White Sox vs Royals Prediction, Odds & Player Prop Bets Today – MLB, May 7

(AP Photo/Colin E. Braley)
  • The Royals are -225 favorites vs the White Sox
  • White Sox vs Royals Over / Under today: 8.5 Runs
  • White Sox / Royals TV Channel: FDKC | CHSN

The Chicago White Sox (+185) visit Kauffman Stadium to take on the Kansas City Royals (-225) on Wednesday, May 7, 2025. First pitch is scheduled for 7:40pm EDT in Kansas City, MO, MO.

This season, the White Sox are 10-26 against the spread (ATS), while the Royals are 18-19 ATS.

White Sox vs Royals Starting Pitchers Today:

  • White Sox starting pitcher: Jonathan Cannon 2-3, 4.27 ERA
  • Royals starting pitcher: Michael Wacha 1-4, 3.52 ERA

White Sox vs. Royals Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 -115O 8.5 -110+185
Royals -1.5 -105U 8.5 -110-225

White Sox vs Royals Prediction for Today’s Game

Based on recent trends the model predicts the Royals will win Wednesday‘s MLB game with 65.1% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Wednesday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Miguel Vargas has hit the Total Bases Over in 12 of his last 15 games (+8.15 Units / 40% ROI)
  • Miguel Vargas has hit the Hits Over in 12 of his last 15 games (+7.00 Units / 33% ROI)
  • Miguel Vargas has hit the Singles Over in 9 of his last 15 games (+6.80 Units / 45% ROI)
  • Jonathan Cannon has hit the Earned Runs Over in his last 6 away games (+6.10 Units / 82% ROI)
  • Chase Meidroth has hit the Runs Over in 5 of his last 7 games (+6.00 Units / 86% ROI)

And here are some favorite MLB player prop bets for Royals players for Wednesday‘s game, looking at profitable historical betting trends:

Best Royals Player Prop Best Bets Today:

  • Kyle Isbel has hit the Home Runs Over in 2 of his last 4 games (+23.00 Units / 575% ROI)
  • Salvador Perez has hit the Runs Under in 20 of his last 25 games (+11.90 Units / 26% ROI)
  • Salvador Perez has hit the Total Bases Over in 8 of his last 10 games (+7.95 Units / 80% ROI)
  • Maikel Garcia has hit the Hits Over in 11 of his last 15 games (+7.15 Units / 27% ROI)
  • Kyle Isbel has hit the Hits Runs and RBIs Over in his last 6 games at home (+6.55 Units / 84% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 11 of their last 13 games (+9.50 Units / 66% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Moneyline in 6 of their last 12 games (+7.35 Units / 60% ROI)
  • The Chicago White Sox have hit the Team Total Under in 12 of their last 17 away games (+6.90 Units / 34% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 11 of their last 15 away games (+6.70 Units / 37% ROI)
  • The Chicago White Sox have hit the Game Total Under in 11 of their last 16 away games (+5.60 Units / 32% ROI)
  • The Kansas City Royals have hit the Team Total Under in 27 of their last 37 games (+16.55 Units / 39% ROI)
  • The Kansas City Royals have hit the Moneyline in 13 of their last 15 games (+13.35 Units / 61% ROI)
  • The Kansas City Royals have hit the Game Total Under in 21 of their last 29 games (+13.25 Units / 41% ROI)
  • The Kansas City Royals have covered the 1st Five Innings (F5) Run Line in 10 of their last 13 games (+6.20 Units / 38% ROI)
  • The Kansas City Royals have covered the Run Line in 10 of their last 13 games (+5.90 Units / 33% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 19-17 against the Run Line (+0.6 Units / 1.44% ROI).

  • 10-26 when betting on the Moneyline for -9.6 Units / -26.67% ROI
  • 17-17 when betting on the total runs Over for -1.8 Units / -4.53% ROI
  • 17-17 when betting on the total runs Under for -1.7 Units / -4.3% ROI

Royals Against the Spread (ATS) Record

Against the spread this season, the Royals are 18-19 against the Run Line (-7.05 Units / -13.47% ROI).

  • 21-16 when betting on the Moneyline for +5.85 Units / 12.59% ROI
  • 12-24 when betting on the total runs Over for -14 Units / -34.78% ROI
  • 24-12 when betting on the total runs Under for +10.75 Units / 26.12% ROI

Royals vs White Sox Home Run Prop Bets Today

Over Under
Bobby Witt Jr. (KC) 0.5 +475 0.5 -650
Salvador Perez (KC) 0.5 +525 0.5 -750
Luis Robert (CWS) 0.5 +625 0.5 -1000
Vinnie Pasquantino (KC) 0.5 +625 0.5 -1000
Andrew Vaughn (CWS) 0.5 +650 0.5 -1100

Royals vs White Sox Total Hits Prop Bets Today

Over Under
Jonathan India (KC) 0.5 -225 0.5 +170
Salvador Perez (KC) 0.5 -225 0.5 +170
Vinnie Pasquantino (KC) 0.5 -225 0.5 +170
Chase Meidroth (CWS) 0.5 -200 0.5 +150
Andrew Vaughn (CWS) 0.5 -200 0.5 +155

Royals vs White Sox RBI Prop Bets Today

Over Under
Salvador Perez (KC) 0.5 +120 0.5 -160
Bobby Witt Jr. (KC) 0.5 +135 0.5 -185
Vinnie Pasquantino (KC) 0.5 +135 0.5 -175
Michael Massey (KC) 0.5 +165 0.5 -220
Maikel Garcia (KC) 0.5 +175 0.5 -235

Royals vs White Sox Strikeout Prop Bets Today

Over Under
Michael Wacha (KC) 4.5 -115 4.5 -115
Jonathan Cannon (CWS) 3.5 +100 3.5 -130

Jonathan Cannon has 5 three-pitch strikeouts over the last 14 days — most in AL over the last two weeks — 100th Percentile.

