White Sox vs Cardinals Prediction, Odds & Player Prop Bets Today – MLB, May 4

St. Louis Cardinals second baseman Nolan Gorman throws out Cincinnati Reds' Elly De La Cruz at first base during the fifth inning of a baseball game, Friday, Sept. 8, 2023, in Cincinnati. (AP Photo/Joshua A. Bickel)
(AP Photo/Joshua A. Bickel)
  • The Cardinals are -185 favorites vs the White Sox
  • White Sox vs Cardinals Over / Under today: 8 Runs
  • White Sox / Cardinals TV Channel: NSCH | BSMW

The Chicago White Sox (+150) visit Busch Stadium to take on the St. Louis Cardinals (-185) on Saturday, May 4, 2024. First pitch is scheduled for 2:15pm EDT in St. Louis, MO.

This season, the White Sox are 6-26 against the spread (ATS), while the Cardinals are 18-14 ATS.

White Sox vs Cardinals Starting Pitchers Today:

  • White Sox starting pitcher: Erick Fedde 2-0, 2.60 ERA
  • Cardinals starting pitcher: Lance Lynn 1-0, 2.64 ERA

White Sox vs. Cardinals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 -135O 8 -110+150
Cardinals -1.5 +110U 8 -110-185

White Sox vs Cardinals Prediction for Today’s Game

Based on recent trends the model predicts the Cardinals will win Saturday‘s MLB game with 59.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Saturday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Andrew Benintendi has hit the Home Runs Over in 2 of his last 6 games (+13.00 Units / 217% ROI)
  • Andrew Vaughn has hit the Total Bases Under in 21 of his last 30 games (+10.45 Units / 24% ROI)
  • Andrew Vaughn has hit the Hits Under in 15 of his last 28 games (+7.05 Units / 20% ROI)
  • Andrew Vaughn has hit the Hits Runs and RBIs Under in 10 of his last 13 away games (+6.60 Units / 39% ROI)
  • Nicky Lopez has hit the Singles Over in 11 of his last 14 games (+6.05 Units / 29% ROI)

And here are some favorite MLB player prop bets for Cardinals players for Saturday‘s game, looking at profitable historical betting trends:

Best Cardinals Player Prop Best Bets Today:

  • Ivan Herrera has hit the Home Runs Over in 3 of his last 9 games at home (+13.90 Units / 154% ROI)
  • Nolan Gorman has hit the Runs Under in 16 of his last 17 games (+13.90 Units / 42% ROI)
  • Nolan Arenado has hit the Hits Over in 24 of his last 30 games (+12.35 Units / 19% ROI)
  • Brendan Donovan has hit the Hits Runs and RBIs Under in 17 of his last 23 games (+12.05 Units / 49% ROI)
  • Nolan Arenado has hit the Singles Over in 21 of his last 30 games (+11.75 Units / 36% ROI)
  • The Chicago White Sox have hit the Game Total Under in 70 of their last 124 games (+16.15 Units / 12% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 16 away games (+8.13 Units / 45% ROI)
  • The Chicago White Sox have hit the Team Total Under in 13 of their last 19 away games (+6.45 Units / 30% ROI)
  • The Chicago White Sox have covered the Run Line in 15 of their last 22 away games (+6.40 Units / 21% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 away games (+1.84 Units / 27% ROI)
  • The St. Louis Cardinals have hit the Game Total Under in 32 of their last 58 games (+5.80 Units / 9% ROI)
  • The St. Louis Cardinals have hit the Moneyline in 13 of their last 26 games (+5.50 Units / 21% ROI)
  • The St. Louis Cardinals have hit the 1st Five Innings (F5) Team Total Under in 8 of their last 11 games (+4.82 Units / 37% ROI)
  • The St. Louis Cardinals have covered the Run Line in 49 of their last 92 games (+1.55 Units / 1% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 14-18 against the Run Line (-6.8 Units / -18.18% ROI).

