White Sox vs Phillies Prediction, Odds & Player Prop Bets Today – MLB, Apr 21

FILE - Philadelphia Phillies' Brandon Marsh hits a home run during the eighth inning of Game 3 of a baseball NL Division Series against the Atlanta Braves Wednesday, Oct. 11, 2023, in Philadelphia. Brandon Marsh underwent successful left knee arthroscopic debridement surgery with Dr. Steven Cohen in Philadelphia, Friday morning Feb. 9, 2024. It is anticipated he will return to playing in three to four weeks and be ready to play opening day.(AP Photo/Matt Rourke, File)
(AP Photo/Matt Rourke)
  • The Phillies are -300 favorites vs the White Sox
  • White Sox vs Phillies Over / Under today: 7.5 Runs
  • White Sox / Phillies TV Channel: NSPA | NSCH

The Chicago White Sox (+240) visit Citizens Bank Park to take on the Philadelphia Phillies (-300) on Sunday, April 21, 2024. First pitch is scheduled for 1:35pm EDT in Philadelphia, PA.

This season, the White Sox are 3-17 against the spread (ATS), while the Phillies are 9-12 ATS.

White Sox vs Phillies Starting Pitchers Today:

  • White Sox starting pitcher: Nick Nastrini 0-1, 3.60 ERA
  • Phillies starting pitcher: Aaron Nola 2-1, 3.58 ERA

White Sox vs. Phillies Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+2.5 -125O 7.5 -110+240
Phillies -2.5 +105U 7.5 -110-300

White Sox vs Phillies Prediction for Today’s Game

Based on recent trends the model predicts the Phillies will win Sunday‘s MLB game with 68.6% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Sunday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Kevin Pillar has hit the Singles Under in 11 of his last 14 games (+6.20 Units / 25% ROI)
  • Robbie Grossman has hit the Total Bases Under in 12 of his last 19 games (+6.00 Units / 28% ROI)
  • Lenyn Sosa has hit the Hits Under in 4 of his last 5 games (+5.45 Units / 109% ROI)
  • Robbie Grossman has hit the Hits Under in 8 of his last 13 away games (+5.15 Units / 39% ROI)
  • Lenyn Sosa has hit the Hits Runs and RBIs Under in his last 5 games (+5.00 Units / 76% ROI)

And here are some favorite MLB player prop bets for Phillies players for Sunday‘s game, looking at profitable historical betting trends:

Best Phillies Player Prop Best Bets Today:

  • Ranger Suarez has hit the Strikeouts Over in 18 of his last 25 games (+10.95 Units / 37% ROI)
  • Aaron Nola has hit the Earned Runs Under in 10 of his last 12 games (+8.05 Units / 52% ROI)
  • Whit Merrifield has hit the Hits Runs and RBIs Under in 7 of his last 8 games at home (+5.80 Units / 56% ROI)
  • Whit Merrifield has hit the Hits Under in 5 of his last 8 games at home (+4.80 Units / 60% ROI)
  • Aaron Nola has hit the Strikeouts Under in 9 of his last 14 games (+4.20 Units / 25% ROI)
  • The Chicago White Sox have hit the Game Total Under in 70 of their last 124 games (+16.15 Units / 12% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 16 away games (+8.13 Units / 45% ROI)
  • The Chicago White Sox have hit the Team Total Under in 13 of their last 19 away games (+6.45 Units / 30% ROI)
  • The Chicago White Sox have covered the Run Line in 15 of their last 22 away games (+6.40 Units / 21% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 away games (+1.84 Units / 27% ROI)
  • The Philadelphia Phillies have hit the Moneyline in 73 of their last 118 games (+13.30 Units / 8% ROI)
  • The Philadelphia Phillies have covered the Run Line in 39 of their last 70 games (+11.85 Units / 15% ROI)
  • The Philadelphia Phillies have hit the 1st Five Innings (F5) Team Total Over in 26 of their last 42 games at home (+8.78 Units / 18% ROI)
  • The Philadelphia Phillies have hit the 1st Five Innings (F5) Moneyline in 9 of their last 13 games (+7.18 Units / 41% ROI)
  • The Philadelphia Phillies have covered the 1st Five Innings (F5) Run Line in 10 of their last 14 games (+6.21 Units / 41% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 8-12 against the Run Line (-6.55 Units / -27.23% ROI).

