White Sox vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 10

Cleveland Guardians' Myles Straw attempts to run to first after grounding out to Los Angeles Angels starting pitcher Kenny Rosenberg who threw to first baseman Mike Moustakas during the first inning of a baseball game, Sunday, Sept. 10, 2023, in Anaheim, Calif.
(AP Photo/Ryan Sun)
  • The Guardians are -250 favorites vs the White Sox
  • White Sox vs Guardians Over / Under today: 7.5 Runs
  • White Sox / Guardians TV Channel: BSGL | NCH+

The Chicago White Sox (+200) visit Progressive Field to take on the Cleveland Guardians (-250) on Wednesday, April 10, 2024. First pitch is scheduled for 6:10pm EDT in Cleveland, OH.

This season, the White Sox are 2-9 against the spread (ATS), while the Guardians are 8-3 ATS.

White Sox vs Guardians Starting Pitchers Today:

  • White Sox starting pitcher: Erick Fedde 0-0, 2.80 ERA
  • Guardians starting pitcher: Tanner Bibee 1-0, 4.00 ERA

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 +100O 7.5 -110+200
Guardians -1.5 -120U 7.5 -110-250

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Wednesday‘s MLB game with 61.0% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Yoan Moncada has hit the Hits Over in 9 of his last 10 games (+7.50 Units / 44% ROI)
  • Yoan Moncada has hit the Singles Over in 7 of his last 8 games (+7.40 Units / 89% ROI)
  • Robbie Grossman has hit the Hits Under in 9 of his last 13 games (+7.30 Units / 56% ROI)
  • Kevin Pillar has hit the Singles Under in 10 of his last 12 games (+7.10 Units / 34% ROI)
  • Andrew Vaughn has hit the Total Bases Under in 9 of his last 11 games (+7.00 Units / 42% ROI)

And here are some favorite MLB player prop bets for Guardians players for Wednesday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Tanner Bibee has hit the Earned Runs Under in 18 of his last 24 games (+9.75 Units / 32% ROI)
  • Kole Calhoun has hit the Singles Under in 18 of his last 24 games (+8.75 Units / 21% ROI)
  • Estevan Florial has hit the Hits Runs and RBIs Over in 13 of his last 18 games (+8.20 Units / 36% ROI)
  • Tyler Freeman has hit the Total Bases Under in 8 of his last 9 games at home (+7.90 Units / 50% ROI)
  • Steven Kwan has hit the Hits Over in 7 of his last 10 games (+7.00 Units / 53% ROI)
  • The Chicago White Sox have hit the Game Total Under in 70 of their last 124 games (+16.15 Units / 12% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 16 away games (+8.13 Units / 45% ROI)
  • The Chicago White Sox have hit the Team Total Under in 13 of their last 19 away games (+6.45 Units / 30% ROI)
  • The Chicago White Sox have covered the Run Line in 15 of their last 22 away games (+6.40 Units / 21% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 away games (+1.84 Units / 27% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 50 of their last 76 games at home (+22.70 Units / 27% ROI)
  • The Cleveland Guardians have covered the Run Line in 64 of their last 120 games (+6.20 Units / 4% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 20 of their last 34 games (+4.72 Units / 12% ROI)
  • The Cleveland Guardians have hit the Moneyline in 35 of their last 62 games at home (+4.25 Units / 5% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 6-5 against the Run Line (-0.15 Units / -1.11% ROI).

  • 2-9 when betting on the Moneyline for -5.4 Units / -49.09% ROI
  • 3-7 when betting on the total runs Over for -5.1 Units / -40.64% ROI
  • 7-3 when betting on the total runs Under for +3.85 Units / 32.91% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 8-3 against the Run Line (+5.65 Units / 39.93% ROI).

  • 8-3 when betting on the Moneyline for +4.45 Units / 29.09% ROI
  • 6-4 when betting on the total runs Over for +1.45 Units / 11.84% ROI
  • 4-6 when betting on the total runs Under for -2.75 Units / -22.92% ROI

Guardians vs White Sox Home Run Prop Bets Today

Over Under
Naylor 0.5 +500 0.5 -700
Ramirez 0.5 +500 0.5 -700
Naylor 0.5 +500 0.5 -700
Sheets 0.5 +525 0.5 -750
Vaughn 0.5 +575 0.5 -800

Guardians vs White Sox Total Hits Prop Bets Today

Over Under
Gimenez 0.5 -275 0.5 +200
Freeman 0.5 -225 0.5 +165
Benintendi 0.5 -225 0.5 +170
Vaughn 0.5 -210 0.5 +155
Sheets 0.5 -190 0.5 +145

Guardians vs White Sox RBI Prop Bets Today

Over Under
Naylor 0.5 +105 0.5 -135
Ramirez 0.5 +105 0.5 -140
Naylor 0.5 +160 0.5 -210
Brennan 0.5 +165 0.5 -225
Gimenez 0.5 +170 0.5 -225

Guardians vs White Sox Strikeout Prop Bets Today

Over Under
Fedde 3.5 -105 3.5 -120
Bibee 6.5 +120 6.5 -160

Erick Fedde has a strike rate of just 42% (30/71) when ahead in the count this season — 2nd lowest among in MLB; League Avg: 61% — fourth Percentile.

Erick Fedde has a strike rate of just 42% (30/71) when ahead in the count this season — 3rd lowest among qualified SPs in MLB; League Avg: 61% — third Percentile.

Erick Fedde has allowed a slugging percentage of .706 (12 Total Bases / 17 ABs) on non-fastballs this season — 5th highest among qualified SPs in MLB; League Avg: .356 — fifth Percentile.