Opponents had a line drive rate of 39% (25/65) versus Jonathan Cannon with runners in scoring position in the 2024 season — highest in MLB among starting pitchers with at least 64 total IP; League Avg: 23% — 0 Percentile.

Jonathan Cannon has an ERA of 7.43 (46.0 IP) against division opponents since last season — 4th highest in MLB among starting pitchers with at least 78 total IP; League Avg: 3.89 — second Percentile.

Jonathan Cannon has allowed an OPS of just .462 with RISP this season — 14th best among starting pitchers with at least 13 total IP– 89th Percentile. He allowed an OPS of .946 (94 PAs) with RISP last season — sixth worst among starting pitchers with at least 64 total IP– fourth Percentile.

Royals Starting Pitcher Stats & Trends

Michael Wacha threw his breaking pitches for a strike just 47% (212/452) of the time in the 2024 season — lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 62% — 0 Percentile.

Michael Wacha has thrown his breaking pitches for a strike just 48% (264/547) of the time since last season — lowest in MLB among starting pitchers with at least 78 total IP; League Avg: 62% — 0 Percentile.

Hitters swung at 28% of Michael Wacha’s breaking pitches (128/452) in the 2024 season — lowest in MLB among starting pitchers with at least 64 total IP; League Avg: 46% — 0 Percentile.

Opponents batted just .188 (45-for-239) against Michael Wacha when going through the lineup the first time in a game in the 2024 season — 5th best among qualified SPs in MLB; League Avg: .231 — 93rd Percentile.

White Sox Keys to the Game vs. the Royals

The White Sox are just 41-25 (.621) when leading entering the 7th inning since last season — lowest in MLB; League Avg: .860.

The White Sox are just 50-124 (.287) when allowing 5 or more extra base hits since last season — lowest in MLB; League Avg: .536.

The White Sox are just 5-52 (.088) when their opponents score in the first inning since last season — lowest in MLB; League Avg: .365.

The White Sox are just 21-78 (.212) on the road since last season — lowest in MLB; League Avg: .467.

Royals Keys to the Game vs. the White Sox

The Royals are just 5-59 (.078) when allowing 5 or more runs since last season — 2nd lowest in MLB; League Avg: .191.

The Royals were just 4-50 (.074) when they allowed 5 or more runs in the 2024 season — 2nd lowest in MLB; League Avg: .196.

The Royals are just 17-83 (.170) when allowing 2 or more home runs since the 2023 season — lowest in MLB; League Avg: .299.

The Royals are just 23-67 (.256) when their opponents score in the first inning since the 2023 season — 2nd lowest in MLB; League Avg: .376.

White Sox hitters have an OBP of just .285 (9,931 PA’s) against RHP since the 2023 season — lowest in MLB; League Avg: .316.

White Sox hitters have an OBP of just .286 (13,166 PA’s) since the 2023 season — lowest in MLB; League Avg: .316.

White Sox hitters have an OBP of just .289 (6,497 PA’s) at home since the 2023 season — lowest in MLB; League Avg: .320.

White Sox hitters had an OBP of just .278 (5,869 PA’s) in the 2024 season — lowest in MLB; League Avg: .312.

Royals hitters had an OBP of just .280 (2,958 PA’s) on the road in 2023 — lowest in MLB; League Avg: .316.

Royals hitters have struck out in just 19% of it’s PA’s since last season — 2nd best in MLB; League Avg: 22%.

The Royals are batting just .319 on the first pitch of at-bats since the 2023 season — tied for 2nd lowest in MLB; League Avg: .340.

Royals hitters have struck out in just 20% of it’s PA’s against LHP since last season — tied for 4th best in MLB; League Avg: 23%.

White Sox pitchers walked 643 of 6,241 batters (10%) in the 2024 season — highest in MLB; League Avg: 8%.

White Sox pitchers have walked 10% of batters since last season — highest in MLB; League Avg: 8%.

White Sox pitchers have walked 10% of batters since the 2023 season — highest in MLB; League Avg: 8%.

White Sox pitchers have a strike rate of just 61% this season — lowest in MLB; League Avg: 64%.

The longest HR allowed by the Royals pitchers in the 2024 season traveled 519.4 feet — — longest in MLB; League Avg: 470.4

Royals pitchers have an ERA of 3.31 (163.1 IP) on the road this season — best in MLB; League Avg: 4.38.

Royals pitchers have a strikeout rate of just 20% in close and late situations since last season — tied for lowest in MLB; League Avg: 25%.

Royals pitchers picked-off 19 runners from first base in 2023 — best in MLB.

More MLB Reading:


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Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.

Our BetMGM betting authors are experts who focus on individual game matchups & player prop bets with an emphasis on betting odds, lines & predictions.