Twins vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 29

Cleveland Guardians catcher Bo Naylor sits near the bullpen during spring training baseball workouts in Goodyear, Ariz., Friday, Feb. 16, 2024.
(AP Photo/Carolyn Kaster)
  • The Guardians are -155 favorites vs the Twins
  • Twins vs Guardians Over / Under today: 8 Runs
  • Twins / Guardians TV Channel: GDTV | TWTV

The Minnesota Twins (+125) visit Progressive Field to take on the Cleveland Guardians (-150) on Tuesday, April 29, 2025. First pitch is scheduled for 6:10pm EDT in Cleveland, OH, OH.

This season, the Twins are 13-16 against the spread (ATS), while the Guardians are 14-14 ATS.

Twins vs Guardians Starting Pitchers Today:

  • Twins starting pitcher: Chris Paddack 0-3, 6.45 ERA
  • Guardians starting pitcher: Tanner Bibee 2-2, 5.26 ERA

Twins vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
Twins+1.5 -185O 8.5 -120+125
Guardians -1.5 +150U 8.5 +100-150

Twins vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Tuesday‘s MLB game with 57.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for Twins players for Tuesday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Bets Today:

  • Trevor Larnach has hit the Home Runs Over in 4 of his last 9 games (+18.10 Units / 201% ROI)
  • Ty France has hit the Hits Under in 14 of his last 25 away games (+11.85 Units / 47% ROI)
  • Ty France has hit the Singles Under in 18 of his last 25 away games (+10.45 Units / 37% ROI)
  • Ty France has hit the Runs Over in 7 of his last 10 away games (+7.80 Units / 78% ROI)
  • Ty France has hit the RBIs Over in 8 of his last 15 games (+7.60 Units / 51% ROI)

And here are some favorite MLB player prop bets for Guardians players for Tuesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Nolan Jones has hit the Runs Under in 21 of his last 25 games (+14.05 Units / 31% ROI)
  • Kyle Manzardo has hit the Home Runs Over in 3 of his last 7 games (+13.60 Units / 194% ROI)
  • Steven Kwan has hit the Hits Over in his last 10 games at home (+11.90 Units / 57% ROI)
  • Steven Kwan has hit the Singles Over in 19 of his last 25 games (+10.25 Units / 28% ROI)
  • Steven Kwan has hit the Total Bases Over in 8 of his last 10 games (+9.05 Units / 90% ROI)
  • The Minnesota Twins have covered the 1st Five Innings (F5) Run Line in 15 of their last 22 games (+8.75 Units / 33% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Moneyline in 13 of their last 22 games (+7.45 Units / 25% ROI)
  • The Minnesota Twins have hit the Game Total Under in 13 of their last 20 games (+6.55 Units / 30% ROI)
  • The Minnesota Twins have covered the Run Line in 12 of their last 19 games (+6.00 Units / 24% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 9 of their last 13 away games (+5.45 Units / 37% ROI)
  • The Cleveland Guardians have hit the Team Total Under in 16 of their last 25 games (+6.45 Units / 22% ROI)
  • The Cleveland Guardians have hit the Moneyline in 12 of their last 19 games (+5.70 Units / 24% ROI)
  • The Cleveland Guardians have hit the Game Total Over in 10 of their last 16 games (+5.60 Units / 32% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 17 of their last 28 games (+4.90 Units / 14% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Moneyline in 9 of their last 18 games (+1.15 Units / 5% ROI)

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 15-14 against the Run Line (+1.65 Units / 4.6% ROI).

  • 13-16 when betting on the Moneyline for -7.05 Units / -17.36% ROI
  • 11-15 when betting on the total runs Over for -5.6 Units / -17.45% ROI
  • 15-11 when betting on the total runs Under for +2.9 Units / 9.15% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 14-14 against the Run Line (-3.25 Units / -8.05% ROI).

  • 15-13 when betting on the Moneyline for +2.55 Units / 7.65% ROI
  • 15-11 when betting on the total runs Over for +3.3 Units / 10.8% ROI
  • 11-15 when betting on the total runs Under for -5.3 Units / -17.07% ROI

Guardians vs Twins Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +360 0.5 -500
Kyle Manzardo (CLE) 0.5 +400 0.5 -525
Jose Ramirez (CLE) 0.5 +450 0.5 -625
Trevor Larnach (MIN) 0.5 +525 0.5 -750
Bo Naylor (CLE) 0.5 +525 0.5 -750