Opponents have a chase percentage of just 22% (296/1,354) against Erick Fedde since the 2022 season — lowest in MLB among starting pitchers with at least 133 total IP; League Avg: 29% — 0 Percentile.

Guardians Starting Pitcher Stats & Trends

Tanner Bibee has allowed a slugging percentage of .933 (14 Total Bases / 15 ABs) on fastballs this season — 2nd highest among qualified SPs in MLB; League Avg: .383 — second Percentile.

Opponents are hitting just .083 (2-for-24) against Tanner Bibee’s non-fastballs this season — 4th best among in MLB; League Avg: .208 — 94th Percentile.

Opponents are hitting just .083 (2-for-24) against Tanner Bibee’s non-fastballs this season — 6th best among qualified SPs in MLB; League Avg: .223 — 94th Percentile.

Opponents are hitting .600 (9-for-15) against Tanner Bibee’s fastball this season — highest among qualified SPs in MLB; League Avg: .247 — first Percentile.

White Sox Keys to the Game vs. the Guardians

The White Sox were just 51-8 (.864) when leading entering the 9th inning in 2023 — lowest in MLB; League Avg: .949.

The White Sox are just 53-8 (.855) when leading entering the 9th inning since the 2023 season — lowest in MLB; League Avg: .949.

The White Sox were just 19-42 (.311) after a win in 2023 — lowest in MLB; League Avg: .514.

The White Sox are just 8-21 (.276) after a road win since the 2023 season — lowest in MLB; League Avg: .493.

Guardians Keys to the Game vs. the White Sox

The Guardians are just 5-16 (.238) when tied entering the 7th inning since the 2023 season — lowest in MLB; League Avg: .494.

The Guardians are 34-115 (.227) when trailing entering the 7th inning since the 2022 season — best in MLB; League Avg: .131.

The Guardians are just 5-16 (.238) when tied entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .496.

The Guardians were just 5-15 (.250) when tied entering the 8th inning in 2023 — 2nd lowest in MLB; League Avg: .500.

White Sox hitters had an OBP of just .213 (3,148 PA’s) with two-strikes in the 2023 season — lowest in MLB; League Avg: .249.

White Sox hitters had an OPS of just .458 (3,148 PA’s) with two-strikes in the 2023 season — lowest in MLB; League Avg: .523.

White Sox hitters had an OBP of just .291 (5,980 PA’s) in the 2023 season — lowest in MLB; League Avg: .320.

White Sox hitters had an OBP of just .293 (2,952 PA’s) at home in the 2023 season — lowest in MLB; League Avg: .324.

Guardians hitters have just 2,349 strikeouts in 12,693 PA’s (18%) since the 2022 season — best in MLB; League Avg: 23%.

Guardians hitters are slugging just .358 against LHP since the 2022 season — lowest in MLB; League Avg: .408.

Guardians hitters have missed on just 22% of swings since the 2022 season — best in MLB; League Avg: 26%.

The Guardians are batting .316 against LHP this season — best in MLB; League Avg: .245.

White Sox pitchers walked 654 of 6,301 batters (10%) in the 2023 season — 2nd highest in MLB; League Avg: 9%.

Opponents have a groundball rate of just 41% against White Sox pitchers since the 2022 season — tied for 3rd lowest in MLB; League Avg: 43%.

Opponents had a groundball rate of just 40% against White Sox pitchers in the 2023 season — 3rd lowest in MLB; League Avg: 43%.

White Sox pitchers have walked 693 of 6,710 batters (10%) since last season — 2nd highest in MLB; League Avg: 9%.

Guardians pitchers have a strikeout rate of 35% with runners in scoring position this season — best in MLB; League Avg: 21%.

Opponents have a miss rate of 32% against Guardians pitchers this season — best in MLB; League Avg: 26%.

Guardians pitchers have a strikeout rate of 28% this season — best in MLB; League Avg: 23%.

Opponents have a groundball rate of just 41% against Guardians pitchers since last season — 5th lowest in MLB; League Avg: 43%.

Guardians vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • Daniel Espino (Cleveland Guardians): Shoulder, Out
  • Gavin Williams (Cleveland Guardians): Elbow, 15-Day IL
  • Ben Lively (Cleveland Guardians): Illness, 15-Day IL
  • Luis Ortiz (Cleveland Guardians): Ankle, 15-Day IL
  • Xzavion Curry (Cleveland Guardians): Illness, 15-Day IL
  • Joey Cantillo (Cleveland Guardians): Hamstring, Out
  • Angel Martinez (Cleveland Guardians): Foot, 10-Day IL
  • Sam Hentges (Cleveland Guardians): Finger, 15-Day IL
  • Trevor Stephan (Cleveland Guardians): Elbow, 60-Day IL
  • George Valera (Cleveland Guardians): Hamstring, Out
  • James Karinchak (Cleveland Guardians): Shoulder, 60-Day IL
  • Eloy Jimenez (Chicago White Sox): Thigh, Day-To-Day
  • Yasmani Grandal (Chicago White Sox): Foot, 10-Day IL
  • Matt Foster (Chicago White Sox): Elbow, 60-Day IL
  • Jake Eder (Chicago White Sox): Shoulder, Day-To-Day
  • Jesse Scholtens (Chicago White Sox): Elbow, 60-Day IL
  • Shane Drohan (Chicago White Sox): Shoulder, 60-Day IL
  • Liam Hendriks (Chicago White Sox): Elbow, 60-Day IL
  • Jimmy Lambert (Chicago White Sox): Shoulder, 60-Day IL
  • Edgar Navarro (Chicago White Sox): Elbow, Out
  • Davis Martin (Chicago White Sox): Elbow, Out
  • Max Stassi (Chicago White Sox): Hip, 10-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.