Wright State fell behind Arizona by 11 points five minutes into a first round game in the 2022 NCAA Tournament and never recovered.
While the Raiders didn’t join UMBC as the only 16-seeds to beat a 1-seed in tourney history – and set the record for biggest March Madness upset ever – they covered the spread (+21.5) to push 16-seeds over .500 against the spread vs. 1-seeds since 2005.
Biggest Spreads for 1-vs-16 Games
Kentucky was a 34.5-point favorite against Hampton in the first round of the 2015 NCAA Tournament.
It’s the biggest spread for a 1-16 game since 2005, per Bet Labs. Only two other 1-seeds have been favored by at least 30 points over that time: Gonzaga (-33) vs. Norfolk State in 2021, and UCLA (-31.5) vs. Mississippi Valley State in 2008.
Spread History for 1 vs. 16 Seeds
16-seeds are 34-33-1 ATS against 1-seeds since 2005:
| Year | 1-Seed | 16-Seed | Spread | Result |
| 2006 | Memphis | Oral Roberts | -10.5 | W |
| 2018 | Kansas | Pennsylvania | -13.5 | W |
| 2012 | Syracuse | NC Asheville | -15.5 | L |
| 2010 | Syracuse | Vermont | -15.5 | W |
| 2012 | North Carolina | Vermont | -16 | W |
| 2014 | Wichita State | Cal Poly | -16.5 | W |
| 2012 | Michigan State | Long Island Brooklyn | -18.5 | W |
| 2011 | Pittsburgh | NC Asheville | -18.5 | W |
| 2010 | Kentucky | E Tennessee St | -18.5 | W |
| 2018 | Xavier | Texas Southern | -19 | P |
| 2007 | Kansas | Niagara | -19 | W |
| 2014 | Virginia | Coastal Carolina | -19.5 | L |
| 2015 | Wisconsin | Coastal Carolina | -20 | L |
| 2014 | Arizona | Weber State | -20 | L |
| 2009 | Connecticut | Tennessee Chat | -20 | W |
| 2007 | Ohio State | Central Conn | -20 | W |
| 2006 | Villanova | Monmouth | -20 | L |
| 2006 | Connecticut | Albany | -20 | L |
| 2005 | Washington | Montana | -20 | L |
| 2022 | Baylor | Norfolk State | -20.5 | W |
| 2018 | Virginia | UMBC | -20.5 | L |
| 2013 | Kansas | Western Kentucky | -20.5 | L |
| 2009 | Pittsburgh | E Tennessee St | -20.5 | L |
| 2008 | Kansas | Portland State | -21 | W |
| 2022 | Arizona | Wright State | -21.5 | L |
| 2014 | Florida | Albany | -21.5 | L |
| 2013 | Indiana | James Madison | -21.5 | L |
| 2009 | Louisville | Morehead State | -21.5 | L |
| 2015 | Villanova | Lafayette | -22 | W |
| 2022 | Kansas | Texas Southern | -22.5 | W |
| 2022 | Gonzaga | Georgia State | -22.5 | L |
| 2021 | Illinois | Drexel | -22.5 | W |
| 2019 | Virginia | Gardner Webb | -22.5 | L |
| 2018 | Villanova | Radford | -22.5 | W |
| 2016 | Oregon | Holy Cross | -22.5 | W |
| 2016 | North Carolina | Florida Gulf Coast | -22.5 | L |
| 2015 | Duke | Robert Morris | -22.5 | W |
| 2013 | Gonzaga | Southern | -22.5 | L |
| 2017 | Kansas | UC Davis | -23 | W |
| 2016 | Virginia | Hampton | -23 | W |
| 2017 | Gonzaga | South Dakota State | -23.5 | L |
| 2011 | Kansas | Boston U | -23.5 | L |
| 2019 | North Carolina | Iona | -24 | L |
| 2021 | Michigan | Texas Southern | -24.5 | L |
| 2016 | Kansas | Austin Peay | -24.5 | W |
| 2011 | Duke | Hampton | -24.5 | W |
| 2010 | Duke | Arkansas Pine Bluff | -24.5 | W |
| 2017 | Villanova | Mount St Marys | -25 | L |
| 2010 | Kansas | Lehigh | -25 | L |
| 2009 | North Carolina | Radford | -25 | W |
| 2008 | North Carolina | Mount St Marys | -25 | W |
| 2021 | Baylor | Hartford | -25.5 | L |
| 2011 | Ohio State | UTSA | -25.5 | W |
| 2008 | Memphis | Texas Arlington | -26 | L |
| 2006 | Duke | Southern | -26 | L |
| 2005 | Illinois | Fairleigh Dickinson | -26 | L |
| 2017 | North Carolina | Texas Southern | -26.5 | W |
| 2013 | Louisville | North Carolina A&T | -26.5 | W |
| 2012 | Kentucky | Western Kentucky | -26.5 | L |
| 2005 | Duke | Delaware State | -26.5 | L |
| 2019 | Duke | North Dakota State | -27.5 | L |
| 2007 | Florida | Jacksonville State | -27.5 | W |
| 2007 | North Carolina | Eastern Kentucky | -27.5 | L |
| 2005 | North Carolina | Oakland | -27.5 | W |
| 2019 | Gonzaga | Fairleigh Dickinson | -28.5 | W |
| 2008 | UCLA | Mississippi Valley State | -31.5 | W |
| 2021 | Gonzaga | Norfolk State | -33 | W |
| 2015 | Kentucky | Hampton | -34.5 | L |
Daily College Basketball Odds at BetMGM
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