Padres vs Astros Prediction, Odds & Player Prop Bets Today – MLB, Apr 19

Houston Astros' Jose Altuve bats during the first inning of a spring training baseball game against the St. Louis Cardinals, Monday, March 6, 2023, in Jupiter, Fla. (AP Photo/Lynne Sladky)
(AP Photo/Lynne Sladky)
  • The Padres are -120 favorites vs the Astros
  • Padres vs Astros Over / Under today: 8 Runs
  • Padres / Astros TV Channel: FS1 | SCHN | PDTV

The San Diego Padres (-120) visit Minute Maid Park to take on the Houston Astros (+100) on Saturday, April 19, 2025. First pitch is scheduled for 7:10pm EDT in Houston, TX, TX.

This season, the Padres are 15-5 against the spread (ATS), while the Astros are 9-10 ATS.

Padres vs Astros Starting Pitchers Today:

  • Padres starting pitcher: Michael King 3-0, 2.38 ERA
  • Astros starting pitcher: Hayden Wesneski 1-1, 4.00 ERA

Padres vs. Astros Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Padres-1.5 +145O 8 -120-120
Astros +1.5 -175U 8 +100+100

Padres vs Astros Prediction for Today’s Game

Based on recent trends the model predicts the Padres will win Saturday‘s MLB game with 54.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Padres players for Saturday‘s game, looking at profitable historical betting trends:

Best Padres Player Prop Bets Today:

  • Luis Arraez has hit the Home Runs Over in 2 of his last 4 games (+23.00 Units / 575% ROI)
  • Fernando Tatis Jr. has hit the Hits Over in 17 of his last 25 games (+10.00 Units / 23% ROI)
  • Fernando Tatis Jr. has hit the Hits Runs and RBIs Over in 18 of his last 25 games (+9.60 Units / 31% ROI)
  • Xander Bogaerts has hit the Total Bases Over in 15 of his last 20 away games (+9.40 Units / 31% ROI)
  • Michael King has hit the Earned Runs Under in 17 of his last 25 games (+7.90 Units / 25% ROI)

And here are some favorite MLB player prop bets for Astros players for Saturday‘s game, looking at profitable historical betting trends:

Best Astros Player Prop Best Bets Today:

  • Isaac Paredes has hit the Home Runs Over in 3 of his last 4 games at home (+15.40 Units / 385% ROI)
  • Christian Walker has hit the RBIs Under in 18 of his last 20 games (+13.20 Units / 31% ROI)
  • Yainer Diaz has hit the Hits Under in 10 of his last 15 games (+9.05 Units / 42% ROI)
  • Yainer Diaz has hit the Hits Runs and RBIs Under in 12 of his last 15 games (+8.80 Units / 51% ROI)
  • Yordan Alvarez has hit the Runs Under in 12 of his last 15 games (+8.60 Units / 47% ROI)
  • The San Diego Padres have hit the Moneyline in 101 of their last 168 games (+19.80 Units / 9% ROI)
  • The San Diego Padres have covered the Run Line in 88 of their last 168 games (+7.55 Units / 4% ROI)
  • The San Diego Padres have hit the Team Total Over in 13 of their last 20 games (+6.00 Units / 27% ROI)
  • The San Diego Padres have covered the 1st Five Innings (F5) Run Line in 12 of their last 18 games (+5.15 Units / 24% ROI)
  • The San Diego Padres have hit the 1st Five Innings (F5) Moneyline in 11 of their last 17 games (+4.40 Units / 18% ROI)
  • The Houston Astros have hit the Game Total Under in 91 of their last 162 games (+19.00 Units / 11% ROI)
  • The Houston Astros have covered the Run Line in 83 of their last 162 games (+5.70 Units / 3% ROI)
  • The Houston Astros have covered the 1st Five Innings (F5) Run Line in 43 of their last 80 games at home (+0.75 Units / 1% ROI)

Padres Against the Spread (ATS) Record

Against the spread this season, the Padres are 14-6 against the Run Line (+8.05 Units / 30.78% ROI).

  • 15-5 when betting on the Moneyline for +10.3 Units / 37.94% ROI
  • 9-10 when betting on the total runs Over for -1.9 Units / -8.72% ROI
  • 10-9 when betting on the total runs Under for -0.2 Units / -0.9% ROI

Astros Against the Spread (ATS) Record

Against the spread this season, the Astros are 9-10 against the Run Line (-0.3 Units / -1.24% ROI).

  • 9-10 when betting on the Moneyline for -3.05 Units / -12.76% ROI
  • 8-9 when betting on the total runs Over for -2.05 Units / -9.74% ROI
  • 9-8 when betting on the total runs Under for +0.15 Units / 0.72% ROI

Astros vs Padres Home Run Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +290 0.5 -350
Yordan Alvarez (HOU) 0.5 +375 0.5 -500
Manny Machado (SD) 0.5 +375 0.5 -500
Christian Walker (HOU) 0.5 +450 0.5 -625
Yainer Diaz (HOU) 0.5 +650 0.5 -1000

Astros vs Padres Total Hits Prop Bets Today

Over Under
Manny Machado (SD) 0.5 -250 0.5 +185
Yainer Diaz (HOU) 0.5 -210 0.5 +155
Jose Altuve (HOU) 0.5 -210 0.5 +155
Jose Iglesias (SD) 0.5 -210 0.5 +160
Oscar Gonzalez (SD) 0.5 -200 0.5 +155

