- The Red Sox are -300 favorites vs the White Sox
- White Sox vs Red Sox Over / Under today: 9 Runs
- White Sox / Red Sox TV Channel: NESN | CHSN | MLBN
The Chicago White Sox (+240) visit Fenway Park to take on the Boston Red Sox (-300) on Monday, April 21, 2025. First pitch is scheduled for 11:10am EDT in Boston, MA, MA.
This season, the White Sox are 5-16 against the spread (ATS), while the Red Sox are 11-12 ATS.
White Sox vs Red Sox Starting Pitchers Today:
- White Sox starting pitcher: Jonathan Cannon 0-2, 4.42 ERA
- Red Sox starting pitcher: Walker Buehler 2-1, 5.23 ERA
White Sox vs. Red Sox Odds, Run Line, Over/Under & Moneyline
| Spread | Over / Under | Moneyline | |
| White Sox | +2.5 -135 | O 9 -105 | +240 |
| Red Sox | -2.5 +110 | U 9 -115 | -300 |
White Sox vs Red Sox Prediction for Today’s Game
Based on recent trends the model predicts the Red Sox will win Monday‘s MLB game with 68.4% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.
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We’ve highlighted some favorite MLB player prop bets for White Sox players for Monday‘s game, looking at profitable historical betting trends:
Best White Sox Player Prop Bets Today:
- Andrew Vaughn has hit the Home Runs Over in 2 of his last 6 games (+10.10 Units / 168% ROI)
- Michael A. Taylor has hit the Hits Runs and RBIs Under in 9 of his last 10 games (+8.75 Units / 86% ROI)
- Brooks Baldwin has hit the Singles Under in 15 of his last 20 away games (+8.20 Units / 27% ROI)
- Brooks Baldwin has hit the Hits Under in 13 of his last 20 away games (+8.05 Units / 40% ROI)
- Michael A. Taylor has hit the Total Bases Under in 9 of his last 10 games (+7.85 Units / 63% ROI)
And here are some favorite MLB player prop bets for Red Sox players for Monday‘s game, looking at profitable historical betting trends:
Best Red Sox Player Prop Best Bets Today:
- Trevor Story has hit the Singles Over in 15 of his last 20 games (+10.35 Units / 48% ROI)
- Triston Casas has hit the Runs Under in his last 10 games (+10.00 Units / 49% ROI)
- Trevor Story has hit the Hits Over in 13 of his last 15 games (+9.00 Units / 30% ROI)
- Rafael Devers has hit the RBIs Under in 9 of his last 10 games (+7.55 Units / 36% ROI)
- Alex Bregman has hit the Total Bases Under in his last 7 games at home (+7.00 Units / 68% ROI)
White Sox Best Bets Today:
- The Chicago White Sox have hit the Team Total Under in 11 of their last 14 games (+7.55 Units / 43% ROI)
- The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Over in 84 of their last 159 games (+4.40 Units / 2% ROI)
- The Chicago White Sox have hit the Game Total Under in 8 of their last 13 games (+3.55 Units / 25% ROI)
- The Chicago White Sox have covered the Run Line in 7 of their last 13 games (+0.40 Units / 3% ROI)
Red Sox Best Bets Today:
- The Boston Red Sox have hit the Team Total Under in 11 of their last 13 games (+8.20 Units / 48% ROI)
- The Boston Red Sox have hit the 1st Five Innings (F5) Moneyline in 11 of their last 18 games (+7.35 Units / 26% ROI)
- The Boston Red Sox have covered the 1st Five Innings (F5) Run Line in their last 5 games (+5.00 Units / 73% ROI)
- The Boston Red Sox have hit the Game Total Under in 13 of their last 23 games (+3.25 Units / 13% ROI)
- The Boston Red Sox have hit the Moneyline in 4 of their last 5 games (+1.45 Units / 14% ROI)
White Sox Against the Spread (ATS) Record
Against the spread this season, the White Sox are 11-10 against the Run Line (-0.2 Units / -0.78% ROI).
- 5-16 when betting on the Moneyline for -7.95 Units / -37.86% ROI
- 9-10 when betting on the total runs Over for -1.95 Units / -8.5% ROI
- 10-9 when betting on the total runs Under for +0 Units / 0% ROI
Red Sox Against the Spread (ATS) Record
Against the spread this season, the Red Sox are 11-12 against the Run Line (-1.7 Units / -5.66% ROI).
- 12-11 when betting on the Moneyline for -3.7 Units / -10.69% ROI
- 9-13 when betting on the total runs Over for -5.05 Units / -20.04% ROI
- 13-9 when betting on the total runs Under for +3.25 Units / 12.8% ROI
Red Sox vs White Sox Home Run Prop Bets Today
| Over | Under | |
|---|---|---|
| Wilyer Abreu (BOS) | 0.5 +400 | 0.5 -550 |
| Rafael Devers (BOS) | 0.5 +400 | 0.5 -550 |
| Alex Bregman (BOS) | 0.5 +500 | 0.5 -700 |
| Jarren Duran (BOS) | 0.5 +500 | 0.5 -700 |
| Luis Robert (CWS) | 0.5 +625 | 0.5 -1000 |
Red Sox vs White Sox Total Hits Prop Bets Today
| Over | Under | |
|---|---|---|
| Alex Bregman (BOS) | 0.5 -275 | 0.5 +195 |
| Rafael Devers (BOS) | 0.5 -250 | 0.5 +185 |
| Trevor Story (BOS) | 0.5 -235 | 0.5 +175 |
| Lenyn Sosa (CWS) | 0.5 -225 | 0.5 +170 |
| Wilyer Abreu (BOS) | 0.5 -220 | 0.5 +165 |
Red Sox vs White Sox RBI Prop Bets Today
| Over | Under | |
|---|---|---|
| Alex Bregman (BOS) | 0.5 +120 | 0.5 -160 |
| Rafael Devers (BOS) | 0.5 +125 | 0.5 -160 |
| Wilyer Abreu (BOS) | 0.5 +135 | 0.5 -175 |
| Jarren Duran (BOS) | 0.5 +155 | 0.5 -210 |
| Kristian Campbell (BOS) | 0.5 +160 | 0.5 -210 |
Red Sox vs White Sox Strikeout Prop Bets Today
| Over | Under | |
|---|---|---|
| Walker Buehler (BOS) | 4.5 -120 | 4.5 -110 |
| Jonathan Cannon (CWS) | 4.5 +120 | 4.5 -155 |
White Sox Starting Pitcher Stats & Trends
Opponents have a line drive rate of just 9% (5/53) against Jonathan Cannon this season — lowest in MLB among starting pitchers with at least 8 total IP; League Avg: 23% — 100th Percentile.