  • 6-26 when betting on the Moneyline for -17.6 Units / -56.77% ROI
  • 15-15 when betting on the total runs Over for -1.65 Units / -4.79% ROI
  • 15-15 when betting on the total runs Under for -1.3 Units / -3.84% ROI

Cardinals Against the Spread (ATS) Record

Against the spread this season, the Cardinals are 18-14 against the Run Line (+2.65 Units / 6.11% ROI).

  • 15-17 when betting on the Moneyline for -2.9 Units / -7.4% ROI
  • 10-20 when betting on the total runs Over for -12.1 Units / -34.33% ROI
  • 20-10 when betting on the total runs Under for +9.1 Units / 25.85% ROI

Cardinals vs White Sox Home Run Prop Bets Today

Over Under
Nolan Gorman (STL) 0.5 +360 0.5 -500
Willson Contreras (STL) 0.5 +425 0.5 -600
Gavin Sheets (CWS) 0.5 +450 0.5 -650
Nolan Arenado (STL) 0.5 +500 0.5 -750
Paul Goldschmidt (STL) 0.5 +525 0.5 -750

Cardinals vs White Sox Total Hits Prop Bets Today

Over Under
Alec Burleson (STL) 0.5 -275 0.5 +200
Brendan Donovan (STL) 0.5 -275 0.5 +210
Nicky Lopez (CWS) 0.5 -275 0.5 +200
Tommy Pham (CWS) 0.5 -250 0.5 +175
Willson Contreras (STL) 0.5 -250 0.5 +180

Cardinals vs White Sox RBI Prop Bets Today

Over Under
Nolan Arenado (STL) 0.5 +145 0.5 -190
Gavin Sheets (CWS) 0.5 +160 0.5 -210
Nolan Gorman (STL) 0.5 +165 0.5 -225
Paul Goldschmidt (STL) 0.5 +165 0.5 -225
Alec Burleson (STL) 0.5 +165 0.5 -225

Cardinals vs White Sox Strikeout Prop Bets Today

Over Under

Erick Fedde has a strike rate of just 46% (94/203) when ahead in the count this season — lowest among among AL Starters; League Avg: 61% — second Percentile.

Erick Fedde has a strike rate of just 46% (94/203) when ahead in the count this season — lowest among qualified SPs in MLB; League Avg: 61% — first Percentile.

Erick Fedde has a strikeout rate of 74% (20 SO in 27 PAs) with two-strikes over the last 14 days — best among AL Starters over the last two weeks; League Avg: 44% — 100th Percentile.

Opponents are hitting just .067 (1-for-15) against Erick Fedde’s elevated fastball this season — 4th best among qualified SPs in MLB; League Avg: .204 — 96th Percentile.

Cardinals Starting Pitcher Stats & Trends

Lance Lynn has located his pitches away 62% of the time (79/127) when behind in the count this season — highest among qualified SPs in MLB; League Avg: 44% — 100th Percentile.

Lance Lynn has allowed 18 home runs with two-strikes since last season — most among pitchers in MLB — 100th Percentile.

Opponents are hitting .270 (82-for-304) against Lance Lynn when going through the lineup the first time in a game since last season — 5th highest among qualified SPs in MLB; League Avg: .231 — 14th Percentile.

Lance Lynn has a strike rate of just 61% (322/529) this season — 10th lowest among qualified SPs in MLB; League Avg: 65% — 10th Percentile.

White Sox Keys to the Game vs. the Cardinals

The White Sox are just 6-13 (.316) after a win as favorites since the 2023 season — 2nd lowest in MLB; League Avg: .575.

The White Sox are just 8-23 (.258) after a road win since the 2023 season — lowest in MLB; League Avg: .489.

The White Sox are just 53-13 (.803) when leading entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .898.

The White Sox are just 52-42 (.553) when allowing 4 or fewer runs since the 2023 season — lowest in MLB; League Avg: .732.

Cardinals Keys to the Game vs. the White Sox

The Cardinals are 28-11 (.718) when tied entering the 8th inning since the 2022 season — best in MLB; League Avg: .500.