  • 3-17 when betting on the Moneyline for -11.9 Units / -59.5% ROI
  • 7-12 when betting on the total runs Over for -6.85 Units / -30.51% ROI
  • 12-7 when betting on the total runs Under for +4.25 Units / 19.63% ROI

Phillies Against the Spread (ATS) Record

Against the spread this season, the Phillies are 9-12 against the Run Line (-3.2 Units / -12.65% ROI).

  • 13-8 when betting on the Moneyline for +1.5 Units / 4.12% ROI
  • 8-13 when betting on the total runs Over for -6.45 Units / -27.8% ROI
  • 13-8 when betting on the total runs Under for +4.15 Units / 18.04% ROI

Phillies vs White Sox Home Run Prop Bets Today

Over Under
Kyle Schwarber (PHI) 0.5 +180 0.5 -225
Bryce Harper (PHI) 0.5 +260 0.5 -350
Trea Turner (PHI) 0.5 +260 0.5 -350
J.T. Realmuto (PHI) 0.5 +300 0.5 -375
Nick Castellanos (PHI) 0.5 +375 0.5 -500

Phillies vs White Sox Total Hits Prop Bets Today

Over Under
Alec Bohm (PHI) 0.5 -250 0.5 +195
J.T. Realmuto (PHI) 0.5 -225 0.5 +165
Bryce Harper (PHI) 0.5 -210 0.5 +160
Eloy Jimenez (CWS) 0.5 -210 0.5 +160
Andrew Vaughn (CWS) 0.5 -200 0.5 +150

Phillies vs White Sox RBI Prop Bets Today

Over Under
Kyle Schwarber (PHI) 0.5 +115 0.5 -150
J.T. Realmuto (PHI) 0.5 +120 0.5 -160
Trea Turner (PHI) 0.5 +120 0.5 -160
Bryce Harper (PHI) 0.5 +130 0.5 -175
Alec Bohm (PHI) 0.5 +150 0.5 -200

Phillies vs White Sox Strikeout Prop Bets Today

Over Under

Nick Nastrini has limited playing time.

Phillies Starting Pitcher Stats & Trends

Aaron Nola has thrown his curveball 35% of the time (228/649) when he’s behind in the count since last season — highest among qualified SPs in MLB; League Avg: 11% — 100th Percentile.

Aaron Nola has struck out just 10% (5/49) of left-handed batters he faced this season — lowest among qualified SPs in MLB; League Avg: 24% — first Percentile.

Aaron Nola has walked 25 of 611 batters (4%) when going through the lineup the first time in a game since the 2022 season — 2nd best among qualified SPs in MLB; League Avg: 7% — 96th Percentile.

Opponents are hitting .278 (83-for-299) against Aaron Nola when going through the lineup the second time in a game since last season — 2nd highest among qualified SPs in MLB; League Avg: .241 — fifth Percentile.

White Sox Keys to the Game vs. the Phillies

The White Sox are just 19-45 (.297) after a win since the 2023 season — lowest in MLB; League Avg: .509.

The White Sox are just 50-40 (.556) when allowing 4 or fewer runs since the 2023 season — lowest in MLB; League Avg: .735.

The White Sox are just 8-23 (.258) after a road win since the 2023 season — lowest in MLB; League Avg: .492.

The White Sox are just 54-8 (.871) when leading entering the 9th inning since the 2023 season — lowest in MLB; League Avg: .948.

Phillies Keys to the Game vs. the White Sox

The Phillies are 20-21 (.488) after a win as underdogs since the 2022 season — 3rd best in MLB; League Avg: .412.