Opponents had a line drive rate of 39% (25/65) versus Jonathan Cannon with runners in scoring position in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 23% — 0 Percentile.
Jonathan Cannon has an ERA of 7.43 (46.0 IP) against division opponents since last season — 2nd highest in MLB among starting pitchers with at least 72 total IP; League Avg: 3.93 — first Percentile.
Opponents had a line drive rate of 33% (51/155) versus Jonathan Cannon on fastballs in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 24% — 0 Percentile.
Red Sox Starting Pitcher Stats & Trends
Walker Buehler has a first-pitch strike rate of 73% (49/67) this month (3 games) — 2nd highest among among AL Starters; League Avg: 63% — 97th Percentile.
Walker Buehler has a strikeout rate of just 11% (3 SO in 27 PAs) when going through the lineup the second time in a game this month (3 games) — tied for 8th lowest among qualified SPs in MLB; League Avg: 23% — 14th Percentile.
Hitters have chased 37 of Walker Buehler’s 85 off-speed pitches out of the zone (43%) this season — tied for highest in MLB among starting pitchers with at least 8 total IP; League Avg: 32% — 100th Percentile.
Hitters have swung at 33% of Walker Buehler’s fastballs (45/135) this season — 2nd lowest in MLB among starting pitchers with at least 8 total IP; League Avg: 48% — first Percentile.
White Sox Keys to the Game vs. the Red Sox
The White Sox were just 33-23 (.589) when leading entering the 7th inning in the 2024 season — lowest in MLB; League Avg: .856.
The White Sox were just 26-95 (.215) after a loss in the 2024 season — lowest in MLB; League Avg: .504.
The White Sox are just 19-71 (.211) on the road since last season — lowest in MLB; League Avg: .469.
The White Sox are just 29-108 (.212) after a loss since last season — lowest in MLB; League Avg: .505.
Red Sox Keys to the Game vs. the White Sox
The Red Sox are just 14-137 (.093) when trailing entering the 7th inning since the 2023 season — 3rd lowest in MLB; League Avg: .140.
The Red Sox are just 4-6 (.400) after a loss this season — 4th lowest in MLB; League Avg: .522.
The Red Sox are 1-9 (.100) when trailing entering the 9th inning this season — tied for 5th best in MLB; League Avg: .034.
The Red Sox are just 0-8 (.000) when trailing entering the 7th inning this season — tied for lowest in MLB; League Avg: .116.
White Sox Hitting Stats & Trends
The White Sox had a winning percentage of just 28% at home last season — lowest in MLB; League Avg: 52%.
White Sox hitters have an OBP of just .284 (12,608 PA’s) since the 2023 season — lowest in MLB; League Avg: .316.
White Sox hitters have an OBP of just .282 (9,493 PA’s) against RHP since the 2023 season — lowest in MLB; League Avg: .315.
White Sox hitters have an OBP of just .287 (6,279 PA’s) at home since the 2023 season — lowest in MLB; League Avg: .320.
Red Sox Hitting Stats & Trends
Red Sox hitters struck out 506 times in 1,816 PA’s (28%) against LHP in the 2024 season — highest in MLB; League Avg: 23%.
Red Sox hitters have put just 32% of their swings in play against LHP since last season — lowest in MLB; League Avg: 36%.
Red Sox hitters have drawn walks in 14% of its PA’s against LHP this season — best in MLB; League Avg: 9%.
Red Sox hitters have struck out in 28% of it’s PA’s against LHP since last season — 2nd highest in MLB; League Avg: 23%.
White Sox Pitching Stats & Trends
The White Sox won just 11% of games in which their opponents scored first last season — lowest in MLB; League Avg: 31%.
White Sox pitchers have walked 10% of batters since last season — highest in MLB; League Avg: 8%.
In games when their opponents scored three or more runs in an inning, the White Sox won just 4% of the time last season — lowest in MLB; League Avg: 24%.
The White Sox have won just 17% of games in which their opponents scored first since the 2023 season — lowest in MLB; League Avg: 33%.
Red Sox Pitching Stats & Trends
Red Sox pitchers have walked 8% of batters this season — tied for 4th best in MLB; League Avg: 9%.
Opponents have a miss rate of just 24% against Red Sox pitchers since last season — 2nd lowest in MLB; League Avg: 25%.
Red Sox pitchers have walked 7% of batters when facing the leadoff batter in the inning since last season — 5th best in MLB; League Avg: 8%.
Opponents have a groundball batting average of .299 against Red Sox pitchers this season — 2nd highest in MLB; League Avg: .248.
More MLB Reading:
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