Astros vs Padres RBI Prop Bets Today

Over Under
Fernando Tatis Jr. (SD) 0.5 +140 0.5 -190
Manny Machado (SD) 0.5 +150 0.5 -200
Yordan Alvarez (HOU) 0.5 +175 0.5 -235
Christian Walker (HOU) 0.5 +185 0.5 -250
Xander Bogaerts (SD) 0.5 +195 0.5 -250

Astros vs Padres Strikeout Prop Bets Today

Over Under
Hayden Wesneski (HOU) 4.5 -135 4.5 +105
Michael King (SD) 6.5 +110 6.5 -145

Michael King has allowed a slugging percentage of just .097 (3 Total Bases / 31 ABs) when going through the lineup the first time in a game this season — best among qualified SPs in MLB; League Avg: .387 — 100th Percentile.

Opponents are hitting just .097 (3-for-31) against Michael King when going through the lineup the first time in a game this season — 4th best among qualified SPs in MLB; League Avg: .234 — 96th Percentile.

Michael King has allowed an OPS of just .319 (36 PA’s) when going through the lineup the first time in a game this season — best among among NL Starters; League Avg: .654 — 100th Percentile.

Michael King has allowed a slugging percentage of just .170 (8 Total Bases / 47 ABs) on non-fastballs this season — 3rd best among qualified SPs in MLB; League Avg: .364 — 97th Percentile.

Astros Starting Pitcher Stats & Trends

Hayden Wesneski allowed a slugging percentage of .722 (39 Total Bases / 54 ABs) on low fastballs in 2023 — 2nd highest in MLB among starting pitchers with at least 64 total IP; League Avg: .430 — first Percentile.

Hayden Wesneski has not walked any of the 47 batters that they have faced in his last two starts — tied for best in MLB over the last two weeks; League Avg: 8% — 100th Percentile.

Left-handed batters are hitting just .074 (2-for-27) against Hayden Wesneski this month (3 games) — best among qualified SPs in MLB; League Avg: .231 — 100th Percentile.

Opponents have a chase percentage of just 22% (11/51) against Hayden Wesneski with two-strikes this season — tied for 2nd lowest in MLB among starting pitchers with at least 7 total IP; League Avg: 38% — second Percentile.

Padres Keys to the Game vs. the Astros

The Padres are 12-1 (.923) at home this season — best in MLB; League Avg: .614.

The Padres are 2-4 (.333) when trailing entering the 7th inning this season — tied for best in MLB; League Avg: .104.

The Padres were 55-38 (.591) after a win in the 2024 season — best in MLB; League Avg: .496.

The Padres were 48-33 (.593) on the road in the 2024 season — 2nd best in MLB; League Avg: .478.

Astros Keys to the Game vs. the Padres

The Astros were just 0-56 (.000) when trailing entering the 9th inning in the 2024 season — tied for lowest in MLB; League Avg: .050.

The Astros are just 0-8 (.000) after a win this season — tied for lowest in MLB; League Avg: .486.

The Astros were 20-18 (.526) vs top 10 scoring offenses in the 2024 season They play the Mariners (21st best runs scored) today.

The Astros are just 6-13 (.316) when tied entering the 8th inning since last season — 3rd lowest in MLB; League Avg: .500.

Padres hitters struck out just 278 times in 1,617 PA’s (17%) against LHP in the 2024 season — best in MLB; League Avg: 23%.

Padres hitters have struck out in just 17% of it’s PA’s against LHP since last season — best in MLB; League Avg: 23%.

The Padres are batting .204 with two-strikes since last season — best in MLB; League Avg: .168.

The Padres batted .275 on the road in the 2024 season — best in MLB; League Avg: .242.

Astros hitters have an OBP of .469 (64 PA’s) when facing the starting pitcher for the 3rd time in a game this season — best in MLB; League Avg: .321.

Astros hitters averaged just 3.66 pitches per plate appearance in the 2024 season — lowest in MLB; League Avg: 3.89.

Astros hitters are averaging just 3.68 pitches per plate appearance since last season — lowest in MLB; League Avg: 3.89.

15% of Astros’ hitters plate appearances lasted only one pitch (926/6,107 PA’s) in the 2024 season — highest in MLB; League Avg: 12%.

The Padres have allowed 2.85 runs per game (57/20) this season — tied for best in MLB; League Avg: 4.29.

The Padres have allowed 1.46 runs per game (19/13) at home this season — best in MLB; League Avg: 3.92.

Padres pitchers have walked 9% of batters when facing the leadoff batter in the inning since last season — tied for 5th highest in MLB; League Avg: 8%.

Opponents had a groundball batting average of just .196 against Padres pitchers with the shift in 2023 — best in MLB; League Avg: .240.

Opponents have a miss rate of 29% against Astros pitchers this season — 2nd best in MLB; League Avg: 26%.

Astros pitchers walked 544 of 6,019 batters (9%) in the 2024 season — 4th highest in MLB; League Avg: 8%.

Opponents had a miss rate of 27% against Astros pitchers in the 2024 season — 2nd best in MLB; League Avg: 25%.

Opponents have a miss rate of 28% against Astros pitchers since the 2023 season — 2nd best in MLB; League Avg: 26%.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.