Guardians vs Twins Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -275 0.5 +200
Nolan Jones (CLE) 0.5 -235 0.5 +175
Carlos Correa (MIN) 0.5 -235 0.5 +175
Trevor Larnach (MIN) 0.5 -220 0.5 +160
Kyle Manzardo (CLE) 0.5 -200 0.5 +150

Guardians vs Twins RBI Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +120 0.5 -160
Kyle Manzardo (CLE) 0.5 +125 0.5 -160
Carlos Santana (CLE) 0.5 +180 0.5 -235
Byron Buxton (MIN) 0.5 +185 0.5 -250
Trevor Larnach (MIN) 0.5 +185 0.5 -250

Guardians vs Twins Strikeout Prop Bets Today

Over Under
Chris Paddack (MIN) 3.5 -155 3.5 +115
Tanner Bibee (CLE) 5.5 -105 5.5 -125

Chris Paddack allowed a slugging percentage of .500 (55 Total Bases / 110 ABs) on low non-fastballs in the 2024 season — 2nd highest in MLB among starting pitchers with at least 64 total IP; League Avg: .316 — first Percentile.

Chris Paddack has a strike rate of just 54% (43/80) with runners in scoring position this season — 3rd lowest in MLB among starting pitchers with at least 10 total IP; League Avg: 64% — second Percentile.

Chris Paddack has a strikeout rate of just 11% (4 SO in 35 PAs) on low non-fastballs this season — 2nd lowest in MLB among starting pitchers with at least 10 total IP; League Avg: 34% — second Percentile.

Chris Paddack has allowed a slugging percentage of .511 (72 Total Bases / 141 ABs) on low non-fastballs since last season — 2nd highest in MLB among starting pitchers with at least 75 total IP; League Avg: .315 — first Percentile.

Guardians Starting Pitcher Stats & Trends

Tanner Bibee has allowed an OPS of .940 (304 PA’s) versus the 2-3-4 hitters since last season — highest among qualified SPs in MLB; League Avg: .720 — second Percentile.

Tanner Bibee has allowed three-ball counts to 37% of batters they faced (22/60 PA’s) against right-handed batters this season — highest in MLB among starting pitchers with at least 10 total IP; League Avg: 19% — 0 Percentile.

Tanner Bibee has allowed a slugging percentage of 1.030 (34 Total Bases / 33 ABs) versus the 2-3-4 hitters this season — highest in MLB among starting pitchers with at least 10 total IP; League Avg: .422 — 0 Percentile.

Tanner Bibee has allowed an OPS of .956 (312 PA’s) versus the top of the order since last season — highest among qualified SPs in MLB; League Avg: .730 — second Percentile.

Twins Keys to the Game vs. the Guardians

The Twins are just 0-13 (.000) when trailing entering the 8th inning this season — tied for lowest in MLB; League Avg: .083.

The Twins are just 1-5 (.167) vs top 10 scoring offenses this season They play the Guardians (14th best runs scored) today.

The Twins are just 4-10 (.286) on the road this season — 5th lowest in MLB; League Avg: .395.

The Twins are just 0-12 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .113.

Guardians Keys to the Game vs. the Twins

The Guardians are 9-0 (1.000) when they’ve had 10 or more hits this season — tied for best in MLB; League Avg: .741.

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians are just 0-13 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .041.

The Guardians were 77-2 (.975) when leading entering the 8th inning in the 2024 season — best in MLB; League Avg: .899.

Twins hitters have struck out in 28% of it’s PA’s against LHP this season — 4th highest in MLB; League Avg: 23%.

Twins hitters have an OPS of just .514 (292 PA’s) in innings 7-9 this season — lowest in MLB; League Avg: .678.

The Twins batted just .150 with two-strikes in the 2023 season — lowest in MLB; League Avg: .172.

The Twins are batting just .194 in lefty-lefty matchups since the 2023 season — lowest in MLB; League Avg: .238.

Guardians hitters slugged just .367 against LHP in the 2023 season — lowest in MLB; League Avg: .419.

The Guardians batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

The Guardians have an average Exit Velocity of 87.6 MPH since the 2023 season — lowest in MLB; League Avg: 88.9.

Guardians hitters have put just 34% of balls in play to the left side of the field since the 2023 season — lowest in MLB; League Avg: 38%.

Twins pitchers have walked 7% of batters this season — best in MLB; League Avg: 9%.

Opponents have a groundball rate of just 38% against Twins pitchers this season — 2nd lowest in MLB; League Avg: 43%.

Twins pitchers had a strikeout rate of 26% in 2023 — best in MLB; League Avg: 23%.

Twins pitchers have walked 7% of batters since last season — tied for 2nd best in MLB; League Avg: 8%.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a groundball batting average of just .220 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.