Mariners vs Red Sox Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

Boston Red Sox's Jarren Duran plays against the Toronto Blue Jays during the first inning of a baseball game, Saturday, Aug. 5, 2023, in Boston.
(AP Photo/Michael Dwyer)
  • The Red Sox are -130 favorites vs the Mariners
  • Mariners vs Red Sox Over / Under today: 9 Runs
  • Mariners / Red Sox TV Channel: RTNW | NESN

The Seattle Mariners (+110) visit Fenway Park to take on the Boston Red Sox (-130) on Tuesday, April 22, 2025. First pitch is scheduled for 6:45pm EDT in Boston, MA, MA.

This season, the Mariners are 12-10 against the spread (ATS), while the Red Sox are 12-12 ATS.

Mariners vs Red Sox Starting Pitchers Today:

  • Mariners starting pitcher: Bryce Miller 1-2, 3.54 ERA
  • Red Sox starting pitcher: Brayan Bello 0-0, 0.00 ERA

Mariners vs. Red Sox Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Mariners+1.5 -200O 9 -115+110
Red Sox -1.5 +165U 9 -105-130

Mariners vs Red Sox Prediction for Today’s Game

Based on recent trends the model predicts the Red Sox will win Tuesday‘s MLB game with 54.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


Bet now on Mariners vs Red Sox and all games with BetMGM


We’ve highlighted some favorite MLB player prop bets for Mariners players for Tuesday‘s game, looking at profitable historical betting trends:

Best Mariners Player Prop Bets Today:

  • Cal Raleigh has hit the Home Runs Over in 6 of his last 9 games (+18.35 Units / 204% ROI)
  • Cal Raleigh has hit the Hits Over in 18 of his last 20 away games (+14.75 Units / 40% ROI)
  • Dylan Moore has hit the Runs Over in 12 of his last 15 away games (+14.45 Units / 93% ROI)
  • Cal Raleigh has hit the Singles Over in 13 of his last 20 away games (+11.60 Units / 58% ROI)
  • Bryce Miller has hit the Earned Runs Under in 18 of his last 25 games (+10.25 Units / 33% ROI)

And here are some favorite MLB player prop bets for Red Sox players for Tuesday‘s game, looking at profitable historical betting trends:

Best Red Sox Player Prop Best Bets Today:

  • Rob Refsnyder has hit the Home Runs Over in 2 of his last 5 games at home (+10.50 Units / 210% ROI)
  • Trevor Story has hit the Singles Over in 15 of his last 20 games (+10.30 Units / 48% ROI)
  • Triston Casas has hit the Runs Under in his last 10 games (+10.00 Units / 50% ROI)
  • Trevor Story has hit the Hits Over in 13 of his last 15 games (+9.00 Units / 29% ROI)
  • Alex Bregman has hit the Total Bases Under in his last 8 games at home (+8.00 Units / 69% ROI)
  • The Seattle Mariners have covered the Run Line in 8 of their last 10 games (+8.15 Units / 65% ROI)
  • The Seattle Mariners have hit the 1st Five Innings (F5) Team Total Over in 12 of their last 16 games (+7.35 Units / 35% ROI)
  • The Seattle Mariners have hit the Moneyline in 8 of their last 10 games (+6.30 Units / 55% ROI)
  • The Seattle Mariners have hit the Team Total Over in 11 of their last 16 games (+5.80 Units / 31% ROI)
  • The Seattle Mariners have hit the 1st Five Innings (F5) Moneyline in 6 of their last 9 games (+4.05 Units / 36% ROI)
  • The Boston Red Sox have hit the Team Total Under in 12 of their last 14 games (+9.20 Units / 50% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 12 of their last 19 games (+8.35 Units / 27% ROI)
  • The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in their last 6 games (+6.00 Units / 74% ROI)
  • The Boston Red Sox have hit the 1st Five Innings (F5) Team Total Under in 10 of their last 14 games (+6.00 Units / 32% ROI)
  • The Boston Red Sox have hit the Game Total Under in 14 of their last 24 games (+4.25 Units / 16% ROI)

Mariners Against the Spread (ATS) Record

Against the spread this season, the Mariners are 12-10 against the Run Line (+3.45 Units / 12.32% ROI).

  • 12-10 when betting on the Moneyline for -0.05 Units / -0.18% ROI
  • 10-10 when betting on the total runs Over for -1.15 Units / -4.73% ROI
  • 10-10 when betting on the total runs Under for -1 Units / -4.14% ROI

Red Sox Against the Spread (ATS) Record

Against the spread this season, the Red Sox are 12-12 against the Run Line (-0.7 Units / -2.22% ROI).

  • 13-11 when betting on the Moneyline for -2.7 Units / -7.2% ROI
  • 9-14 when betting on the total runs Over for -6.15 Units / -23.38% ROI
  • 14-9 when betting on the total runs Under for +4.25 Units / 16.04% ROI

Red Sox vs Mariners Home Run Prop Bets Today

Over Under
Rafael Devers (BOS) 0.5 +300 0.5 -375
Wilyer Abreu (BOS) 0.5 +310 0.5 -400
Cal Raleigh (SEA) 0.5 +360 0.5 -500
Jarren Duran (BOS) 0.5 +450 0.5 -625
Alex Bregman (BOS) 0.5 +475 0.5 -650

Red Sox vs Mariners Total Hits Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 -250 0.5 +190
Randy Arozarena (SEA) 0.5 -210 0.5 +160
Trevor Story (BOS) 0.5 -210 0.5 +155
Ben Williamson (SEA) 0.5 -210 0.5 +155
Cal Raleigh (SEA) 0.5 -210 0.5 +160

Red Sox vs Mariners RBI Prop Bets Today

Over Under
Alex Bregman (BOS) 0.5 +130 0.5 -165
Cal Raleigh (SEA) 0.5 +130 0.5 -175
Rafael Devers (BOS) 0.5 +135 0.5 -175
Wilyer Abreu (BOS) 0.5 +140 0.5 -190
Randy Arozarena (SEA) 0.5 +155 0.5 -210

Red Sox vs Mariners Strikeout Prop Bets Today

Over Under
Brayan Bello (BOS) 4.5 -120 4.5 -105
Bryce Miller (SEA) 5.5 +100 5.5 -130

Bryce Miller has walked 22% of left-handed batters this season — 2nd highest in MLB among starting pitchers with at least 8 total IP; League Avg: 9% — first Percentile.

