White Sox vs Guardians Prediction, Odds & Player Prop Bets Today – MLB, Apr 10

Cleveland Guardians catcher Bo Naylor sits near the bullpen during spring training baseball workouts in Goodyear, Ariz., Friday, Feb. 16, 2024.
(AP Photo/Carolyn Kaster)
  • The Guardians are -235 favorites vs the White Sox
  • White Sox vs Guardians Over / Under today: 7 Runs
  • White Sox / Guardians TV Channel: GDTV | CHSN | MLBN

The Chicago White Sox (+200) visit Progressive Field to take on the Cleveland Guardians (-250) on Thursday, April 10, 2025. First pitch is scheduled for 1:10pm EDT in Cleveland, OH.

This season, the White Sox are 2-9 against the spread (ATS), while the Guardians are 4-7 ATS.

White Sox vs Guardians Starting Pitchers Today:

  • White Sox starting pitcher: Jonathan Cannon 0-1, 3.12 ERA
  • Guardians starting pitcher: Gavin Williams 0-0, 4.32 ERA

White Sox vs. Guardians Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 -110O 7 +100+200
Guardians -1.5 -110U 7 -120-250

White Sox vs Guardians Prediction for Today’s Game

Based on recent trends the model predicts the Guardians will win Thursday‘s MLB game with 65.2% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Thursday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Brooks Baldwin has hit the Hits Under in 13 of his last 20 away games (+8.25 Units / 41% ROI)
  • Brooks Baldwin has hit the Singles Under in 15 of his last 20 away games (+8.20 Units / 27% ROI)
  • Luis Robert has hit the Hits Runs and RBIs Under in his last 7 games (+7.40 Units / 79% ROI)
  • Jonathan Cannon has hit the Hits Allowed Under in 7 of his last 8 games (+6.05 Units / 58% ROI)
  • Brooks Baldwin has hit the Total Bases Under in 13 of his last 20 away games (+5.95 Units / 26% ROI)

And here are some favorite MLB player prop bets for Guardians players for Thursday‘s game, looking at profitable historical betting trends:

Best Guardians Player Prop Best Bets Today:

  • Daniel Schneemann has hit the Home Runs Over in 1 of his last 5 games (+7.00 Units / 140% ROI)
  • Daniel Schneemann has hit the Singles Under in his last 6 games (+6.00 Units / 48% ROI)
  • Daniel Schneemann has hit the Hits Runs and RBIs Under in 5 of his last 6 games (+4.90 Units / 78% ROI)
  • Daniel Schneemann has hit the Hits Under in his last 4 games (+4.00 Units / 77% ROI)
  • Daniel Schneemann has hit the Total Bases Under in his last 4 games (+4.00 Units / 76% ROI)
  • The Chicago White Sox have hit the Team Total Under in 25 of their last 37 away games (+12.40 Units / 29% ROI)
  • The Chicago White Sox have hit the Game Total Under in 20 of their last 34 away games (+9.15 Units / 25% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 8 of their last 13 away games (+3.65 Units / 26% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 5 of their last 13 away games (+3.30 Units / 25% ROI)
  • The Chicago White Sox have hit the Moneyline in 5 of their last 13 away games (+2.80 Units / 22% ROI)
  • The Cleveland Guardians have hit the Game Total Under in 47 of their last 79 games (+17.00 Units / 19% ROI)
  • The Cleveland Guardians have covered the Run Line in 41 of their last 82 games at home (+10.15 Units / 11% ROI)
  • The Cleveland Guardians have hit the Moneyline in 51 of their last 81 games at home (+10.10 Units / 9% ROI)
  • The Cleveland Guardians have hit the 1st Five Innings (F5) Team Total Over in 6 of their last 7 games at home (+5.75 Units / 70% ROI)
  • The Cleveland Guardians have covered the 1st Five Innings (F5) Run Line in 7 of their last 10 games at home (+3.60 Units / 29% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 7-4 against the Run Line (+2.4 Units / 17.39% ROI).

  • 2-9 when betting on the Moneyline for -6 Units / -54.55% ROI
  • 5-5 when betting on the total runs Over for -0.4 Units / -3.33% ROI
  • 5-5 when betting on the total runs Under for -0.55 Units / -4.51% ROI

Guardians Against the Spread (ATS) Record

Against the spread this season, the Guardians are 4-7 against the Run Line (-4.2 Units / -27.45% ROI).

  • 5-6 when betting on the Moneyline for -1.15 Units / -8.55% ROI
  • 5-6 when betting on the total runs Over for -1.25 Units / -10.55% ROI
  • 6-5 when betting on the total runs Under for +0.6 Units / 4.86% ROI

Guardians vs White Sox Home Run Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 +425 0.5 -625
Jhonkensy Noel (CLE) 0.5 +525 0.5 -750
Kyle Manzardo (CLE) 0.5 +550 0.5 -800
Carlos Santana (CLE) 0.5 +575 0.5 -800
Bo Naylor (CLE) 0.5 +675 0.5 -1100

Guardians vs White Sox Total Hits Prop Bets Today

Over Under
Jose Ramirez (CLE) 0.5 -275 0.5 +200
Steven Kwan (CLE) 0.5 -250 0.5 +190
Andrew Vaughn (CWS) 0.5 -210 0.5 +155
Lenyn Sosa (CWS) 0.5 -190 0.5 +140
Carlos Santana (CLE) 0.5 -175 0.5 +130

