White Sox vs Twins Prediction, Odds & Player Prop Bets Today – MLB, Apr 22

Minnesota Twins' Max Kepler celebrates while crossing home plate to score the game-winning run against the San Diego Padres during the 11th inning of a baseball game Wednesday, May 10, 2023, in Minneapolis. (AP Photo/Abbie Parr)
(AP Photo/Abbie Parr)
  • The Twins are -175 favorites vs the White Sox
  • White Sox vs Twins Over / Under today: 8 Runs
  • White Sox / Twins TV Channel: BSNO | FS1 | NSCH

The Chicago White Sox (+155) visit Target Field to take on the Minnesota Twins (-190) on Monday, April 22, 2024. First pitch is scheduled for 7:40pm EDT in Minneapolis, MN.

This season, the White Sox are 3-18 against the spread (ATS), while the Twins are 7-13 ATS.

White Sox vs Twins Starting Pitchers Today:

  • White Sox starting pitcher: Jonathan Cannon 0-0, 1.80 ERA
  • Twins starting pitcher: Chris Paddack 0-1, 8.36 ERA

White Sox vs. Twins Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneyline
White Sox+1.5 -125O 8.5 -115+155
Twins -1.5 +105U 8.5 -105-190

White Sox vs Twins Prediction for Today’s Game

Based on recent trends the model predicts the Twins will win Monday‘s MLB game with 56.8% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.


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We’ve highlighted some favorite MLB player prop bets for White Sox players for Monday‘s game, looking at profitable historical betting trends:

Best White Sox Player Prop Bets Today:

  • Andrew Vaughn has hit the Hits Under in 14 of his last 18 games (+14.35 Units / 53% ROI)
  • Andrew Vaughn has hit the Total Bases Under in 16 of his last 20 games (+10.70 Units / 35% ROI)
  • Andrew Vaughn has hit the Singles Under in 11 of his last 14 games (+8.15 Units / 47% ROI)
  • Andrew Vaughn has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+7.65 Units / 32% ROI)
  • Dominic Fletcher has hit the Hits Runs and RBIs Under in 12 of his last 16 away games (+6.40 Units / 27% ROI)

And here are some favorite MLB player prop bets for Twins players for Monday‘s game, looking at profitable historical betting trends:

Best Twins Player Prop Best Bets Today:

  • Jose Miranda has hit the Hits Under in his last 6 games at home (+9.10 Units / 152% ROI)
  • Manuel Margot has hit the Total Bases Under in his last 6 games (+7.00 Units / 74% ROI)
  • Jose Miranda has hit the Total Bases Under in his last 6 games at home (+6.90 Units / 90% ROI)
  • Jose Miranda has hit the Hits Runs and RBIs Under in his last 6 games at home (+6.05 Units / 77% ROI)
  • Jose Miranda has hit the Singles Under in his last 6 games at home (+6.00 Units / 71% ROI)
  • The Chicago White Sox have hit the Game Total Under in 70 of their last 124 games (+16.15 Units / 12% ROI)
  • The Chicago White Sox have hit the 1st Five Innings (F5) Team Total Under in 12 of their last 16 away games (+8.13 Units / 45% ROI)
  • The Chicago White Sox have hit the Team Total Under in 13 of their last 19 away games (+6.45 Units / 30% ROI)
  • The Chicago White Sox have covered the Run Line in 15 of their last 22 away games (+6.40 Units / 21% ROI)
  • The Chicago White Sox have covered the 1st Five Innings (F5) Run Line in 4 of their last 6 away games (+1.84 Units / 27% ROI)
  • The Minnesota Twins have covered the Run Line in 31 of their last 50 games (+14.40 Units / 24% ROI)
  • The Minnesota Twins have hit the Game Total Over in 47 of their last 78 games (+13.95 Units / 16% ROI)
  • The Minnesota Twins have hit the Team Total Over in 48 of their last 77 games (+13.50 Units / 15% ROI)
  • The Minnesota Twins have hit the 1st Five Innings (F5) Team Total Under in 25 of their last 40 games at home (+7.65 Units / 16% ROI)
  • The Minnesota Twins have hit the Moneyline in 28 of their last 45 games at home (+2.85 Units / 4% ROI)

White Sox Against the Spread (ATS) Record

Against the spread this season, the White Sox are 8-13 against the Run Line (-7.55 Units / -30.14% ROI).

  • 3-18 when betting on the Moneyline for -12.9 Units / -61.43% ROI
  • 8-12 when betting on the total runs Over for -5.85 Units / -24.79% ROI
  • 12-8 when betting on the total runs Under for +3.2 Units / 14.1% ROI

Twins Against the Spread (ATS) Record

Against the spread this season, the Twins are 7-13 against the Run Line (-8.45 Units / -32.63% ROI).