Opponents are hitting just .204 (149-for-730) against Bryce Miller since last season — 4th best among qualified SPs in MLB; League Avg: .236 — 94th Percentile.

Bryce Miller has allowed an OPS of just .538 (373 PA’s) against right-handed batters since last season — 4th best among qualified SPs in MLB; League Avg: .658 — 94th Percentile.

Bryce Miller allowed an OBP of just .233 (279 PA’s) when going through the lineup the second time in a game in the 2024 season — best among qualified SPs in MLB; League Avg: .289 — 100th Percentile.

Red Sox Starting Pitcher Stats & Trends

Opponents had a groundball rate of 55% (97/175) against Brayan Bello in two-strike counts in the 2024 season — 4th highest among qualified SPs in MLB; League Avg: 45% — 94th Percentile.

Brayan Bello allowed an OBP of .352 (270 PA’s) when going through the lineup the first time in a game in the 2024 season — 4th highest among qualified SPs in MLB; League Avg: .290 — sixth Percentile.

Brayan Bello had a strike rate of just 61% (480/788) in two strike counts in the 2024 season — 5th lowest among qualified SPs in MLB; League Avg: 65% — eighth Percentile.

Opponents had a groundball rate of 63% (109/173) against Brayan Bello in two-strike counts in 2023 — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 45% — 100th Percentile.

Mariners Keys to the Game vs. the Red Sox

The Mariners are 2-8 (.200) when trailing entering the 9th inning this season — best in MLB; League Avg: .033.

The Mariners were 58-5 (.921) when they scored 5 or more runs in the 2024 season — best in MLB; League Avg: .804.

The Mariners were 33-7 (.825) when they had 10 or more hits in the 2024 season — tied for 5th best in MLB; League Avg: .750.

The Mariners are 47-6 (.887) when they’ve had 5 or more XBH since the 2023 season — 4th best in MLB; League Avg: .800.

Red Sox Keys to the Game vs. the Mariners

The Red Sox are just 5-66 (.070) when trailing entering the 7th inning since last season — 2nd lowest in MLB; League Avg: .140.

The Red Sox are just 0-8 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .116.

The Red Sox were just 18-69 (.207) when they scored 4 or fewer runs in the 2024 season — 4th lowest in MLB; League Avg: .276.

The Red Sox are 54-11 (.831) when they’ve had 10 or more hits since last season — 4th best in MLB; League Avg: .749.

The Mariners batted just .207 when facing the starting pitcher for the 3rd time in a game in the 2024 season — lowest in MLB; League Avg: .263.

The Mariners are batting just .213 against LHP since last season — lowest in MLB; League Avg: .244.

The Mariners are batting just .149 with two-strikes since the 2023 season — lowest in MLB; League Avg: .170.

The Mariners are batting just .187 at home this season — lowest in MLB; League Avg: .250.

Red Sox hitters struck out 506 times in 1,816 PA’s (28%) against LHP in the 2024 season — highest in MLB; League Avg: 23%.

Red Sox hitters have struck out in 28% of it’s PA’s against LHP since last season — 2nd highest in MLB; League Avg: 23%.

The Red Sox batted .300 when facing the starting pitcher for the 3rd time in a game in 2023 — 2nd best in MLB; League Avg: .267.

Red Sox hitters are averaging 4.31 pitches per plate appearance against LHP this season — highest in MLB; League Avg: 3.92.

Mariners pitchers walked 76 of 1,441 batters (5%) when facing the leadoff batter in the inning in the 2024 season — best in MLB; League Avg: 7%.

Mariners pitchers have walked 5% of batters when facing the leadoff batter in the inning since last season — best in MLB; League Avg: 8%.

Mariners pitchers have allowed an OBP of just .256 (1,643 PA’s) when facing the leadoff batter in the inning since last season — best in MLB; League Avg: .306.

Mariners pitchers walked 369 of 5,801 batters (6%) in the 2024 season — best in MLB; League Avg: 8%.

Opponents had a miss rate of just 24% against Red Sox pitchers in the 2024 season — tied for 2nd lowest in MLB; League Avg: 25%.

Red Sox pitchers have walked 8% of batters this season — tied for 4th best in MLB; League Avg: 9%.

Opponents have a miss rate of just 24% against Red Sox pitchers since last season — tied for 2nd lowest in MLB; League Avg: 25%.

Red Sox pitchers walked 98 of 1,456 batters (7%) when facing the leadoff batter in the inning in the 2024 season — tied for 5th best in MLB; League Avg: 7%.

More MLB Reading:


Bet now on Mariners vs Red Sox and all games with BetMGM


Bet on MLB Odds at BetMGM

Sportsbook promos are always available at BetMGM. For new customers, check out the sportsbook welcome offer and BetMGM Refer a Friend. For existing customers, there are Odds Boosts, Parlay Boosts, contests and more.

Split First Bet Offer FBO March Matchups 1080x610
About the Author

BetMGM Betting

Read More @BETMGM

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.