The Cardinals are just 15-26 (.366) after a win as favorites since the 2023 season — 3rd lowest in MLB; League Avg: .575.

The Cardinals are 12-7 (.632) when tied entering the 8th inning since the 2023 season — 4th best in MLB; League Avg: .500.

The Cardinals are just 19-28 (.404) after a road win since the 2023 season — 4th lowest in MLB; League Avg: .489.

The White Sox are batting just .159 with two outs this season — lowest in MLB; League Avg: .228.

White Sox hitters have an OBP of just .287 (5,538 PA’s) against RHP since last season — lowest in MLB; League Avg: .318.

The White Sox have a winning percentage of just 19% this season — lowest in MLB; League Avg: 50%.

The White Sox are batting just .174 against LHP this season — lowest in MLB; League Avg: .244.

Cardinals hitters are slugging just .301 against LHP this season — 2nd lowest in MLB; League Avg: .382.

Cardinals hitters have an OPS of just .592 (314 PA’s) against LHP this season — 3rd lowest in MLB; League Avg: .699.

Cardinals hitters have just 57 strikeouts in 314 PA’s (18%) against LHP this season — 5th best in MLB; League Avg: 22%.

The Cardinals have an average HR distance of 412.0 feet this season — 2nd best in MLB; League Avg: 395.9.

White Sox pitchers have allowed a run 50% of the time after an opposing score this season — highest in MLB; League Avg: 29%.

In games when their opponents have scored three or more runs in an inning, the White Sox have won just just 14% of the time since the 2022 season — lowest in MLB; League Avg: 24%.

White Sox pitchers have allowed opponents to score in three different innings in 62% of their games this season — highest in MLB; League Avg: 43%.

White Sox pitchers have walked 783 of 7,531 batters (10%) since last season — 2nd highest in MLB; League Avg: 9%.

Opponents have a miss rate of just 23% against Cardinals pitchers since the 2022 season — 2nd lowest in MLB; League Avg: 26%.

Opponents have a miss rate of just 23% against Cardinals pitchers since last season — tied for 2nd lowest in MLB; League Avg: 26%.

Opponents have a groundball rate of 47% against Cardinals pitchers since the 2022 season — 2nd highest in MLB; League Avg: 43%.

Cardinals pitchers have a strikeout rate of just 20% since the 2022 season — tied for 2nd lowest in MLB; League Avg: 23%.

Cardinals vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • Dylan Carlson (St. Louis Cardinals): Shoulder, 10-Day IL
  • Keynan Middleton (St. Louis Cardinals): Forearm, 15-Day IL
  • Lars Nootbaar (St. Louis Cardinals): Ribs, 10-Day IL
  • Drew Rom (St. Louis Cardinals): Biceps, 15-Day IL
  • Sonny Gray (St. Louis Cardinals): Hamstring, 15-Day IL
  • Riley O’Brien (St. Louis Cardinals): Forearm, 15-Day IL
  • Tommy Edman (St. Louis Cardinals): Wrist, 10-Day IL
  • Packy Naughton (St. Louis Cardinals): Elbow, Out
  • Eloy Jimenez (Chicago White Sox): Thigh, Day-To-Day
  • Yasmani Grandal (Chicago White Sox): Foot, 10-Day IL
  • Matt Foster (Chicago White Sox): Elbow, 60-Day IL
  • Jake Eder (Chicago White Sox): Shoulder, Day-To-Day
  • Jesse Scholtens (Chicago White Sox): Elbow, 60-Day IL
  • Shane Drohan (Chicago White Sox): Shoulder, 60-Day IL
  • Liam Hendriks (Chicago White Sox): Elbow, 60-Day IL
  • Jimmy Lambert (Chicago White Sox): Shoulder, 60-Day IL
  • Edgar Navarro (Chicago White Sox): Elbow, Out
  • Davis Martin (Chicago White Sox): Elbow, Out
  • Max Stassi (Chicago White Sox): Hip, 10-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.