The Phillies are 11-9 (.550) after a win as underdogs since the 2023 season — 3rd best in MLB; League Avg: .423.

The Phillies are 7-71 (.090) when trailing entering the 9th inning since the 2023 season — 4th best in MLB; League Avg: .052.

The Phillies are 91-52 (.636) after a win as favorites since the 2022 season — tied for 4th best in MLB; League Avg: .590.

White Sox hitters have an OBP of just .287 (5,137 PA’s) against RHP since last season — lowest in MLB; League Avg: .318.

White Sox hitters have an OBP of just .213 (3,531 PA’s) with two-strikes since last season — lowest in MLB; League Avg: .249.

White Sox hitters are slugging just .290 this season — lowest in MLB; League Avg: .386.

White Sox hitters have an OBP of just .289 (6,680 PA’s) since last season — lowest in MLB; League Avg: .320.

Phillies hitters are slugging .502 when facing the starting pitcher for the 3rd time in a game since the 2022 season — 2nd best in MLB; League Avg: .448.

Phillies hitters have an OPS of .780 (2,164 PA’s) against LHP since last season — 5th best in MLB; League Avg: .738.

Phillies hitters have 538 strikeouts in 2,164 PA’s (25%) against LHP since last season — 5th highest in MLB; League Avg: 22%.

Phillies hitters are slugging .441 against LHP since the 2022 season — 3rd best in MLB; League Avg: .407.

Opponents have a groundball rate of just 41% against White Sox pitchers since last season — 3rd lowest in MLB; League Avg: 43%.

White Sox pitchers have walked 1,271 of 13,206 batters (10%) since the 2022 season — tied for 2nd highest in MLB; League Avg: 8%.

Opponents have a groundball rate of just 41% against White Sox pitchers since the 2022 season — tied for 3rd lowest in MLB; League Avg: 43%.

White Sox pitchers have walked 7 of 174 batters (4%) when facing the leadoff batter in the inning this season — best in MLB; League Avg: 9%.

Opponents have a groundball rate of 45% against Phillies pitchers since the 2022 season — tied for 3rd highest in MLB; League Avg: 43%.

Phillies pitchers have a strikeout rate of 46% with two-strikes this season — 4th best in MLB; League Avg: 42%.

The Phillies won 54% of home games in which their opponents scored first in the 2023 season — highest in MLB; League Avg: 37%.

Opponents have a groundball rate of 51% against Phillies pitchers this season — highest in MLB; League Avg: 43%.

Phillies vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • Taijuan Walker (Philadelphia Phillies): Shoulder, 15-Day IL
  • Orion Kerkering (Philadelphia Phillies): Forearm, 15-Day IL
  • Michael Rucker (Philadelphia Phillies): Hand, 15-Day IL
  • Michael Lorenzen (Philadelphia Phillies): Neck, 15-Day IL
  • Erich Uelmen (Philadelphia Phillies): Forearm, Out
  • Weston Wilson (Philadelphia Phillies): Hand, Day-To-Day
  • Dylan Covey (Philadelphia Phillies): Shoulder, 15-Day IL
  • Rafael Marchan (Philadelphia Phillies): Back, 10-Day IL
  • Eloy Jimenez (Chicago White Sox): Thigh, Day-To-Day
  • Yasmani Grandal (Chicago White Sox): Foot, 10-Day IL
  • Matt Foster (Chicago White Sox): Elbow, 60-Day IL
  • Jake Eder (Chicago White Sox): Shoulder, Day-To-Day
  • Jesse Scholtens (Chicago White Sox): Elbow, 60-Day IL
  • Shane Drohan (Chicago White Sox): Shoulder, 60-Day IL
  • Liam Hendriks (Chicago White Sox): Elbow, 60-Day IL
  • Jimmy Lambert (Chicago White Sox): Shoulder, 60-Day IL
  • Edgar Navarro (Chicago White Sox): Elbow, Out
  • Davis Martin (Chicago White Sox): Elbow, Out
  • Max Stassi (Chicago White Sox): Hip, 10-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.