  • 7-13 when betting on the Moneyline for -7.45 Units / -32.04% ROI
  • 8-11 when betting on the total runs Over for -4.2 Units / -18.75% ROI
  • 11-8 when betting on the total runs Under for +2.4 Units / 11.09% ROI

Twins vs White Sox Home Run Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +270 0.5 -350
Max Kepler (MIN) 0.5 +290 0.5 -375
Trevor Larnach (MIN) 0.5 +350 0.5 -450
Ryan Jeffers (MIN) 0.5 +400 0.5 -550
Gavin Sheets (CWS) 0.5 +425 0.5 -600

Twins vs White Sox Total Hits Prop Bets Today

Over Under
Ryan Jeffers (MIN) 0.5 -275 0.5 +195
Gavin Sheets (CWS) 0.5 -250 0.5 +185
Eloy Jimenez (CWS) 0.5 -250 0.5 +190
Andrew Vaughn (CWS) 0.5 -250 0.5 +180
Byron Buxton (MIN) 0.5 -225 0.5 +165

Twins vs White Sox RBI Prop Bets Today

Over Under
Byron Buxton (MIN) 0.5 +110 0.5 -145
Max Kepler (MIN) 0.5 +115 0.5 -155
Trevor Larnach (MIN) 0.5 +140 0.5 -185
Alex Kirilloff (MIN) 0.5 +145 0.5 -190
Ryan Jeffers (MIN) 0.5 +145 0.5 -200

Twins vs White Sox Strikeout Prop Bets Today

Over Under

Jonathan Cannon has limited playing time.

Twins Starting Pitcher Stats & Trends

Opponents are hitting .533 (8-for-15) against Chris Paddack when facing the leadoff batter in the inning this season — 2nd highest in MLB among starting pitchers with at least 8 total IP; League Avg: .237 — first Percentile.

Chris Paddack has allowed a slugging percentage of .933 (14 Total Bases / 15 ABs) when facing the leadoff batter in the inning this season — 4th highest in MLB among starting pitchers with at least 8 total IP; League Avg: .392 — second Percentile.

Chris Paddack has struck out just 5% (2/40) of left-handed batters he faced this season — lowest in MLB among starting pitchers with at least 8 total IP; League Avg: 22% — first Percentile.

Opponents have a line drive rate of 36% (20/55) against Chris Paddack this season — 4th highest in MLB among starting pitchers with at least 8 total IP; League Avg: 24% — second Percentile.

White Sox Keys to the Game vs. the Twins

The White Sox are just 54-8 (.871) when leading entering the 9th inning since the 2023 season — lowest in MLB; League Avg: .948.

The White Sox are just 47-17 (.734) when leading entering the 7th inning since the 2023 season — 2nd lowest in MLB; League Avg: .856.

The White Sox are just 51-11 (.823) when leading entering the 8th inning since the 2023 season — 2nd lowest in MLB; League Avg: .898.

The White Sox are just 50-40 (.556) when allowing 4 or fewer runs since the 2023 season — lowest in MLB; League Avg: .736.

Twins Keys to the Game vs. the White Sox

The Twins are just 14-29 (.326) when tied entering the 7th inning since the 2022 season — lowest in MLB; League Avg: .500.

The Twins are 19-60 (.241) when trailing entering the 7th inning since the 2023 season — 2nd best in MLB; League Avg: .144.

The Twins are just 14-20 (.412) when tied entering the 8th inning since the 2022 season — 5th lowest in MLB; League Avg: .500.

The Twins are 36-13 (.735) when they’ve scored in the first inning since the 2023 season — 2nd best in MLB; League Avg: .615.

team hitters – away

team hitters – home

team pitchers – away

team pitchers – home

Twins vs. White Sox Injuries Tonight That May Affect Prop Bets 

  • Zack Weiss (Minnesota Twins): Shoulder, 15-Day IL
  • Jhoan Duran (Minnesota Twins): Oblique, 15-Day IL
  • Anthony DeSclafani (Minnesota Twins): Elbow, 60-Day IL
  • Matt Canterino (Minnesota Twins): Shoulder, 7-Day IL
  • Trevor Larnach (Minnesota Twins): Toe, 7-Day IL
  • Royce Lewis (Minnesota Twins): Quadriceps, 10-Day IL
  • Max Kepler (Minnesota Twins): Leg, Day-To-Day
  • Jovani Moran (Minnesota Twins): Elbow, 60-Day IL
  • Josh Staumont (Minnesota Twins): Calf, 15-Day IL
  • Caleb Thielbar (Minnesota Twins): Hamstring, 15-Day IL
  • Justin Topa (Minnesota Twins): Kneecap, 15-Day IL
  • Jose De Leon (Minnesota Twins): Elbow, Out
  • Josh Winder (Minnesota Twins): Shoulder, 60-Day IL
  • Eloy Jimenez (Chicago White Sox): Thigh, Day-To-Day
  • Yasmani Grandal (Chicago White Sox): Foot, 10-Day IL
  • Matt Foster (Chicago White Sox): Elbow, 60-Day IL
  • Jake Eder (Chicago White Sox): Shoulder, Day-To-Day
  • Jesse Scholtens (Chicago White Sox): Elbow, 60-Day IL
  • Shane Drohan (Chicago White Sox): Shoulder, 60-Day IL
  • Liam Hendriks (Chicago White Sox): Elbow, 60-Day IL
  • Jimmy Lambert (Chicago White Sox): Shoulder, 60-Day IL
  • Edgar Navarro (Chicago White Sox): Elbow, Out
  • Davis Martin (Chicago White Sox): Elbow, Out
  • Max Stassi (Chicago White Sox): Hip, 10-Day IL

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Our BetMGM editors and authors are sports experts with a wealth of knowledge of the sports industry at all levels. Their coverage includes sports news, previews and predictions, fun facts, and betting.