Guardians vs White Sox RBI Prop Bets Today

Over Under
Carlos Santana (CLE) 0.5 +155 0.5 -210
Jose Ramirez (CLE) 0.5 +155 0.5 -210
Kyle Manzardo (CLE) 0.5 +165 0.5 -220
Jhonkensy Noel (CLE) 0.5 +185 0.5 -250
Nolan Jones (CLE) 0.5 +210 0.5 -285

Guardians vs White Sox Strikeout Prop Bets Today

Over Under
Gavin Williams (CLE) 5.5 -160 5.5 +125
Jonathan Cannon (CWS) 3.5 -118 3.5 -110

Jonathan Cannon has an ERA of 7.08 (40.2 IP) against division opponents since last season — 2nd highest in MLB among starting pitchers with at least 68 total IP; League Avg: 3.92 — first Percentile.

Opponents had a line drive rate of 39% (25/65) versus Jonathan Cannon with runners in scoring position in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 23% — 0 Percentile.

Jonathan Cannon had an ERA of 7.05 (37.0 IP) against division opponents in the 2024 season — 2nd highest in MLB among starting pitchers with at least 64 total IP; League Avg: 3.95 — first Percentile.

Opponents had a line drive rate of 33% (51/155) versus Jonathan Cannon on fastballs in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 24% — 0 Percentile.

Guardians Starting Pitcher Stats & Trends

21 of Gavin Williams’ 78 breaking pitch strikeouts (27%) have been backdoor since the 2023 season — 6th highest in MLB among starting pitchers with at least 133 total IP; League Avg: 14% — 95th Percentile.

Gavin Williams has thrown fastballs 71% of the time (73/103) in non-two strike counts this season — 7th highest in MLB among starting pitchers with at least 4 total IP; League Avg: 50% — 95th Percentile.

Opponents have a chase percentage of 48% (12/25) against Gavin Williams with runners in scoring position this season — 3rd highest in MLB among starting pitchers with at least 4 total IP; League Avg: 30% — 97th Percentile.

Gavin Williams has thrown elevated pitches 51% of the time (52/103) in non-two strike counts this season — 3rd highest in MLB among starting pitchers with at least 4 total IP; League Avg: 32% — 98th Percentile.

White Sox Keys to the Game vs. the Guardians

The White Sox are just 27-102 (.209) after a loss since last season — lowest in MLB; League Avg: .502.

The White Sox are just 3-61 (.047) when allowing 10 or more hits since last season — lowest in MLB; League Avg: .249.

The White Sox are just 9-41 (.180) vs top 10 scoring offenses since last season They play the Guardians (14th best runs scored) today.

The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.

Guardians Keys to the Game vs. the White Sox

The Guardians were 71-2 (.973) when leading entering the 7th inning in the 2024 season — best in MLB; League Avg: .856.

The Guardians were 82-0 (1.000) when leading entering the 9th inning in the 2024 season — best in MLB; League Avg: .949.

The Guardians are 81-2 (.976) when leading entering the 8th inning since last season — best in MLB; League Avg: .901.

The Guardians are 69-9 (.885) when scoring 5 or more runs since last season — 4th best in MLB; League Avg: .804.

White Sox hitters had an OBP of just .278 (5,869 PA’s) in the 2024 season — lowest in MLB; League Avg: .312.

The White Sox had a winning percentage of just 28% at home last season — lowest in MLB; League Avg: 52%.

The White Sox have a winning percentage of just 31% since the 2023 season — lowest in MLB; League Avg: 50%.

White Sox hitters have an OBP of just .278 (6,257 PA’s) since last season — lowest in MLB; League Avg: .312.

Guardians hitters are slugging just .170 at home this season — lowest in MLB; League Avg: .405.

The Guardians are batting just .113 at home this season — lowest in MLB; League Avg: .247.

The Guardians batted just .232 against LHP in the 2023 season — tied for lowest in MLB; League Avg: .254.

Guardians hitters have an OPS of just .468 (67 PA’s) at home this season — lowest in MLB; League Avg: .729.

The White Sox have won just 17% of games in which their opponents scored first since the 2023 season — lowest in MLB; League Avg: 33%.

In games when their opponents scored three or more runs in an inning, the White Sox won just 4% of the time last season — lowest in MLB; League Avg: 24%.

The White Sox won just 11% of games in which their opponents scored first last season — lowest in MLB; League Avg: 31%.

The White Sox won just 13% of home games in which their opponents scored first last season — lowest in MLB; League Avg: 35%.

Opponents had a groundball batting average of just .207 against Guardians pitchers with runners on base in the 2024 season — best in MLB; League Avg: .262.

Opponents have a groundball batting average of just .211 against Guardians pitchers with runners on base since last season — best in MLB; League Avg: .262.

The Guardians allowed 0.87 runs per game (140/161) in late innings in the 2024 season — best in MLB; League Avg: 1.29.

Opponents had a groundball batting average of just .223 against Guardians pitchers in the 2024 season — best in MLB; League Avg: .249.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.