5 -210

Los Angeles Angels vs Houston Astros Strikeout Prop Bets Today

Over Under
Ryan Gusto (HOU) 5.5 +115 5.5 -150
Kyle Hendricks (LAA) 3.5 +120 3.5 -160

starting pitcher – away

Los Angeles Angels Starting Pitcher Stats & Trends

starting pitcher – home

Houston Astros Keys to the Game vs. the Los Angeles Angels

keys to the game – away

Los Angeles Angels Keys to the Game vs. the Houston Astros

keys to the game – home

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.